Q99189 (MTR10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
mRNA transport regulator MTR10

Gene names

Name:	MTR10
Ordered Locus Names:	YOR160W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	972 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in mRNA transport from nucleus to cytoplasm.
Subcellular location	Nucleus Potential.
Miscellaneous	Present with 6340 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA import into nucleus Inferred from mutant phenotype PubMed 16040803PubMed 17409072. Source: SGD mRNA-binding (hnRNP) protein import into nucleus Inferred from mutant phenotype PubMed 9412460PubMed 9545233. Source: SGD tRNA transport Inferred from mutant phenotype PubMed 17409072PubMed 20032305. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 22842922PubMed 9412460. Source: SGD integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD nuclear periphery Inferred from direct assay PubMed 22842922. Source: SGD nuclear pore Inferred from electronic annotation. Source: InterPro
Molecular_function	nuclear localization sequence binding Inferred from physical interaction PubMed 9545233. Source: SGD protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 972	972	mRNA transport regulator MTR10		PRO_0000096632
Regions
	Compositional bias	196 – 201	6	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q99189 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2201E26626BF4394	FASTA	972	110,745
	10 20 30 40 50 60 MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS KEDPTNALLE 70 80 90 100 110 120 LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ KLIITQLNVA LARLAIQFLE 130 140 150 160 170 180 WQNPIFEIIS LLNSSPSILL NFLRILPEET LDIASTSLTE VEFNSRIHEL IDPIAEDVLK 190 200 210 220 230 240 FLVSCIDLLQ NTDGNSSSSI SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE 250 260 270 280 290 300 SDMEAFDSAI DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD 310 320 330 340 350 360 LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT FPFWFNFKQS 370 380 390 400 410 420 LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE EDKFKDFRYH MGDVLKDCTA 430 440 450 460 470 480 VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA PLFSLRTMAK EISLTENTIL PEIIKIICNL 490 500 510 520 530 540 PEQAKIRYAS TLVLGRYTEW TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM 550 560 570 580 590 600 FFCSDCSKLL VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV 610 620 630 640 650 660 DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS EPLLPRIEFI 670 680 690 700 710 720 WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP ILPSVAEFLI QGYLTTGFGS 730 740 750 760 770 780 YLWCSGSLIV IFGDDESFPI SPSLKDAVWK FALSQCETFI LNFNKFDKLQ LNDYHEAIID 790 800 810 820 830 840 FFSLISDLIM FYPGAFLNST ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT 850 860 870 880 890 900 PPISTVSIEI VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR 910 920 930 940 950 960 ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK VREGIRAFVG 970 WYSRKNINSR FE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV." Bordonne R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P. Yeast 13:73-83(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / FY1678.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S288c / FY1678.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U55020 Genomic DNA. Translation: AAC49646.1. Z75068 Genomic DNA. Translation: CAA99366.1. BK006948 Genomic DNA. Translation: DAA10933.1.
PIR	S67048.
RefSeq	NP_014803.1. NM_001183579.1.
3D structure databases
ProteinModelPortal	Q99189.
SMR	Q99189. Positions 3-739.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2358N.
IntAct	Q99189. 18 interactions.
MINT	MINT-619417.
STRING	4932.YOR160W.
Proteomic databases
PaxDb	Q99189.
PeptideAtlas	Q99189.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR160W; YOR160W; YOR160W.
GeneID	854331.
KEGG	sce:YOR160W.
Organism-specific databases
CYGD	YOR160w.
SGD	S000005686. MTR10.
Phylogenomic databases
eggNOG	NOG237172.
GeneTree	ENSGT00530000063347.
HOGENOM	HOG000181190.
KO	K15436.
OMA	TEWTSKH.
OrthoDB	EOG4BZR9R.
Gene expression databases
Genevestigator	Q99189.
GermOnline	YOR160W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR013598. Exportin-1/Importin-b-like. IPR001494. Importin-beta_N. [Graphical view]
Pfam	PF08389. Xpo1. 1 hit. [Graphical view]
SMART	SM00913. IBN_N. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	976387.

Entry information

Entry name

MTR10_YEAST

Accession

Primary (citable) accession number: Q99189
Secondary accession number(s): D6W2L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program