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Protein

Apoptin

Gene

VP3

Organism
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host mitotic exit by virus, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptin
Gene namesi
Name:VP3
OrganismiChicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Taxonomic identifieri73475 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000007528 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 121121ApoptinPRO_0000223008Add
BLAST

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.1 Publication

Keywords - Developmental stagei

Early protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PIK3R1P279863EBI-1776808,EBI-79464From a different organism.
PPIL3Q9H2H83EBI-1776808,EBI-751051From a different organism.

Protein-protein interaction databases

DIPiDIP-45593N.
IntActiQ99152. 3 interactions.
MINTiMINT-7303383.

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus apoptin family.Curated

Family and domain databases

InterProiIPR006858. CAV_VP3.
[Graphical view]
PfamiPF04771. CAV_VP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALQEDTPP GPSTVFRPPT SSRPLETPHC REIRIGIAGI TITLSLCGCA
60 70 80 90 100
NARAPTLRSA TADNSESTGF KNVPDLRTDQ PKPPSKKRSC DPSEYRVSEL
110 120
KESLITTTPS RPRTAKRRIR L
Length:121
Mass (Da):13,270
Last modified:October 1, 1996 - v1
Checksum:iD2AAB3869BC12A3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701F → S in AAA42883 (PubMed:1605740).Curated
Sequence conflicti116 – 1161K → R (PubMed:1605740).Curated
Sequence conflicti118 – 1181R → C (PubMed:1605740).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55918 Genomic DNA. Translation: AAA91823.1.
M81223 Genomic DNA. Translation: AAA42883.1.
PIRiB39926.
B48343.
RefSeqiNP_056774.1. NC_001427.1.

Genome annotation databases

GeneIDi1494446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55918 Genomic DNA. Translation: AAA91823.1.
M81223 Genomic DNA. Translation: AAA42883.1.
PIRiB39926.
B48343.
RefSeqiNP_056774.1. NC_001427.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-45593N.
IntActiQ99152. 3 interactions.
MINTiMINT-7303383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1494446.

Family and domain databases

InterProiIPR006858. CAV_VP3.
[Graphical view]
PfamiPF04771. CAV_VP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle."
    Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C., Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A., Koch G., van Ormondt H., van der Eb A.J.
    J. Virol. 65:3131-3139(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments."
    Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S.
    Arch. Virol. 124:301-319(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification of a 24 kDa protein expressed by chicken anaemia virus."
    Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L.
    J. Gen. Virol. 76:1557-1562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiVP3_CAVC1
AccessioniPrimary (citable) accession number: Q99152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.