Q98VG9 (R1AB_FIPV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Replicase polyprotein 1ab
Short name=pp1ab

Alternative name(s):
ORF1ab polyprotein

Cleaved into the following 16 chains:

1. Non-structural protein 1
   Short name=nsp1
2. Non-structural protein 2
   Short name=nsp2
3. Non-structural protein 3
   Short name=nsp3
   EC=3.4.19.12
   EC=3.4.22.-
   Alternative name(s):
   PL1-PRO/PL2-PRO
   PLP1/PLP2
   Papain-like proteinases 1/2
   p195
4. Non-structural protein 4
   Short name=nsp4
   Alternative name(s):
   Peptide HD2
5. 3C-like proteinase
   Short name=3CL-PRO
   Short name=3CLp
   EC=3.4.22.-
   Alternative name(s):
   M-PRO
   nsp5
6. Non-structural protein 6
   Short name=nsp6
7. Non-structural protein 7
   Short name=nsp7
8. Non-structural protein 8
   Short name=nsp8
9. Non-structural protein 9
   Short name=nsp9
10. Non-structural protein 10
    Short name=nsp10
11. Non-structural protein 11
    Short name=nsp11
12. RNA-directed RNA polymerase
    Short name=Pol
    Short name=RdRp
    EC=2.7.7.48
    Alternative name(s):
    nsp12
13. Helicase
    Short name=Hel
    EC=3.6.4.12
    EC=3.6.4.13
    Alternative name(s):
    nsp13
14. Exoribonuclease
    Short name=ExoN
    EC=3.1.13.-
    Alternative name(s):
    nsp14
15. Uridylate-specific endoribonuclease
    EC=3.1.-.-
    Alternative name(s):
    NendoU
    nsp15
16. Putative 2'-O-methyl transferase
    EC=2.1.1.-
    Alternative name(s):
    nsp16

Gene names

Name:	rep
ORF Names:	1a-1b

Organism

Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) [Reference proteome]

Taxonomic identifier

33734 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nidovirales › Coronaviridae › Coronavirinae › Alphacoronavirus › Alphacoronavirus 1 › Feline coronavirus › Feline infectious peritonitis virus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	6709 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products. The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 By similarity. The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function By similarity. The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) By similarity. The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction By similarity. Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter By similarity. Nsp9 is a ssRNA-binding protein By similarity. NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). ATP + H2O = ADP + phosphate.
Subunit structure	3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer By similarity.
Subcellular location	Non-structural protein 3: Host membrane; Multi-pass membrane protein Potential. Non-structural protein 4: Host membrane; Multi-pass membrane protein Potential. Non-structural protein 6: Host membrane; Multi-pass membrane protein Potential. Non-structural protein 7: Host cytoplasm › host perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity. Non-structural protein 8: Host cytoplasm › host perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity. Non-structural protein 9: Host cytoplasm › host perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity. Non-structural protein 10: Host cytoplasm › host perinuclear region By similarity. Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes By similarity. Helicase: Host endoplasmic reticulum-Golgi intermediate compartment Potential. Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA By similarity. Uridylate-specific endoribonuclease: Host cytoplasm › host perinuclear region By similarity.
Domain	The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane By similarity.
Post-translational modification	Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed By similarity.
Sequence similarities	Belongs to the coronaviruses polyprotein 1ab family. Contains 1 (+)RNA virus helicase ATP-binding domain. Contains 1 (+)RNA virus helicase C-terminal domain. Contains 1 CV MBD (coronavirus metal-binding) domain. Contains 1 Macro domain. Contains 2 peptidase C16 domains. Contains 1 peptidase C30 domain. Contains 1 RdRp catalytic domain.
Sequence caution	The sequence AAY16374.1 differs from that shown. Reason: Frameshift at position 4033.

Ontologies

Keywords
Biological process	Activation of host autophagy by virus Host-virus interaction Inhibition of host IFN-mediated response initiation by virus Inhibition of host IRF3 by virus Inhibition of host innate immune response by virus Modulation of host ubiquitin pathway by viral deubiquitinase Modulation of host ubiquitin pathway by virus Ubl conjugation pathway Viral RNA replication Viral immunoevasion
Cellular component	Host cytoplasm Host membrane Membrane
Coding sequence diversity	Ribosomal frameshifting
Domain	Repeat Transmembrane Transmembrane helix Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding RNA-binding Zinc
Molecular function	Endonuclease Exonuclease Helicase Hydrolase Nuclease Nucleotidyltransferase Protease RNA-directed RNA polymerase Thiol protease Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction by virus of host autophagy Inferred from electronic annotation. Source: UniProtKB-KW methylation Inferred from electronic annotation. Source: GOC modulation by virus of host protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC proteolysis Inferred from electronic annotation. Source: UniProtKB-KW suppression by virus of host IRF3 activity Inferred from electronic annotation. Source: UniProtKB-KW suppression by virus of host type I interferon production Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro viral protein processing Inferred from electronic annotation. Source: InterPro
Cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment Inferred from electronic annotation. Source: UniProtKB-SubCell host cell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral replication complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW exoribonuclease activity, producing 5'-phosphomonoesters Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: UniProtKB-KW methyltransferase activity Inferred from electronic annotation. Source: InterPro omega peptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]

Isoform Replicase polyprotein 1ab (identifier: Q98VG9-1)

Also known as: pp1ab;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Isoform Replicase polyprotein 1a (identifier: Q98VG9-2)

Also known as: pp1a; ORF1a polyprotein;

The sequence of this isoform differs from the canonical sequence as follows:
     4043-6709: Missing.

