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Protein

Apoptin

Gene

VP3

Organism
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host mitotic exit by virus, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptin
Gene namesi
Name:VP3
OrganismiChicken anemia virus (isolate Germany Cuxhaven-1) (CAV)
Taxonomic identifieri73475 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000007528 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002230081 – 121ApoptinAdd BLAST121

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.1 Publication

Keywords - Developmental stagei

Early protein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PIK3R1P279863EBI-1776808,EBI-79464From a different organism.
PPIL3Q9H2H83EBI-1776808,EBI-751051From a different organism.

Protein-protein interaction databases

DIPiDIP-45593N.
IntActiQ99152. 3 interactors.
MINTiMINT-7303383.

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus apoptin family.Curated

Family and domain databases

InterProiIPR006858. CAV_VP3.
[Graphical view]
PfamiPF04771. CAV_VP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q99152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALQEDTPP GPSTVFRPPT SSRPLETPHC REIRIGIAGI TITLSLCGCA
60 70 80 90 100
NARAPTLRSA TADNSESTGF KNVPDLRTDQ PKPPSKKRSC DPSEYRVSEL
110 120
KESLITTTPS RPRTAKRRIR L
Length:121
Mass (Da):13,270
Last modified:October 1, 1996 - v1
Checksum:iD2AAB3869BC12A3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70F → S in AAA42883 (PubMed:1605740).Curated1
Sequence conflicti116K → R (PubMed:1605740).Curated1
Sequence conflicti118R → C (PubMed:1605740).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55918 Genomic DNA. Translation: AAA91823.1.
M81223 Genomic DNA. Translation: AAA42883.1.
PIRiB39926.
B48343.
RefSeqiNP_056774.1. NC_001427.1.

Genome annotation databases

GeneIDi1494446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55918 Genomic DNA. Translation: AAA91823.1.
M81223 Genomic DNA. Translation: AAA42883.1.
PIRiB39926.
B48343.
RefSeqiNP_056774.1. NC_001427.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-45593N.
IntActiQ99152. 3 interactors.
MINTiMINT-7303383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1494446.

Family and domain databases

InterProiIPR006858. CAV_VP3.
[Graphical view]
PfamiPF04771. CAV_VP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVP3_CAVC1
AccessioniPrimary (citable) accession number: Q99152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.