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Q99170

- GRP78_YARLI

UniProt

Q99170 - GRP78_YARLI

Protein

78 kDa glucose-regulated protein homolog

Gene

KAR2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to unfolded protein Source: UniProtKB

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Alternative name(s):
    Immunoglobulin heavy chain-binding protein homolog
    Short name:
    BiP
    Gene namesi
    Name:KAR2
    Ordered Locus Names:YALI0E13706g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome E

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 67064478 kDa glucose-regulated protein homologPRO_0000013586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ99170.

    Interactioni

    Protein-protein interaction databases

    IntActiQ99170. 1 interaction.
    MINTiMINT-1540646.
    STRINGi4952.Q99170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99170.
    SMRiQ99170. Positions 37-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi667 – 6704Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    HOGENOMiHOG000228135.
    KOiK09490.
    OMAiRDIKFLP.
    OrthoDBiEOG728916.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFSMPSWGV VFYALLVCLL PFLSKAGVQA DDVDSYGTVI GIDLGTTYSC    50
    VGVMKGGRVE ILANDQGSRI TPSYVAFTED ERLVGDAAKN QAANNPFNTI 100
    FDIKRLIGLK YKDESVQRDI KHFPYKVKNK DGKPVVVVET KGEKKTYTPE 150
    EISAMILTKM KDIAQDYLGK KVTHAVVTVP AYFNDAQRQA TKDAGIIAGL 200
    NVLRIVNEPT AAAIAYGLDH TDDEKQIVVY DLGGGTFDVS LLSIESGVFE 250
    VLATAGDTHL GGEDFDYRVI KHFVKQYNKK HDVDITKNAK TIGKLKREVE 300
    KAKRTLSSQM STRIEIESFF DGEDFSETLT RAKFEELNID LFKRTLKPVE 350
    QVLKDSGVKK EDVHDIVLVG GSTRIPKVQE LLEKFFDGKK ASKGINPDEA 400
    VAYGAAVQAG VLSGEDGVED IVLLDVNPLT LGIETTGGVM TKLINRNTNI 450
    PTKKSQIFST AVDNQSTVLI QVFEGERTMS KDNNLLGKFE LKGIPPAPRG 500
    VPQIEVTFEL DANGILRVTA HDKGTGKSET ITITNDKGRL SKDEIERMVE 550
    EAERFAEEDA LIRETIEAKN SLENYAHSLR NQVADKSGLG GKISADDKEA 600
    LNDAVTETLE WLEANSVSAT KEDFEEKKEA LSAIAYPITS KIYEGGEGGD 650
    ESNDGGFYAD DDEAPFHDEL 670
    Length:670
    Mass (Da):73,524
    Last modified:November 1, 1997 - v1
    Checksum:i2C2DFB436BCC9C0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63136 Genomic DNA. Translation: AAC49736.1.
    CR382131 Genomic DNA. Translation: CAG79506.1.
    RefSeqiXP_503913.1. XM_503913.1.

    Genome annotation databases

    EnsemblFungiiCAG79506; CAG79506; YALI0_E13706g.
    GeneIDi2912786.
    KEGGiyli:YALI0E13706g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U63136 Genomic DNA. Translation: AAC49736.1 .
    CR382131 Genomic DNA. Translation: CAG79506.1 .
    RefSeqi XP_503913.1. XM_503913.1.

    3D structure databases

    ProteinModelPortali Q99170.
    SMRi Q99170. Positions 37-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q99170. 1 interaction.
    MINTi MINT-1540646.
    STRINGi 4952.Q99170.

    Proteomic databases

    PRIDEi Q99170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG79506 ; CAG79506 ; YALI0_E13706g .
    GeneIDi 2912786.
    KEGGi yli:YALI0E13706g.

    Phylogenomic databases

    eggNOGi COG0443.
    HOGENOMi HOG000228135.
    KOi K09490.
    OMAi RDIKFLP.
    OrthoDBi EOG728916.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yarrowia lipolytica SRP54 homolog and translocation of Kar2p."
      Lee I.H., Ogrydziak D.M.
      Yeast 13:499-513(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 32338 / CX-161-1B.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.

    Entry informationi

    Entry nameiGRP78_YARLI
    AccessioniPrimary (citable) accession number: Q99170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3