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Q99049

- LAC3_TRAVI

UniProt

Q99049 - LAC3_TRAVI

Protein

Laccase-3

Gene

LCC3

Organism
Trametes villosa (White-rot fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Copper 1; type 2By similarity
    Metal bindingi87 – 871Copper 2; type 3By similarity
    Metal bindingi130 – 1301Copper 2; type 3By similarity
    Metal bindingi132 – 1321Copper 3; type 3By similarity
    Metal bindingi410 – 4101Copper 4; type 1By similarity
    Metal bindingi413 – 4131Copper 1; type 2By similarity
    Metal bindingi415 – 4151Copper 3; type 3By similarity
    Metal bindingi426 – 4261Copper 3; type 3By similarity
    Metal bindingi427 – 4271Copper 4; type 1By similarity
    Metal bindingi428 – 4281Copper 2; type 3By similarity
    Metal bindingi432 – 4321Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-3 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 3
    Diphenol oxidase 3
    Urishiol oxidase 3
    Gene namesi
    Name:LCC3
    OrganismiTrametes villosa (White-rot fungus)
    Taxonomic identifieri47662 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 473452Laccase-3PRO_0000002945Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ99049.
    SMRiQ99049. Positions 22-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 148126Plastocyanin-like 1Add
    BLAST
    Domaini160 – 298139Plastocyanin-like 2Add
    BLAST
    Domaini365 – 44480Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 4 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSSLRRAL VFLGACSSAL ASIGPVTELD IVNKVIAPDG VARDTVLAGG    50
    TFPGPLITGK KGDNFRINVV DKLVNQTMLT STTIHWHGMF QHTTNWADGP 100
    AFVTQCPITT GDDFLYNFRV PDQTGTYWYH SHLALQYCDG LRGPLVIYDP 150
    HDPQAYLYDV DDESTVITLA DWYHTPAPLL PPAATLINGL GRWPGNPTAD 200
    LAVIEVQHGK RYRFRLVSTS CDPNYNFTID GHTMTIIEAD GQNTQPHQVD 250
    GLQIFAAQRY SFVLNANQAV NNYWIRANPN RANTTGFANG INSAILRYKG 300
    APIKEPTTNQ TTIRNFLWET DLHPLTDPRA PGLPFKGGVD HALNLNLTFN 350
    GSEFFINDAP FVPPTVPVLL QILNGTLDAN DLLPPGSVYN LPPDSTIELS 400
    IPGGVTGGPH PFHLHGTDNP GPWFLHCHID FHLQAGLAIV FAEDAQDTKL 450
    VNPVPEDWNK LCPTFDKAMN ITV 473
    Length:473
    Mass (Da):51,924
    Last modified:November 1, 1996 - v1
    Checksum:iB29FDE944DCCE547
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L78076 Genomic DNA. Translation: AAB47733.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L78076 Genomic DNA. Translation: AAB47733.1 .

    3D structure databases

    ProteinModelPortali Q99049.
    SMRi Q99049. Positions 22-466.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 4 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 2 hits.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
      Yaver D.S., Golightly E.J.
      Gene 181:95-102(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLAC3_TRAVI
    AccessioniPrimary (citable) accession number: Q99049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3