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Q99052 (Q99052_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor receptor PIRNR PIRNR000628

EC=2.7.10.1 PIRNR PIRNR000628
Gene names
Name:Fgfr3 MGI 95524
Synonyms:Flg-2 EMBL CAA41209.1
OrganismMus musculus (Mouse) EMBL CAA41209.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length800 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS013098

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628

Contains 1 protein kinase domain.

Contains protein kinase domain. SAAS SAAS013098

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain RuleBase RU003326 SAAS SAAS013151
Repeat SAAS SAAS013098
Signal EMBL CAA41209.1
Transmembrane
Transmembrane helix SAAS SAAS013098
   LigandATP-binding PIRNR PIRNR000628 SAAS SAAS013098
Nucleotide-binding
   Molecular functionKinase
Receptor PIRNR PIRNR000628 SAAS SAAS013098 EMBL CAA41209.1
Transferase
Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS013098
   PTMDisulfide bond SAAS SAAS013151
Phosphoprotein SAAS SAAS020635
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from direct assay PubMed 14699054. Source: MGI

alveolar secondary septum development

Inferred from genetic interaction PubMed 9716527. Source: MGI

axonogenesis involved in innervation

Inferred from mutant phenotype PubMed 17557302. Source: MGI

bone morphogenesis

Inferred from mutant phenotype PubMed 19407216. Source: MGI

cartilage development

Inferred from mutant phenotype PubMed 15781473. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 17557302. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 12574417. Source: MGI

cochlea development

Inferred from mutant phenotype PubMed 17557302. Source: MGI

digestive tract morphogenesis

Inferred from mutant phenotype PubMed 19407216. Source: MGI

epithelial cell fate commitment

Inferred from mutant phenotype PubMed 19407216. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from direct assay PubMed 14699054. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 15708559. Source: MGI

inner ear development

Inferred from mutant phenotype PubMed 17117437. Source: MGI

inner ear receptor cell differentiation

Inferred from mutant phenotype PubMed 17117437. Source: MGI

lens fiber cell development

Inferred from genetic interaction PubMed 18455718. Source: MGI

lens morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 11290300. Source: MGI

morphogenesis of an epithelium

Inferred from mutant phenotype PubMed 17117437. Source: MGI

negative regulation of astrocyte differentiation

Inferred from mutant phenotype PubMed 12574417. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 15708559. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 11290300PubMed 17192470. Source: MGI

negative regulation of mitosis

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 9811582. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 9811582. Source: MGI

oligodendrocyte development

Inferred from mutant phenotype PubMed 12574417. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 11290300. Source: MGI

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 18187602. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 19407216. Source: MGI

positive regulation of cell differentiation

Inferred from mutant phenotype PubMed 12417662PubMed 17117437. Source: MGI

positive regulation of cell proliferation

Inferred from genetic interaction PubMed 18187602. Source: MGI

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 16291864. Source: MGI

positive regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 15708559. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 14699054. Source: MGI

positive regulation of protein ubiquitination

Inferred from direct assay PubMed 14699054. Source: MGI

response to axon injury

Inferred from mutant phenotype PubMed 16009496. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 19407216. Source: MGI

substantia nigra development

Inferred from mutant phenotype PubMed 17234579. Source: MGI

   Cellular_componentcytoplasmic side of plasma membrane

Inferred from direct assay PubMed 14699054. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosome

Inferred from direct assay PubMed 14699054. Source: MGI

perinuclear region of cytoplasm

Inferred from direct assay PubMed 14699054. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fibroblast growth factor-activated receptor activity

Inferred from direct assay PubMed 14699054. Source: MGI

protein binding

Inferred from physical interaction PubMed 16436388. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential EMBL CAA41209.1
Chain21 – 800780fibroblast growth factor receptor EMBL CAA41209.1
PRO_5000145779

Sites

Active site6111Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

Sequence LengthMass (Da)Tools
Q99052 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B376D47DBE8BB312

FASTA80087,692
        10         20         30         40         50         60 
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG SGDTVELSCH 

        70         80         90        100        110        120 
PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE DAGVYSCQHR LTRRVLCHFS 

       130        140        150        160        170        180 
VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP ERMDKKLLAV PAANTVRFRC PAAGNPTPSI 

       190        200        210        220        230        240 
SWLKNGKEFR GQHRIGGIKL RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL 

       250        260        270        280        290        300 
ERSPHRPILQ AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYD 

       310        320        330        340        350        360 
TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV LPAEEELMET 

       370        380        390        400        410        420 
DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL GSPTVHKVSR FPLKRQVSLE 

       430        440        450        460        470        480 
SNSSMNSNTP LVRIARLSSG EGPVLANVSE LELPADPKWE LSRTRLTLGK PLGEGCFGQV 

       490        500        510        520        530        540 
VMAEAIGIDK DRTAKPVTVA VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT 

       550        560        570        580        590        600 
QGGPLYVLVE YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME 

       610        620        630        640        650        660 
YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL PVKWMAPEAL 

       670        680        690        700        710        720 
FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ASCTHDLYMI 

       730        740        750        760        770        780 
MRECWHAVPS QRPTFKQLVE DLDRILTVTS TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD 

       790        800 
SVFTHDLLPP GPPSNGGPRT 

« Hide

References

[1]"Flg-2, a new member of the family of fibroblast growth factor receptors."
Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
Oncogene 6:1089-1092(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Skin EMBL CAA41209.1.
[2]"Errata: lg-2, a new member of the family of fibroblast growth factor receptor."
Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
Oncogene 7:823-823(1992)
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Skin EMBL CAA41209.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58255 mRNA. Translation: CAA41209.1.
UniGeneMm.6904.

3D structure databases

ProteinModelPortalQ99052.
SMRQ99052. Positions 144-356, 452-750.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000110053.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95524. Fgfr3.

Phylogenomic databases

HOVERGENHBG000345.

Gene expression databases

GenevestigatorQ99052.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000628. FGFR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGFR3. mouse.
SOURCESearch...

Entry information

Entry nameQ99052_MOUSE
AccessionPrimary (citable) accession number: Q99052
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)