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Protein

Glutamate decarboxylase 1

Gene

GAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the production of GABA.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

pyridoxal 5'-phosphate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei567Substrate1

GO - Molecular functioni

  • glutamate binding Source: Ensembl
  • glutamate decarboxylase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: Ensembl

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • gamma-aminobutyric acid biosynthetic process Source: Ensembl
  • glutamate catabolic process Source: UniProtKB
  • glutamate decarboxylation to succinate Source: ProtInc
  • neurotransmitter biosynthetic process Source: UniProtKB-KW
  • neurotransmitter secretion Source: Reactome
  • protein-pyridoxal-5-phosphate linkage Source: UniProtKB
  • response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Neurotransmitter biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS05215-MONOMER.
ZFISH:HS05215-MONOMER.
BRENDAi4.1.1.15. 2681.
ReactomeiR-HSA-888568. GABA synthesis.
R-HSA-888590. GABA synthesis, release, reuptake and degradation.
SIGNORiQ99259.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 1 (EC:4.1.1.15)
Alternative name(s):
67 kDa glutamic acid decarboxylase
Short name:
GAD-67
Glutamate decarboxylase 67 kDa isoform
Gene namesi
Name:GAD1
Synonyms:GAD, GAD67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4092. GAD1.

Subcellular locationi

GO - Cellular componenti

  • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Source: Reactome
  • intracellular Source: UniProtKB
  • plasma membrane Source: Reactome
  • presynaptic active zone Source: Ensembl
  • vesicle membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Cerebral palsy, spastic quadriplegic 1 (CPSQ1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.
See also OMIM:603513
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03102112S → C in CPSQ1. 1 PublicationCorresponds to variant rs121918345dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2571.
MalaCardsiGAD1.
MIMi603513. phenotype.
OpenTargetsiENSG00000128683.
Orphaneti210141. Inherited congenital spastic tetraplegia.
PharmGKBiPA28507.

Chemistry databases

ChEMBLiCHEMBL2614.

Polymorphism and mutation databases

BioMutaiGAD1.
DMDMi1352213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469631 – 594Glutamate decarboxylase 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei405N6-(pyridoxal phosphate)lysine1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99259.
PaxDbiQ99259.
PeptideAtlasiQ99259.
PRIDEiQ99259.

PTM databases

iPTMnetiQ99259.
PhosphoSitePlusiQ99259.

Expressioni

Tissue specificityi

Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain.1 Publication

Gene expression databases

BgeeiENSG00000128683.
CleanExiHS_GAD1.
ExpressionAtlasiQ99259. baseline and differential.
GenevisibleiQ99259. HS.

Organism-specific databases

HPAiCAB004415.
HPA031949.
HPA048871.
HPA058412.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-743184,EBI-741181
CMTM5Q96DZ94EBI-743184,EBI-2548702
HAAOP469526EBI-743184,EBI-743215
NCK1P163332EBI-743184,EBI-389883
STK3Q131883EBI-743184,EBI-992580

Protein-protein interaction databases

BioGridi108845. 8 interactors.
DIPiDIP-29292N.
IntActiQ99259. 10 interactors.
MINTiMINT-3058814.
STRINGi9606.ENSP00000350928.

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni94 – 97Combined sources4
Helixi100 – 102Combined sources3
Helixi110 – 131Combined sources22
Helixi144 – 149Combined sources6
Helixi165 – 177Combined sources13
Beta strandi187 – 192Combined sources6
Helixi197 – 209Combined sources13
Beta strandi212 – 214Combined sources3
Turni216 – 218Combined sources3
Helixi220 – 237Combined sources18
Beta strandi241 – 243Combined sources3
Beta strandi245 – 251Combined sources7
Helixi252 – 267Combined sources16
Helixi270 – 274Combined sources5
Helixi276 – 278Combined sources3
Beta strandi282 – 287Combined sources6
Helixi293 – 300Combined sources8
Helixi305 – 307Combined sources3
Beta strandi308 – 311Combined sources4
Helixi321 – 333Combined sources13
Beta strandi337 – 346Combined sources10
Beta strandi348 – 350Combined sources3
Helixi356 – 366Combined sources11
Beta strandi369 – 374Combined sources6
Helixi377 – 382Combined sources6
Turni384 – 386Combined sources3
Helixi387 – 390Combined sources4
Helixi393 – 395Combined sources3
Beta strandi397 – 401Combined sources5
Beta strandi414 – 420Combined sources7
Helixi423 – 428Combined sources6
Turni433 – 435Combined sources3
Helixi444 – 446Combined sources3
Helixi449 – 451Combined sources3
Helixi461 – 495Combined sources35
Beta strandi500 – 506Combined sources7
Beta strandi509 – 511Combined sources3
Beta strandi513 – 517Combined sources5
Helixi520 – 522Combined sources3
Helixi529 – 549Combined sources21
Beta strandi553 – 559Combined sources7
Beta strandi562 – 568Combined sources7
Helixi577 – 591Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OKJX-ray2.30A/B93-594[»]
3VP6X-ray2.10A/B90-594[»]
ProteinModelPortaliQ99259.
SMRiQ99259.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99259.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 192Substrate binding3

