Q99102 (MUC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-4
Short name=MUC-4

Alternative name(s):
Ascites sialoglycoprotein
Short name=ASGP
Pancreatic adenocarcinoma mucin
Testis mucin
Tracheobronchial mucin

Cleaved into the following 2 chains:

1. Mucin-4 alpha chain
   Alternative name(s):
   Ascites sialoglycoprotein 1
   Short name=ASGP-1
2. Mucin-4 beta chain
   Alternative name(s):
   Ascites sialoglycoprotein 2
   Short name=ASGP-2

Gene names

Name:

MUC4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Ref.8 Ref.9 Ref.10 Ref.11
Subunit structure	A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3 By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential. Secreted. Note: Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. Ref.8 Mucin-4 beta chain: Cell membrane; Single-pass membrane protein Ref.8. Mucin-4 alpha chain: Secreted Ref.8. Isoform 3: Cell membrane; Single-pass membrane protein Ref.8. Isoform 11: Secreted Ref.8. Isoform 15: Secreted Ref.8. Isoform 17: Cell membrane; Single-pass membrane protein Ref.8.
Tissue specificity	Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. Ref.1 Ref.2 Ref.4 Ref.10
Developmental stage	Expressed early in the primitive gut before respiratory and digestive epithelial cells have acquired their tissue and cell specificity. Expressed at the basal surface of the epithelium from week 14 to 26 weeks and then predominantly localized in only parietal cells. Immediately before birth, found in the cytoplasm of the mucous columnar epithelial cells. In the embryo expressed in skin, then disappears late in gestation. Ref.11
Post-translational modification	Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. mucrnin-4 alpha chain is highly O-glycosylated. Ref.12 mucin-4 beta chain is predominantly N-glycosylated. Ref.12
Miscellaneous	Expression is a very useful predictor of poor prognosis in patients with invasive ductal carcinoma and intrahepatic cholangiocarcinoma, mass forming type (IDC,ICC-MF). Patients with IDC or ICC-MF who have high MUC4 expression had a worse survival rate than those with low MUC4 expression.
Sequence similarities	Contains 1 AMOP domain. Contains 2 EGF-like domains. Contains 1 NIDO domain. Contains 1 VWFD domain.
Sequence caution	The sequence AAA63230.1 differs from that shown. Reason: May be derived from an intron translation. The sequence CAC14139.1 differs from that shown. Reason: Frameshift at position 1171. The sequence CAC14141.1 differs from that shown. Reason: Frameshift at position 1256.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell-matrix adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc proteinaceous extracellular matrix Non-traceable author statement Ref.2. Source: UniProtKB
Molecular function	ErbB-2 class receptor binding Traceable author statement. Source: ProtInc extracellular matrix constituent, lubricant activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 14 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms exist.

Isoform 1 (identifier: Q99102-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q99102-2)

Also known as: Sv12; Sv13;

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1157: FTDNGQIIFP...PVALVAPFWD → ASQAGTLWPW...TRRSMVNTAC
     1158-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: Q99102-3)

Also known as: Sv20;

The sequence of this isoform differs from the canonical sequence as follows:
     1814-1827: VAGCKCDGGTFGRY → LWGALSCVRTSPAL
     1828-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: Q99102-5)

Also known as: Sv18; Sv19;

The sequence of this isoform differs from the canonical sequence as follows:
     1172-1223: Missing.
     1258-1267: GNPVLMGFSS → VEMAFSKTAH
     1268-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 7 (identifier: Q99102-7)

Also known as: Sv16;

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1201: FTDNGQIIFP...RKMTNNGGYK → ASQAGTLWPW...VPASVGEVSP
     1202-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 8 (identifier: Q99102-8)

Also known as: Sv15;

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1199: FTDNGQIIFP...WIRKMTNNGG → ASQAGTLWPW...VEMAFSKTAH
     1200-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 9 (identifier: Q99102-9)

Also known as: Sv11;

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1107: RGVSLFPYGAGAGDLEFVRRTVDFTSPLFKPATGFPL → SPLWGRRRGPGVRQEDRGLHLPTLQAGDWLPP
     1108-2169: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 10 (identifier: Q99102-10)

Also known as: Sv3; Sv17;

The sequence of this isoform differs from the canonical sequence as follows:
     1172-1223: Missing.

Isoform 11 (identifier: Q99102-11)

Also known as: Sv2;

The sequence of this isoform differs from the canonical sequence as follows:
     1073-1187: VSLFPYGAGA...GEHSLLVQQA → EAIQEFPSSP...TRRSMVNTAC
     1188-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 12 (identifier: Q99102-12)

Also known as: SvX;

The sequence of this isoform differs from the canonical sequence as follows:
     29-1072: Missing.

Note: May be preferentially expressed in tumor tissues.

Isoform 13 (identifier: Q99102-13)

Also known as: SvY;

The sequence of this isoform differs from the canonical sequence as follows:
     29-1021: Missing.

Note: May be preferentially expressed in tumor tissues.

Isoform 15 (identifier: Q99102-15)

Also known as: Sv1;

The sequence of this isoform differs from the canonical sequence as follows:
     1073-1177: VSLFPYGAGA...TFYQEYETFY → AIQEFPSSPM...LVGGPHFIRL
     1178-2169: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 16 (identifier: Q99102-16)

Also known as: Sv6;

The sequence of this isoform differs from the canonical sequence as follows:
     1336-1384: VSCPCSWQQG...GVCCSYGPWG → AAPPRLAQPR...QSVSCWITRL
     1385-2169: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Isoform 17 (identifier: Q99102-17)

Also known as: Sv8;

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1579: Missing.

