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Q98VG9

- R1AB_FIPV

UniProt

Q98VG9 - R1AB_FIPV

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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).By similarity
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).By similarity
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei110 – 1112Cleavage; by PL1-PROBy similarity
Sitei879 – 8802Cleavage; by PL1-PROBy similarity
Active sitei1117 – 11171For PL1-PRO activityPROSITE-ProRule annotation
Active sitei1268 – 12681For PL1-PRO activityPROSITE-ProRule annotation
Active sitei1599 – 15991For PL2-PRO activityPROSITE-ProRule annotation
Active sitei1752 – 17521For PL2-PRO activityPROSITE-ProRule annotation
Sitei2413 – 24142Cleavage; by PL2-PROBy similarity
Sitei2903 – 29042Cleavage; by 3CL-PROBy similarity
Active sitei2944 – 29441For 3CL-PRO activity
Active sitei3047 – 30471For 3CL-PRO activity
Sitei3053 – 30531Important for substrate recognition
Sitei3205 – 32062Cleavage; by 3CL-PROBy similarity
Sitei3499 – 35002Cleavage; by 3CL-PROBy similarity
Sitei3582 – 35832Cleavage; by 3CL-PROBy similarity
Sitei3777 – 37782Cleavage; by 3CL-PROBy similarity
Sitei3888 – 38892Cleavage; by 3CL-PROBy similarity
Sitei4023 – 40242Cleavage; by 3CL-PROBy similarity
Sitei4952 – 49532Cleavage; by 3CL-PROBy similarity
Sitei5551 – 55522Cleavage; by 3CL-PROBy similarity
Sitei6070 – 60712Cleavage; by 3CL-PROBy similarity
Sitei6409 – 64102Cleavage; by 3CL-PROBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1188 – 121932C4-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1678 – 170730C4-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3962 – 397817By similarityAdd
BLAST
Zinc fingeri4004 – 401714By similarityAdd
BLAST
Nucleotide bindingi5235 – 52428ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cysteine-type endopeptidase activity Source: InterPro
  3. endonuclease activity Source: UniProtKB-KW
  4. exoribonuclease activity, producing 5'-phosphomonoesters Source: InterPro
  5. helicase activity Source: UniProtKB-KW
  6. methyltransferase activity Source: InterPro
  7. omega peptidase activity Source: InterPro
  8. RNA binding Source: UniProtKB-KW
  9. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  10. zinc ion binding Source: InterPro

GO - Biological processi

  1. induction by virus of host autophagy Source: UniProtKB-KW
  2. modulation by virus of host protein ubiquitination Source: UniProtKB-KW
  3. suppression by virus of host IRF3 activity Source: UniProtKB-KW
  4. transcription, DNA-templated Source: InterPro
  5. viral genome replication Source: InterPro
  6. viral protein processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Helicase, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase

Keywords - Biological processi

Activation of host autophagy by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Protein family/group databases

MEROPSiC30.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 16 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
PL1-PRO/PL2-PRO
PLP1/PLP2
Papain-like proteinases 1/2
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Non-structural protein 11
Short name:
nsp11
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Alternative name(s):
NendoU
nsp15
Alternative name(s):
nsp16
Gene namesi
Name:rep
ORF Names:1a-1b
OrganismiFeline coronavirus (strain FIPV WSU-79/1146) (FCoV)
Taxonomic identifieri33734 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiFelidae (cat family) [TaxID: 9681]
ProteomesiUP000000835: Genome

