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Q99170 (GRP78_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name=BiP
Gene names
Name:KAR2
Ordered Locus Names:YALI0E13706g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis By similarity.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to unfolded protein

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 67064478 kDa glucose-regulated protein homolog
PRO_0000013586

Regions

Motif667 – 6704Prevents secretion from ER Potential

Amino acid modifications

Glycosylation4641N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q99170 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2C2DFB436BCC9C0E

FASTA67073,524
        10         20         30         40         50         60 
MKFSMPSWGV VFYALLVCLL PFLSKAGVQA DDVDSYGTVI GIDLGTTYSC VGVMKGGRVE 

        70         80         90        100        110        120 
ILANDQGSRI TPSYVAFTED ERLVGDAAKN QAANNPFNTI FDIKRLIGLK YKDESVQRDI 

       130        140        150        160        170        180 
KHFPYKVKNK DGKPVVVVET KGEKKTYTPE EISAMILTKM KDIAQDYLGK KVTHAVVTVP 

       190        200        210        220        230        240 
AYFNDAQRQA TKDAGIIAGL NVLRIVNEPT AAAIAYGLDH TDDEKQIVVY DLGGGTFDVS 

       250        260        270        280        290        300 
LLSIESGVFE VLATAGDTHL GGEDFDYRVI KHFVKQYNKK HDVDITKNAK TIGKLKREVE 

       310        320        330        340        350        360 
KAKRTLSSQM STRIEIESFF DGEDFSETLT RAKFEELNID LFKRTLKPVE QVLKDSGVKK 

       370        380        390        400        410        420 
EDVHDIVLVG GSTRIPKVQE LLEKFFDGKK ASKGINPDEA VAYGAAVQAG VLSGEDGVED 

       430        440        450        460        470        480 
IVLLDVNPLT LGIETTGGVM TKLINRNTNI PTKKSQIFST AVDNQSTVLI QVFEGERTMS 

       490        500        510        520        530        540 
KDNNLLGKFE LKGIPPAPRG VPQIEVTFEL DANGILRVTA HDKGTGKSET ITITNDKGRL 

       550        560        570        580        590        600 
SKDEIERMVE EAERFAEEDA LIRETIEAKN SLENYAHSLR NQVADKSGLG GKISADDKEA 

       610        620        630        640        650        660 
LNDAVTETLE WLEANSVSAT KEDFEEKKEA LSAIAYPITS KIYEGGEGGD ESNDGGFYAD 

       670 
DDEAPFHDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U63136 Genomic DNA. Translation: AAC49736.1.
CR382131 Genomic DNA. Translation: CAG79506.1.
RefSeqXP_503913.1. XM_503913.1.

3D structure databases

ProteinModelPortalQ99170.
SMRQ99170. Positions 37-576.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ99170. 1 interaction.
MINTMINT-1540646.
STRING4952.Q99170.

Proteomic databases

PRIDEQ99170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG79506; CAG79506; YALI0_E13706g.
GeneID2912786.
KEGGyli:YALI0E13706g.

Phylogenomic databases

eggNOGCOG0443.
HOGENOMHOG000228135.
KOK09490.
OMACWIALLF.
OrthoDBEOG728916.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_YARLI
AccessionPrimary (citable) accession number: Q99170
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 13, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families