Note: Dubious isoform produced through aberrant splice sites.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 2169	2141	Mucin-4		PRO_0000158956
	Chain	29 – 1444	1416	Mucin-4 alpha chain		PRO_0000274225
	Chain	1445 – 2169	725	Mucin-4 beta chain		PRO_0000274226
Regions
	Transmembrane	2126 – 2146	21	Helical; Potential
	Domain	1154 – 1309	156	NIDO
	Domain	1310 – 1425	116	AMOP
	Domain	1438 – 1673	236	VWFD
	Domain	1875 – 1914	40	EGF-like 1
	Domain	2078 – 2117	40	EGF-like 2
	Region	1002 – 1038	37	Repeat
	Compositional bias	793 – 1013	221	Ser-rich
Sites
	Site	1444 – 1445	2	Cleavage
Amino acid modifications
	Glycosylation	161	1	O-linked (GalNAc...) Potential
	Glycosylation	235	1	N-linked (GlcNAc...) Potential
	Glycosylation	260	1	N-linked (GlcNAc...) Potential
	Glycosylation	622	1	N-linked (GlcNAc...) Potential
	Glycosylation	1472	1	N-linked (GlcNAc...) Potential
	Glycosylation	1525	1	N-linked (GlcNAc...) Potential
	Glycosylation	1544	1	N-linked (GlcNAc...) Potential
	Glycosylation	1553	1	N-linked (GlcNAc...) Potential
	Glycosylation	1588	1	N-linked (GlcNAc...) Potential
	Glycosylation	1609	1	N-linked (GlcNAc...) Potential
	Glycosylation	1632	1	N-linked (GlcNAc...) Potential
	Glycosylation	1659	1	N-linked (GlcNAc...) Potential
	Glycosylation	1685	1	N-linked (GlcNAc...) Potential
	Glycosylation	1703	1	N-linked (GlcNAc...) Potential
	Glycosylation	1739	1	N-linked (GlcNAc...) Potential
	Glycosylation	1754	1	N-linked (GlcNAc...) Potential
	Glycosylation	1802	1	N-linked (GlcNAc...) Potential
	Glycosylation	1809	1	N-linked (GlcNAc...) Ref.12
	Glycosylation	1857	1	N-linked (GlcNAc...) Potential
	Glycosylation	1876	1	N-linked (GlcNAc...) Potential
	Glycosylation	1942	1	N-linked (GlcNAc...) Potential
	Glycosylation	1949	1	N-linked (GlcNAc...) Potential
	Glycosylation	2049	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1879 ↔ 1890		By similarity
	Disulfide bond	1884 ↔ 1902		By similarity
	Disulfide bond	1904 ↔ 1913		By similarity
	Disulfide bond	2081 ↔ 2092		By similarity
	Disulfide bond	2086 ↔ 2101		By similarity
	Disulfide bond	2103 ↔ 2116		By similarity
Natural variations
	Alternative sequence	29 – 1072	1044	Missing in isoform 12.		VSP_022650
	Alternative sequence	29 – 1021	993	Missing in isoform 13.		VSP_022651
	Alternative sequence	1071 – 1107	37	RGVSL…TGFPL → SPLWGRRRGPGVRQEDRGLH LPTLQAGDWLPP in isoform 9.		VSP_022652
	Alternative sequence	1073 – 1187	115	VSLFP…LVQQA → EAIQEFPSSPMGQTPGTWSS SGGPWTSPPHSSSRRLASPL APLSVIPSTSQTMARSSSQS QTTRFSPTPTHSQQASQAGT LWPWWLRSGTMLTSPLVGGP HFIRNTRRSMVNTAC in isoform 11.		VSP_022653
	Alternative sequence	1073 – 1177	105	VSLFP…YETFY → AIQEFPSSPMGQTPGTWSSS GGPWTSPPHSSSRRLASPLA PLSVIPSTSQTMARSSSQSQ TTRFSPTPTHSQQASQAGTL WPWWLRSGTMLTSPLVGGPH FIRL in isoform 15.		VSP_022654
	Alternative sequence	1108 – 2169	1062	Missing in isoform 9.		VSP_022655
	Alternative sequence	1117 – 1201	85	FTDNG…NGGYK → ASQAGTLWPWWLRSGTMLTS PLVGGPHFIRATPTKPSSPR TGAGPMPCFSTRAVGCSGTW PSAQWRWLFRKQPTDVPASV GEVSP in isoform 7.		VSP_022656
	Alternative sequence	1117 – 1199	83	FTDNG…TNNGG → ASQAGTLWPWWLRSGTMLTS PLVGGPHFIRATPTKPSSPR TGAGPMPCFSTRAVGCSGTW PSAQASRCSWASLVEMAFSK TAH in isoform 8.		VSP_022657
	Alternative sequence	1117 – 1157	41	FTDNG…APFWD → ASQAGTLWPWWLRSGTMLTS PLVGGPHFIRNTRRSMVNTA C in isoform 2.		VSP_022658
	Alternative sequence	1158 – 2169	1012	Missing in isoform 2.		VSP_022659
	Alternative sequence	1172 – 1223	52	Missing in isoform 5 and isoform 10.		VSP_022661
	Alternative sequence	1178 – 2169	992	Missing in isoform 15.		VSP_022662
	Alternative sequence	1188 – 2169	982	Missing in isoform 11.		VSP_022663
	Alternative sequence	1200 – 2169	970	Missing in isoform 8.		VSP_022664
	Alternative sequence	1202 – 2169	968	Missing in isoform 7.		VSP_022665
	Alternative sequence	1258 – 1267	10	GNPVLMGFSS → VEMAFSKTAH in isoform 5.		VSP_022669
	Alternative sequence	1268 – 2169	902	Missing in isoform 5.		VSP_022670
