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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei611 – 6111Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • alveolar secondary septum development Source: MGI
  • axonogenesis involved in innervation Source: MGI
  • bone morphogenesis Source: MGI
  • cartilage development Source: MGI
  • cell differentiation Source: MGI
  • central nervous system myelination Source: MGI
  • cochlea development Source: MGI
  • digestive tract morphogenesis Source: MGI
  • epithelial cell fate commitment Source: MGI
  • fibroblast growth factor receptor apoptotic signaling pathway Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • forebrain development Source: MGI
  • inner ear development Source: MGI
  • inner ear receptor cell differentiation Source: MGI
  • lens fiber cell development Source: MGI
  • lens morphogenesis in camera-type eye Source: MGI
  • MAPK cascade Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • negative regulation of astrocyte differentiation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of mitotic nuclear division Source: MGI
  • negative regulation of smoothened signaling pathway Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • oligodendrocyte development Source: MGI
  • peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: MGI
  • positive regulation of neuron apoptotic process Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  • positive regulation of phospholipase activity Source: MGI
  • positive regulation of protein ubiquitination Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  • protein autophosphorylation Source: MGI
  • response to axon injury Source: MGI
  • somatic stem cell maintenance Source: MGI
  • substantia nigra development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
Synonyms:Flg-2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95524. Fgfr3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic side of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of plasma membrane Source: MGI
  • lysosome Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • transport vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 800780fibroblast growth factor receptorImportedPRO_5000145779Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133064.

Structurei

3D structure databases

ProteinModelPortaliQ99052.
SMRiQ99052. Positions 144-356, 452-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG000345.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG
60 70 80 90 100
SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE
110 120 130 140 150
DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP
160 170 180 190 200
ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GQHRIGGIKL
210 220 230 240 250
RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ
260 270 280 290 300
AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYD
310 320 330 340 350
TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV
360 370 380 390 400
LPAEEELMET DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL
410 420 430 440 450
GSPTVHKVSR FPLKRQVSLE SNSSMNSNTP LVRIARLSSG EGPVLANVSE
460 470 480 490 500
LELPADPKWE LSRTRLTLGK PLGEGCFGQV VMAEAIGIDK DRTAKPVTVA
510 520 530 540 550
VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QGGPLYVLVE
560 570 580 590 600
YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME
610 620 630 640 650
YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL
660 670 680 690 700
PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL
710 720 730 740 750
LKEGHRMDKP ASCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRILTVTS
760 770 780 790 800
TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD SVFTHDLLPP GPPSNGGPRT
Length:800
Mass (Da):87,692
Last modified:November 1, 1996 - v1
Checksum:iB376D47DBE8BB312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58255 mRNA. Translation: CAA41209.1.
UniGeneiMm.6904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58255 mRNA. Translation: CAA41209.1.
UniGeneiMm.6904.

3D structure databases

ProteinModelPortaliQ99052.
SMRiQ99052. Positions 144-356, 452-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95524. Fgfr3.

Phylogenomic databases

HOVERGENiHBG000345.

Miscellaneous databases

ChiTaRSiFgfr3. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Flg-2, a new member of the family of fibroblast growth factor receptors."
    Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
    Oncogene 6:1089-1092(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.
  2. "Errata: lg-2, a new member of the family of fibroblast growth factor receptor."
    Avivi A., Zimmer Y., Yayon A., Yarden Y., Givol D.
    Oncogene 7:823-823(1992)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SkinImported.

Entry informationi

Entry nameiQ99052_MOUSE
AccessioniPrimary (citable) accession number: Q99052
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.