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Q99170

- GRP78_YARLI

UniProt

Q99170 - GRP78_YARLI

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Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:KAR2
Ordered Locus Names:YALI0E13706g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome E

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 67064478 kDa glucose-regulated protein homologPRO_0000013586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ99170.

Interactioni

Protein-protein interaction databases

IntActiQ99170. 1 interaction.
MINTiMINT-1540646.
STRINGi4952.Q99170.

Structurei

3D structure databases

ProteinModelPortaliQ99170.
SMRiQ99170. Positions 37-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi667 – 6704Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
HOGENOMiHOG000228135.
InParanoidiQ99170.
KOiK09490.
OMAiRDIKFLP.
OrthoDBiEOG728916.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99170-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFSMPSWGV VFYALLVCLL PFLSKAGVQA DDVDSYGTVI GIDLGTTYSC
60 70 80 90 100
VGVMKGGRVE ILANDQGSRI TPSYVAFTED ERLVGDAAKN QAANNPFNTI
110 120 130 140 150
FDIKRLIGLK YKDESVQRDI KHFPYKVKNK DGKPVVVVET KGEKKTYTPE
160 170 180 190 200
EISAMILTKM KDIAQDYLGK KVTHAVVTVP AYFNDAQRQA TKDAGIIAGL
210 220 230 240 250
NVLRIVNEPT AAAIAYGLDH TDDEKQIVVY DLGGGTFDVS LLSIESGVFE
260 270 280 290 300
VLATAGDTHL GGEDFDYRVI KHFVKQYNKK HDVDITKNAK TIGKLKREVE
310 320 330 340 350
KAKRTLSSQM STRIEIESFF DGEDFSETLT RAKFEELNID LFKRTLKPVE
360 370 380 390 400
QVLKDSGVKK EDVHDIVLVG GSTRIPKVQE LLEKFFDGKK ASKGINPDEA
410 420 430 440 450
VAYGAAVQAG VLSGEDGVED IVLLDVNPLT LGIETTGGVM TKLINRNTNI
460 470 480 490 500
PTKKSQIFST AVDNQSTVLI QVFEGERTMS KDNNLLGKFE LKGIPPAPRG
510 520 530 540 550
VPQIEVTFEL DANGILRVTA HDKGTGKSET ITITNDKGRL SKDEIERMVE
560 570 580 590 600
EAERFAEEDA LIRETIEAKN SLENYAHSLR NQVADKSGLG GKISADDKEA
610 620 630 640 650
LNDAVTETLE WLEANSVSAT KEDFEEKKEA LSAIAYPITS KIYEGGEGGD
660 670
ESNDGGFYAD DDEAPFHDEL
Length:670
Mass (Da):73,524
Last modified:November 1, 1997 - v1
Checksum:i2C2DFB436BCC9C0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63136 Genomic DNA. Translation: AAC49736.1.
CR382131 Genomic DNA. Translation: CAG79506.1.
RefSeqiXP_503913.1. XM_503913.1.

Genome annotation databases

EnsemblFungiiCAG79506; CAG79506; YALI0_E13706g.
GeneIDi2912786.
KEGGiyli:YALI0E13706g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63136 Genomic DNA. Translation: AAC49736.1 .
CR382131 Genomic DNA. Translation: CAG79506.1 .
RefSeqi XP_503913.1. XM_503913.1.

3D structure databases

ProteinModelPortali Q99170.
SMRi Q99170. Positions 37-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q99170. 1 interaction.
MINTi MINT-1540646.
STRINGi 4952.Q99170.

Proteomic databases

PRIDEi Q99170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG79506 ; CAG79506 ; YALI0_E13706g .
GeneIDi 2912786.
KEGGi yli:YALI0E13706g.

Phylogenomic databases

eggNOGi COG0443.
HOGENOMi HOG000228135.
InParanoidi Q99170.
KOi K09490.
OMAi RDIKFLP.
OrthoDBi EOG728916.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yarrowia lipolytica SRP54 homolog and translocation of Kar2p."
    Lee I.H., Ogrydziak D.M.
    Yeast 13:499-513(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 32338 / CX-161-1B.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiGRP78_YARLI
AccessioniPrimary (citable) accession number: Q99170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3