Note: Produced by conventional translation.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 6709

6709

Replicase polyprotein 1ab

PRO_0000283825

Chain

1 – 110

110

Non-structural protein 1 By similarity

PRO_5000140208

Chain

111 – 879

769

Non-structural protein 2 By similarity

PRO_5000140209

Chain

880 – 2413

1534

Non-structural protein 3 By similarity

PRO_5000140210

Chain

2414 – 2903

490

Non-structural protein 4 By similarity

PRO_5000140211

Chain

2904 – 3205

302

3C-like proteinase By similarity

PRO_5000140212

Chain

3206 – 3499

294

Non-structural protein 6 By similarity

PRO_5000140213

Chain

3500 – 3582

83

Non-structural protein 7 By similarity

PRO_5000140214

Chain

3583 – 3777

195

Non-structural protein 8 By similarity

PRO_5000140215

Chain

3778 – 3888

111

Non-structural protein 9 By similarity

PRO_5000140216

Chain

3889 – 4023

135

Non-structural protein 10 By similarity

PRO_5000140217

Chain

4024 – 4952

929

RNA-directed RNA polymerase By similarity

PRO_5000140219

Chain

4024 – 4042

19

Non-structural protein 11 By similarity

PRO_5000140218

Chain

4953 – 5551

599

Helicase By similarity

PRO_5000140220

Chain

5552 – 6070

519

Exoribonuclease Potential

PRO_5000140221

Chain

6071 – 6409

339

Uridylate-specific endoribonuclease Potential

PRO_5000140222

Chain

6410 – 6709

300

Putative 2'-O-methyl transferase Potential

PRO_5000140223

Regions

Transmembrane

1860 – 1878

19

Helical; Potential

Transmembrane

1921 – 1941

21

Helical; Potential

Transmembrane

2006 – 2026

21

Helical; Potential

Transmembrane

2043 – 2065

23

Helical; Potential

Transmembrane

2426 – 2446

21

Helical; Potential

Transmembrane

2691 – 2711

21

Helical; Potential

Transmembrane

2720 – 2740

21

Helical; Potential

Transmembrane

2771 – 2791

21

Helical; Potential

Transmembrane

3212 – 3232

21

Helical; Potential

Transmembrane

3242 – 3262

21

Helical; Potential

Transmembrane

3267 – 3287

21

Helical; Potential

Transmembrane

3306 – 3326

21

Helical; Potential

Transmembrane

3339 – 3359

21

Helical; Potential

Transmembrane

3396 – 3416

21

Helical; Potential

Transmembrane

3419 – 3439

21

Helical; Potential

Domain

1079 – 1330

252

Peptidase C16 1

Domain

1329 – 1500

172

Macro

Domain

1561 – 1814

254

Peptidase C16 2

Domain

2904 – 3205

302

Peptidase C30

Domain

4632 – 4794

163

RdRp catalytic

Domain

4953 – 5036

84

CV MBD

Domain

5200 – 5391

192

(+)RNA virus helicase ATP-binding

Domain

5392 – 5561

170

(+)RNA virus helicase C-terminal

Zinc finger

1188 – 1219

32

C4-type 1 By similarity

Zinc finger

1678 – 1707

30

C4-type 2; atypical By similarity

Zinc finger

3962 – 3978

17

By similarity

Zinc finger

4004 – 4017

14

By similarity

Nucleotide binding

5235 – 5242

8

ATP By similarity

Region

1860 – 2065

206

HD1 By similarity

Region

2426 – 2791

366

HD2 By similarity

Region

3212 – 3439

228

HD3 By similarity

Sites

Active site

1117

1

For PL1-PRO activity By similarity

Active site

1268

1

For PL1-PRO activity By similarity

Active site

1599

1

For PL2-PRO activity By similarity

Active site

1752

1

For PL2-PRO activity By similarity

Active site

2944

1

For 3CL-PRO activity

Active site

3047

1

For 3CL-PRO activity

Site

110 – 111

2

Cleavage; by PL1-PRO By similarity

Site

879 – 880

2

Cleavage; by PL1-PRO By similarity

Site

2413 – 2414

2

Cleavage; by PL2-PRO By similarity

Site

2903 – 2904

2

Cleavage; by 3CL-PRO By similarity

Site

3053

1

Important for substrate recognition

Site

3205 – 3206

2

Cleavage; by 3CL-PRO By similarity

Site

3499 – 3500

2

Cleavage; by 3CL-PRO By similarity

Site

3582 – 3583

2

Cleavage; by 3CL-PRO By similarity

Site

3777 – 3778

2

Cleavage; by 3CL-PRO By similarity

Site

3888 – 3889

2

Cleavage; by 3CL-PRO By similarity

Site

4023 – 4024

2

Cleavage; by 3CL-PRO By similarity

Site

4952 – 4953

2

Cleavage; by 3CL-PRO By similarity

Site

5551 – 5552

2

Cleavage; by 3CL-PRO By similarity

Site

6070 – 6071

2

Cleavage; by 3CL-PRO By similarity

Site

6409 – 6410

2

Cleavage; by 3CL-PRO By similarity

Natural variations

Alternative sequence

4043 – 6709

2667

Missing in isoform Replicase polyprotein 1a.

VSP_032885

Natural variant

162

1

W → C.

Natural variant

177

1

D → G.

Natural variant

388

1

W → C.

Natural variant

808

1

K → T.

Natural variant

1784

1

A → V.

Natural variant

2889

1

M → K.

Natural variant

3280

1

A → V.

Natural variant

3992

1

Q → R.

Natural variant

4304

1

H → Q.

Natural variant

5846

1

Y → H.

Experimental info

Mutagenesis

2944

1

H → Y or R: Complete loss of 3CL-PRO activity. Ref.3

Mutagenesis

2967

1

N → A or D: Increase of 3CL-PRO activity. Ref.3

Mutagenesis

2986

1

G → A: 5% loss of 3CL-PRO activity. Ref.3

Mutagenesis

2986

1

G → D: Increase of 3CL-PRO activity. Ref.3

Mutagenesis

2986

1

G → E: 50% loss of 3CL-PRO activity. Ref.3

Mutagenesis

2986

1

G → P or V: 95% loss of 3CL-PRO activity. Ref.3

Mutagenesis

2986

1

G → R, T or W: 70% loss of 3CL-PRO activity. Ref.3

Mutagenesis

3041

1

S → A: 80% loss of 3CL-PRO activity. Ref.3

Mutagenesis

3041

1

S → T: 40% loss of 3CL-PRO activity. Ref.3

Mutagenesis

3047

1

C → A or S: Complete loss of 3CL-PRO activity. Ref.3

Mutagenesis

3063

1

Y → A, F, G or T: Almost complete loss of 3CL-PRO activity. Ref.3

Mutagenesis

3064

1

M → A: Increase of 3CL-PRO activity. Ref.3

Mutagenesis

3065

1

H → A: Complete loss of 3CL-PRO activity. Ref.3

Sequence conflict

1016 – 1092

77

Missing in AAY32594. Ref.1

Secondary structure

1

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6709

Helix Strand Turn

Details...