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ99259.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ99259.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99259-1) [UniParc]FASTAAdd to basket
Also known as: GAD67

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF
60 70 80 90 100
LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA
110 120 130 140 150
RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG
160 170 180 190 200
MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL
210 220 230 240 250
AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP
260 270 280 290 300
GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA
310 320 330 340 350
LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY
360 370 380 390 400
GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT
410 420 430 440 450
WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD
460 470 480 490 500
KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF
510 520 530 540 550
EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG
560 570 580 590
TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
Length:594
Mass (Da):66,897
Last modified:February 1, 1996 - v1
Checksum:i6D761C471C81FDAE
GO
Isoform 2 (identifier: Q99259-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: Q99259-3) [UniParc]FASTAAdd to basket
Also known as: GAD25

The sequence of this isoform differs from the canonical sequence as follows:
     214-224: FTYEIAPVFVL → PSDMRECWLLR
     225-594: Missing.

Note: Lacks enzymatic activity.
Show »
Length:224
Mass (Da):25,279
Checksum:i2CDCB04ECD6BC2E9
GO
Isoform 4 (identifier: Q99259-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     374-425: AAWGGGLLMS...ILVKEKGILQ → GFNFSQLANR...WAAHVQEAPP
     426-594: Missing.

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):47,440
Checksum:iF392B68338CC6800
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9Missing in AAA35900 (Ref. 7) Curated1
Sequence conflicti16 – 17GA → EP in AAB59427 (PubMed:1339255).Curated2
Sequence conflicti16 – 17GA → EP in CAA80435 (PubMed:1339255).Curated2
Sequence conflicti17A → Q in AAA35900 (Ref. 7) Curated1
Sequence conflicti18D → N in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti31T → N in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti68K → R in AAA62368 (PubMed:8088791).Curated1
Sequence conflicti116F → L in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti136T → A in AAA35900 (Ref. 7) Curated1
Sequence conflicti140D → E in AAA35900 (Ref. 7) Curated1
Sequence conflicti142H → R in AAA35900 (Ref. 7) Curated1
Sequence conflicti155N → T in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti206T → N in AAB59427 (PubMed:1339255).Curated1
Sequence conflicti206T → N in CAA80435 (PubMed:1339255).Curated1
Sequence conflicti302G → C in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti436F → L in AAB26937 (PubMed:8507202).Curated1
Sequence conflicti477E → G in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti492A → G in AAB26938 (PubMed:8507203).Curated1
Sequence conflicti512N → S in AAB26937 (PubMed:8507202).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03102112S → C in CPSQ1. 1 PublicationCorresponds to variant rs121918345dbSNPEnsembl.1
Natural variantiVAR_018861228I → L.1 PublicationCorresponds to variant rs45566933dbSNPEnsembl.1
Natural variantiVAR_011882474V → G.Corresponds to variant rs769403dbSNPEnsembl.1
Natural variantiVAR_011883532R → Q.1 PublicationCorresponds to variant rs769402dbSNPEnsembl.1
Natural variantiVAR_011884565F → L.Corresponds to variant rs1049736dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009123214 – 224FTYEIAPVFVL → PSDMRECWLLR in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_009124225 – 594Missing in isoform 3. 2 PublicationsAdd BLAST370
Alternative sequenceiVSP_054473374 – 425AAWGG…KGILQ → GFNFSQLANRIICLATELMT NKGCVTWHPNYSVNMHHGCL GRWAAHVQEAPP in isoform 4. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_054474426 – 594Missing in isoform 4. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81883 mRNA. Translation: AAA62368.1.
L16888 mRNA. Translation: AAB59427.1.
Z22750 mRNA. Translation: CAA80435.1.
S61897 mRNA. Translation: AAB26937.1.
S61898 mRNA. Translation: AAB26938.1.
M86522 Genomic DNA. Translation: AAA35900.1.
AF178853 mRNA. Translation: AAF18390.2.
AY337516 Genomic DNA. Translation: AAP88035.1.
AC007405 Genomic DNA. Translation: AAY24237.1.
CH471058 Genomic DNA. Translation: EAX11228.1.
CH471058 Genomic DNA. Translation: EAX11229.1.
BC002815 mRNA. Translation: AAH02815.1.
BC026349 mRNA. Translation: AAH26349.1.
BC036552 mRNA. Translation: AAH36552.1.
M70434 mRNA. Translation: AAA52512.1.
M55574 mRNA. Translation: AAA72938.1.
CCDSiCCDS2239.1. [Q99259-1]
CCDS2240.1. [Q99259-3]
PIRiB41935.
S48135.
S51775.
S51776.
RefSeqiNP_000808.2. NM_000817.2. [Q99259-1]
NP_038473.2. NM_013445.3. [Q99259-3]
XP_005246501.1. XM_005246444.2. [Q99259-3]
XP_011509224.1. XM_011510922.1. [Q99259-1]
XP_016859245.1. XM_017003756.1. [Q99259-1]
XP_016859247.1. XM_017003758.1. [Q99259-3]
UniGeneiHs.420036.