	Alternative sequence	1336 – 1384	49	VSCPC…YGPWG → AAPPRLAQPRPPTSSPLRLS TAPAAWAPSRSNGSLSLTTQ SVSCWITRL in isoform 16.		VSP_022671
	Alternative sequence	1354 – 1579	226	Missing in isoform 17.		VSP_022672
	Alternative sequence	1385 – 2169	785	Missing in isoform 16.		VSP_022673
	Alternative sequence	1814 – 1827	14	VAGCK…TFGRY → LWGALSCVRTSPAL in isoform 3.		VSP_022674
	Alternative sequence	1828 – 2169	342	Missing in isoform 3.		VSP_022675
	Natural variant	37	1	G → D. Corresponds to variant rs2259292 [ dbSNP | Ensembl ].		VAR_030211
	Natural variant	41	1	A → P. Ref.2 Ref.3 Corresponds to variant rs3107764 [ dbSNP | Ensembl ].		VAR_065261
	Natural variant	161	1	T → A. Corresponds to variant rs2293232 [ dbSNP | Ensembl ].		VAR_030212
	Natural variant	585	1	S → A. Corresponds to variant rs2246901 [ dbSNP | Ensembl ].		VAR_030213
	Natural variant	721	1	A → T. Corresponds to variant rs3749331 [ dbSNP | Ensembl ].		VAR_056585
	Natural variant	1081	1	G → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs2259292 [ dbSNP | Ensembl ].		VAR_065262
	Natural variant	1205	1	A → T. Corresponds to variant rs2293232 [ dbSNP | Ensembl ].		VAR_056586
	Natural variant	1578	1	A → S. Ref.3 Corresponds to variant rs2246901 [ dbSNP | Ensembl ].		VAR_056587
Experimental info
	Sequence conflict	1194	1	M → I in CAB85602. Ref.1
	Sequence conflict	1194	1	M → I in CAB85603. Ref.1
	Sequence conflict	1194	1	M → I in CAB85604. Ref.1
	Sequence conflict	1194	1	M → I in CAB85605. Ref.1
	Sequence conflict	1194	1	M → I in CAB85606. Ref.1
	Sequence conflict	1194	1	M → I in CAB81773. Ref.2
	Sequence conflict	1194	1	M → I in CAC14141. Ref.2
	Sequence conflict	1194	1	M → I in CAC14142. Ref.2
	Sequence conflict	1194	1	M → I in CAC14143. Ref.2
	Sequence conflict	1194	1	M → I in AAM66747. Ref.3
	Sequence conflict	1194	1	M → I in CAD22550. Ref.4
	Sequence conflict	1194	1	M → I in CAB38059. Ref.5
	Sequence conflict	1259	1	N → K in CAB81773. Ref.2
	Sequence conflict	1259	1	N → K in CAC14143. Ref.2
	Sequence conflict	1259	1	N → K in CAC10061. Ref.2
	Sequence conflict	1259	1	N → K in AAM66747. Ref.3
	Sequence conflict	1271	1	Y → F in CAB81773. Ref.2
	Sequence conflict	1271	1	Y → F in CAC14143. Ref.2
	Sequence conflict	1271	1	Y → F in CAC10061. Ref.2
	Sequence conflict	1271	1	Y → F in AAM66747. Ref.3
	Sequence conflict	1305	1	R → G in CAB81773. Ref.2
	Sequence conflict	1305	1	R → G in CAC14143. Ref.2
	Sequence conflict	1305	1	R → G in CAC10061. Ref.2
	Sequence conflict	1305	1	R → G in AAM66747. Ref.3
	Sequence conflict	1557	1	V → A in CAB81773. Ref.2
	Sequence conflict	1557	1	V → A in CAC14143. Ref.2
	Sequence conflict	1557	1	V → A in CAC10061. Ref.2
	Sequence conflict	1557	1	V → A in AAM66747. Ref.3
	Sequence conflict	1920 – 1921	2	Missing in CAC14143. Ref.2
	Sequence conflict	2039	1	G → E in CAB85604. Ref.1
	Sequence conflict	2039	1	G → E in CAB85605. Ref.1
	Sequence conflict	2039	1	G → E in CAB85606. Ref.1
	Sequence conflict	2039	1	G → E in CAD22550. Ref.4
	Sequence conflict	2039	1	G → E in CAB38059. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 28, 2011. Version 4. Checksum: 53615AF8DD416957	FASTA	2,169	231,518
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QEYETFYGEH SLLVQQAESW IRKMTNNGGY 1210 1220 1230 1240 1250 1260 KARWALKVTW VNAHAYPAQW TLGSNTYQAI LSTDGSRSYA LFLYQSGGMQ WDVAQRSGNP 1270 1280 1290 1300 1310 1320 VLMGFSSGDG YFENSPLMSQ PVWERYRPDR FLNSNSGLQG LQFYRLHREE RPNYRLECLQ 1330 1340 1350 1360 1370 1380 WLKSQPRWPS WGWNQVSCPC SWQQGRRDLR FQPVSIGRWG LGSRQLCSFT SWRGGVCCSY 1390 1400 1410 1420 1430 1440 GPWGEFREGW HVQRPWQLAQ ELEPQSWCCR WNDKPYLCAL YQQRRPHVGC ATYRPPQPAW 1450 1460 1470 1480 1490 1500 MFGDPHITTL DGVSYTFNGL GDFLLVGAQD GNSSFLLQGR TAQTGSAQAT NFIAFAAQYR 1510 1520 1530 1540 1550 1560 SSSLGPVTVQ WLLEPHDAIR VLLDNQTVTF QPDHEDGGGQ ETFNATGVLL SRNGSEVSAS 1570 1580 1590 1600 1610 1620 FDGWATVSVI ALSNILHASA SLPPEYQNRT EGLLGVWNNN PEDDFRMPNG STIPPGSPEE 1630 1640 1650 1660 1670 1680 MLFHFGMTWQ INGTGLLGKR NDQLPSNFTP VFYSQLQKNS