Reviewed, UniProtKB/Swiss-Prot Q99152 (VP3_CAVC1)

Names and origin

Protein names

Recommended name:
    Apoptin

Gene names

Name:

VP3

Organism

Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) [Complete proteome]

Taxonomic identifier

73475 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Circoviridae › Gyrovirus

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle.
Subcellular location	Host nucleus. Note: Host nucleus of infected cells.
Induction	VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours. Ref.3
Sequence similarities	Belongs to the gyrovirus apoptin family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Host nucleus
Developmental stage	Early protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	induction by virus of host apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PPIL3	Q9H2H8	1	EBI-1776808,EBI-751051	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 121	121	Apoptin		PRO_0000223008
Experimental info
	Sequence conflict	70	1	F → S in AAA42883. Ref.2
	Sequence conflict	116	1	K → R Ref.2
	Sequence conflict	118	1	R → C Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q99152-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D2AAB3869BC12A3E	FASTA	121	13,270
	10 20 30 40 50 60 MNALQEDTPP GPSTVFRPPT SSRPLETPHC REIRIGIAGI TITLSLCGCA NARAPTLRSA 70 80 90 100 110 120 TADNSESTGF KNVPDLRTDQ PKPPSKKRSC DPSEYRVSEL KESLITTTPS RPRTAKRRIR L

References

[1]	"Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle." Noteborn M.H.M., de Boer G.F., van Roozelaar D.J., Karreman C., Kranenburg O., Vos J.G., Jeurissen S.H.M., Hoeben R.C., Zantema A., Koch G., van Ormondt H., van der Eb A.J. J. Virol. 65:3131-3139(1991) [PubMed: 1851873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments." Meehan B.M., Todd D., Creelan J.L., Earle J.A.P., Hoey E.M., McNulty M.S. Arch. Virol. 124:301-319(1992) [PubMed: 1605740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of a 24 kDa protein expressed by chicken anaemia virus." Douglas A.J., Phenix K., Mawhinney K.A., Todd D., Mackie D.P., Curran W.L. J. Gen. Virol. 76:1557-1562(1995) [PubMed: 9049362] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M55918 Genomic DNA. Translation: AAA91823.1. M81223 Genomic DNA. Translation: AAA42883.1.
PIR	B39926. B48343.
RefSeq	NP_056774.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99152. 1 interaction.
Genome annotation databases
GeneID	1494446.
Family and domain databases
InterPro	IPR006858. CAV_VP3. [Graphical view]
Pfam	PF04771. CAV_VP3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP3_CAVC1

Accession

Primary (citable) accession number: Q99152

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)