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Protein

Transcription factor 12

Gene

TCF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

GO - Molecular functioni

  1. bHLH transcription factor binding Source: BHF-UCL
  2. E-box binding Source: Ensembl
  3. enhancer binding Source: BHF-UCL
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  6. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  7. SMAD binding Source: BHF-UCL
  8. transcription factor binding Source: BHF-UCL

GO - Biological processi

  1. immune response Source: ProtInc
  2. muscle organ development Source: ProtInc
  3. positive regulation of neuron differentiation Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 12
Short name:
TCF-12
Alternative name(s):
Class B basic helix-loop-helix protein 20
Short name:
bHLHb20
DNA-binding protein HTF4
E-box-binding protein
Transcription factor HTF-4
Gene namesi
Name:TCF12
Synonyms:BHLHB20, HEB, HTF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:11623. TCF12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nuclear chromatin Source: BHF-UCL
  3. nucleus Source: LIFEdb
  4. RNA polymerase II transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Craniosynostosis 32 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.

See also OMIM:615314
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831L → R in CRS3. 1 Publication
VAR_072271
Natural varianti600 – 6001L → P in CRS3. 1 Publication
VAR_070096
Natural varianti614 – 6141Q → E in CRS3. 1 Publication
VAR_070097

Keywords - Diseasei

Craniosynostosis, Disease mutation

Organism-specific databases

MIMi615314. phenotype.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
35099. Isolated brachycephaly.
35098. Isolated plagiocephaly.
PharmGKBiPA36381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Transcription factor 12PRO_0000127228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Phosphoserine1 Publication
Modified residuei313 – 3131Phosphothreonine1 Publication
Modified residuei333 – 3331Phosphoserine1 Publication
Modified residuei557 – 5571Phosphothreonine1 Publication
Modified residuei559 – 5591Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ99081.
PaxDbiQ99081.
PRIDEiQ99081.

Expressioni

Tissue specificityi

Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line.

Gene expression databases

BgeeiQ99081.
CleanExiHS_TCF12.
ExpressionAtlasiQ99081. baseline and differential.
GenevestigatoriQ99081.

Organism-specific databases

HPAiCAB004432.
HPA002103.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1A. Interacts with NEUROD2 (By similarity). Interacts with RUNX1T1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FOXH1O755932EBI-722877,EBI-1759806

Protein-protein interaction databases

BioGridi112798. 59 interactions.
DIPiDIP-29403N.
IntActiQ99081. 15 interactions.
MINTiMINT-4713897.
STRINGi9606.ENSP00000331057.

Structurei

Secondary structure

1
682
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 184Combined sources
Turni24 – 263Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KNHNMR-B11-28[»]
4JOLX-ray2.91E/F/G/H177-200[»]
ProteinModelPortaliQ99081.
SMRiQ99081. Positions 578-637.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99081.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini577 – 63054bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 14022Leucine-zipperAdd
BLAST
Regioni632 – 65524Class A specific domainAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 2799aaTAD

Domaini

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG282899.
GeneTreeiENSGT00510000046438.
HOGENOMiHOG000234180.
HOVERGENiHBG003854.
InParanoidiQ99081.
KOiK15603.
OMAiYYSFSAT.
OrthoDBiEOG72G16Q.
PhylomeDBiQ99081.
TreeFamiTF321672.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q99081-1) [UniParc]FASTAAdd to Basket

Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG
60 70 80 90 100
IDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT
110 120 130 140 150
PFMNSNLMGK TSERGSFSLY SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG
160 170 180 190 200
KPGTAYYSFS ATSSRRRPLH DSAALDPLQA KKVRKVPPGL PSSVYAPSPN
210 220 230 240 250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS SNGMSQPGFG
260 270 280 290 300
GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG
310 320 330 340 350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD
360 370 380 390 400
HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLQSRM
410 420 430 440 450
EDRLDRLDDA IHVLRNHAVG PSTSLPAGHS DIHSLLGPSH NAPIGSLNSN
460 470 480 490 500
YGGSSLVASS RSASMVGTHR EDSVSLNGNH SVLSSTVTTS STDLNHKTQE
510 520 530 540 550
NYRGGLQSQS GTVVTTEIKT ENKEKDENLH EPPSSDDMKS DDESSQKDIK
560 570 580 590 600
VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL
610 620 630 640 650
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE
660 670 680
EEKVSAVSAE PPTTLPGTHP GLSETTNPMG HM
Length:682
Mass (Da):72,965
Last modified:October 1, 1996 - v1
Checksum:i9736113D9361D3F5
GO
Isoform 2 (identifier: Q99081-2) [UniParc]FASTAAdd to Basket

Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     171-193: DSAALDPLQAKKVRKVPPGLPSS → MYCAYPVPGMGSNSLMYYYNGKT

Show »
Length:512
Mass (Da):55,142
Checksum:i98AF7F83F8A2AEF4
GO
Isoform 3 (identifier: Q99081-3) [UniParc]FASTAAdd to Basket

Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     396-396: L → LKNRVEQQLHEHLQDAMSFLKDVCE

Show »
Length:706
Mass (Da):75,845
Checksum:i75B7B4173C9B660D
GO
Isoform 4 (identifier: Q99081-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MNPQQQRMAA...PVNSGKTRPT → MGKRYMHHPQ...VCSLALSLCK
     40-275: Missing.

