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Reviewed, UniProtKB/Swiss-Prot Q99056 (LAC5_TRAVI)

Last modified November 24, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-5
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 5
    Urishiol oxidase 5
    Diphenol oxidase 5
Gene names
Name: LCC5
OrganismTrametes villosa (White-rot fungus)
Taxonomic identifier47662 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Aphyllophorales › Trametes

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products Probable.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

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Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 527504Laccase-5
PRO_0000002947

Regions

Domain25 – 150126Plastocyanin-like 1
Domain162 – 306145Plastocyanin-like 2
Domain373 – 498126Plastocyanin-like 3

Sites

Metal binding871Copper 1; type 2 By similarity
Metal binding891Copper 2; type 3 By similarity
Metal binding1321Copper 2; type 3 By similarity
Metal binding1341Copper 3; type 3 By similarity
Metal binding4251Copper 4; type 1 By similarity
Metal binding4281Copper 1; type 2 By similarity
Metal binding4301Copper 3; type 3 By similarity
Metal binding4801Copper 3; type 3 By similarity
Metal binding4811Copper 4; type 1 By similarity
Metal binding4821Copper 2; type 3 By similarity
Metal binding4861Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation771N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q99056-1 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: F1BE638D65FFA478

FASTA52756,247
        10         20         30         40         50         60 
MGKYHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA GGVFPGPLIT 

        70         80         90        100        110        120 
GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD GAAFVNQCPI ATGNSFLYDF 

       130        140        150        160        170        180 
TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY DPDDPNASLY DVDDDTTVIT LADWYHTAAK 

       190        200        210        220        230        240 
LGPAFPAGPD SVLINGLGRF SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG 

       250        260        270        280        290        300 
HNMTIIEVDG VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 

       310        320        330        340        350        360 
SAILRYDTAE DIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA MSLDFSFNGS 

       370        380        390        400        410        420 
NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP SNSTIEISFP IITTDGVLNA 

       430        440        450        460        470        480 
PGAPHPFHLH GHTFSVVRSA GSSTFNYANP VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH 

       490        500        510        520 
CHIDFHLEAG FAIVWGEDTA DTASANPVPT AWSDLCPTYD ALDSSDL

« Hide

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References

[1]"Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
Yaver D.S., Golightly E.J.
Gene 181:95-102(1996) [PubMed: 8973314] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Yaver D.S., Golightly E.J.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L78078 Genomic DNA. Translation: AAB47735.2.
PIRJC5357.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.10.3.2. 259651.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC5_TRAVI
AccessionPrimary (citable) accession number: Q99056
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: November 24, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents