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Q99055

- LAC4_TRAVI

UniProt

Q99055 - LAC4_TRAVI

Protein

Laccase-4

Gene

LCC4

Organism
Trametes villosa (White-rot fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Copper 1; type 2By similarity
    Metal bindingi88 – 881Copper 2; type 3By similarity
    Metal bindingi131 – 1311Copper 2; type 3By similarity
    Metal bindingi133 – 1331Copper 3; type 3By similarity
    Metal bindingi418 – 4181Copper 4; type 1By similarity
    Metal bindingi421 – 4211Copper 1; type 2By similarity
    Metal bindingi423 – 4231Copper 3; type 3By similarity
    Metal bindingi473 – 4731Copper 3; type 3By similarity
    Metal bindingi474 – 4741Copper 4; type 1By similarity
    Metal bindingi475 – 4751Copper 2; type 3By similarity
    Metal bindingi479 – 4791Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-4 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 4
    Diphenol oxidase 4
    Urishiol oxidase 4
    Gene namesi
    Name:LCC4
    OrganismiTrametes villosa (White-rot fungus)
    Taxonomic identifieri47662 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 520502Laccase-4PRO_0000002946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ99055.
    SMRiQ99055. Positions 23-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 149126Plastocyanin-like 1Add
    BLAST
    Domaini161 – 303143Plastocyanin-like 2Add
    BLAST
    Domaini370 – 491122Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99055-1 [UniParc]FASTAAdd to Basket

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    MGRFSSLCAL TAVIHSFGRV SAAIGPVTDL TISNGDVSPD GFTRAAVLAN    50
    GVFPGPLITG NKGDNFQINV IDNLSNETML KSTSIHWHGF FQKGTNWADG 100
    AAFVNQCPIA TGNSFLYDFT ATDQAGTFWY HSHLSTQYCD GLRGPMVVYD 150
    PSDPHADLYD VDDETTIITL SDWYHTAASL GAAFPIGSDS TLINGLGRFA 200
    GGDSTDLAVI TVEQGKRYRM RLLSLSCDPN YVFSIDGHNM TIIEADAVNH 250
    EPLTVDSIQI YAGQRYSFVL TADQDIDNYF IRALPSAGTT SFDGGINSAI 300
    LRYSGASEVD PTTTETTSVL PLDEANLVPL DSPAAPGDPN IGGVDYALNL 350
    DFNFDGTNFF INDVSFVSPT VPVLLQILSG TTSAADLLPS GSLFAVPSNS 400
    TIEISFPITA TNAPGAPHPF HLHGHTFSIV RTAGSTDTNF VNPVRRDVVN 450
    TGTVGDNVTI RFTTDNPGPW FLHCHIDFHL EAGFAIVFSE DTADVSNTTT 500
    PSTAWEDLCP TYNALDSSDL 520
    Length:520
    Mass (Da):55,644
    Last modified:November 1, 1996 - v1
    Checksum:i16469DC547C61F3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L78077 Genomic DNA. Translation: AAB47734.1.
    PIRiJC5356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L78077 Genomic DNA. Translation: AAB47734.1 .
    PIRi JC5356.

    3D structure databases

    ProteinModelPortali Q99055.
    SMRi Q99055. Positions 23-519.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
      Yaver D.S., Golightly E.J.
      Gene 181:95-102(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLAC4_TRAVI
    AccessioniPrimary (citable) accession number: Q99055
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3