Beta strand

1336 – 1339

4

Beta strand

1342 – 1347

6

Helix

1349 – 1356

8

Beta strand

1359 – 1365

7

Helix

1376 – 1382

7

Turn

1383 – 1385

3

Helix

1386 – 1395

10

Beta strand

1405 – 1413

9

Beta strand

1416 – 1422

7

Helix

1431 – 1443

13

Beta strand

1449 – 1451

3

Helix

1463 – 1473

11

Beta strand

1479 – 1483

5

Helix

1486 – 1497

12

Helix

2818 – 2823

6

Beta strand

2826 – 2828

3

Helix

2830 – 2837

8

Turn

2838 – 2840

3

Helix

2842 – 2850

9

Helix

2852 – 2856

5

Helix

2864 – 2884

21

Beta strand

2889 – 2891

3

Beta strand

2895 – 2899

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform Replicase polyprotein 1ab (pp1ab) [UniParc]. Last modified April 17, 2007. Version 2. Checksum: F26AC0FFF5FE27F9	FASTA	6,709	751,196
	10 20 30 40 50 60 MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD LVDCNRKDHY 70 80 90 100 110 120 VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF DLKFARTGNG AIYVDQYMCG 130 140 150 160 170 180 ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH 190 200 210 220 230 240 KLPNCAIREV APPVKKNSKV VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC 250 260 270 280 290 300 PCGAESSGVG DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY 310 320 330 340 350 360 AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA FITGEVDDAV 370 380 390 400 410 420 HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA WKVVEELLCS LKLTYKQIYD 430 440 450 460 470 480 VVASLCTSAF TIMDYKPVFV VSSNSVKDLV DKCVKILVKA FDVFTQTITI AGVEAKCFVL 490 500 510 520 530 540 GSKYLLFNNA LVKLVSVKIL GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD 550 560 570 580 590 600 VVTPGGGHIV IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK 610 620 630 640 650 660 MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY LKKYKMPVCL 670 680 690 700 710 720 KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI KNIICPDLLL ELDFGAIWYR 730 740 750 760 770 780 CMPACSDKSI LGNVKIMLGN GVKVVCDGCH SFANRLTINY NKLCDTARKD IEIGGIPFST 790 800 810 820 830 840 FKTPSSSFID MKDAIYSVVE YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK 850 860 870 880 890 900 DNGDVIVIAG YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR 910 920 930 940 950 960 VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA EQGVELEGYF 970 980 990 1000 1010 1020 IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI SLISDNEDVE QIEEDNTSTD 1030 1040 1050 1060 1070 1080 DAEDVSSVEG ETVSVVDVED FVEQVSLVEE NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW 1090 1100 1110 1120 1130 1140 AAAVDEQEAE QPKPSLTPFK TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF 1150 1160 1170 1180 1190 1200 KKDDVMPFVD FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT 1210 1220 1230 1240 1250 1260 VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF IVTPTMHAVY 1270 1280 1290 1300 1310 1320 TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN ANVMTAKSKT MVEPPVPVED 1330 1340 1350 1360 1370 1380 KCVEDCQSPK DLILPFYKAG KVSFYQGDLD VLINFLEPDV LVNAANGDLR HVGGVARAID 1390 1400 1410 1420 1430 1440 VFTGGKLTKR SKEYLKSSKA IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK 1450 1460 1470 1480 1490 1500 AIAKCDGKIL TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI 1510 1520 1530 1540 1550 1560 PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK VVKALDVDWN 1570 1580 1590 1600 1610 1620 AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW VNAICLALQR LKPTWKFPGV 1630 1640 1650 1660 1670 1680 KSLWDAFLTR KTAGFVHMLY HISGLTKGQP GDAELTLHKL VDLMSSDSAV TVTHTTACDK 1690 1700 1710 1720 1730 1740 CAKVETFTGP VVAAPLLVCG TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG 1750 1760 1770 1780 1790 1800 YICYTGLNSR GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT 1810 1820 