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Protein

Voltage-dependent L-type calcium channel subunit alpha-1D

Gene

Cacna1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei364Calcium ion selectivity and permeabilityBy similarity1
Sitei725Calcium ion selectivity and permeabilityBy similarity1
Sitei1121Calcium ion selectivity and permeabilityBy similarity1
Sitei1426Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi1513 – 1524By similarityAdd BLAST12

GO - Molecular functioni

  • alpha-actinin binding Source: MGI
  • ankyrin binding Source: BHF-UCL
  • high voltage-gated calcium channel activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • voltage-gated calcium channel activity Source: MGI
  • voltage-gated calcium channel activity involved SA node cell action potential Source: MGI

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • calcium ion import Source: MGI
  • calcium ion transmembrane transport Source: MGI
  • calcium ion transport Source: MGI
  • cardiac conduction Source: UniProtKB
  • membrane depolarization during SA node cell action potential Source: MGI
  • positive regulation of calcium ion transport Source: MGI
  • regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
  • regulation of heart rate by cardiac conduction Source: MGI
  • regulation of potassium ion transmembrane transport Source: BHF-UCL
  • regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  • sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-419037. NCAM1 interactions.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1D
Alternative name(s):
Calcium channel, L type, alpha-1 polypeptide isoform 2
Voltage-gated calcium channel subunit alpha Cav1.3
Gene namesi
Name:Cacna1d
Synonyms:Cach3, Cacn4, Cacnl1a2, Cchl1a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88293. Cacna1d.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 126CytoplasmicSequence analysisAdd BLAST126
Transmembranei127 – 145Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini146 – 163ExtracellularSequence analysisAdd BLAST18
Transmembranei164 – 183Helical; Name=S2 of repeat ISequence analysisAdd BLAST20
Topological domaini184 – 195CytoplasmicSequence analysisAdd BLAST12
Transmembranei196 – 214Helical; Name=S3 of repeat ISequence analysisAdd BLAST19
Topological domaini215 – 235ExtracellularSequence analysisAdd BLAST21
Transmembranei236 – 254Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini255 – 273CytoplasmicSequence analysisAdd BLAST19
Transmembranei274 – 293Helical; Name=S5 of repeat ISequence analysisAdd BLAST20
Topological domaini294 – 381ExtracellularSequence analysisAdd BLAST88
Transmembranei382 – 406Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini407 – 543CytoplasmicSequence analysisAdd BLAST137
Transmembranei544 – 563Helical; Name=S1 of repeat IISequence analysisAdd BLAST20
Topological domaini564 – 578ExtracellularSequence analysisAdd BLAST15
Transmembranei579 – 597Helical; Name=S2 of repeat IISequence analysisAdd BLAST19
Topological domaini598 – 605CytoplasmicSequence analysis8
Transmembranei606 – 624Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini625 – 634ExtracellularSequence analysis10
Transmembranei635 – 653Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini654 – 672CytoplasmicSequence analysisAdd BLAST19
Transmembranei673 – 693Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini694 – 747ExtracellularSequence analysisAdd BLAST54
Transmembranei748 – 772Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini773 – 906CytoplasmicSequence analysisAdd BLAST134
Transmembranei907 – 925Helical; Name=S1 of repeat IIISequence analysisAdd BLAST19
Topological domaini926 – 941ExtracellularSequence analysisAdd BLAST16
Transmembranei942 – 961Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini962 – 973CytoplasmicSequence analysisAdd BLAST12
Transmembranei974 – 992Helical; Name=S3 of repeat IIISequence analysisAdd BLAST19
Topological domaini993 – 998ExtracellularSequence analysis6
Transmembranei999 – 1018Helical; Name=S4 of repeat IIISequence analysisAdd BLAST20
Topological domaini1019 – 1037CytoplasmicSequence analysisAdd BLAST19
Transmembranei1038 – 1057Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1058 – 1147ExtracellularSequence analysisAdd BLAST90
Transmembranei1148 – 1168Helical; Name=S6 of repeat IIISequence analysisAdd BLAST21
Topological domaini1169 – 1225CytoplasmicSequence analysisAdd BLAST57
Transmembranei1226 – 1244Helical; Name=S1 of repeat IVSequence analysisAdd BLAST19
Topological domaini1245 – 1259ExtracellularSequence analysisAdd BLAST15
Transmembranei1260 – 1279Helical; Name=S2 of repeat IVSequence analysisAdd BLAST20
Topological domaini1280 – 1286CytoplasmicSequence analysis7
Transmembranei1287 – 1308Helical; Name=S3 of repeat IVSequence analysisAdd BLAST22
Topological domaini1309 – 1333ExtracellularSequence analysisAdd BLAST25
Transmembranei1334 – 1353Helical; Name=S4 of repeat IVSequence analysisAdd BLAST20
Topological domaini1354 – 1372CytoplasmicSequence analysisAdd BLAST19
Transmembranei1373 – 1392Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1393 – 1459ExtracellularSequence analysisAdd BLAST67
Transmembranei1460 – 1484Helical; Name=S6 of repeat IVSequence analysisAdd BLAST25
Topological domaini1485 – 2179CytoplasmicSequence analysisAdd BLAST695

