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Protein

Regulator of G-protein signaling 2

Gene

RGS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activating protein for GPA2. Negatively down-regulates glucose-induced cAMP signaling via GPA2.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: SGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Gene namesi
Name:RGS2
Ordered Locus Names:YOR107W
ORF Names:YOR3224w
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR107W.
SGDiS000005633. RGS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi63 – 631N → S: Decreases the ability to suppress glucose-induced cAMP signaling when overexpressed. 1 Publication
Mutagenesisi144 – 1441L → H: Abolishes the ability to suppress glucose-induced cAMP signaling when overexpressed. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Regulator of G-protein signaling 2PRO_0000268701Add
BLAST

Interactioni

Subunit structurei

Interacts with GPA2.1 Publication

Protein-protein interaction databases

BioGridi34503. 13 interactions.
DIPiDIP-5571N.
IntActiQ99188. 2 interactions.
MINTiMINT-487417.

Structurei

3D structure databases

ProteinModelPortaliQ99188.
SMRiQ99188. Positions 37-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 161125RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ99188.
OMAiCHENSSI.
OrthoDBiEOG092C5WUJ.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPSLCDI LIPLEKNSRS DGDAESSNTV LIQLRKGHHE RMRSPYTIQK
60 70 80 90 100
FYKFLKRAHC EENLEFFEKA HQFLQLKQNR SISEEKLLEV WNKSLYIKYI
110 120 130 140 150
AVDSPKECNF SQDTREIFEK CFANNEVPAD VDVLCAISHV MGLLMDGYHR
160 170 180 190 200
FVSSVNEKKY SATYAHNDSA TEQDLKNEST TSFSSLGVED ISEDRNSYLK
210 220 230 240 250
KPDINGLSTI IQETSANTTN ESQCSDRTSR PSESSSSLNT TSSTYKNTST
260 270 280 290 300
RNLQKPQNTG ILNSGKGLLQ KLNFVKKRKS FKQPSGVICS HYNSNVQNRL

KGQNSHQQR
Length:309
Mass (Da):35,100
Last modified:November 1, 1996 - v1
Checksum:i875CCEA36173EDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64027.1.
Z75015 Genomic DNA. Translation: CAA99305.1.
AY692864 Genomic DNA. Translation: AAT92883.1.
BK006948 Genomic DNA. Translation: DAA10882.1.
PIRiS61665.
RefSeqiNP_014750.3. NM_001183526.3.

Genome annotation databases

EnsemblFungiiYOR107W; YOR107W; YOR107W.
GeneIDi854274.
KEGGisce:YOR107W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA. Translation: CAA64027.1.
Z75015 Genomic DNA. Translation: CAA99305.1.
AY692864 Genomic DNA. Translation: AAT92883.1.
BK006948 Genomic DNA. Translation: DAA10882.1.
PIRiS61665.
RefSeqiNP_014750.3. NM_001183526.3.

3D structure databases

ProteinModelPortaliQ99188.
SMRiQ99188. Positions 37-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34503. 13 interactions.
DIPiDIP-5571N.
IntActiQ99188. 2 interactions.
MINTiMINT-487417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR107W; YOR107W; YOR107W.
GeneIDi854274.
KEGGisce:YOR107W.

Organism-specific databases

EuPathDBiFungiDB:YOR107W.
SGDiS000005633. RGS2.

Phylogenomic databases

InParanoidiQ99188.
OMAiCHENSSI.
OrthoDBiEOG092C5WUJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-33638-MONOMER.

Miscellaneous databases

PROiQ99188.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS2_YEAST
AccessioniPrimary (citable) accession number: Q99188
Secondary accession number(s): D6W2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.