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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).By similarity
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).By similarity
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1117For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1268For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1599For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei1752For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei2944For 3CL-PRO activity1
Active sitei3047For 3CL-PRO activity1
Sitei3053Important for substrate recognition1
Metal bindingi4957Zinc 1PROSITE-ProRule annotation1
Metal bindingi4960Zinc 1PROSITE-ProRule annotation1
Metal bindingi4968Zinc 2PROSITE-ProRule annotation1
Metal bindingi4971Zinc 1PROSITE-ProRule annotation1
Metal bindingi4978Zinc 1PROSITE-ProRule annotation1
Metal bindingi4981Zinc 2PROSITE-ProRule annotation1
Metal bindingi4985Zinc 2PROSITE-ProRule annotation1
Metal bindingi4991Zinc 2PROSITE-ProRule annotation1
Metal bindingi5002Zinc 3PROSITE-ProRule annotation1
Metal bindingi5007Zinc 3PROSITE-ProRule annotation1
Metal bindingi5024Zinc 3PROSITE-ProRule annotation1
Metal bindingi5027Zinc 3PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1188 – 1219C4-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1678 – 1707C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30
Zinc fingeri3962 – 3978By similarityAdd BLAST17
Zinc fingeri4004 – 4017By similarityAdd BLAST14
Nucleotide bindingi5235 – 5242ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Activation of host autophagy by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Protein family/group databases

MEROPSiC30.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 16 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
PL1-PRO/PL2-PRO
PLP1/PLP2
Papain-like proteinases 1/2
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Non-structural protein 11
Short name:
nsp11
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Alternative name(s):
NendoU
nsp15
Alternative name(s):
nsp16
Gene namesi
Name:rep
ORF Names:1a-1b
OrganismiFeline coronavirus (strain FIPV WSU-79/1146) (FCoV)
Taxonomic identifieri33734 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiFelidae (cat family) [TaxID: 9681]
Proteomesi
  • UP000000835 Componenti: Genome

Subcellular locationi

Non-structural protein 7 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 8 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 9 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 10 :
  • Host cytoplasmhost perinuclear region By similarity

  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Helicase :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1860 – 1878HelicalSequence analysisAdd BLAST19
Transmembranei1921 – 1941HelicalSequence analysisAdd BLAST21
Transmembranei2006 – 2026HelicalSequence analysisAdd BLAST21
Transmembranei2043 – 2065HelicalSequence analysisAdd BLAST23
Transmembranei2426 – 2446HelicalSequence analysisAdd BLAST21
Transmembranei2691 – 2711HelicalSequence analysisAdd BLAST21
Transmembranei2720 – 2740HelicalSequence analysisAdd BLAST21
Transmembranei2771 – 2791HelicalSequence analysisAdd BLAST21
Transmembranei3212 – 3232HelicalSequence analysisAdd BLAST21
Transmembranei3242 – 3262HelicalSequence analysisAdd BLAST21
Transmembranei3267 – 3287HelicalSequence analysisAdd BLAST21
Transmembranei3306 – 3326HelicalSequence analysisAdd BLAST21
Transmembranei3339 – 3359HelicalSequence analysisAdd BLAST21
Transmembranei3396 – 3416HelicalSequence analysisAdd BLAST21
Transmembranei3419 – 3439HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2944H → Y or R: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2967N → A or D: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → A: 5% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → D: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → E: 50% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → P or V: 95% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → R, T or W: 70% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3041S → A: 80% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3041S → T: 40% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3047C → A or S: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3063Y → A, F, G or T: Almost complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3064M → A: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi3065H → A: Complete loss of 3CL-PRO activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002838251 – 6709Replicase polyprotein 1abAdd BLAST6709
ChainiPRO_50001402081 – 110Non-structural protein 1By similarityAdd BLAST110
ChainiPRO_5000140209111 – 879Non-structural protein 2By similarityAdd BLAST769
ChainiPRO_5000140210880 – 2413Non-structural protein 3By similarityAdd BLAST1534
ChainiPRO_50001402112414 – 2903Non-structural protein 4By similarityAdd BLAST490
ChainiPRO_50001402122904 – 32053C-like proteinaseBy similarityAdd BLAST302
ChainiPRO_50001402133206 – 3499Non-structural protein 6By similarityAdd BLAST294
ChainiPRO_50001402143500 – 3582Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_50001402153583 – 3777Non-structural protein 8By similarityAdd BLAST195
ChainiPRO_50001402163778 – 3888Non-structural protein 9By similarityAdd BLAST111
ChainiPRO_50001402173889 – 4023Non-structural protein 10By similarityAdd BLAST135
ChainiPRO_50001402194024 – 4952RNA-directed RNA polymeraseBy similarityAdd BLAST929
ChainiPRO_50001402184024 – 4042Non-structural protein 11By similarityAdd BLAST19
ChainiPRO_50001402204953 – 5551HelicaseBy similarityAdd BLAST599
ChainiPRO_50001402215552 – 6070ExoribonucleaseSequence analysisAdd BLAST519
ChainiPRO_50001402226071 – 6409Uridylate-specific endoribonucleaseSequence analysisAdd BLAST339
ChainiPRO_50001402236410 – 6709Putative 2'-O-methyl transferaseSequence analysisAdd BLAST300

Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei110 – 111Cleavage; by PL1-PROBy similarity2
Sitei879 – 880Cleavage; by PL1-PROBy similarity2
Sitei2413 – 2414Cleavage; by PL2-PROBy similarity2
Sitei2903 – 2904Cleavage; by 3CL-PROBy similarity2
Sitei3205 – 3206Cleavage; by 3CL-PROBy similarity2
Sitei3499 – 3500Cleavage; by 3CL-PROBy similarity2
Sitei3582 – 3583Cleavage; by 3CL-PROBy similarity2
Sitei3777 – 3778Cleavage; by 3CL-PROBy similarity2
Sitei3888 – 3889Cleavage; by 3CL-PROBy similarity2
Sitei4023 – 4024Cleavage; by 3CL-PROBy similarity2
Sitei4952 – 4953Cleavage; by 3CL-PROBy similarity2
Sitei5551 – 5552Cleavage; by 3CL-PROBy similarity2
Sitei6070 – 6071Cleavage; by 3CL-PROBy similarity2
Sitei6409 – 6410Cleavage; by 3CL-PROBy similarity2

Interactioni

Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).By similarity

Structurei

Secondary structure

16709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1336 – 1339Combined sources4
Beta strandi1342 – 1347Combined sources6
Helixi1349 – 1356Combined sources8
Beta strandi1359 – 1365Combined sources7
Helixi1376 – 1382Combined sources7
Turni1383 – 1385Combined sources3
Helixi1386 – 1395Combined sources10
Beta strandi1405 – 1413Combined sources9
Beta strandi1416 – 1422Combined sources7
Helixi1431 – 1443Combined sources13
Beta strandi1449 – 1451Combined sources3
Helixi1463 – 1473Combined sources11
Beta strandi1479 – 1483Combined sources5
Helixi1486 – 1497Combined sources12
Helixi2818 – 2823Combined sources6
Beta strandi2826 – 2828Combined sources3
Helixi2830 – 2837Combined sources8
Turni2838 – 2840Combined sources3
Helixi2842 – 2850Combined sources9
Helixi2852 – 2856Combined sources5
Helixi2864 – 2884Combined sources21
Beta strandi2889 – 2891Combined sources3
Beta strandi2895 – 2899Combined sources5
Turni2914 – 2916Combined sources3
Helixi2917 – 2919Combined sources3
Beta strandi2920 – 2925Combined sources6
Beta strandi2928 – 2935Combined sources8
Beta strandi2938 – 2942Combined sources5
Helixi2943 – 2946Combined sources4
Beta strandi2950 – 2952Combined sources3
Helixi2956 – 2962Combined sources7
Helixi2965 – 2967Combined sources3
Beta strandi2968 – 2972Combined sources5
Beta strandi2975 – 2977Combined sources3
Beta strandi2979 – 2985Combined sources7
Beta strandi2988 – 2995Combined sources8
Beta strandi3013 – 3020Combined sources8
Beta strandi3023 – 3031Combined sources9
Beta strandi3050 – 3055Combined sources6
Beta strandi3058 – 3068Combined sources11
Beta strandi3074 – 3077Combined sources4
Beta strandi3079 – 3081Combined sources3
Helixi3084 – 3086Combined sources3
Beta strandi3089 – 3092Combined sources4
Helixi3103 – 3115Combined sources13
Helixi3129 – 3136Combined sources8
Turni3137 – 3140Combined sources4
Helixi3147 – 3150Combined sources4
Helixi3151 – 3157Combined sources7
Helixi3161 – 3171Combined sources11
Beta strandi3183 – 3185Combined sources3
Helixi3192 – 3200Combined sources9
Helixi3510 – 3518Combined sources9
Helixi3521 – 3523Combined sources3
Helixi3525 – 3540Combined sources16
Helixi3544 – 3561Combined sources18
Helixi3568 – 3577Combined sources10
Helixi3579 – 3581Combined sources3
Beta strandi3583 – 3585Combined sources3
Helixi3587 – 3609Combined sources23
Helixi3614 – 3652Combined sources39
Helixi3663 – 3680Combined sources18
Helixi3683 – 3693Combined sources11
Beta strandi3697 – 3702Combined sources6
Beta strandi3709 – 3714Combined sources6
Helixi3717 – 3723Combined sources7
Beta strandi3728 – 3731Combined sources4
Beta strandi3734 – 3742Combined sources9
Helixi3751 – 3753Combined sources3
Helixi3756 – 3761Combined sources6
Beta strandi3766 – 3772Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETIX-ray2.20A/B/C/D/E/F/G/H1331-1498[»]
3EW5X-ray3.10A/B/C1331-1498[»]
3GZFX-ray2.76A/B/C/D/E2808-2902[»]
3JZTX-ray3.91A/B/C/D/E/F/G/H1331-1498[»]
3UB0X-ray2.60A/D3583-3777[»]
B/C/E/F3500-3582[»]
4ZROX-ray2.06A/B/C/D2904-3202[»]
5EU8X-ray2.45A2904-3205[»]
ProteinModelPortaliQ98VG9.
SMRiQ98VG9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98VG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1079 – 1330Peptidase C16 1PROSITE-ProRule annotationAdd BLAST252
Domaini1329 – 1500MacroPROSITE-ProRule annotationAdd BLAST172
Domaini1561 – 1814Peptidase C16 2PROSITE-ProRule annotationAdd BLAST254
Domaini2904 – 3205Peptidase C30PROSITE-ProRule annotationAdd BLAST302
Domaini4632 – 4794RdRp catalyticAdd BLAST163
Domaini4953 – 5036CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5200 – 5391(+)RNA virus helicase ATP-bindingAdd BLAST192
Domaini5392 – 5561(+)RNA virus helicase C-terminalAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1860 – 2065HD1By similarityAdd BLAST206
Regioni2426 – 2791HD2By similarityAdd BLAST366
Regioni3212 – 3439HD3By similarityAdd BLAST228

Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Sequence similaritiesi

Contains 1 CV ZBD (coronavirus zinc-binding) domain.PROSITE-ProRule annotation
Contains 1 Macro domain.PROSITE-ProRule annotation
Contains 2 peptidase C16 domains.PROSITE-ProRule annotation
Contains 1 peptidase C30 domain.PROSITE-ProRule annotation
Contains 1 RdRp catalytic domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1188 – 1219C4-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1678 – 1707C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30
Zinc fingeri3962 – 3978By similarityAdd BLAST17
Zinc fingeri4004 – 4017By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
IPR032039. A-CoV_nsp1.
IPR032505. Corona_NSP4_C.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16688. CNV-Replicase_N. 1 hit.
PF16348. Corona_NSP4_C. 1 hit.
PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51653. CV_ZBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
PS51657. PSRV_HELICASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform Replicase polyprotein 1ab (identifier: Q98VG9-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD
60 70 80 90 100
LVDCNRKDHY VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF
110 120 130 140 150
DLKFARTGNG AIYVDQYMCG ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC
160 170 180 190 200
AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH KLPNCAIREV APPVKKNSKV
210 220 230 240 250
VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC PCGAESSGVG
260 270 280 290 300
DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY
310 320 330 340 350
AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA
360 370 380 390 400
FITGEVDDAV HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA
410 420 430 440 450
WKVVEELLCS LKLTYKQIYD VVASLCTSAF TIMDYKPVFV VSSNSVKDLV
460 470 480 490 500
DKCVKILVKA FDVFTQTITI AGVEAKCFVL GSKYLLFNNA LVKLVSVKIL
510 520 530 540 550
GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD VVTPGGGHIV
560 570 580 590 600
IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK
610 620 630 640 650
MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY
660 670 680 690 700
LKKYKMPVCL KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI
710 720 730 740 750
KNIICPDLLL ELDFGAIWYR CMPACSDKSI LGNVKIMLGN GVKVVCDGCH
760 770 780 790 800
SFANRLTINY NKLCDTARKD IEIGGIPFST FKTPSSSFID MKDAIYSVVE
810 820 830 840 850
YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK DNGDVIVIAG
860 870 880 890 900
YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR
910 920 930 940 950
VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA
960 970 980 990 1000
EQGVELEGYF IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI
1010 1020 1030 1040 1050
SLISDNEDVE QIEEDNTSTD DAEDVSSVEG ETVSVVDVED FVEQVSLVEE
1060 1070 1080 1090 1100
NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW AAAVDEQEAE QPKPSLTPFK
1110 1120 1130 1140 1150
TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF KKDDVMPFVD
1160 1170 1180 1190 1200
FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT
1210 1220 1230 1240 1250
VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF
1260 1270 1280 1290 1300
IVTPTMHAVY TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN
1310 1320 1330 1340 1350
ANVMTAKSKT MVEPPVPVED KCVEDCQSPK DLILPFYKAG KVSFYQGDLD
1360 1370 1380 1390 1400
VLINFLEPDV LVNAANGDLR HVGGVARAID VFTGGKLTKR SKEYLKSSKA
1410 1420 1430 1440 1450
IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK AIAKCDGKIL
1460 1470 1480 1490 1500
TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI
1510 1520 1530 1540 1550
PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK
1560 1570 1580 1590 1600
VVKALDVDWN AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW
1610 1620 1630 1640 1650
VNAICLALQR LKPTWKFPGV KSLWDAFLTR KTAGFVHMLY HISGLTKGQP
1660 1670 1680 1690 1700
GDAELTLHKL VDLMSSDSAV TVTHTTACDK CAKVETFTGP VVAAPLLVCG
1710 1720 1730 1740 1750
TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG YICYTGLNSR
1760 1770 1780 1790 1800
GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT
1810 1820 1830 1840 1850
QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA
1860 1870 1880 1890 1900
DVFFMAGDKI LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK
1910 1920 1930 1940 1950
VRTLNYVRQL NKPALWRYIK LVLLLIALYH FFYLFVSIPV VHKLACSGSV
1960 1970 1980 1990 2000
QAYSNSSFVK SEVCGNSILC KACLASYDEL ADFDHLQVSW DYKSDPLWNR
2010 2020 2030 2040 2050
VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV KYSWFLHVVN
2060 2070 2080 2090 2100
FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV
2110 2120 2130 2140 2150
VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS
2160 2170 2180 2190 2200
IKQTVYATDR SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV
2210 2220 2230 2240 2250
LKTMFLLDDF IVYNPSGSSL ASVRNVCVYF SQLIGRPIKI VNSELLEDLS
2260 2270 2280 2290 2300
VDFKGALFNA KKNVIKNSFN VDVSECKNLE ECYKLCNLDV TFSTFEMAIN
2310 2320 2330 2340 2350
NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF DAKIVNAKVL
2360 2370 2380 2390 2400
TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP
2410 2420 2430 2440 2450
YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY
2460 2470 2480 2490 2500
IDSAEGYDYM VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK
2510 2520 2530 2540 2550
SCPIVLGTVF DLGNMRPIPD VPAYVALVGR SLVFAINAAF GVTNVCYDHT
2560 2570 2580 2590 2600
GAAVSKNSYF DTCVFNSACT TLTGIGGTVV YCAKQGLVEG AKLYSELLPD
2610 2620 2630 2640 2650
YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE SQAGFCFGGD
2660 2670 2680 2690 2700
NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA
2710 2720 2730 2740 2750
CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY
2760 2770 2780 2790 2800
AIIYYFTTRK LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF
2810 2820 2830 2840 2850
KLKVTTNLFE GDKFVGSFES AAMGTFVIDM RSYETLVNST SLDRIKSYAN
2860 2870 2880 2890 2900
SFNKYKYYTG SMGEADYRMA CYAHLGKALM DYSVSRNDML YTPPTVSVNS
2910 2920 2930 2940 2950
TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI CPRHVIASDT
2960 2970 2980 2990 3000
SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT
3010 3020 3030 3040 3050
PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV
3060 3070 3080 3090 3100
GYVLENGTLY FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV
3110 3120 3130 3140 3150
MSSDNVVAFL YAALINGERW FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF
3160 3170 3180 3190 3200
NMLAAKTGYS VEKLLECIVR LNKGFGGRTI LSYGSLCDEF TPTEVIRQMY
3210 3220 3230 3240 3250
GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN PTFVSVVLAI
3260 3270 3280 3290 3300
TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE
3310 3320 3330 3340 3350
NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF
3360 3370 3380 3390 3400
NIVKLLGMIG EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI
3410 3420 3430 3440 3450
VVYVMQPAFV QDFGFVKCVS IIYMACGYLF CCYYGILYWV NRFTCMTCGV
3460 3470 3480 3490 3500
YQFTVSPAEL KYMTANNLSA PKTAYDAMIL SFKLMGIGGG RNIKISTVQS
3510 3520 3530 3540 3550
KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL CDDPDAVLEK
3560 3570 3580 3590 3600
LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA
3610 3620 3630 3640 3650
RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA
3660 3670 3680 3690 3700
SMYKEARAVD RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS
3710 3720 3730 3740 3750
IIPAASATRL IVVTPNLEVL SKVRQENNVH YAGAIWSIVE VKDANGAQVH
3760 3770 3780 3790 3800
LKEVTAANEL NITWPLSITC ERTTKLQNNE ILPGKLKEKA VKASATIDGD
3810 3820 3830 3840 3850
AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI PIELEAPLRF
3860 3870 3880 3890 3900
YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG
3910 3920 3930 3940 3950
LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN
3960 3970 3980 3990 4000
TQQDSYGGAS VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE
4010 4020 4030 4040 4050
NEVCVVCGCW LTNGCMCDRT SIQGTTIDQS YLNECGVLVQ LDLEPCNGTD
4060 4070 4080 4090 4100
PDHVSRAFDI YNKDVACIGK FLKTNCSRFR NLDKHDAYYV VKRCTKSVMD
4110 4120 4130 4140 4150
HEQVCYNDLK DSGVVAEHDF FLYKEGRCEF GNVARKDLTK YTMMDLCYAI
4160 4170 4180 4190 4200
RNFDEKNCEV LKEILVTLGA CNESFFENKD WFDPVENEAI HEVYARLGPI
4210 4220 4230 4240 4250
VANAMLKCVA FCDAIVEKGY IGIITLDNQD LNGNFYDFGD FVKTTPGFGC
4260 4270 4280 4290 4300
ACVTSYYSYM MPLMGMTSCL ESENFVKSDI YGADYKQYDL LAYDFTDHKE
4310 4320 4330 4340 4350
KLFHKYFKHW DRTYHPNCSD CTSDECIIHC ANFNTLFSMT IPSTAFGPLV
4360 4370 4380 4390 4400
RKVHIDGVPV VVTAGYHFKQ LGIVWNLDVK LDTMKLSMTD LLRFVTDPTL
4410 4420 4430 4440 4450
LVASSPALLD QRTVCFSIAA LSTGVTYQTV KPGHFNKDFY DFITERGFFE
4460 4470 4480 4490 4500
EGSELTLKHF FFAQGGEAAM TDFNYYRYNR VTVLDICQAQ FVYKIVGKYF
4510 4520 4530 4540 4550
ECYDGGCINA REVVVTNYDK SAGYPLNKFG KARLYYETLS YEEQDALFAL
4560 4570 4580 4590 4600
TKRNVLPTMT QMNLKYAISG KARARTVGGV SLLSTMTTRQ YHQKHLKSIA
4610 4620 4630 4640 4650
ATRNATVVIG STKFYGGWDN MLKNLMRDVD NGCLMGWDYP KCDRALPNMI
4660 4670 4680 4690 4700
RMASAMILGS KHVGCCTHSD RFYRLSNELA QVLTEVVHCT GGFYFKPGGT
4710 4720 4730 4740 4750
TSGDGTTAYA NSAFNIFQAV SANVNKLLGV DSNACNNVTV KSIQRKIYDN
4760 4770 4780 4790 4800
CYRSSSIDEE FVVEYFSYLR KHFSMMILSD DGVVCYNKDY ADLGYVADIN