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • L-type voltage-gated calcium channel complex Source: MGI
  • plasma membrane Source: BHF-UCL
  • voltage-gated calcium channel complex Source: MGI
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

deafness, bradycardia and diabetic traits.3 Publications

Chemistry databases

GuidetoPHARMACOLOGYi530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539351 – 2179Voltage-dependent L-type calcium channel subunit alpha-1DAdd BLAST2179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei469PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1
Modified residuei1495Phosphoserine; by PKABy similarity1
Modified residuei1719PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ99246.
PRIDEiQ99246.

PTM databases

iPTMnetiQ99246.
PhosphoSitePlusiQ99246.

Expressioni

Tissue specificityi

Expressed in the inner hair cells (IHC) of the cochlea.1 Publication

Developmental stagei

Isoform 2 and isoform 3 are expressed in heart at 12.5 dpc (at protein level). Expressed in the heart at 9.5, 12.5 and 15.5 dpc. Isoform 2 and isoform 3 are expressed in heart at 9.5 and 12.5 dpc.1 Publication

Inductioni

Up-regulated in CACNA1C knockout mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000015968.
GenevisibleiQ99246. MM.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner. Interacts with RIMBP2 (By similarity).By similarity

GO - Molecular functioni

  • alpha-actinin binding Source: MGI
  • ankyrin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi198433. 2 interactors.
IntActiQ99246. 1 interactor.
STRINGi10090.ENSMUSP00000107869.

Structurei

3D structure databases

ProteinModelPortaliQ99246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati113 – 409IAdd BLAST297
Repeati529 – 775IIAdd BLAST247
Repeati893 – 1175IIIAdd BLAST283
Repeati1212 – 1487IVAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni429 – 446Binding to the beta subunitBy similarityAdd BLAST18
Regioni1095 – 1185Dihydropyridine bindingBy similarityAdd BLAST91
Regioni1440 – 1506Dihydropyridine bindingBy similarityAdd BLAST67
Regioni1452 – 1495Phenylalkylamine bindingBy similarityAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili771 – 810Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 7Poly-Met7
Compositional biasi673 – 679Poly-Leu7
Compositional biasi847 – 858Poly-GluAdd BLAST12