Note: No experimental confirmation available.

Show »
Length:446
Mass (Da):48,157
Checksum:i1165CAD3B87F74DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti523 – 5231K → E in CAD89914. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001G → S.
Corresponds to variant rs12442879 [ dbSNP | Ensembl ].
VAR_049543
Natural varianti483 – 4831L → R in CRS3. 1 Publication
VAR_072271
Natural varianti600 – 6001L → P in CRS3. 1 Publication
VAR_070096
Natural varianti614 – 6141Q → E in CRS3. 1 Publication
VAR_070097

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 170170Missing in isoform 2. 1 PublicationVSP_039109Add
BLAST
Alternative sequencei1 – 3939MNPQQ…KTRPT → MGKRYMHHPQIQMISTVNLL VIHLLSHQPVCSLALSLCK in isoform 4. 1 PublicationVSP_057419Add
BLAST
Alternative sequencei40 – 275236Missing in isoform 4. 1 PublicationVSP_057420Add
BLAST
Alternative sequencei171 – 19323DSAAL…GLPSS → MYCAYPVPGMGSNSLMYYYN GKT in isoform 2. 1 PublicationVSP_039110Add
BLAST
Alternative sequencei396 – 3961L → LKNRVEQQLHEHLQDAMSFL KDVCE in isoform 3. 1 PublicationVSP_040024

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83233 mRNA. Translation: AAB62389.1.
M80627 mRNA. Translation: AAA58632.1.
AL831981 mRNA. Translation: CAD89914.1.
AK304007 mRNA. Translation: BAG64923.1.
BX537967 mRNA. Translation: CAD97931.1.
AC010999 Genomic DNA. No translation available.
AC016525 Genomic DNA. No translation available.
AC090511 Genomic DNA. No translation available.
AC090532 Genomic DNA. No translation available.
KF456057 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77512.1.
BC050556 mRNA. Translation: AAH50556.1.
M65209 mRNA. Translation: AAC37571.1.
BK001049 mRNA. Translation: DAA01129.1.
CCDSiCCDS10159.1. [Q99081-1]
CCDS10160.1. [Q99081-3]
CCDS42042.1. [Q99081-2]
PIRiA42121.
RefSeqiNP_003196.1. NM_003205.3. [Q99081-1]
NP_996919.1. NM_207036.1. [Q99081-3]
NP_996920.1. NM_207037.1. [Q99081-3]
NP_996921.1. NM_207038.1. [Q99081-1]
NP_996923.1. NM_207040.1. [Q99081-2]
UniGeneiHs.511504.

Genome annotation databases

EnsembliENST00000267811; ENSP00000267811; ENSG00000140262. [Q99081-1]
ENST00000333725; ENSP00000331057; ENSG00000140262. [Q99081-3]
ENST00000343827; ENSP00000342459; ENSG00000140262. [Q99081-2]
ENST00000438423; ENSP00000388940; ENSG00000140262. [Q99081-3]
ENST00000557843; ENSP00000453737; ENSG00000140262. [Q99081-1]
GeneIDi6938.
KEGGihsa:6938.
UCSCiuc002aea.3. human. [Q99081-3]
uc002aec.3. human. [Q99081-1]
uc002aee.3. human. [Q99081-2]