4810 4820 4830 4840 4850
AFKATLYYQN NVFMSTSKCW VEPDLSVGPH EFCSQHTLQI VGPDGDYYLP
4860 4870 4880 4890 4900
YPDPSRILSA GVFVDDIVKT DNVIMLERYV SLAIDAYPLT KHPKPAYQKV
4910 4920 4930 4940 4950
FYTLLDWVKH LQKNLNAGVL DSFSVTMLEE GQDKFWSEEF YASLYEKSTV
4960 4970 4980 4990 5000
LQAAGMCVVC GSQTVLRCGD CLRRPLLCTK CAYDHVMGTK HKFIMSITPY
5010 5020 5030 5040 5050
VCSFNGCNVN DVTKLFLGGL SYYCMDHKPQ LSFPLCANGN VFGLYKSSAV
5060 5070 5080 5090 5100
GSEDVEDFNK LAVSDWTNVE DYKLANNVKE SLKIFAAETV KAKEESVKSE
5110 5120 5130 5140 5150
YAYAILKEVI GPKEIVLQWE ASKTKPPLNR NSVFTCFQIS KDTKIQLGEF
5160 5170 5180 5190 5200
VFEQSEYGSD SVYYKSTSTY KLTPGMIFVL TSHNVSPLKA TILVNQEKYN
5210 5220 5230 5240 5250
TISKLYPVFN IAEAYNTLVP YYQMIGKQKF TTIQGPPGSG KSHCVIGLGL
5260 5270 5280 5290 5300
YYPQARIVYT ACSHAAVDAL CEKAAKNFNV DRCSRIIPQR IRVDCYTGFK
5310 5320 5330 5340 5350
PNNTNAQYLF CTVNALPEAS CDIVVVDEVS MCTNYDLSVI NSRLSYKHIV
5360 5370 5380 5390 5400
YVGDPQQLPA PRTLINKGVL QPQDYNVVTQ RVCTLGPDVF LHKCYRCPAE
5410 5420 5430 5440 5450
IVKTVSALVY ENKFVPVNPE SKQCFKMFVK GQVQIESNSS INNKQLEVVK
5460 5470 5480 5490 5500
AFLAHNPKWR KAVFISPYNS QNYVARRLLG LQTQTVDSAQ GSEYDYVIYT
5510 5520 5530 5540 5550
QTSDTQHATN VNRFNVAITR AKVGILCIMC DRTMYENLDF YELKDSKIGL
5560 5570 5580 5590 5600
QAKPETCGLF KDCSKSEQYI PPAYATTYMS LSDNFKTSDG LAVNIGTKDV
5610 5620 5630 5640 5650
KYANVISYMG FRFEANIPGY HTLFCTRDFA MRNVRAWLGF DVEGAHVCGD
5660 5670 5680 5690 5700
NVGTNVPLQL GFSNGVDFVV QTEGCVVTEK GNSIEVVKAR APPGEQFAHL
5710 5720 5730 5740 5750
IPLMRKGQPW HIVRRRIVQM VCDYFDGLSD ILIFVLWAGG LELTTMRYFV
5760 5770 5780 5790 5800
KIGRPQKCEC GKSATCYSSS QCVYACFKHA LGCDYLYNPY CIDIQQWGYT
5810 5820 5830 5840 5850
GSLSMNHHEV CNIHRNEHVA SGDAIMTRCL AIHDCFVKRV DWSIVYPFID
5860 5870 5880 5890 5900
NEEKINKAGR IVQSHVMKAA LKIFNPAAIH DVGNPKGIRC ATTPIPWFCY
5910 5920 5930 5940 5950
DRDPINNNVR CLEYDYMVHG QMNGLMLFWN CNVDMYPEFS IVCRFDTRTR
5960 5970 5980 5990 6000
SKLSLEGCNG GALYVNNHAF HTPAYDRRAF AKLKPMPFFY YDDSNCELVD
6010 6020 6030 6040 6050
GQPNYVPLKS NVCITKCNIG GAVCKKHAAL YRAYVEDYNM FMQAGFTIWC
6060 6070 6080 6090 6100
PQNFDTYMLW HGFVNSKALQ SLENVAFNVV KKGAFTGLKG DLPTAVIADK
6110 6120 6130 6140 6150
IMVRDGPTDK CIFTNKTSLP TNVAFELYAK RKLGLTPPLT ILRNLGVVAT
6160 6170 6180 6190 6200
YKFVLWDYEA ECPFSNFTKQ VCSYTDLDSE VVTCFDNSIA GSFERFTTTK
6210 6220 6230 6240 6250
DAVLISNNAV KGLSAIKLQY GFLNDLPVST VGNKPVTWYI YVRKNGEYVE
6260 6270 6280 6290 6300
QIDSYYTHGR TFETFKPRST MEEDFLSMDT TLFIQKYGLE DYGFEHVVFG
6310 6320 6330 6340 6350
DVSKTTIGGM HLLISQVRLA KMGLFSVQEF MTNSDSTLKS CCITYADDPS
6360 6370 6380 6390 6400
SKNVCTYMDI LLDDFVTIIK SLDLNVVSKV VDVIVDCKAW RWMLWCENSQ
6410 6420 6430 6440 6450
IKTFYPQLQS AEWNPGYSMP TLYKIQRMCL ERCNLYNYGA QVRLPDGITT
6460 6470 6480 6490 6500
NVVKYTQLCQ YLNTTTVCVP HKMRVLHLGA AGASGVAPGS TVLRRWLPDD
6510 6520 6530 6540 6550
AILVDNDLRD YVSDADFSVT GDCTSLYIED KFDLLISDLY DGSTKSIDGE
6560 6570 6580 6590 6600
NTSKDGFFTY INGFIKEKLS LGGSAAIKIT EFSWNKDLYE LIQRFEYWTV
6610 6620 6630 6640 6650
FCTSVNTSSS EGFLIGINYL GPYCDKAIVD GNIMHANYIF WRNSTIMALS
6660 6670 6680 6690 6700
HNSVLDTPKF KCRCNNALIV NLKEKELNEM VVGLLRKGKL LIRNNGKLLN

