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Q99044

- LAC1_TRAVI

UniProt

Q99044 - LAC1_TRAVI

Protein

Laccase-1

Gene

LCC1

Organism
Trametes villosa (White-rot fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.Curated

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Copper 1; type 2By similarity
    Metal bindingi87 – 871Copper 2; type 3By similarity
    Metal bindingi130 – 1301Copper 2; type 3By similarity
    Metal bindingi132 – 1321Copper 3; type 3By similarity
    Metal bindingi416 – 4161Copper 4; type 1By similarity
    Metal bindingi419 – 4191Copper 1; type 2By similarity
    Metal bindingi421 – 4211Copper 3; type 3By similarity
    Metal bindingi473 – 4731Copper 3; type 3By similarity
    Metal bindingi474 – 4741Copper 4; type 1By similarity
    Metal bindingi475 – 4751Copper 2; type 3By similarity
    Metal bindingi479 – 4791Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-1 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 1
    Diphenol oxidase 1
    Urishiol oxidase 1
    Gene namesi
    Name:LCC1
    OrganismiTrametes villosa (White-rot fungus)
    Taxonomic identifieri47662 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 520499Laccase-1PRO_0000002943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ99044.
    SMRiQ99044. Positions 22-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 148126Plastocyanin-like 1Add
    BLAST
    Domaini160 – 302143Plastocyanin-like 2Add
    BLAST
    Domaini369 – 491123Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q99044-1 [UniParc]FASTAAdd to Basket

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    MSRFHSLLAF VVASLTAVAH AGIGPVADLT ITNAAVSPDG FSRQAVVVNG    50
    GTPGPLITGN MGDRFQLNVI DNLTNHTMVK STSIHWHGFF QKGTNWADGP 100
    AFINQCPISS GHSFLYDFQV PDQAGTFWYH SHLSTQYCDG LRGPFVVYDP 150
    NDPAADLYDV DNDDTVITLV DWYHVAAKLG PAFPLGADAT LINGKGRSPS 200
    TTTADLSVIS VTPGKRYRFR LVSLSCDPNY TFSIDGHNMT IIETDSINTA 250
    PLVVDSIQIF AAQRYSFVLE ANQAVDNYWI RANPNFGNVG FTGGINSAIL 300
    RYDGAAAVEP TTTQTTSTAP LNEVNLHPLV TTAVPGSPVA GGVDLAINMA 350
    FNFNGTNFFI NGTSFTPPTV PVLLQIISGA QNAQDLLPSG SVYSLPSNAD 400
    IEISFPATAA APGAPHPFHL HGHAFAVVRS AGSTVYNYDN PIFRDVVSTG 450
    TPAAGDNVTI RFRTDNPGPW FLHCHIDFHL EAGFAVVFAE DIPDVASANP 500
    VPQAWSDLCP TYDALDPSDQ 520
    Length:520
    Mass (Da):55,545
    Last modified:November 1, 1996 - v1
    Checksum:i046AB6D74737C60E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49376 Genomic DNA. Translation: AAC41686.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L49376 Genomic DNA. Translation: AAC41686.1 .

    3D structure databases

    ProteinModelPortali Q99044.
    SMRi Q99044. Positions 22-520.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, characterization, molecular cloning, and expression of two laccase genes from the white rot basidiomycete Trametes villosa."
      Yaver D.S., Xu F., Golightly E.J., Brown K.M., Brown S.H., Rey M.W., Schneider P., Halkier T., Mondorf K., Dalboge H.
      Appl. Environ. Microbiol. 62:834-841(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Mycelium.

    Entry informationi

    Entry nameiLAC1_TRAVI
    AccessioniPrimary (citable) accession number: Q99044
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3