SWAEHLISNC DGDSSCIYDT 1690 1700 1710 1720 1730 1740 LALRNASIGL HTREVSKNYE QANATLNQYP PSINGGRVIE AYKGQTTLIQ YTSNAEDANF 1750 1760 1770 1780 1790 1800 TLRDSCTDLE LFENGTLLWT PKSLEPFTLE ILARSAKIGL ASALQPRTVV CHCNAESQCL 1810 1820 1830 1840 1850 1860 YNQTSRVGNS SLEVAGCKCD GGTFGRYCEG SEDACEEPCF PSVHCVPGKG CEACPPNLTG 1870 1880 1890 1900 1910 1920 DGRHCAALGS SFLCQNQSCP VNYCYNQGHC YISQTLGCQP MCTCPPAFTD SRCFLAGNNF 1930 1940 1950 1960 1970 1980 SPTVNLELPL RVIQLLLSEE ENASMAEVNA SVAYRLGTLD MRAFLRNSQV ERIDSAAPAS 1990 2000 2010 2020 2030 2040 GSPIQHWMVI SEFQYRPRGP VIDFLNNQLL AAVVEAFLYH VPRRSEEPRN DVVFQPISGE 2050 2060 2070 2080 2090 2100 DVRDVTALNV STLKAYFRCD GYKGYDLVYS PQSGFTCVSP CSRGYCDHGG QCQHLPSGPR 2110 2120 2130 2140 2150 2160 CSCVSFSIYT AWGEHCEHLS MKLDAFFGIF FGALGGLLLL GVGTFVVLRF WGCSGARFSY FLNSAEALP
	Isoform 2 (Sv12) (Sv13) [UniParc]. Checksum: 563F538E94C8D17F	FASTA	1,157	118,842
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYASQA GTLWPWWLRS GTMLTSPLVG 1150 GPHFIRNTRR SMVNTAC
	Isoform 3 (Sv20) [UniParc]. Checksum: 7C0F057C7FFD9B61	FASTA	1,827	194,147
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QEYETFYGEH SLLVQQAESW IRKMTNNGGY 1210 1220 1230 1240 1250 1260 KARWALKVTW VNAHAYPAQW TLGSNTYQAI LSTDGSRSYA LFLYQSGGMQ WDVAQRSGNP 1270 1280 1290 1300 1310 1320 VLMGFSSGDG YFENSPLMSQ PVWERYRPDR FLNSNSGLQG LQFYRLHREE RPNYRLECLQ 1330 1340 1350 1360 1370 1380 WLKSQPRWPS WGWNQVSCPC SWQQGRRDLR FQPVSIGRWG LGSRQLCSFT SWRGGVCCSY 1390 1400 1410 1420 1430 1440 GPWGEFREGW HVQRPWQLAQ ELEPQSWCCR WNDKPYLCAL YQQRRPHVGC ATYRPPQPAW 1450 1460 1470 1480 1490 1500 MFGDPHITTL DGVSYTFNGL GDFLLVGAQD GNSSFLLQGR TAQTGSAQAT NFIAFAAQYR 1510 1520 1530 1540 1550 1560 SSSLGPVTVQ WLLEPHDAIR VLLDNQTVTF QPDHEDGGGQ ETFNATGVLL SRNGSEVSAS 1570 1580 1590 1600 1610 1620 FDGWATVSVI ALSNILHASA SLPPEYQNRT EGLLGVWNNN PEDDFRMPNG STIPPGSPEE 1630 1640 1650 1660 1670 1680 MLFHFGMTWQ INGTGLLGKR NDQLPSNFTP VFYSQLQKNS SWAEHLISNC DGDSSCIYDT 1690 1700 1710 1720 1730 1740 LALRNASIGL HTREVSKNYE QANATLNQYP PSINGGRVIE AYKGQTTLIQ YTSNAEDANF 1750 1760 1770 1780 1790 1800 TLRDSCTDLE LFENGTLLWT PKSLEPFTLE ILARSAKIGL ASALQPRTVV CHCNAESQCL 1810 1820 YNQTSRVGNS SLELWGALSC VRTSPAL
	Isoform 5 (Sv18) (Sv19) [UniParc]. Checksum: 6394DD971A6AC6AA	FASTA	1,215	125,352
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QSNTYQAILS TDGSRSYALF LYQSGGMQWD 1210 VAQRSVEMAF SKTAH
	Isoform 7 (Sv16) [UniParc]. Checksum: 90CCFA911DF8A6DC	FASTA	1,201	123,420
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYASQA GTLWPWWLRS GTMLTSPLVG 1150 1160 1170 1180 1190 1200 GPHFIRATPT KPSSPRTGAG PMPCFSTRAV GCSGTWPSAQ WRWLFRKQPT DVPASVGEVS P
	Isoform 8 (Sv15) [UniParc]. Checksum: C297274BF47EE49E	FASTA	1,199	123,047
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYASQA GTLWPWWLRS GTMLTSPLVG 1150 1160 1170 1180 1190 GPHFIRATPT KPSSPRTGAG PMPCFSTRAV GCSGTWPSAQ ASRCSWASLV EMAFSKTAH
	Isoform 9 (Sv11) [UniParc]. Checksum: A533603C2182BFD7	FASTA	1,102	112,954
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE SPLWGRRRGP 1090 1100 GVRQEDRGLH LPTLQAGDWL PP
	Isoform 10 (Sv3) (Sv17) [UniParc]. Checksum: 6A59FC9B7497C05F	FASTA	2,117	225,434
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QSNTYQAILS TDGSRSYALF LYQSGGMQWD 1210 1220 1230 1240 1250 1260 VAQRSGNPVL MGFSSGDGYF ENSPLMSQPV WERYRPDRFL NSNSGLQGLQ FYRLHREERP 1270 1280 1290 1300 1310 1320 NYRLECLQWL KSQPRWPSWG WNQVSCPCSW QQGRRDLRFQ PVSIGRWGLG SRQLCSFTSW 1330 1340 1350 1360 1370 1380 RGGVCCSYGP WGEFREGWHV QRPWQLAQEL EPQSWCCRWN DKPYLCALYQ QRRPHVGCAT 1390 1400 1410 1420 1430 1440 YRPPQPAWMF GDPHITTLDG VSYTFNGLGD FLLVGAQDGN SSFLLQGRTA QTGSAQATNF 1450 1460 1470 1480 1490 1500 IAFAAQYRSS SLGPVTVQWL LEPHDAIRVL LDNQTVTFQP DHEDGGGQET FNATGVLLSR 1510 1520 1530 1540 1550 1560 NGSEVSASFD GWATVSVIAL SNILHASASL PPEYQNRTEG LLGVWNNNPE DDFRMPNGST 1570 1580 1590 1600 1610 1620 IPPGSPEEML FHFGMTWQIN GTGLLGKRND QLPSNFTPVF YSQLQKNSSW AEHLISNCDG 1630 1640 1650 1660 1670 1680 DSSCIYDTLA LRNASIGLHT REVSKNYEQA