FGNHLVNVP
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:6,709
Mass (Da):751,196
Last modified:April 17, 2007 - v2
Checksum:iF26AC0FFF5FE27F9
GO
Isoform Replicase polyprotein 1a (identifier: Q98VG9-2) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform differs from the canonical sequence as follows:
     4043-6709: Missing.

Note: Produced by conventional translation.
Show »
Length:4,042
Mass (Da):449,790
Checksum:i34663B2576D09550
GO

Sequence cautioni

The sequence AAY16374 differs from that shown. Reason: Frameshift at position 4033.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1016 – 1092Missing in AAY32594 (PubMed:16033972).CuratedAdd BLAST77

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti162W → C.1
Natural varianti177D → G.1
Natural varianti388W → C.1
Natural varianti808K → T.1
Natural varianti1784A → V.1
Natural varianti2889M → K.1
Natural varianti3280A → V.1
Natural varianti3992Q → R.1
Natural varianti4304H → Q.1
Natural varianti5846Y → H.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328854043 – 6709Missing in isoform Replicase polyprotein 1a. CuratedAdd BLAST2667

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010921 Genomic RNA. Translation: AAY32594.1.
DQ010921 Genomic RNA. Translation: AAY32595.1.
AY994055 Genomic RNA. Translation: AAY16374.1. Frameshift.
AF326575 Genomic RNA. Translation: AAK09095.1.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010921 Genomic RNA. Translation: AAY32594.1.
DQ010921 Genomic RNA. Translation: AAY32595.1.
AY994055 Genomic RNA. Translation: AAY16374.1. Frameshift.
AF326575 Genomic RNA. Translation: AAK09095.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETIX-ray2.20A/B/C/D/E/F/G/H1331-1498[»]
3EW5X-ray3.10A/B/C1331-1498[»]
3GZFX-ray2.76A/B/C/D/E2808-2902[»]
3JZTX-ray3.91A/B/C/D/E/F/G/H1331-1498[»]
3UB0X-ray2.60A/D3583-3777[»]
B/C/E/F3500-3582[»]
4ZROX-ray2.06A/B/C/D2904-3202[»]
5EU8X-ray2.45A2904-3205[»]
ProteinModelPortaliQ98VG9.
SMRiQ98VG9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC30.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ98VG9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
IPR032039. A-CoV_nsp1.
IPR032505. Corona_NSP4_C.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009003. Peptidase_S1_PA.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF16688. CNV-Replicase_N. 1 hit.
PF16348. Corona_NSP4_C. 1 hit.
PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 1 hit.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51653. CV_ZBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
PS51657. PSRV_HELICASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR1AB_FIPV
AccessioniPrimary (citable) accession number: Q98VG9
Secondary accession number(s): Q4U5G1, Q4U5G2, Q52PA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.