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
InParanoidiQ99246.
KOiK04851.
OMAiIQVERPE.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR005452. LVDCC_a1dsu.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF139. PTHR10037:SF139. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01636. LVDCCALPHA1D.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99246-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMMMMMMKKM QHQRQHQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV
60 70 80 90 100
LSWQAAIDAA RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS
110 120 130 140 150
RPARALFCLS LNNPIRRACI SIVEWKPFDI FILLAIFANC VALAIYIPFP
160 170 180 190 200
EDDSNSTNHN LEKVEYAFLI IFTVETFLKI IAYGLLLHPN AYVRNGWNLL
210 220 230 240 250
DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR AFRVLRPLRL
260 270 280 290 300
VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
310 320 330 340 350
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF
360 370 380 390 400
AFAMLTVFQC ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL
410 420 430 440 450
VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP
460 470 480 490 500
ENEEEGGEEG KRNTSMPTSE TESVNTENVS GEGETQGCCG TLWCWWKRRG
510 520 530 540 550
AAKTGPSGCR RWGQAISKSK LSRRWRRWNR FNRRRCRAAV KSVTFYWLVI
560 570 580 590 600
VLVFLNTLTI SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ
610 620 630 640 650
AYFVSLFNRF DCFVVCGGIT ETILVELELM SPLGVSVFRC VRLLRIFKVT
660 670 680 690 700
RHWTSLSNLV ASLLNSMKSI ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDE
710 720 730 740 750
TQTKRSTFDN FPQALLTVFQ ILTGEDWNAV MYDGIMAYGG PSSSGMIVCI
760 770 780 790 800
YFIILFICGN YILLNVFLAI AVDNLADAES LNTAQKEEAE EKERKKIARK
810 820 830 840 850
ESLENKKNNK PEVNQIANSD NKVTIDDYQE DAEDKDPYPP CDVPVGEEEE
860 870 880 890 900
EEEEDEPEVP AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH
910 920 930 940 950
KLINHHIFTN LILVFIMLSS AALAAEDPIR SHSFRNTILG YFDYAFTAIF
960 970 980 990 1000
TVEILLKMTT FGAFLHKGAF CRNYFNLLDM LVVGVSLVSF GIQSSAISVV
1010 1020 1030 1040 1050
KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIMI VTTLLQFMFA
1060 1070 1080 1090 1100
CIGVQLFKGK FYRCTDEAKS NPEECRGLFI LYKDGDVDSP VVRERIWQNS
1110 1120 1130 1140 1150
DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENVGP VYNYRVEISI
1160 1170 1180 1190 1200
FFIIYIIIVA FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL
1210 1220 1230 1240 1250
KARPLRRYIP KNPYQYKFWY VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS
1260 1270 1280 1290 1300
KMFNDAMDIL NMVFTGVFTV EMVLKVIAFK PKGYFSDAWN TFDSLIVIGS
1310 1320 1330 1340 1350
IIDVALSEAD PSESETIPLP TATPGNSEES NRISITFFRL FRVMRLVKLL
1360 1370 1380 1390 1400
SRGEGIRTLL WTFIKSFQAL PYVALLIAML FFIYAVIGMQ MFGKVAMRDN
1410 1420 1430 1440 1450
NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL CDPDSDYNPG
1460 1470 1480 1490 1500
EEYTCGSNFA IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH
1510 1520 1530 1540 1550
HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR
1560 1570 1580 1590 1600
LVAMNMPLNS DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI
1610 1620 1630 1640 1650
WKKTSMKLLD QVVPPAGDDE VTVGKFYATF LIQDYFRKFK KRKEQGLVGK
1660 1670 1680 1690 1700
YPAKNTTIAL QAGLRTLHDI GPEIRRAISC DLQDDEPEDS KPEEEDVFKR
1710 1720 1730 1740 1750
NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSMPPA SDTEKPLFPP
1760 1770 1780 1790 1800
AGNSGCHNHH NHNSIGKQAP TSTNANLNNA NMSKAAHGKP PSIGNLEHVS
1810 1820 1830 1840 1850
ENGHYSCKHD RELQRRSSIK RTRYYETYIR SESGDEQFPT ICREDPEIHG
1860 1870 1880 1890 1900
YFRDPRCLGE QEYFSSEECC EDDSSPTWSR QNYNYYNRYP GSSMDFERPR
1910 1920 1930 1940 1950
GYHHPQGFLE DDDSPTGYDS RRSPRRRLLP PTPPSHRRSS FNFECLRRQS
1960 1970 1980 1990 2000
SQDDVLPSPA LPHRAALPLH LMQQQIMAVA GLDSSKAQKY SPSHSTRSWA
2010 2020 2030 2040 2050
TPPATPPYRD WSPCYTPLIQ VDRSESMDQV NGSLPSLHRS SWYTDEPDIS
2060 2070 2080 2090 2100
YRTFTPASLT VPSSFRNKNS DKQRSADSLV EAVLISEGLG RYARDPKFVS
2110 2120 2130 2140 2150
ATKHEIADAC DLTIDEMESA ASTLLNGSVC PRANGDMGPI SHRQDYELQD
2160 2170
FGPGYSDEEP DPGREEEDLA DEMICITTL
Length:2,179
Mass (Da):247,061
Last modified:July 27, 2011 - v3
Checksum:iBEED5EF140E75782
GO
Isoform 2 (identifier: Q99246-3) [UniParc]FASTAAdd to basket
Also known as: Cav1.3(1a)

The sequence of this isoform differs from the canonical sequence as follows:
     493-513: WCWWKRRGAAKTGPSGCRRWG → C
     1311-1325: Missing.

Show »
Length:2,144
Mass (Da):243,198
Checksum:i2CDC0111051527D3
GO
Isoform 3 (identifier: Q99246-4) [UniParc]FASTAAdd to basket
Also known as: Cav1.3(1b)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MMMMMMMKKMQHQRQHQEDHAN → MNLPTFSSDLILIKSVLSQETDARYKGRVVSAVESTEDFSQAFA
     493-513: WCWWKRRGAAKTGPSGCRRWG → C
     1311-1325: Missing.

