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Protein

Laccase-3

Gene

LCC3

Organism
Trametes villosa (White-rot fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Copper 1; type 2By similarity1
Metal bindingi87Copper 2; type 3By similarity1
Metal bindingi130Copper 2; type 3By similarity1
Metal bindingi132Copper 3; type 3By similarity1
Metal bindingi410Copper 4; type 1By similarity1
Metal bindingi413Copper 1; type 2By similarity1
Metal bindingi415Copper 3; type 3By similarity1
Metal bindingi426Copper 3; type 3By similarity1
Metal bindingi427Copper 4; type 1By similarity1
Metal bindingi428Copper 2; type 3By similarity1
Metal bindingi432Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-3 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 3
Diphenol oxidase 3
Urishiol oxidase 3
Gene namesi
Name:LCC3
OrganismiTrametes villosa (White-rot fungus)
Taxonomic identifieri47662 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPolyporaceaeTrametes

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000294522 – 473Laccase-3Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ99049

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ99049
SMRiQ99049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 148Plastocyanin-like 1Add BLAST126
Domaini160 – 298Plastocyanin-like 2Add BLAST139
Domaini365 – 444Plastocyanin-like 3Add BLAST80

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420, 4 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 2 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLRRAL VFLGACSSAL ASIGPVTELD IVNKVIAPDG VARDTVLAGG
60 70 80 90 100
TFPGPLITGK KGDNFRINVV DKLVNQTMLT STTIHWHGMF QHTTNWADGP
110 120 130 140 150
AFVTQCPITT GDDFLYNFRV PDQTGTYWYH SHLALQYCDG LRGPLVIYDP
160 170 180 190 200
HDPQAYLYDV DDESTVITLA DWYHTPAPLL PPAATLINGL GRWPGNPTAD
210 220 230 240 250
LAVIEVQHGK RYRFRLVSTS CDPNYNFTID GHTMTIIEAD GQNTQPHQVD
260 270 280 290 300
GLQIFAAQRY SFVLNANQAV NNYWIRANPN RANTTGFANG INSAILRYKG
310 320 330 340 350
APIKEPTTNQ TTIRNFLWET DLHPLTDPRA PGLPFKGGVD HALNLNLTFN
360 370 380 390 400
GSEFFINDAP FVPPTVPVLL QILNGTLDAN DLLPPGSVYN LPPDSTIELS
410 420 430 440 450
IPGGVTGGPH PFHLHGTDNP GPWFLHCHID FHLQAGLAIV FAEDAQDTKL
460 470
VNPVPEDWNK LCPTFDKAMN ITV
Length:473
Mass (Da):51,924
Last modified:November 1, 1996 - v1
Checksum:iB29FDE944DCCE547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78076 Genomic DNA Translation: AAB47733.1

Similar proteinsi

Entry informationi

Entry nameiLAC3_TRAVI
AccessioniPrimary (citable) accession number: Q99049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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