1830 1840 1850 1860 QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA DVFFMAGDKI 1870 1880 1890 1900 1910 1920 LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK VRTLNYVRQL NKPALWRYIK 1930 1940 1950 1960 1970 1980 LVLLLIALYH FFYLFVSIPV VHKLACSGSV QAYSNSSFVK SEVCGNSILC KACLASYDEL 1990 2000 2010 2020 2030 2040 ADFDHLQVSW DYKSDPLWNR VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV 2050 2060 2070 2080 2090 2100 KYSWFLHVVN FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV 2110 2120 2130 2140 2150 2160 VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS IKQTVYATDR 2170 2180 2190 2200 2210 2220 SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV LKTMFLLDDF IVYNPSGSSL 2230 2240 2250 2260 2270 2280 ASVRNVCVYF SQLIGRPIKI VNSELLEDLS VDFKGALFNA KKNVIKNSFN VDVSECKNLE 2290 2300 2310 2320 2330 2340 ECYKLCNLDV TFSTFEMAIN NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF 2350 2360 2370 2380 2390 2400 DAKIVNAKVL TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP 2410 2420 2430 2440 2450 2460 YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY IDSAEGYDYM 2470 2480 2490 2500 2510 2520 VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK SCPIVLGTVF DLGNMRPIPD 2530 2540 2550 2560 2570 2580 VPAYVALVGR SLVFAINAAF GVTNVCYDHT GAAVSKNSYF DTCVFNSACT TLTGIGGTVV 2590 2600 2610 2620 2630 2640 YCAKQGLVEG AKLYSELLPD YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE 2650 2660 2670 2680 2690 2700 SQAGFCFGGD NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA 2710 2720 2730 2740 2750 2760 CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY AIIYYFTTRK 2770 2780 2790 2800 2810 2820 LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF KLKVTTNLFE GDKFVGSFES 2830 2840 2850 2860 2870 2880 AAMGTFVIDM RSYETLVNST SLDRIKSYAN SFNKYKYYTG SMGEADYRMA CYAHLGKALM 2890 2900 2910 2920 2930 2940 DYSVSRNDML YTPPTVSVNS TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI 2950 2960 2970 2980 2990 3000 CPRHVIASDT SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT 3010 3020 3030 3040 3050 3060 PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV GYVLENGTLY 3070 3080 3090 3100 3110 3120 FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV MSSDNVVAFL YAALINGERW 3130 3140 3150 3160 3170 3180 FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF NMLAAKTGYS VEKLLECIVR LNKGFGGRTI 3190 3200 3210 3220 3230 3240 LSYGSLCDEF TPTEVIRQMY GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN 3250 3260 3270 3280 3290 3300 PTFVSVVLAI TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE 3310 3320 3330 3340 3350 3360 NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF NIVKLLGMIG 3370 3380 3390 3400 3410 3420 EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI VVYVMQPAFV QDFGFVKCVS 3430 3440 3450 3460 3470 3480 IIYMACGYLF CCYYGILYWV NRFTCMTCGV YQFTVSPAEL KYMTANNLSA PKTAYDAMIL 3490 3500 3510 3520 3530 3540 SFKLMGIGGG RNIKISTVQS KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL 3550 3560 3570 3580 3590 3600 CDDPDAVLEK LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA 3610 3620 3630 3640 3650 3660 RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA SMYKEARAVD 3670 3680 3690 3700 3710 3720 RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS IIPAASATRL IVVTPNLEVL 3730 3740 3750 3760 3770 3780 SKVRQENNVH YAGAIWSIVE VKDANGAQVH LKEVTAANEL NITWPLSITC ERTTKLQNNE 3790 3800 3810 3820 3830 3840 ILPGKLKEKA VKASATIDGD AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI 3850 3860 3870 3880 3890 3900 PIELEAPLRF YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG 3910 3920 3930 3940 3950 3960 LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN TQQDSYGGAS 3970 3980 3990 4000 4010 4020 VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE NEVCVVCGCW LTNGCMCDRT 4030 4040 4050 4060 4070 4080 SIQGTTIDQS YLNECGVLVQ LDLEPCNGTD PDHVSRAFDI YNKDVACIGK FLKTNCSRFR 4090 4100 4110 4120 4130 4140 NLDKHDAYYV VKRCTKSVMD HEQVCYNDLK DSGVVAEHDF FLYKEGRCEF GNVARKDLTK 4150 4160 4170 4180 4190 4200 YTMMDLCYAI RNFDEKNCEV LKEILVTLGA CNESFFENKD WFDPVENEAI HEVYARLGPI 4210 4220 4230 4240 4250 4260 VANAMLKCVA FCDAIVEKGY IGIITLDNQD LNGNFYDFGD FVKTTPGFGC ACVTSYYSYM 4270 4280 4290 4300 4310 4320 MPLMGMTSCL ESENFVKSDI YGADYKQYDL LAYDFTDHKE KLFHKYFKHW DRTYHPNCSD 4330 4340 4350 4360 4370 4380 CTSDECIIHC ANFNTLFSMT IPSTAFGPLV RKVHIDGVPV VVTAGYHFKQ LGIVWNLDVK 4390 4400 4410 4420 4430 4440 LDTMKLSMTD LLRFVTDPTL LVASSPALLD QRTVCFSIAA LSTGVTYQTV KPGHFNKDFY 4450 4460 4470 4480 4490 4500 DFITERGFFE EGSELTLKHF FFAQGGEAAM TDFNYYRYNR VTVLDICQAQ FVYKIVGKYF 4510 4520 4530 4540 4550 4560 ECYDGGCINA REVVVTNYDK SAGYPLNKFG KARLYYETLS YEEQDALFAL TKRNVLPTMT 4570 4580 4590 4600 4610 4620 QMNLKYAISG KARARTVGGV SLLSTMTTRQ YHQKHLKSIA ATRNATVVIG STKFYGGWDN 4630 4640 4650 4660 4670 4680 MLKNLMRDVD NGCLMGWDYP KCDRALPNMI RMASAMILGS KHVGCCTHSD RFYRLSNELA 4690 4700 4710 4720 4730 4740 QVLTEVVHCT GGFYFKPGGT TSGDGTTAYA NSAFNIFQAV SANVNKLLGV DSNACNNVTV 4750 4760 4770 4780 4790 4800 KSIQRKIYDN CYRSSSIDEE FVVEYFSYLR KHFSMMILSD DGVVCYNKDY ADLGYVADIN 4810 4820 4830 4840 4850 4860 AFKATLYYQN NVFMSTSKCW VEPDLSVGPH EFCSQHTLQI VGPDGDYYLP YPDPSRILSA 4870 4880 4890 4900 4910 4920 GVFVDDIVKT DNVIMLERYV SLAIDAYPLT KHPKPAYQKV FYTLLDWVKH LQKNLNAGVL 4930 4940 4950 4960 4970 4980 DSFSVTMLEE GQDKFWSEEF YASLYEKSTV LQAAGMCVVC GSQTVLRCGD CLRRPLLCTK 4990 5000 5010 5020 5030 5040 CAYDHVMGTK HKFIMSITPY VCSFNGCNVN DVTKLFLGGL SYYCMDHKPQ LSFPLCANGN 5050 5060 5070 5080 5090 5100 VFGLYKSSAV GSEDVEDFNK LAVSDWTNVE DYKLANNVKE SLKIFAAETV KAKEESVKSE 5110 5120 5130 5140 5150 5160 YAYAILKEVI GPKEIVLQWE ASKTKPPLNR NSVFTCFQIS KDTKIQLGEF VFEQSEYGSD 5170 5180 5190 5200 5210 5220 SVYYKSTSTY KLTPGMIFVL TSHNVSPLKA TILVNQEKYN TISKLYPVFN IAEAYNTLVP 5230 5240 5250 5260 5270 5280 YYQMIGKQKF TTIQGPPGSG KSHCVIGLGL YYPQARIVYT ACSHAAVDAL CEKAAKNFNV 5290 5300 5310 5320 5330 5340 DRCSRIIPQR IRVDCYTGFK PNNTNAQYLF CTVNALPEAS CDIVVVDEVS MCTNYDLSVI 5350 5360 5370 5380 5390 5400 NSRLSYKHIV YVGDPQQLPA PRTLINKGVL QPQDYNVVTQ RVCTLGPDVF LHKCYRCPAE 5410 5420 5430 5440 5450 5460 IVKTVSALVY ENKFVPVNPE SKQCFKMFVK GQVQIESNSS INNKQLEVVK AFLAHNPKWR 5470 5480 5490 5500 5510 5520 KAVFISPYNS QNYVARRLLG LQTQTVDSAQ GSEYDYVIYT QTSDTQHATN VNRFNVAITR 5530 5540 5550 5560 5570 5580 AKVGILCIMC DRTMYENLDF YELKDSKIGL QAKPETCGLF KDCSKSEQYI PPAYATTYMS 5590 5600 5610 5620 5630 5640 LSDNFKTSDG LAVNIGTKDV KYANVISYMG FRFEANIPGY HTLFCTRDFA MRNVRAWLGF 5650 5660 5670 5680 5690 5700 DVEGAHVCGD NVGTNVPLQL GFSNGVDFVV QTEGCVVTEK GNSIEVVKAR APPGEQFAHL 5710 5720 5730 5740 5750 5760 IPLMRKGQPW HIVRRRIVQM VCDYFDGLSD ILIFVLWAGG LELTTMRYFV KIGRPQKCEC 5770 5780 5790 5800 5810 5820 GKSATCYSSS QCVYACFKHA LGCDYLYNPY CIDIQQWGYT GSLSMNHHEV CNIHRNEHVA 5830 5840 5850 5860 5870 5880 SGDAIMTRCL AIHDCFVKRV DWSIVYPFID NEEKINKAGR IVQSHVMKAA LKIFNPAAIH 5890 5900 5910 5920 5930 5940 DVGNPKGIRC ATTPIPWFCY DRDPINNNVR CLEYDYMVHG QMNGLMLFWN CNVDMYPEFS 5950 5960 5970 5980 5990 6000 IVCRFDTRTR SKLSLEGCNG GALYVNNHAF HTPAYDRRAF AKLKPMPFFY YDDSNCELVD 6010 6020 6030 6040 6050 6060 GQPNYVPLKS NVCITKCNIG GAVCKKHAAL YRAYVEDYNM FMQAGFTIWC PQNFDTYMLW 6070 6080 6090 6100 6110 6120 HGFVNSKALQ SLENVAFNVV KKGAFTGLKG DLPTAVIADK IMVRDGPTDK CIFTNKTSLP 6130 6140 6150 6160 6170 6180 TNVAFELYAK RKLGLTPPLT ILRNLGVVAT YKFVLWDYEA ECPFSNFTKQ VCSYTDLDSE 6190 6200 6210 6220 6230 6240 VVTCFDNSIA GSFERFTTTK DAVLISNNAV KGLSAIKLQY GFLNDLPVST VGNKPVTWYI 6250 6260 6270 6280 6290 6300 YVRKNGEYVE QIDSYYTHGR TFETFKPRST MEEDFLSMDT TLFIQKYGLE DYGFEHVVFG 6310 6320 6330 6340 6350 6360 DVSKTTIGGM HLLISQVRLA