Genome annotation databases

EnsembliENST00000344257; ENSP00000341167; ENSG00000128683. [Q99259-3]
ENST00000358196; ENSP00000350928; ENSG00000128683. [Q99259-1]
ENST00000375272; ENSP00000364421; ENSG00000128683. [Q99259-3]
ENST00000493875; ENSP00000434696; ENSG00000128683. [Q99259-4]
ENST00000625689; ENSP00000486612; ENSG00000128683. [Q99259-4]
GeneIDi2571.
KEGGihsa:2571.
UCSCiuc002ugh.4. human. [Q99259-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Glutamate decarboxylase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81883 mRNA. Translation: AAA62368.1.
L16888 mRNA. Translation: AAB59427.1.
Z22750 mRNA. Translation: CAA80435.1.
S61897 mRNA. Translation: AAB26937.1.
S61898 mRNA. Translation: AAB26938.1.
M86522 Genomic DNA. Translation: AAA35900.1.
AF178853 mRNA. Translation: AAF18390.2.
AY337516 Genomic DNA. Translation: AAP88035.1.
AC007405 Genomic DNA. Translation: AAY24237.1.
CH471058 Genomic DNA. Translation: EAX11228.1.
CH471058 Genomic DNA. Translation: EAX11229.1.
BC002815 mRNA. Translation: AAH02815.1.
BC026349 mRNA. Translation: AAH26349.1.
BC036552 mRNA. Translation: AAH36552.1.
M70434 mRNA. Translation: AAA52512.1.
M55574 mRNA. Translation: AAA72938.1.
CCDSiCCDS2239.1. [Q99259-1]
CCDS2240.1. [Q99259-3]
PIRiB41935.
S48135.
S51775.
S51776.
RefSeqiNP_000808.2. NM_000817.2. [Q99259-1]
NP_038473.2. NM_013445.3. [Q99259-3]
XP_005246501.1. XM_005246444.2. [Q99259-3]
XP_011509224.1. XM_011510922.1. [Q99259-1]
XP_016859245.1. XM_017003756.1. [Q99259-1]
XP_016859247.1. XM_017003758.1. [Q99259-3]
UniGeneiHs.420036.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OKJX-ray2.30A/B93-594[»]
3VP6X-ray2.10A/B90-594[»]
ProteinModelPortaliQ99259.
SMRiQ99259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108845. 8 interactors.
DIPiDIP-29292N.
IntActiQ99259. 10 interactors.
MINTiMINT-3058814.
STRINGi9606.ENSP00000350928.

Chemistry databases

ChEMBLiCHEMBL2614.

PTM databases

iPTMnetiQ99259.
PhosphoSitePlusiQ99259.

Polymorphism and mutation databases

BioMutaiGAD1.
DMDMi1352213.

Proteomic databases

EPDiQ99259.
PaxDbiQ99259.
PeptideAtlasiQ99259.
PRIDEiQ99259.

Protocols and materials databases

DNASUi2571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344257; ENSP00000341167; ENSG00000128683. [Q99259-3]
ENST00000358196; ENSP00000350928; ENSG00000128683. [Q99259-1]
ENST00000375272; ENSP00000364421; ENSG00000128683. [Q99259-3]
ENST00000493875; ENSP00000434696; ENSG00000128683. [Q99259-4]
ENST00000625689; ENSP00000486612; ENSG00000128683. [Q99259-4]
GeneIDi2571.
KEGGihsa:2571.
UCSCiuc002ugh.4. human. [Q99259-1]

Organism-specific databases

CTDi2571.
DisGeNETi2571.
GeneCardsiGAD1.
HGNCiHGNC:4092. GAD1.
HPAiCAB004415.
HPA031949.
HPA048871.
HPA058412.
MalaCardsiGAD1.
MIMi603513. phenotype.
605363. gene.
neXtProtiNX_Q99259.
OpenTargetsiENSG00000128683.
Orphaneti210141. Inherited congenital spastic tetraplegia.
PharmGKBiPA28507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ99259.
KOiK01580.
OMAiEYLYTKI.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ99259.
TreeFamiTF314688.

Enzyme and pathway databases

BioCyciMetaCyc:HS05215-MONOMER.
ZFISH:HS05215-MONOMER.
BRENDAi4.1.1.15. 2681.
ReactomeiR-HSA-888568. GABA synthesis.
R-HSA-888590. GABA synthesis, release, reuptake and degradation.
SIGNORiQ99259.

Miscellaneous databases

ChiTaRSiGAD1. human.
EvolutionaryTraceiQ99259.
GenomeRNAii2571.
PROiQ99259.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128683.
CleanExiHS_GAD1.
ExpressionAtlasiQ99259. baseline and differential.
GenevisibleiQ99259. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCE1_HUMAN
AccessioniPrimary (citable) accession number: Q99259
Secondary accession number(s): Q49AK1
, Q53TQ7, Q9BU91, Q9UHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.