Subcellular locationi

Chain Non-structural protein 7 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Chain Non-structural protein 8 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Chain Non-structural protein 9 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Chain Non-structural protein 10 : Host cytoplasmhost perinuclear region By similarity
Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Chain Helicase : Host endoplasmic reticulum-Golgi intermediate compartment Curated
Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1860 – 187819HelicalSequence AnalysisAdd
BLAST
Transmembranei1921 – 194121HelicalSequence AnalysisAdd
BLAST
Transmembranei2006 – 202621HelicalSequence AnalysisAdd
BLAST
Transmembranei2043 – 206523HelicalSequence AnalysisAdd
BLAST
Transmembranei2426 – 244621HelicalSequence AnalysisAdd
BLAST
Transmembranei2691 – 271121HelicalSequence AnalysisAdd
BLAST
Transmembranei2720 – 274021HelicalSequence AnalysisAdd
BLAST
Transmembranei2771 – 279121HelicalSequence AnalysisAdd
BLAST
Transmembranei3212 – 323221HelicalSequence AnalysisAdd
BLAST
Transmembranei3242 – 326221HelicalSequence AnalysisAdd
BLAST
Transmembranei3267 – 328721HelicalSequence AnalysisAdd
BLAST
Transmembranei3306 – 332621HelicalSequence AnalysisAdd
BLAST
Transmembranei3339 – 335921HelicalSequence AnalysisAdd
BLAST
Transmembranei3396 – 341621HelicalSequence AnalysisAdd
BLAST
Transmembranei3419 – 343921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. host cell membrane Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2944 – 29441H → Y or R: Complete loss of 3CL-PRO activity. 1 Publication
Mutagenesisi2967 – 29671N → A or D: Increase of 3CL-PRO activity. 1 Publication
Mutagenesisi2986 – 29861G → A: 5% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi2986 – 29861G → D: Increase of 3CL-PRO activity. 1 Publication
Mutagenesisi2986 – 29861G → E: 50% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi2986 – 29861G → P or V: 95% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi2986 – 29861G → R, T or W: 70% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi3041 – 30411S → A: 80% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi3041 – 30411S → T: 40% loss of 3CL-PRO activity. 1 Publication
Mutagenesisi3047 – 30471C → A or S: Complete loss of 3CL-PRO activity. 1 Publication
Mutagenesisi3063 – 30631Y → A, F, G or T: Almost complete loss of 3CL-PRO activity. 1 Publication
Mutagenesisi3064 – 30641M → A: Increase of 3CL-PRO activity. 1 Publication
Mutagenesisi3065 – 30651H → A: Complete loss of 3CL-PRO activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 67096709Replicase polyprotein 1abPRO_0000283825Add
BLAST
Chaini1 – 110110Non-structural protein 1By similarityPRO_5000140208Add
BLAST
Chaini111 – 879769Non-structural protein 2By similarityPRO_5000140209Add
BLAST
Chaini880 – 24131534Non-structural protein 3By similarityPRO_5000140210Add
BLAST
Chaini2414 – 2903490Non-structural protein 4By similarityPRO_5000140211Add
BLAST
Chaini2904 – 32053023C-like proteinaseBy similarityPRO_5000140212Add
BLAST
Chaini3206 – 3499294Non-structural protein 6By similarityPRO_5000140213Add
BLAST
Chaini3500 – 358283Non-structural protein 7By similarityPRO_5000140214Add
BLAST
Chaini3583 – 3777195Non-structural protein 8By similarityPRO_5000140215Add
BLAST
Chaini3778 – 3888111Non-structural protein 9By similarityPRO_5000140216Add
BLAST
Chaini3889 – 4023135Non-structural protein 10By similarityPRO_5000140217Add
BLAST
Chaini4024 – 4952929RNA-directed RNA polymeraseBy similarityPRO_5000140219Add
BLAST
Chaini4024 – 404219Non-structural protein 11By similarityPRO_5000140218Add
BLAST
Chaini4953 – 5551599HelicaseBy similarityPRO_5000140220Add
BLAST
Chaini5552 – 6070519ExoribonucleaseSequence AnalysisPRO_5000140221Add
BLAST
Chaini6071 – 6409339Uridylate-specific endoribonucleaseSequence AnalysisPRO_5000140222Add
BLAST
Chaini6410 – 6709300Putative 2'-O-methyl transferaseSequence AnalysisPRO_5000140223Add
BLAST

Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Interactioni

Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).By similarity

Structurei

Secondary structure

1
6709
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1336 – 13394Combined sources
Beta strandi1342 – 13476Combined sources
Helixi1349 – 13568Combined sources
Beta strandi1359 – 13657Combined sources
Helixi1376 – 13827Combined sources
Turni1383 – 13853Combined sources
Helixi1386 – 139510Combined sources
Beta strandi1405 – 14139Combined sources
Beta strandi1416 – 14227Combined sources
Helixi1431 – 144313Combined sources
Beta strandi1449 – 14513Combined sources
Helixi1463 – 147311Combined sources
Beta strandi1479 – 14835Combined sources
Helixi1486 – 149712Combined sources
Helixi2818 – 28236Combined sources
Beta strandi2826 – 28283Combined sources
Helixi2830 – 28378Combined sources
Turni2838 – 28403Combined sources
Helixi2842 – 28509Combined sources
Helixi2852 – 28565Combined sources
Helixi2864 – 288421Combined sources
Beta strandi2889 – 28913Combined sources
Beta strandi2895 – 28995Combined sources
Helixi3510 – 35189Combined sources
Helixi3521 – 35233Combined sources
Helixi3525 – 354016Combined sources
Helixi3544 – 356118Combined sources
Helixi3568 – 357710Combined sources
Helixi3579 – 35813Combined sources
Beta strandi3583 – 35853Combined sources
Helixi3587 – 360923Combined sources
Helixi3614 – 365239Combined sources
Helixi3663 – 368018Combined sources
Helixi3683 – 369311Combined sources
Beta strandi3697 – 37026Combined sources
Beta strandi3709 – 37146Combined sources
Helixi3717 – 37237Combined sources
Beta strandi3728 – 37314Combined sources
Beta strandi3734 – 37429Combined sources
Helixi3751 – 37533Combined sources
Helixi3756 – 37616Combined sources
Beta strandi3766 – 37727Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ETIX-ray2.20A/B/C/D/E/F/G/H1331-1498[»]
3EW5X-ray3.10A/B/C1331-1498[»]
3GZFX-ray2.76A/B/C/D/E2808-2902[»]
3JZTX-ray3.91A/B/C/D/E/F/G/H1331-1498[»]
3UB0X-ray2.60A/D3583-3777[»]
B/C/E/F3500-3582[»]
ProteinModelPortaliQ98VG9.
SMRiQ98VG9. Positions 2904-3204, 3894-4019.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98VG9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1079 – 1330252Peptidase C16 1PROSITE-ProRule annotationAdd
BLAST
Domaini1329 – 1500172MacroPROSITE-ProRule annotationAdd
BLAST
Domaini1561 – 1814254Peptidase C16 2PROSITE-ProRule annotationAdd
BLAST
Domaini2904 – 3205302Peptidase C30PROSITE-ProRule annotationAdd
BLAST
Domaini4632 – 4794163RdRp catalyticAdd
BLAST
Domaini4953 – 503684CV MBDAdd
BLAST
Domaini5200 – 5391192(+)RNA virus helicase ATP-bindingAdd
BLAST
Domaini5392 – 5561170(+)RNA virus helicase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1860 – 2065206HD1By similarityAdd
BLAST
Regioni2426 – 2791366HD2By similarityAdd
BLAST
Regioni3212 – 3439228HD3By similarityAdd
BLAST

Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Sequence similaritiesi

Contains 1 Macro domain.PROSITE-ProRule annotation
Contains 2 peptidase C16 domains.PROSITE-ProRule annotation
Contains 1 peptidase C30 domain.PROSITE-ProRule annotation
Contains 1 RdRp catalytic domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1188 – 121932C4-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1678 – 170730C4-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri3962 – 397817By similarityAdd
BLAST
Zinc fingeri4004 – 401714By similarityAdd
BLAST

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027351. (+)RNA_virus_helicase_core_dom.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view]
PfamiPF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 2 hits.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
SUPFAMiSSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS51653. CV_MBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
PS51657. PSRV_HELICASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform Replicase polyprotein 1ab (identifier: Q98VG9-1) [UniParc]FASTAAdd to Basket