KMGLFSVQEF MTNSDSTLKS CCITYADDPS SKNVCTYMDI 6370 6380 6390 6400 6410 6420 LLDDFVTIIK SLDLNVVSKV VDVIVDCKAW RWMLWCENSQ IKTFYPQLQS AEWNPGYSMP 6430 6440 6450 6460 6470 6480 TLYKIQRMCL ERCNLYNYGA QVRLPDGITT NVVKYTQLCQ YLNTTTVCVP HKMRVLHLGA 6490 6500 6510 6520 6530 6540 AGASGVAPGS TVLRRWLPDD AILVDNDLRD YVSDADFSVT GDCTSLYIED KFDLLISDLY 6550 6560 6570 6580 6590 6600 DGSTKSIDGE NTSKDGFFTY INGFIKEKLS LGGSAAIKIT EFSWNKDLYE LIQRFEYWTV 6610 6620 6630 6640 6650 6660 FCTSVNTSSS EGFLIGINYL GPYCDKAIVD GNIMHANYIF WRNSTIMALS HNSVLDTPKF 6670 6680 6690 6700 KCRCNNALIV NLKEKELNEM VVGLLRKGKL LIRNNGKLLN FGNHLVNVP
	Isoform Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [UniParc]. Checksum: 34663B2576D09550	FASTA	4,042	449,790
	10 20 30 40 50 60 MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD LVDCNRKDHY 70 80 90 100 110 120 VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF DLKFARTGNG AIYVDQYMCG 130 140 150 160 170 180 ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH 190 200 210 220 230 240 KLPNCAIREV APPVKKNSKV VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC 250 260 270 280 290 300 PCGAESSGVG DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY 310 320 330 340 350 360 AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA FITGEVDDAV 370 380 390 400 410 420 HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA WKVVEELLCS LKLTYKQIYD 430 440 450 460 470 480 VVASLCTSAF TIMDYKPVFV VSSNSVKDLV DKCVKILVKA FDVFTQTITI AGVEAKCFVL 490 500 510 520 530 540 GSKYLLFNNA LVKLVSVKIL GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD 550 560 570 580 590 600 VVTPGGGHIV IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK 610 620 630 640 650 660 MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY LKKYKMPVCL 670 680 690 700 710 720 KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI KNIICPDLLL ELDFGAIWYR 730 740 750 760 770 780 CMPACSDKSI LGNVKIMLGN GVKVVCDGCH SFANRLTINY NKLCDTARKD IEIGGIPFST 790 800 810 820 830 840 FKTPSSSFID MKDAIYSVVE YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK 850 860 870 880 890 900 DNGDVIVIAG YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR 910 920 930 940 950 960 VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA EQGVELEGYF 970 980 990 1000 1010 1020 IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI SLISDNEDVE QIEEDNTSTD 1030 1040 1050 1060 1070 1080 DAEDVSSVEG ETVSVVDVED FVEQVSLVEE NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW 1090 1100 1110 1120 1130 1140 AAAVDEQEAE QPKPSLTPFK TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF 1150 1160 1170 1180 1190 1200 KKDDVMPFVD FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT 1210 1220 1230 1240 1250 1260 VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF IVTPTMHAVY 1270 1280 1290 1300 1310 1320 TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN ANVMTAKSKT MVEPPVPVED 1330 1340 1350 1360 1370 1380 KCVEDCQSPK DLILPFYKAG KVSFYQGDLD VLINFLEPDV LVNAANGDLR HVGGVARAID 1390 1400 1410 1420 1430 1440 VFTGGKLTKR SKEYLKSSKA IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK 1450 1460 1470 1480 1490 1500 AIAKCDGKIL TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI 1510 1520 1530 1540 1550 1560 PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK VVKALDVDWN 1570 1580 1590 1600 1610 1620 AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW VNAICLALQR LKPTWKFPGV 1630 1640 1650 1660 1670 1680 KSLWDAFLTR KTAGFVHMLY HISGLTKGQP GDAELTLHKL VDLMSSDSAV TVTHTTACDK 1690 1700 1710 1720 1730 1740 CAKVETFTGP VVAAPLLVCG TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG 1750 1760 1770 1780 1790 1800 YICYTGLNSR GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT 1810 1820 1830 1840 1850 1860 QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA