ID   MTR10_YEAST             Reviewed;         972 AA.
AC   Q99189; D6W2L7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 168.
DE   RecName: Full=mRNA transport regulator MTR10;
GN   Name=MTR10; OrderedLocusNames=YOR160W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S288c / FY1678;
RX   PubMed=9046089;
RX   DOI=10.1002/(sici)1097-0061(199701)13:1<73::aid-yea52>3.0.co;2-m;
RA   Bordonne R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B.,
RA   Martin R.P.;
RT   "Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae
RT   chromosome XV.";
RL   Yeast 13:73-83(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Involved in mRNA transport from nucleus to cytoplasm.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- MISCELLANEOUS: Present with 6340 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; U55020; AAC49646.1; -; Genomic_DNA.
DR   EMBL; Z75068; CAA99366.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA10933.1; -; Genomic_DNA.
DR   PIR; S67048; S67048.
DR   RefSeq; NP_014803.1; NM_001183579.1.
DR   AlphaFoldDB; Q99189; -.
DR   SMR; Q99189; -.
DR   BioGRID; 34556; 286.
DR   DIP; DIP-2358N; -.
DR   IntAct; Q99189; 18.
DR   STRING; 4932.YOR160W; -.
DR   iPTMnet; Q99189; -.
DR   MaxQB; Q99189; -.
DR   PaxDb; 4932-YOR160W; -.
DR   PeptideAtlas; Q99189; -.
DR   EnsemblFungi; YOR160W_mRNA; YOR160W; YOR160W.
DR   GeneID; 854331; -.
DR   KEGG; sce:YOR160W; -.
DR   AGR; SGD:S000005686; -.
DR   SGD; S000005686; MTR10.
DR   VEuPathDB; FungiDB:YOR160W; -.
DR   eggNOG; KOG2081; Eukaryota.
DR   GeneTree; ENSGT00530000063347; -.
DR   HOGENOM; CLU_005996_0_0_1; -.
DR   InParanoid; Q99189; -.
DR   OMA; LECITSW; -.
DR   OrthoDB; 35663at2759; -.
DR   BioCyc; YEAST:G3O-33677-MONOMER; -.
DR   BioGRID-ORCS; 854331; 0 hits in 10 CRISPR screens.
DR   PRO; PR:Q99189; -.
DR   Proteomes; UP000002311; Chromosome XV.
DR   RNAct; Q99189; Protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR   GO; GO:0034399; C:nuclear periphery; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IDA:SGD.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IDA:SGD.
DR   GO; GO:0006404; P:RNA import into nucleus; IMP:SGD.
DR   GO; GO:0006403; P:RNA localization; IMP:SGD.
DR   GO; GO:0061015; P:snRNA import into nucleus; IMP:SGD.
DR   GO; GO:0051031; P:tRNA transport; IMP:SGD.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   PANTHER; PTHR12363:SF53; MRNA TRANSPORT REGULATOR MTR10; 1.
DR   PANTHER; PTHR12363; TRANSPORTIN 3 AND IMPORTIN 13; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..972
FT                   /note="mRNA transport regulator MTR10"
FT                   /id="PRO_0000096632"
SQ   SEQUENCE   972 AA;  110745 MW;  2201E26626BF4394 CRC64;
     MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS KEDPTNALLE
     LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ KLIITQLNVA LARLAIQFLE
     WQNPIFEIIS LLNSSPSILL NFLRILPEET LDIASTSLTE VEFNSRIHEL IDPIAEDVLK
     FLVSCIDLLQ NTDGNSSSSI SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE
     SDMEAFDSAI DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD
     LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT FPFWFNFKQS
     LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE EDKFKDFRYH MGDVLKDCTA
     VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA PLFSLRTMAK EISLTENTIL PEIIKIICNL
     PEQAKIRYAS TLVLGRYTEW TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM
     FFCSDCSKLL VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV
     DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS EPLLPRIEFI
     WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP ILPSVAEFLI QGYLTTGFGS
     YLWCSGSLIV IFGDDESFPI SPSLKDAVWK FALSQCETFI LNFNKFDKLQ LNDYHEAIID
     FFSLISDLIM FYPGAFLNST ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT
     PPISTVSIEI VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR
     ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK VREGIRAFVG
     WYSRKNINSR FE
//