Show »
Length:2,166
Mass (Da):245,217
Checksum:i842E4AD6D5F07A91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti445A → V in CAD26883 (PubMed:12900400).Curated1
Sequence conflicti445A → V in CAD26884 (PubMed:12900400).Curated1
Sequence conflicti868I → T in CAD26883 (PubMed:12900400).Curated1
Sequence conflicti868I → T in CAD26884 (PubMed:12900400).Curated1
Sequence conflicti1871E → G in CAD26883 (PubMed:12900400).Curated1
Sequence conflicti1871E → G in CAD26884 (PubMed:12900400).Curated1
Sequence conflicti2043Y → S in BAC77259 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0270901 – 22MMMMM…EDHAN → MNLPTFSSDLILIKSVLSQE TDARYKGRVVSAVESTEDFS QAFA in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_027091493 – 513WCWWK…CRRWG → C in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0270921311 – 1325Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437291 mRNA. Translation: CAD26883.1.
AJ437292 mRNA. Translation: CAD26884.1.
AB086123 mRNA. Translation: BAC77259.1.
AC119886 Genomic DNA. No translation available.
AC154305 Genomic DNA. No translation available.
AC154669 Genomic DNA. No translation available.
AC154690 Genomic DNA. No translation available.
CT009536 Genomic DNA. No translation available.
M57975 mRNA. Translation: AAA63292.1.
CCDSiCCDS36846.1. [Q99246-4]
CCDS36847.1. [Q99246-3]
RefSeqiNP_001077085.1. NM_001083616.2. [Q99246-3]
NP_001289566.1. NM_001302637.1. [Q99246-2]
NP_083257.2. NM_028981.3. [Q99246-4]
UniGeneiMm.9772.

Genome annotation databases

EnsembliENSMUST00000112249; ENSMUSP00000107868; ENSMUSG00000015968. [Q99246-3]
ENSMUST00000112250; ENSMUSP00000107869; ENSMUSG00000015968. [Q99246-4]
GeneIDi12289.
KEGGimmu:12289.
UCSCiuc007suu.2. mouse. [Q99246-3]
uc007suw.2. mouse. [Q99246-2]
uc007sux.2. mouse. [Q99246-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ437291 mRNA. Translation: CAD26883.1.
AJ437292 mRNA. Translation: CAD26884.1.
AB086123 mRNA. Translation: BAC77259.1.
AC119886 Genomic DNA. No translation available.
AC154305 Genomic DNA. No translation available.
AC154669 Genomic DNA. No translation available.
AC154690 Genomic DNA. No translation available.
CT009536 Genomic DNA. No translation available.
M57975 mRNA. Translation: AAA63292.1.
CCDSiCCDS36846.1. [Q99246-4]
CCDS36847.1. [Q99246-3]
RefSeqiNP_001077085.1. NM_001083616.2. [Q99246-3]
NP_001289566.1. NM_001302637.1. [Q99246-2]
NP_083257.2. NM_028981.3. [Q99246-4]
UniGeneiMm.9772.

3D structure databases

ProteinModelPortaliQ99246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198433. 2 interactors.
IntActiQ99246. 1 interactor.
STRINGi10090.ENSMUSP00000107869.

Chemistry databases

GuidetoPHARMACOLOGYi530.

PTM databases

iPTMnetiQ99246.
PhosphoSitePlusiQ99246.

Proteomic databases

PaxDbiQ99246.
PRIDEiQ99246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112249; ENSMUSP00000107868; ENSMUSG00000015968. [Q99246-3]
ENSMUST00000112250; ENSMUSP00000107869; ENSMUSG00000015968. [Q99246-4]
GeneIDi12289.
KEGGimmu:12289.
UCSCiuc007suu.2. mouse. [Q99246-3]
uc007suw.2. mouse. [Q99246-2]
uc007sux.2. mouse. [Q99246-4]

Organism-specific databases

CTDi776.
MGIiMGI:88293. Cacna1d.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
InParanoidiQ99246.
KOiK04851.
OMAiIQVERPE.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Enzyme and pathway databases

ReactomeiR-MMU-419037. NCAM1 interactions.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

ChiTaRSiCacna1d. mouse.
PROiQ99246.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015968.
GenevisibleiQ99246. MM.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR005452. LVDCC_a1dsu.
IPR014873. VDCC_a1su_IQ.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF139. PTHR10037:SF139. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01636. LVDCCALPHA1D.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1D_MOUSE
AccessioniPrimary (citable) accession number: Q99246
Secondary accession number(s): Q7TSD2, Q8R2I9, Q8R2J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.