DVFFMAGDKI 1870 1880 1890 1900 1910 1920 LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK VRTLNYVRQL NKPALWRYIK 1930 1940 1950 1960 1970 1980 LVLLLIALYH FFYLFVSIPV VHKLACSGSV QAYSNSSFVK SEVCGNSILC KACLASYDEL 1990 2000 2010 2020 2030 2040 ADFDHLQVSW DYKSDPLWNR VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV 2050 2060 2070 2080 2090 2100 KYSWFLHVVN FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV 2110 2120 2130 2140 2150 2160 VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS IKQTVYATDR 2170 2180 2190 2200 2210 2220 SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV LKTMFLLDDF IVYNPSGSSL 2230 2240 2250 2260 2270 2280 ASVRNVCVYF SQLIGRPIKI VNSELLEDLS VDFKGALFNA KKNVIKNSFN VDVSECKNLE 2290 2300 2310 2320 2330 2340 ECYKLCNLDV TFSTFEMAIN NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF 2350 2360 2370 2380 2390 2400 DAKIVNAKVL TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP 2410 2420 2430 2440 2450 2460 YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY IDSAEGYDYM 2470 2480 2490 2500 2510 2520 VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK SCPIVLGTVF DLGNMRPIPD 2530 2540 2550 2560 2570 2580 VPAYVALVGR SLVFAINAAF GVTNVCYDHT GAAVSKNSYF DTCVFNSACT TLTGIGGTVV 2590 2600 2610 2620 2630 2640 YCAKQGLVEG AKLYSELLPD YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE 2650 2660 2670 2680 2690 2700 SQAGFCFGGD NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA 2710 2720 2730 2740 2750 2760 CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY AIIYYFTTRK 2770 2780 2790 2800 2810 2820 LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF KLKVTTNLFE GDKFVGSFES 2830 2840 2850 2860 2870 2880 AAMGTFVIDM RSYETLVNST SLDRIKSYAN SFNKYKYYTG SMGEADYRMA CYAHLGKALM 2890 2900 2910 2920 2930 2940 DYSVSRNDML YTPPTVSVNS TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI 2950 2960 2970 2980 2990 3000 CPRHVIASDT SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT 3010 3020 3030 3040 3050 3060 PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV GYVLENGTLY 3070 3080 3090 3100 3110 3120 FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV MSSDNVVAFL YAALINGERW 3130 3140 3150 3160 3170 3180 FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF NMLAAKTGYS VEKLLECIVR LNKGFGGRTI 3190 3200 3210 3220 3230 3240 LSYGSLCDEF TPTEVIRQMY GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN 3250 3260 3270 3280 3290 3300 PTFVSVVLAI TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE 3310 3320 3330 3340 3350 3360 NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF NIVKLLGMIG 3370 3380 3390 3400 3410 3420 EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI VVYVMQPAFV QDFGFVKCVS 3430 3440 3450 3460 3470 3480 IIYMACGYLF CCYYGILYWV NRFTCMTCGV YQFTVSPAEL KYMTANNLSA PKTAYDAMIL 3490 3500 3510 3520 3530 3540 SFKLMGIGGG RNIKISTVQS KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL 3550 3560 3570 3580 3590 3600 CDDPDAVLEK LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA 3610 3620 3630 3640 3650 3660 RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA SMYKEARAVD 3670 3680 3690 3700 3710 3720 RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS IIPAASATRL IVVTPNLEVL 3730 3740 3750 3760 3770 3780 SKVRQENNVH YAGAIWSIVE VKDANGAQVH LKEVTAANEL NITWPLSITC ERTTKLQNNE 3790 3800 3810 3820 3830 3840 ILPGKLKEKA VKASATIDGD AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI 3850 3860 3870 3880 3890 3900 PIELEAPLRF YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG 3910 3920 3930 3940 3950 3960 LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN TQQDSYGGAS 3970 3980 3990 4000 4010 4020 VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE NEVCVVCGCW LTNGCMCDRT 4030 4040 SIQGTTIDQS YLNECGVLVQ LD

