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Q99044 (LAC1_TRAVI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Laccase-1
EC=1.10.3.2
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene names
Name:LCC1
OrganismTrametes villosa (White-rot fungus)
Taxonomic identifier47662 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Aphyllophorales › Trametes

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products Probable.

Catalytic activity

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

Ontologies

Keywords
   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

hydroquinone:oxygen oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 520499Laccase-1
PRO_0000002943

Regions

Domain23 – 148126Plastocyanin-like 1
Domain160 – 302143Plastocyanin-like 2
Domain369 – 491123Plastocyanin-like 3

Sites

Metal binding851Copper 1; type 2 By similarity
Metal binding871Copper 2; type 3 By similarity
Metal binding1301Copper 2; type 3 By similarity
Metal binding1321Copper 3; type 3 By similarity
Metal binding4161Copper 4; type 1 By similarity
Metal binding4191Copper 1; type 2 By similarity
Metal binding4211Copper 3; type 3 By similarity
Metal binding4731Copper 3; type 3 By similarity
Metal binding4741Copper 4; type 1 By similarity
Metal binding4751Copper 2; type 3 By similarity
Metal binding4791Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2381N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation3611N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q99044 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 046AB6D74737C60E

FASTA52055,545
        10         20         30         40         50         60 
MSRFHSLLAF VVASLTAVAH AGIGPVADLT ITNAAVSPDG FSRQAVVVNG GTPGPLITGN 

        70         80         90        100        110        120 
MGDRFQLNVI DNLTNHTMVK STSIHWHGFF QKGTNWADGP AFINQCPISS GHSFLYDFQV 

       130        140        150        160        170        180 
PDQAGTFWYH SHLSTQYCDG LRGPFVVYDP NDPAADLYDV DNDDTVITLV DWYHVAAKLG 

       190        200        210        220        230        240 
PAFPLGADAT LINGKGRSPS TTTADLSVIS VTPGKRYRFR LVSLSCDPNY TFSIDGHNMT 

       250        260        270        280        290        300 
IIETDSINTA PLVVDSIQIF AAQRYSFVLE ANQAVDNYWI RANPNFGNVG FTGGINSAIL 

       310        320        330        340        350        360 
RYDGAAAVEP TTTQTTSTAP LNEVNLHPLV TTAVPGSPVA GGVDLAINMA FNFNGTNFFI 

       370        380        390        400        410        420 
NGTSFTPPTV PVLLQIISGA QNAQDLLPSG SVYSLPSNAD IEISFPATAA APGAPHPFHL 

       430        440        450        460        470        480 
HGHAFAVVRS AGSTVYNYDN PIFRDVVSTG TPAAGDNVTI RFRTDNPGPW FLHCHIDFHL 

       490        500        510        520 
EAGFAVVFAE DIPDVASANP VPQAWSDLCP TYDALDPSDQ

« Hide

References

[1]"Purification, characterization, molecular cloning, and expression of two laccase genes from the white rot basidiomycete Trametes villosa."
Yaver D.S., Xu F., Golightly E.J., Brown K.M., Brown S.H., Rey M.W., Schneider P., Halkier T., Mondorf K., Dalboge H.
Appl. Environ. Microbiol. 62:834-841(1996) [PubMed: 8975613] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Mycelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L49376 Genomic DNA. Translation: AAC41686.1.

3D structure databases

ProteinModelPortalQ99044.
SMRQ99044. Positions 22-520.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 3 hits.
PROSITEPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAC1_TRAVI
AccessionPrimary (citable) accession number: Q99044
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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