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Q99049

- LAC3_TRAVI

UniProt

Q99049 - LAC3_TRAVI

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Protein

Laccase-3

Gene
LCC3
Organism
Trametes villosa (White-rot fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products Inferred.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Copper 1; type 2 By similarity
Metal bindingi87 – 871Copper 2; type 3 By similarity
Metal bindingi130 – 1301Copper 2; type 3 By similarity
Metal bindingi132 – 1321Copper 3; type 3 By similarity
Metal bindingi410 – 4101Copper 4; type 1 By similarity
Metal bindingi413 – 4131Copper 1; type 2 By similarity
Metal bindingi415 – 4151Copper 3; type 3 By similarity
Metal bindingi426 – 4261Copper 3; type 3 By similarity
Metal bindingi427 – 4271Copper 4; type 1 By similarity
Metal bindingi428 – 4281Copper 2; type 3 By similarity
Metal bindingi432 – 4321Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-3 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 3
Diphenol oxidase 3
Urishiol oxidase 3
Gene namesi
Name:LCC3
OrganismiTrametes villosa (White-rot fungus)
Taxonomic identifieri47662 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 473452Laccase-3PRO_0000002945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi346 – 3461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ99049.
SMRiQ99049. Positions 22-466.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 148126Plastocyanin-like 1Add
BLAST
Domaini160 – 298139Plastocyanin-like 2Add
BLAST
Domaini365 – 44480Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99049-1 [UniParc]FASTAAdd to Basket

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MSFSSLRRAL VFLGACSSAL ASIGPVTELD IVNKVIAPDG VARDTVLAGG    50
TFPGPLITGK KGDNFRINVV DKLVNQTMLT STTIHWHGMF QHTTNWADGP 100
AFVTQCPITT GDDFLYNFRV PDQTGTYWYH SHLALQYCDG LRGPLVIYDP 150
HDPQAYLYDV DDESTVITLA DWYHTPAPLL PPAATLINGL GRWPGNPTAD 200
LAVIEVQHGK RYRFRLVSTS CDPNYNFTID GHTMTIIEAD GQNTQPHQVD 250
GLQIFAAQRY SFVLNANQAV NNYWIRANPN RANTTGFANG INSAILRYKG 300
APIKEPTTNQ TTIRNFLWET DLHPLTDPRA PGLPFKGGVD HALNLNLTFN 350
GSEFFINDAP FVPPTVPVLL QILNGTLDAN DLLPPGSVYN LPPDSTIELS 400
IPGGVTGGPH PFHLHGTDNP GPWFLHCHID FHLQAGLAIV FAEDAQDTKL 450
VNPVPEDWNK LCPTFDKAMN ITV 473
Length:473
Mass (Da):51,924
Last modified:November 1, 1996 - v1
Checksum:iB29FDE944DCCE547
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L78076 Genomic DNA. Translation: AAB47733.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L78076 Genomic DNA. Translation: AAB47733.1 .

3D structure databases

ProteinModelPortali Q99049.
SMRi Q99049. Positions 22-466.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 4 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of three laccase genes from the white-rot basidiomycete Trametes villosa: genomic organization of the laccase gene family."
    Yaver D.S., Golightly E.J.
    Gene 181:95-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLAC3_TRAVI
AccessioniPrimary (citable) accession number: Q99049
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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