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Protein

Uncharacterized WD repeat-containing protein YOL087C

Gene

YOL087C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the resistance to phenanthroline, sanguinarine, nordihydroguaiaretic acid (NDGA), isopropyl (N-3-chloro-phenyl)-carbamate (IPCPC) and guanosine 5'-O-(2-thiodiphosphate).

GO - Molecular functioni

  • ubiquitin binding Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized WD repeat-containing protein YOL087C
Gene namesi
Ordered Locus Names:YOL087C
ORF Names:O0944
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL087C.
SGDiS000005447. YOL087C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11161116Uncharacterized WD repeat-containing protein YOL087CPRO_0000235919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei668 – 6681PhosphoserineCombined sources
Modified residuei693 – 6931PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99247.

PTM databases

iPTMnetiQ99247.

Interactioni

GO - Molecular functioni

  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi34315. 46 interactions.
DIPiDIP-6391N.
IntActiQ99247. 10 interactions.
MINTiMINT-673002.

Structurei

3D structure databases

ProteinModelPortaliQ99247.
SMRiQ99247. Positions 423-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 6242WD 1Add
BLAST
Repeati91 – 13242WD 2Add
BLAST
Repeati160 – 20041WD 3Add
BLAST
Repeati219 – 26244WD 4Add
BLAST
Repeati266 – 30540WD 5Add
BLAST
Repeati387 – 42640WD 6Add
BLAST
Repeati428 – 46639WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi364 – 37411Poly-HisAdd
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000141726.
InParanoidiQ99247.
OMAiHVITENT.
OrthoDBiEOG092C082D.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021772. DUF3337.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF11816. DUF3337. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQLTVSYGL ISPDYCTSQD AHILPITKIL YPDIPGKNYF LTSGRDGSII
60 70 80 90 100
LHKNTQLSNE PETAATTIKN DAIRMQVHSD WASDLIHVNM KNSDPSAGDT
110 120 130 140 150
FISVSHDFSI VLISVNAQLT TWDKKIIGDH DDYIKCIVPI HYEMSNDYEL
160 170 180 190 200
EEQEGGPDNV HDGINNGIVV DEQNNFLFVT GGLDRKIKLW CLSSGPEKMA
210 220 230 240 250
TLLHTFDNAQ SNDTGSIYSM SPIIPKYSFD DNQTSRPFDF VAGDCNGDLI
260 270 280 290 300
FYSCKYRKEV IRIQNAHRTN IKVVRTLDDS TRLISTSSDG VINVWDLNCR
310 320 330 340 350
HDQTTGALQL PKKIGSWSWD SSIWCVQGTS LDKLYFGDSQ GNVMRANLSS
360 370 380 390 400
YEDAKLTRIF KPDHHHHHHH HHEHEEQNIS TTDAKVKKYG GILDIALLPN
410 420 430 440 450
EKLLFSFCTD SNLNVLDLTN NHFSVNEGGF ALTRSSLLTN RRHVITENTK
460 470 480 490 500
GQMQRWDIVS CELLNTFDSS EGSFDDIVMK YTSKEILSHW CTVSVKVGML
510 520 530 540 550
FVKINPKFLK TEVYGSALKD YQVVNNIEIN SDERYNLGKI VINSLFNEFI
560 570 580 590 600
SYEVQKDKLL RKKIFSLKKK DLTNSLTLDT GYNSESKKNN KDKKRKSTFK
610 620 630 640 650
ISSTLSIGNT NSSGTPPNSA PATPVMAETI VLEEQPLLQS ASDKAIDDSL
660 670 680 690 700
ELVQPLPASK KPYFRTQSSG SLLSRKFKSF RSTSGRATTG LNTPEEPKGI
710 720 730 740 750
LPDTPHVIND DSAFPQAINT TQQSKDATPE SMLWNHPFKL EQKLSAISSQ
760 770 780 790 800
DLPSNNTHNK LRSSENSRAN STSTLEGNEK KKPEFMPDLL EQIQESYKQQ
810 820 830 840 850
YMNTSSLKYL TKRLPVTKII KASSCPIIRV KSATLVLVHL WKEGSCGGRV
860 870 880 890 900
LFSTLLPPSH VDNETVSGGK ENSKPPDDEE VDLQAVDDDK LGKYDLIDGE
910 920 930 940 950
LGSRLNRRQI FEQLEENLPY WFAKALFRDI KTVEEQPKLN FLIMPWSSVG
960 970 980 990 1000
GSEAAGNENK KKFISASDTT ESSGNDSSDS SLGNGNEAVS PSTQQQFHNM
1010 1020 1030 1040 1050
LKFGRPKTSE QELNPTDLPR ISEANVKLVA PGMIRVKKIK LYVADRFETK
1060 1070 1080 1090 1100
TPEMKAKMEP SLWLDLLCRG QVLDNDMTLN TVRTLYWKSQ GDIVLEYRRK
1110
VHNSPLVHEV NGNEGK
Length:1,116
Mass (Da):125,382
Last modified:November 1, 1996 - v1
Checksum:i0691CFEA2B0D09F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58192.1.
Z74829 Genomic DNA. Translation: CAA99099.1.
BK006948 Genomic DNA. Translation: DAA10697.1.
PIRiS57382.
RefSeqiNP_014554.1. NM_001183341.1.

Genome annotation databases

EnsemblFungiiYOL087C; YOL087C; YOL087C.
GeneIDi854066.
KEGGisce:YOL087C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83121 Genomic DNA. Translation: CAA58192.1.
Z74829 Genomic DNA. Translation: CAA99099.1.
BK006948 Genomic DNA. Translation: DAA10697.1.
PIRiS57382.
RefSeqiNP_014554.1. NM_001183341.1.

3D structure databases

ProteinModelPortaliQ99247.
SMRiQ99247. Positions 423-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34315. 46 interactions.
DIPiDIP-6391N.
IntActiQ99247. 10 interactions.
MINTiMINT-673002.

PTM databases

iPTMnetiQ99247.

Proteomic databases

MaxQBiQ99247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL087C; YOL087C; YOL087C.
GeneIDi854066.
KEGGisce:YOL087C.

Organism-specific databases

EuPathDBiFungiDB:YOL087C.
SGDiS000005447. YOL087C.

Phylogenomic databases

HOGENOMiHOG000141726.
InParanoidiQ99247.
OMAiHVITENT.
OrthoDBiEOG092C082D.

Enzyme and pathway databases

BioCyciYEAST:G3O-33488-MONOMER.

Miscellaneous databases

PROiQ99247.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021772. DUF3337.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF11816. DUF3337. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYO087_YEAST
AccessioniPrimary (citable) accession number: Q99247
Secondary accession number(s): D6W1Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.