NATLNQYPPS INGGRVIEAY KGQTTLIQYT 1690 1700 1710 1720 1730 1740 SNAEDANFTL RDSCTDLELF ENGTLLWTPK SLEPFTLEIL ARSAKIGLAS ALQPRTVVCH 1750 1760 1770 1780 1790 1800 CNAESQCLYN QTSRVGNSSL EVAGCKCDGG TFGRYCEGSE DACEEPCFPS VHCVPGKGCE 1810 1820 1830 1840 1850 1860 ACPPNLTGDG RHCAALGSSF LCQNQSCPVN YCYNQGHCYI SQTLGCQPMC TCPPAFTDSR 1870 1880 1890 1900 1910 1920 CFLAGNNFSP TVNLELPLRV IQLLLSEEEN ASMAEVNASV AYRLGTLDMR AFLRNSQVER 1930 1940 1950 1960 1970 1980 IDSAAPASGS PIQHWMVISE FQYRPRGPVI DFLNNQLLAA VVEAFLYHVP RRSEEPRNDV 1990 2000 2010 2020 2030 2040 VFQPISGEDV RDVTALNVST LKAYFRCDGY KGYDLVYSPQ SGFTCVSPCS RGYCDHGGQC 2050 2060 2070 2080 2090 2100 QHLPSGPRCS CVSFSIYTAW GEHCEHLSMK LDAFFGIFFG ALGGLLLLGV GTFVVLRFWG 2110 CSGARFSYFL NSAEALP
	Isoform 11 (Sv2) [UniParc]. Checksum: 79896412E450E46B	FASTA	1,187	121,900
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGEAIQEFPS 1090 1100 1110 1120 1130 1140 SPMGQTPGTW SSSGGPWTSP PHSSSRRLAS PLAPLSVIPS TSQTMARSSS QSQTTRFSPT 1150 1160 1170 1180 PTHSQQASQA GTLWPWWLRS GTMLTSPLVG GPHFIRNTRR SMVNTAC
	Isoform 12 (SvX) [UniParc]. Checksum: D1750D4908B75B6D	FASTA	1,125	125,130
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGVS LFPYGAGAGD LEFVRRTVDF TSPLFKPATG 70 80 90 100 110 120 FPLGSSLRDS LYFTDNGQII FPESDYQIFS YPNPLPTGFT GRDPVALVAP FWDDADFSTG 130 140 150 160 170 180 RGTTFYQEYE TFYGEHSLLV QQAESWIRKM TNNGGYKARW ALKVTWVNAH AYPAQWTLGS 190 200 210 220 230 240 NTYQAILSTD GSRSYALFLY QSGGMQWDVA QRSGNPVLMG FSSGDGYFEN SPLMSQPVWE 250 260 270 280 290 300 RYRPDRFLNS NSGLQGLQFY RLHREERPNY RLECLQWLKS QPRWPSWGWN QVSCPCSWQQ 310 320 330 340 350 360 GRRDLRFQPV SIGRWGLGSR QLCSFTSWRG GVCCSYGPWG EFREGWHVQR PWQLAQELEP 370 380 390 400 410 420 QSWCCRWNDK PYLCALYQQR RPHVGCATYR PPQPAWMFGD PHITTLDGVS YTFNGLGDFL 430 440 450 460 470 480 LVGAQDGNSS FLLQGRTAQT GSAQATNFIA FAAQYRSSSL GPVTVQWLLE PHDAIRVLLD 490 500 510 520 530 540 NQTVTFQPDH EDGGGQETFN ATGVLLSRNG SEVSASFDGW ATVSVIALSN ILHASASLPP 550 560 570 580 590 600 EYQNRTEGLL GVWNNNPEDD FRMPNGSTIP PGSPEEMLFH FGMTWQINGT GLLGKRNDQL 610 620 630 640 650 660 PSNFTPVFYS QLQKNSSWAE HLISNCDGDS SCIYDTLALR NASIGLHTRE VSKNYEQANA 670 680 690 700 710 720 TLNQYPPSIN GGRVIEAYKG QTTLIQYTSN AEDANFTLRD SCTDLELFEN GTLLWTPKSL 730 740 750 760 770 780 EPFTLEILAR SAKIGLASAL QPRTVVCHCN AESQCLYNQT SRVGNSSLEV AGCKCDGGTF 790 800 810 820 830 840 GRYCEGSEDA CEEPCFPSVH CVPGKGCEAC PPNLTGDGRH CAALGSSFLC QNQSCPVNYC 850 860 870 880 890 900 YNQGHCYISQ TLGCQPMCTC PPAFTDSRCF LAGNNFSPTV NLELPLRVIQ LLLSEEENAS 910 920 930 940 950 960 MAEVNASVAY RLGTLDMRAF LRNSQVERID SAAPASGSPI QHWMVISEFQ YRPRGPVIDF 970 980 990 1000 1010 1020 LNNQLLAAVV EAFLYHVPRR SEEPRNDVVF QPISGEDVRD VTALNVSTLK AYFRCDGYKG 1030 1040 1050 1060 1070 1080 YDLVYSPQSG FTCVSPCSRG YCDHGGQCQH LPSGPRCSCV SFSIYTAWGE HCEHLSMKLD 1090 1100 1110 1120 AFFGIFFGAL GGLLLLGVGT FVVLRFWGCS GARFSYFLNS AEALP
	Isoform 13 (SvY) [UniParc]. Checksum: 92B845E20A242187	FASTA	1,176	130,415
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGMT TPSLKTDGGR RTATSPPPTT SQTIISTIPS 70 80 90 100 110 120 TAMHTRSTAA PIPILPERGV SLFPYGAGAG DLEFVRRTVD FTSPLFKPAT GFPLGSSLRD 130 140 150 160 170 180 SLYFTDNGQI IFPESDYQIF SYPNPLPTGF TGRDPVALVA PFWDDADFST GRGTTFYQEY 190 200 210 220 230 240 ETFYGEHSLL VQQAESWIRK MTNNGGYKAR WALKVTWVNA HAYPAQWTLG SNTYQAILST 250 260 270 280 290 300 DGSRSYALFL YQSGGMQWDV AQRSGNPVLM GFSSGDGYFE NSPLMSQPVW ERYRPDRFLN 310 320 330 340 350 360 SNSGLQGLQF YRLHREERPN YRLECLQWLK SQPRWPSWGW NQVSCPCSWQ QGRRDLRFQP 370 380 390 400 410 420 VSIGRWGLGS RQLCSFTSWR GGVCCSYGPW GEFREGWHVQ RPWQLAQELE PQSWCCRWND 430 440 450 460 470 480 KPYLCALYQQ RRPHVGCATY RPPQPAWMFG DPHITTLDGV SYTFNGLGDF LLVGAQDGNS 490 500 510 520 530 540 SFLLQGRTAQ TGSAQATNFI AFAAQYRSSS LGPVTVQWLL EPHDAIRVLL DNQTVTFQPD 550 560 570 580 590 600 HEDGGGQETF NATGVLLSRN GSEVSASFDG WATVSVIALS NILHASASLP PEYQNRTEGL 610 620 630 640 650 660 LGVWNNNPED DFRMPNGSTI PPGSPEEMLF HFGMTWQING TGLLGKRNDQ LPSNFTPVFY 670 680 690 700 710 720 SQLQKNSSWA EHLISNCDGD SSCIYDTLAL