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Q99052

- Q99052_MOUSE

UniProt

Q99052 - Q99052_MOUSE

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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei611 – 6111Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: MGI

GO - Biological processi

  1. alveolar secondary septum development Source: MGI
  2. axonogenesis involved in innervation Source: MGI
  3. bone morphogenesis Source: MGI
  4. cartilage development Source: MGI
  5. cell differentiation Source: MGI
  6. central nervous system myelination Source: MGI
  7. cochlea development Source: MGI
  8. digestive tract morphogenesis Source: MGI
  9. epithelial cell fate commitment Source: MGI
  10. fibroblast growth factor receptor signaling pathway Source: MGI
  11. forebrain development Source: MGI
  12. inner ear development Source: MGI
  13. inner ear receptor cell differentiation Source: MGI
  14. lens fiber cell development Source: MGI
  15. lens morphogenesis in camera-type eye Source: MGI
  16. MAPK cascade Source: MGI
  17. morphogenesis of an epithelium Source: MGI
  18. negative regulation of astrocyte differentiation Source: MGI
  19. negative regulation of cell proliferation Source: MGI
  20. negative regulation of epithelial cell proliferation Source: MGI
  21. negative regulation of mitosis Source: MGI
  22. negative regulation of smoothened signaling pathway Source: MGI
  23. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  24. oligodendrocyte development Source: MGI
  25. positive regulation of canonical Wnt signaling pathway Source: MGI
  26. positive regulation of cell differentiation Source: MGI
  27. positive regulation of cell proliferation Source: MGI
  28. positive regulation of endothelial cell proliferation Source: MGI
  29. positive regulation of MAPK cascade Source: MGI
  30. positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
  31. positive regulation of neuron apoptotic process Source: MGI
  32. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  33. positive regulation of protein ubiquitination Source: MGI
  34. response to axon injury Source: MGI
  35. somatic stem cell maintenance Source: MGI
  36. substantia nigra development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
Synonyms:Flg-2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95524. Fgfr3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 800780fibroblast growth factor receptorImportedPRO_5000145779Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ99052.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110053.

Structurei

3D structure databases

ProteinModelPortaliQ99052.
SMRiQ99052. Positions 144-356, 452-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG000345.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99052-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG
60 70 80 90 100
SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE
110 120 130 140 150
DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP
160 170 180 190 200
ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GQHRIGGIKL
210 220 230 240 250
RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ
260 270 280 290 300
AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYD
310 320 330 340 350
TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV
360 370 380 390 400
LPAEEELMET DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL
410 420 430 440 450
GSPTVHKVSR FPLKRQVSLE SNSSMNSNTP LVRIARLSSG EGPVLANVSE
460 470 480 490 500
LELPADPKWE LSRTRLTLGK PLGEGCFGQV VMAEAIGIDK DRTAKPVTVA
510 520 530 540 550
VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QGGPLYVLVE
560 570 580 590 600
YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME
610 620 630 640 650
YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL
660 670 680 690 700
PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL
710 720 730 740 750
LKEGHRMDKP ASCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRILTVTS
760 770 780 790 800
TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD SVFTHDLLPP GPPSNGGPRT
Length:800
Mass (Da):87,692
Last modified:November 1, 1996 - v1
Checksum:iB376D47DBE8BB312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58255 mRNA. Translation: CAA41209.1.
UniGeneiMm.6904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58255 mRNA. Translation: CAA41209.1 .
UniGenei Mm.6904.

3D structure databases

ProteinModelPortali Q99052.
SMRi Q99052. Positions 144-356, 452-750.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000110053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95524. Fgfr3.

Phylogenomic databases

HOVERGENi HBG000345.

Miscellaneous databases

ChiTaRSi Fgfr3. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q99052.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000628. FGFR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Flg-2, a new member of the family of fibroblast growth factor receptors."
    Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
    Oncogene 6:1089-1092(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.
  2. "Errata: lg-2, a new member of the family of fibroblast growth factor receptor."
    Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
    Oncogene 7:823-823(1992)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.

Entry informationi

Entry nameiQ99052_MOUSE
AccessioniPrimary (citable) accession number: Q99052
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)