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Q98ZP7

- Q98ZP7_SV40

UniProt

Q98ZP7 - Q98ZP7_SV40

Protein
Submitted name:

Truncated large tumor antigen

Gene
N/A
Organism
Simian virus 40 (SV40)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA replication origin binding Source: InterPro
    3. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: InterPro

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Truncated large tumor antigenImported
    OrganismiSimian virus 40 (SV40)Imported
    Taxonomic identifieri10633 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePolyomaviridaePolyomavirus
    Virus hostiMacaca (macaques) [TaxID: 9539]

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IF9X-ray2.59A/B131-260[»]
    2IPRX-ray1.50A/B131-259[»]
    2ITJX-ray2.50A/B131-259[»]
    2ITLX-ray1.65A/B131-259[»]
    2NL8X-ray2.30A131-259[»]
    2NTCX-ray2.40A/B131-260[»]
    2TBDNMR-A131-260[»]
    ProteinModelPortaliQ98ZP7.
    SMRiQ98ZP7. Positions 7-117, 131-260, 265-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains SF3 helicase domain.SAAS annotation
    Contains SFhelicase domain.SAAS annotation

    Family and domain databases

    Gene3Di1.10.10.510. 1 hit.
    1.10.287.110. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR014015. Helicase_SF3_DNA-vir.
    IPR010932. Lg_T_Ag_Polyomavir_C.
    IPR027417. P-loop_NTPase.
    IPR003133. T_Ag_DNA-bd.
    IPR017910. Znf_lg_T-Ag_D1-typ.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF06431. Polyoma_lg_T_C. 1 hit.
    PF02217. T_Ag_DNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50076. DNAJ_2. 1 hit.
    PS51206. SF3_HELICASE_1. 1 hit.
    PS51287. T_AG_OBD. 1 hit.
    PS51341. ZF_LTAG_D1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98ZP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKVLNREES LQLMDLLGLE RSAWGNIPLM RKAYLKKCKE FHPDKGGDEE    50
    KMKKMNTLYK KMEDGVKYAH QPDFGGFWDA TEIPTYGTDE WEQWWNAFNE 100
    ENLFCSEEMP SSDDEATADS QHSTPPKKKR KVEDPKDFPS ELLSFLSHAV 150
    FSNRTLACFA IYTTKEKAAL LYKKIMEKYS VTFISRHNSY NHNILFFLTP 200
    HRHRVSAINN YAQKLCTFSF LICKGVNKEY LMYSALTRDP FSVIEESLPG 250
    GLKEHDFNPE EAEETKQVSW KLVTEYAMET KCDDVLLLLG MYLEFQYSFE 300
    MCLKCIKKEQ PSHYKYHEKH YANAAIFADS KNQKTICQQA VDTVLAKKRV 350
    DSLQLTREQM LTNRFNDLLD RMDIMFGSTG SADIEEWMAG VAWLHCLLPK 400
    MDSVVYDFLK CMVYNIPKKR YWLFKGPIDS GKTTLAAALL ELCGGKALNV 450
    NLPLDRLNFE LGVAIDQFLV VFEDVKGTGG ESRDLPSGQG INNLSHITSV 500
    EVLLALKNLP HLPLNLKHKM NAIVVVNLFI AAYNGYK 537
    Length:537
    Mass (Da):61,675
    Last modified:June 1, 2001 - v1
    Checksum:i3337EFB55B957FA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345345 Genomic DNA. Translation: AAK29054.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF345345 Genomic DNA. Translation: AAK29054.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IF9 X-ray 2.59 A/B 131-260 [» ]
    2IPR X-ray 1.50 A/B 131-259 [» ]
    2ITJ X-ray 2.50 A/B 131-259 [» ]
    2ITL X-ray 1.65 A/B 131-259 [» ]
    2NL8 X-ray 2.30 A 131-259 [» ]
    2NTC X-ray 2.40 A/B 131-260 [» ]
    2TBD NMR - A 131-260 [» ]
    ProteinModelPortali Q98ZP7.
    SMRi Q98ZP7. Positions 7-117, 131-260, 265-509.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.10.510. 1 hit.
    1.10.287.110. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR014015. Helicase_SF3_DNA-vir.
    IPR010932. Lg_T_Ag_Polyomavir_C.
    IPR027417. P-loop_NTPase.
    IPR003133. T_Ag_DNA-bd.
    IPR017910. Znf_lg_T-Ag_D1-typ.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF06431. Polyoma_lg_T_C. 1 hit.
    PF02217. T_Ag_DNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50076. DNAJ_2. 1 hit.
    PS51206. SF3_HELICASE_1. 1 hit.
    PS51287. T_AG_OBD. 1 hit.
    PS51341. ZF_LTAG_D1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Solution structure of the origin DNA-binding domain of SV40 T-antigen."
      Luo X., Sanford D.G., Bullock P.A., Bachovchin W.W.
      Nat. Struct. Biol. 3:1034-1039(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 131-260.
    2. "Complete DNA sequence of SV40-GM00637H, defective variant 12."
      Lednicky J.A., Butel J.S., Lewis A.M.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GM00637HImported.
    3. "Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA."
      Bochkareva E., Martynowski D., Seitova A., Bochkarev A.
      EMBO J. 25:5961-5969(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 131-259.
    4. "The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA."
      Meinke G., Phelan P., Moine S., Bochkareva E., Bochkarev A., Bullock P.A., Bohm A.
      PLoS Biol. 5:e23-e23(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 131-260.

    Entry informationi

    Entry nameiQ98ZP7_SV40
    AccessioniPrimary (citable) accession number: Q98ZP7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3