RNASIGLHTR EVSKNYEQAN ATLNQYPPSI 730 740 750 760 770 780 NGGRVIEAYK GQTTLIQYTS NAEDANFTLR DSCTDLELFE NGTLLWTPKS LEPFTLEILA 790 800 810 820 830 840 RSAKIGLASA LQPRTVVCHC NAESQCLYNQ TSRVGNSSLE VAGCKCDGGT FGRYCEGSED 850 860 870 880 890 900 ACEEPCFPSV HCVPGKGCEA CPPNLTGDGR HCAALGSSFL CQNQSCPVNY CYNQGHCYIS 910 920 930 940 950 960 QTLGCQPMCT CPPAFTDSRC FLAGNNFSPT VNLELPLRVI QLLLSEEENA SMAEVNASVA 970 980 990 1000 1010 1020 YRLGTLDMRA FLRNSQVERI DSAAPASGSP IQHWMVISEF QYRPRGPVID FLNNQLLAAV 1030 1040 1050 1060 1070 1080 VEAFLYHVPR RSEEPRNDVV FQPISGEDVR DVTALNVSTL KAYFRCDGYK GYDLVYSPQS 1090 1100 1110 1120 1130 1140 GFTCVSPCSR GYCDHGGQCQ HLPSGPRCSC VSFSIYTAWG EHCEHLSMKL DAFFGIFFGA 1150 1160 1170 LGGLLLLGVG TFVVLRFWGC SGARFSYFLN SAEALP
	Isoform 15 (Sv1) [UniParc]. Checksum: 922532E6C031907A	FASTA	1,176	120,650
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGAIQEFPSS 1090 1100 1110 1120 1130 1140 PMGQTPGTWS SSGGPWTSPP HSSSRRLASP LAPLSVIPST SQTMARSSSQ SQTTRFSPTP 1150 1160 1170 THSQQASQAG TLWPWWLRSG TMLTSPLVGG PHFIRL
	Isoform 16 (Sv6) [UniParc]. Checksum: 24DAF864CC4008DD	FASTA	1,384	144,847
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QEYETFYGEH SLLVQQAESW IRKMTNNGGY 1210 1220 1230 1240 1250 1260 KARWALKVTW VNAHAYPAQW TLGSNTYQAI LSTDGSRSYA LFLYQSGGMQ WDVAQRSGNP 1270 1280 1290 1300 1310 1320 VLMGFSSGDG YFENSPLMSQ PVWERYRPDR FLNSNSGLQG LQFYRLHREE RPNYRLECLQ 1330 1340 1350 1360 1370 1380 WLKSQPRWPS WGWNQAAPPR LAQPRPPTSS PLRLSTAPAA WAPSRSNGSL SLTTQSVSCW ITRL
	Isoform 17 (Sv8) [UniParc]. Checksum: 8AB442BDDA613D41	FASTA	1,943	206,605
	10 20 30 40 50 60 MKGARWRRVP WVSLSCLCLC LLPHVVPGTT EDTLITGSKT AAPVTSTGST TATLEGQSTA 70 80 90 100 110 120 ASSRTSNQDI SASSQNHQTK STETTSKAQT DTLTQMMTST LFSSPSVHNV METVTQETAP 130 140 150 160 170 180 PDEMTTSFPS SVTNTLMMTS KTITMTTSTD STLGNTEETS TAGTESSTPV TSAVSITAGQ 190 200 210 220 230 240 EGQSRTTSWR TSIQDTSASS QNHWTRSTQT TRESQTSTLT HRTTSTPSFS PSVHNVTGTV 250 260 270 280 290 300 SQKTSPSGET ATSSLCSVTN TSMMTSEKIT VTTSTGSTLG NPGETSSVPV TGSLMPVTSA 310 320 330 340 350 360 ALVTVDPEGQ SPATFSRTST QDTTAFSKNH QTQSVETTRV SQINTLNTLT PVTTSTVLSS 370 380 390 400 410 420 PSGFNPSGTV SQETFPSGET TISSPSSVSN TFLVTSKVFR MPISRDSTLG NTEETSLSVS 430 440 450 460 470 480 GTISAITSKV STIWWSDTLS TALSPSSLPP KISTAFHTQQ SEGAETTGRP HERSSFSPGV 490 500 510 520 530 540 SQEIFTLHET TTWPSSFSSK GHTTWSQTEL PSTSTGAATR LVTGNPSTRA AGTIPRVPSK 550 560 570 580 590 600 VSAIGEPGEP TTYSSHSTTL PKTTGAGAQT QWTQETGTTG EALLSSPSYS VIQMIKTATS 610 620 630 640 650 660 PSSSPMLDRH TSQQITTAPS TNHSTIHSTS TSPQESPAVS QRGHTRAPQT TQESQTTRSV 670 680 690 700 710 720 SPMTDTKTVT TPGSSFTASG HSPSEIVPQD APTISAATTF APAPTGNGHT TQAPTTALQA 730 740 750 760 770 780 APSSHDATLG PSGGTSLSKT GALTLANSVV STPGGPEGQW TSASASTSPD TAAAMTHTHQ 790 800 810 820 830 840 AESTEASGQT QTSEPASSGS RTTSAGTATP SSSGASGTTP SGSEGISTSG ETTRFSSNPS 850 860 870 880 890 900 RDSHTTQSTT ELLSASASHG AIPVSTGMAS SIVPGTFHPT LSEASTAGRP TGQSSPTSPS 910 920 930 940 950 960 ASPQETAAIS RMAQTQRTGT SRGSDTISLA SQATDTFSTV PPTPPSITSS GLTSPQTQTH 970 980 990 1000 1010 1020 TLSPSGSGKT FTTALISNAT PLPVTSTSSA STGHATPLAV SSATSASTVS SDSPLKMETS 1030 1040 1050 1060 1070 1080 GMTTPSLKTD GGRRTATSPP PTTSQTIIST IPSTAMHTRS TAAPIPILPE RGVSLFPYGA 1090 1100 1110 1120 1130 1140 GAGDLEFVRR TVDFTSPLFK PATGFPLGSS LRDSLYFTDN GQIIFPESDY QIFSYPNPLP 1150 1160 1170 1180 1190 1200 TGFTGRDPVA LVAPFWDDAD FSTGRGTTFY QEYETFYGEH SLLVQQAESW IRKMTNNGGY 1210 1220 1230 1240 1250 1260 KARWALKVTW VNAHAYPAQW TLGSNTYQAI LSTDGSRSYA LFLYQSGGMQ WDVAQRSGNP 1270 1280 1290 1300 1310 1320 VLMGFSSGDG YFENSPLMSQ PVWERYRPDR FLNSNSGLQG LQFYRLHREE RPNYRLECLQ 1330 1340 1350 1360 1370 1380 WLKSQPRWPS WGWNQVSCPC SWQQGRRDLR FQPASLPPEY QNRTEGLLGV WNNNPEDDFR 1390 1400 1410 1420 1430 1440 MPNGSTIPPG SPEEMLFHFG MTWQINGTGL LGKRNDQLPS NFTPVFYSQL QKNSSWAEHL 1450 1460 1470 1480 1490 1500 ISNCDGDSSC IYDTLALRNA SIGLHTREVS KNYEQANATL NQYPPSINGG RVIEAYKGQT 1510 1520 1530 1540 1550 1560 TLIQYTSNAE DANFTLRDSC TDLELFENGT LLWTPKSLEP