Polymorphism databases

DMDMi1708332.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83233 mRNA. Translation: AAB62389.1.
M80627 mRNA. Translation: AAA58632.1.
AL831981 mRNA. Translation: CAD89914.1.
AK304007 mRNA. Translation: BAG64923.1.
BX537967 mRNA. Translation: CAD97931.1.
AC010999 Genomic DNA. No translation available.
AC016525 Genomic DNA. No translation available.
AC090511 Genomic DNA. No translation available.
AC090532 Genomic DNA. No translation available.
KF456057 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77512.1.
BC050556 mRNA. Translation: AAH50556.1.
M65209 mRNA. Translation: AAC37571.1.
BK001049 mRNA. Translation: DAA01129.1.
CCDSiCCDS10159.1. [Q99081-1]
CCDS10160.1. [Q99081-3]
CCDS42042.1. [Q99081-2]
PIRiA42121.
RefSeqiNP_003196.1. NM_003205.3. [Q99081-1]
NP_996919.1. NM_207036.1. [Q99081-3]
NP_996920.1. NM_207037.1. [Q99081-3]
NP_996921.1. NM_207038.1. [Q99081-1]
NP_996923.1. NM_207040.1. [Q99081-2]
UniGeneiHs.511504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KNHNMR-B11-28[»]
4JOLX-ray2.91E/F/G/H177-200[»]
ProteinModelPortaliQ99081.
SMRiQ99081. Positions 578-637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112798. 59 interactions.
DIPiDIP-29403N.
IntActiQ99081. 15 interactions.
MINTiMINT-4713897.
STRINGi9606.ENSP00000331057.

Polymorphism databases

DMDMi1708332.

Proteomic databases

MaxQBiQ99081.
PaxDbiQ99081.
PRIDEiQ99081.

Protocols and materials databases

DNASUi6938.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267811; ENSP00000267811; ENSG00000140262. [Q99081-1]
ENST00000333725; ENSP00000331057; ENSG00000140262. [Q99081-3]
ENST00000343827; ENSP00000342459; ENSG00000140262. [Q99081-2]
ENST00000438423; ENSP00000388940; ENSG00000140262. [Q99081-3]
ENST00000557843; ENSP00000453737; ENSG00000140262. [Q99081-1]
GeneIDi6938.
KEGGihsa:6938.
UCSCiuc002aea.3. human. [Q99081-3]
uc002aec.3. human. [Q99081-1]
uc002aee.3. human. [Q99081-2]

Organism-specific databases

CTDi6938.
GeneCardsiGC15P057210.
HGNCiHGNC:11623. TCF12.
HPAiCAB004432.
HPA002103.
MIMi600480. gene.
615314. phenotype.
neXtProtiNX_Q99081.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
35099. Isolated brachycephaly.
35098. Isolated plagiocephaly.
PharmGKBiPA36381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG282899.
GeneTreeiENSGT00510000046438.
HOGENOMiHOG000234180.
HOVERGENiHBG003854.
InParanoidiQ99081.
KOiK15603.
OMAiYYSFSAT.
OrthoDBiEOG72G16Q.
PhylomeDBiQ99081.
TreeFamiTF321672.

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.

Miscellaneous databases

ChiTaRSiTCF12. human.
EvolutionaryTraceiQ99081.
GeneWikiiTCF12.
GenomeRNAii6938.
NextBioi27145.
PROiQ99081.
SOURCEiSearch...

Gene expression databases

BgeeiQ99081.
CleanExiHS_TCF12.
ExpressionAtlasiQ99081. baseline and differential.
GenevestigatoriQ99081.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of the human transcription factor HTF4a cDNA."
    Zhang Y., Bina M.
    DNA Seq. 2:397-403(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors."
    Hu J.S., Olson E.N., Kingston R.E.
    Mol. Cell. Biol. 12:1031-1042(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Endometrium and Skeletal muscle.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 352-682.
  9. "Genomic organization of human TCF12 gene and spliced mRNA variants producing isoforms of transcription factor HTF4."
    Gan T.I., Rowen L., Nesbitt R., Roe B.A., Wu H., Hu P., Yao Z., Kim U.J., O'Sickey T., Bina M.
    Cytogenet. Genome Res. 98:245-248(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE ORGANIZATION, ALTERNATIVE SPLICING.
  10. "The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity."
    Liu Y., Cheney M.D., Gaudet J.J., Chruszcz M., Lukasik S.M., Sugiyama D., Lary J., Cole J., Dauter Z., Minor W., Speck N.A., Bushweller J.H.
    Cancer Cell 9:249-260(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RUNX1T1.
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Nine-amino-acid transactivation domain: establishment and prediction utilities."
    Piskacek S., Gregor M., Nemethova M., Grabner M., Kovarik P., Piskacek M.
    Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  14. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-333 AND THR-557, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity."
    Park S., Chen W., Cierpicki T., Tonelli M., Cai X., Speck N.A., Bushweller J.H.
    Blood 113:3558-3567(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 11-28 IN COMPLEX WITH RUNX1T1, SUBUNIT.
  20. Cited for: VARIANTS CRS3 PRO-600 AND GLU-614.
  21. Cited for: VARIANT CRS3 ARG-483.

Entry informationi

Entry nameiHTF4_HUMAN
AccessioniPrimary (citable) accession number: Q99081
Secondary accession number(s): B4E1W1
, Q7Z3D9, Q86TC1, Q86VM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.