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Reviewed, UniProtKB/Swiss-Prot Q99055 (LAC4_TRAVI)

Last modified June 16, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-4
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 4
    Urishiol oxidase 4
    Diphenol oxidase 4
Gene names
Name: LCC4
OrganismTrametes villosa (White-rot fungus)
Taxonomic identifier47662 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Aphyllophorales › Trametes

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Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products Probable.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

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Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 520502Laccase-4
PRO_0000002946

Regions

Domain24 – 149126Plastocyanin-like 1
Domain161 – 303143Plastocyanin-like 2
Domain370 – 491122Plastocyanin-like 3

Sites

Metal binding861Copper 1; type 2 By similarity
Metal binding881Copper 2; type 3 By similarity
Metal binding1311Copper 2; type 3 By similarity
Metal binding1331Copper 3; type 3 By similarity
Metal binding4181Copper 4; type 1 By similarity
Metal binding4211Copper 1; type 2 By similarity
Metal binding4231Copper 3; type 3 By similarity
Metal binding4731Copper 3; type 3 By similarity
Metal binding4741Copper 4; type 1 By similarity
Metal binding4751Copper 2; type 3 By similarity
Metal binding4791Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation3991N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q99055-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 16469DC547C61F3C

FASTA52055,644
        10         20         30         40         50         60 
MGRFSSLCAL TAVIHSFGRV SAAIGPVTDL TISNGDVSPD GFTRAAVLAN GVFPGPLITG 

        70         80         90        100        110        120 
NKGDNFQINV IDNLSNETML KSTSIHWHGF FQKGTNWADG AAFVNQCPIA TGNSFLYDFT 

       130        140        150        160        170        180 
ATDQAGTFWY HSHLSTQYCD GLRGPMVVYD PSDPHADLYD VDDETTIITL SDWYHTAASL 

       190        200        210        220        230        240 
GAAFPIGSDS TLINGLGRFA GGDSTDLAVI TVEQGKRYRM RLLSLSCDPN YVFSIDGHNM 

       250        260        270        280        290        300 
TIIEADAVNH EPLTVDSIQI YAGQRYSFVL TADQDIDNYF IRALPSAGTT SFDGGINSAI 

       310        320        330        340        350        360 
LRYSGASEVD PTTTETTSVL PLDEANLVPL DSPAAPGDPN IGGVDYALNL DFNFDGTNFF 

       370        380        390        400        410        420 
INDVSFVSPT VPVLLQILSG TTSAADLLPS GSLFAVPSNS TIEISFPITA TNAPGAPHPF 

       430        440        450        460        470        480 
HLHGHTFSIV RTAGSTDTNF VNPVRRDVVN TGTVGDNVTI RFTTDNPGPW FLHCHIDFHL 

       490        500        510        520 
EAGFAIVFSE DTADVSNTTT PSTAWEDLCP TYNALDSSDL

« Hide

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References

[1]"Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
Yaver D.S., Golightly E.J.
Gene 181:95-102(1996) [PubMed: 8973314] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

L78077 Genomic DNA. Translation: AAB47734.1.
PIRJC5356.

3D structure databases

HSSPHSSP built from PDB template 1KYA based on UniProtKB Q96UT7.
SMRQ99055. Positions 23-519.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.10.3.2. 259651.

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC4_TRAVI
AccessionPrimary (citable) accession number: Q99055
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents