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Q99014 (KPC1_HYPJE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase C-like
EC=2.7.11.13
Gene names
Name:pkc1
OrganismHypocrea jecorina (Trichoderma reesei)
Taxonomic identifier51453 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Hypocrea

Protein attributes

Sequence length1139 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Stimulated about twofold by phospholipids or phorbol esters.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Contains 1 protein kinase domain.

Contains 2 REM (Hr1) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11391139Protein kinase C-like
PRO_0000055745

Regions

Repeat5 – 7773REM 1
Repeat154 – 22976REM 2
Domain814 – 1073260Protein kinase
Domain1074 – 113966AGC-kinase C-terminal
Zinc finger454 – 50249Phorbol-ester/DAG-type 1
Zinc finger522 – 57251Phorbol-ester/DAG-type 2
Nucleotide binding820 – 8289ATP By similarity
Compositional bias667 – 67812Poly-Ala
Compositional bias733 – 7397Poly-Gln
Compositional bias762 – 7687Poly-Gln

Sites

Active site9391Proton acceptor By similarity
Binding site8431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q99014 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 937BB0DAB727B65C

FASTA1,139126,055
        10         20         30         40         50         60 
MNEDEAIQNI TKKIEREKAL INAANAMRSQ TNNEAVRSPL DSQMRDGRRN LQFFEEKLRD 

        70         80         90        100        110        120 
IQLRKVGQGV EGMSLGADDA GRPPPPPKDA SSAAWGDQAA YGQQSQVGPP SDLAPPRHNF 

       130        140        150        160        170        180 
GAPGPGAASK ARPNFTKLDL IKYDTPYLGP RIQHMLSQIQ FKLNVEEQYL KGVEKMVQLY 

       190        200        210        220        230        240 
GMEGDRKSKA DAAARRVESK QKILLLKQAL KRYEELHVDM DSADAQDDDS INTPNLRKPL 

       250        260        270        280        290        300 
SGQLSIRVVA IKDVDHATTG RFARGPETFV AVKVEDTVMA RTKVSRNDRW EAEYHNMEVD 

       310        320        330        340        350        360 
KANEIELTIY DKPGEHPMPI AMLWVRISDI VEEMRRKRIE AEMNSSGWVS ADRMGSTGAP 

       370        380        390        400        410        420 
SQFPMSPTSG SFGGSPQAPG GGQGQAPGPF GDPAPQPQVV TGPIDGWFNL EPAGQIQLEF 

       430        440        450        460        470        480 
SFVKENRDKR QVDLGLGRKG AVRQRKEEVH EMFGHKFVQH QFYNIMPCAL CGDFLKYSAG 

       490        500        510        520        530        540 
MQCEDCKYTC HNKCYPSVVT KCISKSNAET DPDEEKINHR IPHRFQPFSN VTANWCCHCG 

       550        560        570        580        590        600 
YILPFGKKNC RKCSECGLTS HAQCVHLVPD FCGMSMAVAN QILEGIRVQK QRQQKTTSLS 

       610        620        630        640        650        660 
EKTLRSGATK SPTTAGHGSS ASFSSAGAGS VPGTPSAEAT EAARLMYNQT SPQRPGQPGR 

       670        680        690        700        710        720 
APSDLSAAAA ASAAMAAAQG RTGYDSGPQD PYGQGHYGAA GPAPQHHKYN PADYANVDQG 

       730        740        750        760        770        780 
FPAQPPAQQR PPQPQQQQQA PPAQMPPQQP PPQQPLPPQP GQQYQQQQPA AQKPQPQPPA 

       790        800        810        820        830        840 
TAQGAAAGPP GSQRKALPSA TDPGTGARIG LDHFNFLAVL GKGNFGKVML AETKRSKRLF 

       850        860        870        880        890        900 
AIKVLKKEFI IENDEVESIK SEKRVFLIAN RERHPFLTNL HACFQTETRV YFVMEYISGG 

       910        920        930        940        950        960 
DLMLHIQRGQ FGTKRAQFYA AEVCLALKYF HENGVIYRDL KLDNIMLTLD GHIKIADYGL 

       970        980        990       1000       1010       1020 
CKEDMWYGST TSTFCGTPEF MAPEILLDKK YGRAVDWWAF GVLIYQMLLQ QSPFRGEDED 

      1030       1040       1050       1060       1070       1080 
EIYDAILADE PLYPIHMPRD SVSILQKLLT REPDQRLGSG PTDAQEVMSQ PFFRNINWDD 

      1090       1100       1110       1120       1130 
IYHKRVQPPF LPQIKSATDT SNFDSEFTSV TPVLTPVQSV LSQAMQEEFR GFSYTADLD

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References

[1]"Cloning and characterisation of genes (pkc1 and pkcA) encoding protein kinase C homologues from Trichoderma reesei and Aspergillus niger."
Morawetz R., Lendenfeld T., Mischak H., Muehlbauer M., Gruber F., Goodnight J., de Graaff L.H., Visser J., Mushinski J.F., Kubicek C.P.
Mol. Gen. Genet. 250:17-28(1996) [PubMed: 8569684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: QM9414 / Rut C-30.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U10016 Unassigned DNA. Translation: AAA97432.1.
PIRS61918.

3D structure databases

ProteinModelPortalQ99014.
SMRQ99014. Positions 811-1137.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.13. 6451.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR011072. HR1_rho-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
Gene3DG3DSA:1.10.287.160. HR1_rho-bd. 1 hit.
PfamPF00130. C1_1. 2 hits.
PF02185. HR1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00109. C1. 2 hits.
SM00239. C2. 1 hit.
SM00742. Hr1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 1 hit.
SSF56112. Kinase_like. 1 hit.
SSF46585. PKN_effector. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPC1_HYPJE
AccessionPrimary (citable) accession number: Q99014
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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