Q99052 (Q99052_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Fibroblast growth factor receptor PIRNR PIRNR000628
EC=2.7.10.1 PIRNR PIRNR000628

Gene names

Name:	Fgfr3 MGI 95524
Synonyms:	Flg-2 EMBL CAA41209.1

Organism

Mus musculus (Mouse) EMBL CAA41209.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	800 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS008266
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain SAAS SAAS008266 Repeat SAAS SAAS008266 Signal EMBL CAA41209.1 Transmembrane Transmembrane helix SAAS SAAS008266
Ligand	ATP-binding PIRNR PIRNR000628 SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor PIRNR PIRNR000628 SAAS SAAS008266 EMBL CAA41209.1 Transferase Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS008266
PTM	Phosphoprotein SAAS SAAS008266
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from direct assay PubMed 14699054. Source: MGI alveolar secondary septum development Inferred from genetic interaction PubMed 9716527. Source: MGI axonogenesis involved in innervation Inferred from mutant phenotype PubMed 17557302. Source: MGI bone morphogenesis Inferred from mutant phenotype PubMed 19407216. Source: MGI cartilage development Inferred from mutant phenotype PubMed 15781473. Source: MGI central nervous system myelination Inferred from mutant phenotype PubMed 12574417. Source: MGI cochlea development Inferred from mutant phenotype PubMed 17557302. Source: MGI digestive tract morphogenesis Inferred from mutant phenotype PubMed 19407216. Source: MGI epithelial cell fate commitment Inferred from mutant phenotype PubMed 19407216. Source: MGI inner ear receptor cell differentiation Inferred from mutant phenotype PubMed 17117437. Source: MGI lens fiber cell development Inferred from genetic interaction PubMed 18455718. Source: MGI lens morphogenesis in camera-type eye Inferred from mutant phenotype PubMed 11290300. Source: MGI morphogenesis of an epithelium Inferred from mutant phenotype PubMed 17117437. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 12574417. Source: MGI negative regulation of astrocyte differentiation Inferred from mutant phenotype PubMed 12574417. Source: MGI negative regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 11290300PubMed 17192470. Source: MGI negative regulation of mitosis Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of smoothened signaling pathway Inferred from mutant phenotype PubMed 9811582. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 9811582. Source: MGI positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Inferred from genetic interaction PubMed 18187602. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 15708559. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 19407216. Source: MGI positive regulation of cell differentiation Inferred from mutant phenotype PubMed 12417662PubMed 17117437. Source: MGI positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 16291864. Source: MGI positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 14699054. Source: MGI positive regulation of protein ubiquitination Inferred from direct assay PubMed 14699054. Source: MGI response to axon injury Inferred from mutant phenotype PubMed 16009496. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 19407216. Source: MGI substantia nigra development Inferred from mutant phenotype PubMed 17234579. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW internal side of plasma membrane Inferred from direct assay PubMed 14699054. Source: MGI lysosome Inferred from direct assay PubMed 14699054. Source: MGI perinuclear region of cytoplasm Inferred from direct assay PubMed 14699054. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fibroblast growth factor-activated receptor activity Inferred from direct assay PubMed 14699054. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential EMBL CAA41209.1
	Chain	21 – 800	780	fibroblast growth factor receptor EMBL CAA41209.1		PRO_5000145779
Sites
	Active site	611	1	Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

	Sequence		Length	Mass (Da)
	Q99052 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B376D47DBE8BB312	FASTA	800	87,692
	10 20 30 40 50 60 MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG SGDTVELSCH 70 80 90 100 110 120 PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE DAGVYSCQHR LTRRVLCHFS 130 140 150 160 170 180 VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP ERMDKKLLAV PAANTVRFRC PAAGNPTPSI 190 200 210 220 230 240 SWLKNGKEFR GQHRIGGIKL RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL 250 260 270 280 290 300 ERSPHRPILQ AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYD 310 320 330 340 350 360 TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV LPAEEELMET 370 380 390 400 410 420 DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL GSPTVHKVSR FPLKRQVSLE 430 440 450 460 470 480 SNSSMNSNTP LVRIARLSSG EGPVLANVSE LELPADPKWE LSRTRLTLGK PLGEGCFGQV 490 500 510 520 530 540 VMAEAIGIDK DRTAKPVTVA VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT 550 560 570 580 590 600 QGGPLYVLVE YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME 610 620 630 640 650 660 YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL PVKWMAPEAL 670 680 690 700 710 720 FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ASCTHDLYMI 730 740 750 760 770 780 MRECWHAVPS QRPTFKQLVE DLDRILTVTS TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD 790 800 SVFTHDLLPP GPPSNGGPRT

References

[1]	"Flg-2, a new member of the family of fibroblast growth factor receptors." Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D. Oncogene 6:1089-1092(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skin EMBL CAA41209.1.
[2]	"Errata: lg-2, a new member of the family of fibroblast growth factor receptor." Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D. Oncogene 7:823-823(1992) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Skin EMBL CAA41209.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X58255 mRNA. Translation: CAA41209.1.
IPI	IPI01016233.
UniGene	Mm.6904.
3D structure databases
HSSP	HSSP built from PDB template 1RY7 based on UniProtKB P22607.
ProteinModelPortal	Q99052.
SMR	Q99052. Positions 144-356, 452-750.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000110053.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:95524. Fgfr3.
Phylogenomic databases
HOVERGEN	HBG000345.
Gene expression databases
Genevestigator	Q99052.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016248. Tyr_kinase_fibroblast_GF_rcpt. [Graphical view]
Pfam	PF07679. I-set. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000628. FGFR. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00408. IGc2. 3 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FGFR3. mouse.
SOURCE	Search...

Entry information

Entry name

Q99052_MOUSE

Accession

Primary (citable) accession number: Q99052

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)