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Q98ZP7

- Q98ZP7_SV40

UniProt

Q98ZP7 - Q98ZP7_SV40

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Protein
Submitted name:

Truncated large tumor antigen

Gene
N/A
Organism
Simian virus 40 (SV40)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA replication origin binding Source: InterPro
  3. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Truncated large tumor antigenImported
OrganismiSimian virus 40 (SV40)Imported
Taxonomic identifieri10633 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridaePolyomavirus
Virus hostiMacaca (macaques) [TaxID: 9539]

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF9X-ray2.59A/B131-260[»]
2IPRX-ray1.50A/B131-259[»]
2ITJX-ray2.50A/B131-259[»]
2ITLX-ray1.65A/B131-259[»]
2NL8X-ray2.30A131-259[»]
2NTCX-ray2.40A/B131-260[»]
2TBDNMR-A131-260[»]
ProteinModelPortaliQ98ZP7.
SMRiQ98ZP7. Positions 7-117, 131-260, 265-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains SF3 helicase domain.SAAS annotation
Contains SFhelicase domain.SAAS annotation

Family and domain databases

Gene3Di1.10.10.510. 1 hit.
1.10.287.110. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR014015. Helicase_SF3_DNA-vir.
IPR010932. Lg_T_Ag_Polyomavir_C.
IPR027417. P-loop_NTPase.
IPR003133. T_Ag_DNA-bd.
IPR017910. Znf_lg_T-Ag_D1-typ.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF06431. Polyoma_lg_T_C. 1 hit.
PF02217. T_Ag_DNA_bind. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
PS51206. SF3_HELICASE_1. 1 hit.
PS51287. T_AG_OBD. 1 hit.
PS51341. ZF_LTAG_D1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98ZP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKVLNREES LQLMDLLGLE RSAWGNIPLM RKAYLKKCKE FHPDKGGDEE
60 70 80 90 100
KMKKMNTLYK KMEDGVKYAH QPDFGGFWDA TEIPTYGTDE WEQWWNAFNE
110 120 130 140 150
ENLFCSEEMP SSDDEATADS QHSTPPKKKR KVEDPKDFPS ELLSFLSHAV
160 170 180 190 200
FSNRTLACFA IYTTKEKAAL LYKKIMEKYS VTFISRHNSY NHNILFFLTP
210 220 230 240 250
HRHRVSAINN YAQKLCTFSF LICKGVNKEY LMYSALTRDP FSVIEESLPG
260 270 280 290 300
GLKEHDFNPE EAEETKQVSW KLVTEYAMET KCDDVLLLLG MYLEFQYSFE
310 320 330 340 350
MCLKCIKKEQ PSHYKYHEKH YANAAIFADS KNQKTICQQA VDTVLAKKRV
360 370 380 390 400
DSLQLTREQM LTNRFNDLLD RMDIMFGSTG SADIEEWMAG VAWLHCLLPK
410 420 430 440 450
MDSVVYDFLK CMVYNIPKKR YWLFKGPIDS GKTTLAAALL ELCGGKALNV
460 470 480 490 500
NLPLDRLNFE LGVAIDQFLV VFEDVKGTGG ESRDLPSGQG INNLSHITSV
510 520 530
EVLLALKNLP HLPLNLKHKM NAIVVVNLFI AAYNGYK
Length:537
Mass (Da):61,675
Last modified:June 1, 2001 - v1
Checksum:i3337EFB55B957FA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345345 Genomic DNA. Translation: AAK29054.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF345345 Genomic DNA. Translation: AAK29054.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IF9 X-ray 2.59 A/B 131-260 [» ]
2IPR X-ray 1.50 A/B 131-259 [» ]
2ITJ X-ray 2.50 A/B 131-259 [» ]
2ITL X-ray 1.65 A/B 131-259 [» ]
2NL8 X-ray 2.30 A 131-259 [» ]
2NTC X-ray 2.40 A/B 131-260 [» ]
2TBD NMR - A 131-260 [» ]
ProteinModelPortali Q98ZP7.
SMRi Q98ZP7. Positions 7-117, 131-260, 265-509.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.10.510. 1 hit.
1.10.287.110. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR014015. Helicase_SF3_DNA-vir.
IPR010932. Lg_T_Ag_Polyomavir_C.
IPR027417. P-loop_NTPase.
IPR003133. T_Ag_DNA-bd.
IPR017910. Znf_lg_T-Ag_D1-typ.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
PF06431. Polyoma_lg_T_C. 1 hit.
PF02217. T_Ag_DNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50076. DNAJ_2. 1 hit.
PS51206. SF3_HELICASE_1. 1 hit.
PS51287. T_AG_OBD. 1 hit.
PS51341. ZF_LTAG_D1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Solution structure of the origin DNA-binding domain of SV40 T-antigen."
    Luo X., Sanford D.G., Bullock P.A., Bachovchin W.W.
    Nat. Struct. Biol. 3:1034-1039(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 131-260.
  2. "Complete DNA sequence of SV40-GM00637H, defective variant 12."
    Lednicky J.A., Butel J.S., Lewis A.M.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GM00637HImported.
  3. "Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA."
    Bochkareva E., Martynowski D., Seitova A., Bochkarev A.
    EMBO J. 25:5961-5969(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 131-259.
  4. "The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA."
    Meinke G., Phelan P., Moine S., Bochkareva E., Bochkarev A., Bullock P.A., Bohm A.
    PLoS Biol. 5:e23-e23(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 131-260.

Entry informationi

Entry nameiQ98ZP7_SV40
AccessioniPrimary (citable) accession number: Q98ZP7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3