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Q99056

- LAC5_TRAVI

UniProt

Q99056 - LAC5_TRAVI

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Protein

Laccase-5

Gene
LCC5
Organism
Trametes villosa (White-rot fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Copper 1; type 2 By similarity
Metal bindingi89 – 891Copper 2; type 3 By similarity
Metal bindingi132 – 1321Copper 2; type 3 By similarity
Metal bindingi134 – 1341Copper 3; type 3 By similarity
Metal bindingi425 – 4251Copper 4; type 1 By similarity
Metal bindingi428 – 4281Copper 1; type 2 By similarity
Metal bindingi430 – 4301Copper 3; type 3 By similarity
Metal bindingi480 – 4801Copper 3; type 3 By similarity
Metal bindingi481 – 4811Copper 4; type 1 By similarity
Metal bindingi482 – 4821Copper 2; type 3 By similarity
Metal bindingi486 – 4861Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-5 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 5
Diphenol oxidase 5
Urishiol oxidase 5
Gene namesi
Name:LCC5
OrganismiTrametes villosa (White-rot fungus)
Taxonomic identifieri47662 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 527504Laccase-5PRO_0000002947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi358 – 3581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99056.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 150126Plastocyanin-like 1Add
BLAST
Domaini162 – 306145Plastocyanin-like 2Add
BLAST
Domaini373 – 498126Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99056-1 [UniParc]FASTAAdd to Basket

« Hide

MGKYHSFVNV VALSLSLSGR VFGAIGPVTD LTISNADVTP DGITRAAVLA    50
GGVFPGPLIT GNKGDEFQIN VIDNLTNETM LKSTTIHWHG IFQAGTNWAD 100
GAAFVNQCPI ATGNSFLYDF TVPDQAGTFW YHSHLSTQYC DGLRGPLVVY 150
DPDDPNASLY DVDDDTTVIT LADWYHTAAK LGPAFPAGPD SVLINGLGRF 200
SGDGGGATNL TVITVTQGKR YRFRLVSISC DPNFTFSIDG HNMTIIEVDG 250
VNHEALDVDS IQIFAGQRYS FILNANQSID NYWIRAIPNT GTTDTTGGVN 300
SAILRYDTAE DIEPTTNATT SVIPLTETDL VPLDNPAAPG DPQVGGVDLA 350
MSLDFSFNGS NFFINNETFV PPTVPVLLQI LSGAQDAASL LPNGSVYTLP 400
SNSTIEISFP IITTDGVLNA PGAPHPFHLH GHTFSVVRSA GSSTFNYANP 450
VRRDTVSTGN SGDNVTIRFT TDNPGPWFLH CHIDFHLEAG FAIVWGEDTA 500
DTASANPVPT AWSDLCPTYD ALDSSDL 527
Length:527
Mass (Da):56,247
Last modified:August 14, 2001 - v2
Checksum:iF1BE638D65FFA478
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L78078 Genomic DNA. Translation: AAB47735.2.
PIRiJC5357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L78078 Genomic DNA. Translation: AAB47735.2 .
PIRi JC5357.

3D structure databases

ProteinModelPortali Q99056.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
    Yaver D.S., Golightly E.J.
    Gene 181:95-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Yaver D.S., Golightly E.J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiLAC5_TRAVI
AccessioniPrimary (citable) accession number: Q99056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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