Reviewed, UniProtKB/Swiss-Prot Q99042 (OXDA_TRIVR)

Names and origin

Protein names

Recommended name:
    D-amino-acid oxidase
      Short name=DAMOX
      Short name=DAAO
      Short name=DAO
    EC=1.4.3.3

Gene names

Name:

DAO1

Organism

Trigonopsis variabilis (Yeast)

Taxonomic identifier

34364 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Trigonopsis

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	A D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.
Cofactor	FAD.
Sequence similarities	Belongs to the DAMOX/DASOX family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-amino-acid oxidase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	D-amino-acid oxidase		PRO_0000162768
Regions
	Nucleotide binding	4 – 18	15	FAD By similarity
	Nucleotide binding	32 – 33	2	FAD By similarity
	Nucleotide binding	43 – 44	2	FAD By similarity
	Nucleotide binding	48 – 50	3	FAD By similarity
	Nucleotide binding	329 – 333	5	FAD By similarity
Sites
	Binding site	171	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	194	1	FAD By similarity
	Binding site	243	1	Substrate By similarity
	Binding site	302	1	Substrate By similarity
	Binding site	330	1	Substrate; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q99042-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A2935E9DB71A49FC	FASTA	356	39,301
	10 20 30 40 50 60 MAKIVVIGAG VAGLTTALQL LRKGHEVTIV SEFTPGDLSI GYTSPWAGAN WLTFYDGGKL 70 80 90 100 110 120 ADYDAVSYPI LRELARSSPE AGIRLISQRS HVLKRDLPKL EVAMSAICQR NPWFKNTVDS 130 140 150 160 170 180 FEIIEDRSRI VHDDVAYLVE FRSVCIHTGV YLNWLMSQCL SLGATVVKRR VNHIKDANLL 190 200 210 220 230 240 HSSGSRPDVI VNCSGLFARF LGGVEDKKMY PIRGQVVLVR NSLPFMASFS STPEKENEDE 250 260 270 280 290 300 ALYIMTRFDG TSIIGGCFQP NNWSSEPDPS LTHRILSRAL DRFPELTKDG PLDIVRECVG 310 320 330 340 350 HRPGREGGPR VELEKIPGVG FVVHNYGAAG AGYQSSYGMA DEAVSYVERA LTRPNL

References

[1]

"Molecular cloning of TvDAO1, a gene encoding a D-amino acid oxidase from Trigonopsis variabilis and its expression in Saccharomyces cerevisiae and Kluyveromyces lactis." Gonzalez F.J., Montes J., Martin F., Lopez M.C., Ferminan E., Catalan J., Galan M.A., Dominguez A. Yeast 13:1399-1408(1997) [PubMed: 9434346] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CBS 4095.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z50019 Genomic DNA. Translation: CAA90322.1.
PIR	S39437.
3D structure databases
HSSP	HSSP built from PDB template 1C0P based on UniProtKB P80324.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.4.3.3. 142970.
Family and domain databases
InterPro	IPR006181. D-amino_acid_oxidase_CS. IPR006076. FAD-dep_OxRdtase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
PROSITE	PS00677. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OXDA_TRIVR

Accession

Primary (citable) accession number: Q99042

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)