FTLEILARSA KIGLASALQP 1570 1580 1590 1600 1610 1620 RTVVCHCNAE SQCLYNQTSR VGNSSLEVAG CKCDGGTFGR YCEGSEDACE EPCFPSVHCV 1630 1640 1650 1660 1670 1680 PGKGCEACPP NLTGDGRHCA ALGSSFLCQN QSCPVNYCYN QGHCYISQTL GCQPMCTCPP 1690 1700 1710 1720 1730 1740 AFTDSRCFLA GNNFSPTVNL ELPLRVIQLL LSEEENASMA EVNASVAYRL GTLDMRAFLR 1750 1760 1770 1780 1790 1800 NSQVERIDSA APASGSPIQH WMVISEFQYR PRGPVIDFLN NQLLAAVVEA FLYHVPRRSE 1810 1820 1830 1840 1850 1860 EPRNDVVFQP ISGEDVRDVT ALNVSTLKAY FRCDGYKGYD LVYSPQSGFT CVSPCSRGYC 1870 1880 1890 1900 1910 1920 DHGGQCQHLP SGPRCSCVSF SIYTAWGEHC EHLSMKLDAF FGIFFGALGG LLLLGVGTFV 1930 1940 VLRFWGCSGA RFSYFLNSAE ALP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins." Moniaux N., Escande F., Batra S.K., Porchet N., Laine A., Aubert J.-P. Eur. J. Biochem. 267:4536-4544(2000) [PubMed: 10880978] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12 AND 13), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 11; 15; 16 AND 17), TISSUE SPECIFICITY, VARIANT ASP-1081. Tissue: Lung and Testis.
[2]	"Human MUC4 mucin cDNA and its variants in pancreatic carcinoma." Choudhury A., Moniaux N., Winpenny J.P., Hollingsworth M.A., Aubert J.-P., Batra S.K. J. Biochem. 128:233-243(2000) [PubMed: 10920259] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 5; 7; 8; 9; 10 AND 11), TISSUE SPECIFICITY, VARIANTS PRO-41 AND ASP-1081. Tissue: Pancreatic tumor.
[3]	"Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4." Desseyn J.-L., Clavereau I., Laine A. Eur. J. Biochem. 269:3150-3159(2002) [PubMed: 12084055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-41; ASP-1081 AND SER-1578.
[4]	"Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin." Moniaux N., Nollet S., Porchet N., Degand P., Laine A., Aubert J.-P. Biochem. J. 338:325-333(1999) [PubMed: 10024507] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1014-2169 (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ASP-1081. Tissue: Colon mucosa.
[5]	"Genomic organization of MUC4 mucin gene: towards the characterization of splice variants." Escande F., Lemaitre L., Moniaux N., Batra S.K., Aubert J.-P., Buisine M.P. Eur. J. Biochem. 269:3637-3644(2002) [PubMed: 12153560] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1014-2169, VARIANT ASP-1081.
[6]	"Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs." Porchet N., van Cong N., Dufosse J., Audie J.P., Guyonnet-Duperat V., Gross M.S., Denis C., Degand P., Bernheim A., Aubert J.-P. Biochem. Biophys. Res. Commun. 175:414-422(1991) [PubMed: 1673336] [Abstract] Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
[7]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive." Carraway K.L., Perez A., Idris N., Jepson S., Arango M.E., Komatsu M., Haq B., Price-Schiavi S.A., Zhang J., Carraway C.A. Prog. Nucleic Acid Res. Mol. Biol. 71:149-185(2002) [PubMed: 12102554] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[9]	"MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas." Saitou M., Goto M., Horinouchi M., Tamada S., Nagata K., Hamada T., Osako M., Takao S., Batra S.K., Aikou T., Imai K., Yonezawa S. J. Clin. Pathol. 58:845-852(2005) [PubMed: 16049287] [Abstract] Cited for: FUNCTION.
[10]	"MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC)." Karg A., Dinc Z.A., Basok O., Ucvet A. Pathol. Res. Pract. 202:577-583(2006) [PubMed: 16814944] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[11]	"MUC4 expression and localization in gastrointestinal tract and skin of human embryos." Zhang J., Yasin M., Carraway C.A., Carraway K.L. Tissue Cell 38:271-275(2006) [PubMed: 16914178] [Abstract] Cited for: DEVELOPMENTAL STAGE, FUNCTION.
[12]	"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry." Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F. Proteomics 8:3833-3847(2008) [PubMed: 18780401] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809, MASS SPECTROMETRY. Tissue: Milk.
+	Additional computationally mapped references.