References

[1]	"Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146." Dye C., Siddell S.G. J. Gen. Virol. 86:2249-2253(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	Haijema B.J., de Groot-Mijnes J.D.F., Vennema H., Raamsman M.J., Rottier P.J.M., de Groot R.J. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]	"Mutational analysis of the active centre of coronavirus 3C-like proteases." Hegyi A., Friebe A., Gorbalenya A.E., Ziebuhr J. J. Gen. Virol. 83:581-593(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 2894-3215, MUTAGENESIS OF HIS-2944; ASN-2967; GLY-2986; SER-3041; CYS-3047; TYR-3063; MET-3064 AND HIS-3065.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ010921 Genomic RNA. Translation: AAY32594.1.
DQ010921 Genomic RNA. Translation: AAY32595.1.
AY994055 Genomic RNA. Translation: AAY16374.1. Frameshift.
AF326575 Genomic RNA. Translation: AAK09095.1.

RefSeq

YP_004070193.1. NC_002306.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ETI	X-ray	2.20	A/B/C/D/E/F/G/H	1331-1498	[»]
3EW5	X-ray	3.10	A/B/C	1331-1498	[»]
3GZF	X-ray	2.76	A/B/C/D/E	2808-2902	[»]
3JZT	X-ray	3.91	A/B/C/D/E/F/G/H	1331-1498	[»]
3UB0	X-ray	2.60	A/D	3583-3777	[»]
			B/C/E/F	3500-3582	[»]

ProteinModelPortal

Q98VG9.

SMR

Q98VG9. Positions 2904-3204, 3894-4019.

ModBase

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Protein family/group databases

MEROPS

C30.004.

Protocols and materials databases

StructuralBiologyKnowledgebase

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Genome annotation databases

GeneID

1724653.

Family and domain databases

InterPro

IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002589. A1pp.
IPR009461. Coronavirus_NSP13.
IPR027352. CV_MBD_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view]

Pfam

PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 2 hits.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view]

SMART

SM00506. A1pp. 1 hit.
[Graphical view]

SUPFAM

SSF101816. Nsp9. 1 hit.
SSF50494. Pept_Ser_Cys. 1 hit.
SSF144246. SSF144246. 2 hits.

PROSITE

PS51653. CV_MBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. False negative.
[Graphical view]

ProtoNet

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Other

EvolutionaryTrace

Q98VG9.

Entry information

Entry name

R1AB_FIPV

Accession

Primary (citable) accession number: Q98VG9
Secondary accession number(s): Q4U5G1, Q4U5G2, Q52PA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program