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Q99052

- Q99052_MOUSE

UniProt

Q99052 - Q99052_MOUSE

Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei611 – 6111Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fibroblast growth factor-activated receptor activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. alveolar secondary septum development Source: MGI
    2. axonogenesis involved in innervation Source: MGI
    3. bone morphogenesis Source: MGI
    4. cartilage development Source: MGI
    5. cell differentiation Source: MGI
    6. central nervous system myelination Source: MGI
    7. cochlea development Source: MGI
    8. digestive tract morphogenesis Source: MGI
    9. epithelial cell fate commitment Source: MGI
    10. fibroblast growth factor receptor signaling pathway Source: MGI
    11. forebrain development Source: MGI
    12. inner ear development Source: MGI
    13. inner ear receptor cell differentiation Source: MGI
    14. lens fiber cell development Source: MGI
    15. lens morphogenesis in camera-type eye Source: MGI
    16. MAPK cascade Source: MGI
    17. morphogenesis of an epithelium Source: MGI
    18. negative regulation of astrocyte differentiation Source: MGI
    19. negative regulation of cell proliferation Source: MGI
    20. negative regulation of epithelial cell proliferation Source: MGI
    21. negative regulation of mitosis Source: MGI
    22. negative regulation of smoothened signaling pathway Source: MGI
    23. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    24. oligodendrocyte development Source: MGI
    25. positive regulation of canonical Wnt signaling pathway Source: MGI
    26. positive regulation of cell differentiation Source: MGI
    27. positive regulation of cell proliferation Source: MGI
    28. positive regulation of endothelial cell proliferation Source: MGI
    29. positive regulation of MAPK cascade Source: MGI
    30. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
    31. positive regulation of neuron apoptotic process Source: MGI
    32. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    33. positive regulation of protein ubiquitination Source: MGI
    34. response to axon injury Source: MGI
    35. somatic stem cell maintenance Source: MGI
    36. substantia nigra development Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:Fgfr3Imported
    Synonyms:Flg-2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95524. Fgfr3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosome Source: MGI
    4. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020 PotentialImportedAdd
    BLAST
    Chaini21 – 800780fibroblast growth factor receptorImportedPRO_5000145779Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ99052.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000110053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99052.
    SMRiQ99052. Positions 144-356, 452-750.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG000345.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
    PfamiPF07679. I-set. 2 hits.
    PF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000628. FGFR. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99052-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG    50
    SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE 100
    DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP 150
    ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GQHRIGGIKL 200
    RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ 250
    AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYD 300
    TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV 350
    LPAEEELMET DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL 400
    GSPTVHKVSR FPLKRQVSLE SNSSMNSNTP LVRIARLSSG EGPVLANVSE 450
    LELPADPKWE LSRTRLTLGK PLGEGCFGQV VMAEAIGIDK DRTAKPVTVA 500
    VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QGGPLYVLVE 550
    YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME 600
    YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL 650
    PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL 700
    LKEGHRMDKP ASCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRILTVTS 750
    TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD SVFTHDLLPP GPPSNGGPRT 800
    Length:800
    Mass (Da):87,692
    Last modified:November 1, 1996 - v1
    Checksum:iB376D47DBE8BB312
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58255 mRNA. Translation: CAA41209.1.
    UniGeneiMm.6904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58255 mRNA. Translation: CAA41209.1 .
    UniGenei Mm.6904.

    3D structure databases

    ProteinModelPortali Q99052.
    SMRi Q99052. Positions 144-356, 452-750.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000110053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95524. Fgfr3.

    Phylogenomic databases

    HOVERGENi HBG000345.

    Miscellaneous databases

    ChiTaRSi FGFR3. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q99052.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR028176. FGF_rcpt_3.
    IPR016248. FGF_rcpt_fam.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR013151. Immunoglobulin.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
    Pfami PF07679. I-set. 2 hits.
    PF00047. ig. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000628. FGFR. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00408. IGc2. 3 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Flg-2, a new member of the family of fibroblast growth factor receptors."
      Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
      Oncogene 6:1089-1092(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: SkinImported.
    2. "Errata: lg-2, a new member of the family of fibroblast growth factor receptor."
      Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
      Oncogene 7:823-823(1992)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: SkinImported.

    Entry informationi

    Entry nameiQ99052_MOUSE
    AccessioniPrimary (citable) accession number: Q99052
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)