Web resources

Mucin database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ242541 mRNA. Translation: CAB85597.1. AJ242542 mRNA. Translation: CAB85598.1. AJ242543 mRNA. Translation: CAB85599.1. AJ242544 mRNA. Translation: CAB85600.1. AJ242545 mRNA. Translation: CAB85601.1. AJ242546 mRNA. Translation: CAB85602.1. AJ242547 mRNA. Translation: CAB85603.1. AJ242548 mRNA. Translation: CAB85604.1. AJ242549 mRNA. Translation: CAB85605.1. AJ242550 mRNA. Translation: CAB85606.1. AJ276359 mRNA. Translation: CAB81773.1. AJ277412 mRNA. Translation: CAC10061.1. AJ277505 mRNA. Translation: CAC14585.1. AJ400633 mRNA. Translation: CAC10062.1. AJ400849 mRNA. Translation: CAC14134.1. AJ400850 mRNA. Translation: CAC14135.1. AJ400851 mRNA. Translation: CAC14136.1. AJ400852 mRNA. Translation: CAC14137.1. AJ400855 mRNA. Translation: CAC14140.1. AJ400853 mRNA. Translation: CAC14138.1. AJ400854 mRNA. Translation: CAC14139.1. Frameshift. AJ400856 mRNA. Translation: CAC14141.1. Frameshift. AJ400857 mRNA. Translation: CAC14142.1. AJ400858 mRNA. Translation: CAC14143.1. AF522055 , AF522031, AF522032, AF522033, AF522034, AF522035, AF522036, AF522037, AF522038, AF522039, AF522040, AF522041, AF522042, AF522043, AF522044, AF522045, AF522046, AF522047, AF522048, AF522049, AF522050, AF522051, AF522052, AF522053, AF522054 Genomic DNA. Translation: AAM66747.1. AJ010901 mRNA. Translation: CAB38059.1. AJ430032, AJ430033, AJ430034 Genomic DNA. Translation: CAD22550.1. M64594 mRNA. Translation: AAA63230.1. Sequence problems. AC069513 Genomic DNA. No translation available. AC233280 Genomic DNA. No translation available.
IPI	IPI00178316. IPI00302162. IPI00302258. IPI00479285. IPI00789419. IPI00790855. IPI00795577. IPI00797458. IPI00827725. IPI00827732. IPI00827758. IPI00827768. IPI00828047. IPI00828180.
PIR	PN0012.
RefSeq	NP_004523.3. NM_004532.5. NP_060876.5. NM_018406.6. NP_612154.2. NM_138297.4.
UniGene	Hs.369646.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q99102. 1 interaction.
STRING	Q99102.
PTM databases
GlycoSuiteDB	Q99102.
PhosphoSite	Q99102.
Polymorphism databases
DMDM	300669685.
Proteomic databases
PRIDE	Q99102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000346145; ENSP00000304207; ENSG00000145113. ENST00000349607; ENSP00000338109; ENSG00000145113.
GeneID	4585.
KEGG	hsa:4585.
UCSC	uc003fvg.1. human. uc003fvk.1. human. uc010hzt.1. human.
Organism-specific databases
CTD	4585.
GeneCards	GC03M195473.
H-InvDB	HIX0003957.
HGNC	HGNC:7514. MUC4.
HPA	CAB013536. HPA005895.
MIM	158372. gene.
neXtProt	NX_Q99102.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000077082.
HOVERGEN	HBG081997.
Gene expression databases
Bgee	Q99102.
Genevestigator	Q99102.
Family and domain databases
InterPro	IPR005533. AMOP. IPR006210. EGF-like. IPR000742. EGF_3. IPR003886. Nidogen_extracell_dom. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF03782. AMOP. 1 hit. PF06119. NIDO. 1 hit. PF00094. VWD. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00539. NIDO. 1 hit. SM00216. VWD. 1 hit. [Graphical view]
PROSITE	PS50856. AMOP. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 2 hits. PS51220. NIDO. 1 hit. PS51233. VWFD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	17619.
SOURCE	Search...

Entry information

Entry name

MUC4_HUMAN

Accession

Primary (citable) accession number: Q99102
Secondary accession number(s): O95938 , Q9GZM2, Q9GZV6, Q9H481, Q9H482, Q9H483, Q9H484, Q9H485, Q9H486, Q9H487, Q9H4D6, Q9H4D8, Q9NPJ0, Q9NY09, Q9NY75, Q9NY76, Q9NY77, Q9NY78, Q9NY79, Q9NY80, Q9NY81

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 28, 2011
Last modified:	January 25, 2012
This is version 98 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.