Also known as: pp1ab

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD
60 70 80 90 100
LVDCNRKDHY VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF
110 120 130 140 150
DLKFARTGNG AIYVDQYMCG ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC
160 170 180 190 200
AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH KLPNCAIREV APPVKKNSKV
210 220 230 240 250
VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC PCGAESSGVG
260 270 280 290 300
DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY
310 320 330 340 350
AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA
360 370 380 390 400
FITGEVDDAV HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA
410 420 430 440 450
WKVVEELLCS LKLTYKQIYD VVASLCTSAF TIMDYKPVFV VSSNSVKDLV
460 470 480 490 500
DKCVKILVKA FDVFTQTITI AGVEAKCFVL GSKYLLFNNA LVKLVSVKIL
510 520 530 540 550
GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD VVTPGGGHIV
560 570 580 590 600
IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK
610 620 630 640 650
MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY
660 670 680 690 700
LKKYKMPVCL KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI
710 720 730 740 750
KNIICPDLLL ELDFGAIWYR CMPACSDKSI LGNVKIMLGN GVKVVCDGCH
760 770 780 790 800
SFANRLTINY NKLCDTARKD IEIGGIPFST FKTPSSSFID MKDAIYSVVE
810 820 830 840 850
YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK DNGDVIVIAG
860 870 880 890 900
YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR
910 920 930 940 950
VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA
960 970 980 990 1000
EQGVELEGYF IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI
1010 1020 1030 1040 1050
SLISDNEDVE QIEEDNTSTD DAEDVSSVEG ETVSVVDVED FVEQVSLVEE
1060 1070 1080 1090 1100
NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW AAAVDEQEAE QPKPSLTPFK
1110 1120 1130 1140 1150
TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF KKDDVMPFVD
1160 1170 1180 1190 1200
FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT
1210 1220 1230 1240 1250
VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF
1260 1270 1280 1290 1300
IVTPTMHAVY TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN
1310 1320 1330 1340 1350
ANVMTAKSKT MVEPPVPVED KCVEDCQSPK DLILPFYKAG KVSFYQGDLD
1360 1370 1380 1390 1400
VLINFLEPDV LVNAANGDLR HVGGVARAID VFTGGKLTKR SKEYLKSSKA
1410 1420 1430 1440 1450
IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK AIAKCDGKIL
1460 1470 1480 1490 1500
TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI
1510 1520 1530 1540 1550
PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK
1560 1570 1580 1590 1600
VVKALDVDWN AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW
1610 1620 1630 1640 1650
VNAICLALQR LKPTWKFPGV KSLWDAFLTR KTAGFVHMLY HISGLTKGQP
1660 1670 1680 1690 1700
GDAELTLHKL VDLMSSDSAV TVTHTTACDK CAKVETFTGP VVAAPLLVCG
1710 1720 1730 1740 1750
TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG YICYTGLNSR
1760 1770 1780 1790 1800
GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT
1810 1820 1830 1840 1850
QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA
1860 1870 1880 1890 1900
DVFFMAGDKI LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK
1910 1920 1930 1940 1950
VRTLNYVRQL NKPALWRYIK LVLLLIALYH FFYLFVSIPV VHKLACSGSV
1960 1970 1980 1990 2000
QAYSNSSFVK SEVCGNSILC KACLASYDEL ADFDHLQVSW DYKSDPLWNR
2010 2020 2030 2040 2050
VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV KYSWFLHVVN
2060 2070 2080 2090 2100
FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV
2110 2120 2130 2140 2150
VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS
2160 2170 2180 2190 2200
IKQTVYATDR SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV
2210 2220 2230 2240 2250
LKTMFLLDDF IVYNPSGSSL ASVRNVCVYF SQLIGRPIKI VNSELLEDLS
2260 2270 2280 2290 2300
VDFKGALFNA KKNVIKNSFN VDVSECKNLE ECYKLCNLDV TFSTFEMAIN
2310 2320 2330 2340 2350
NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF DAKIVNAKVL
2360 2370 2380 2390 2400
TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP
2410 2420 2430 2440 2450
YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY
2460 2470 2480 2490 2500
IDSAEGYDYM VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK
2510 2520 2530 2540 2550
SCPIVLGTVF DLGNMRPIPD VPAYVALVGR SLVFAINAAF GVTNVCYDHT
2560 2570 2580 2590 2600
GAAVSKNSYF DTCVFNSACT TLTGIGGTVV YCAKQGLVEG AKLYSELLPD
2610 2620 2630 2640 2650
YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE SQAGFCFGGD
2660 2670 2680 2690 2700
NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA
2710 2720 2730 2740 2750
CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY
2760 2770 2780 2790 2800
AIIYYFTTRK LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF
2810 2820 2830 2840 2850
KLKVTTNLFE GDKFVGSFES AAMGTFVIDM RSYETLVNST SLDRIKSYAN
2860 2870 2880 2890 2900
SFNKYKYYTG SMGEADYRMA CYAHLGKALM DYSVSRNDML YTPPTVSVNS
2910 2920 2930 2940 2950
TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI CPRHVIASDT
2960 2970 2980 2990 3000
SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT
3010 3020 3030 3040 3050
PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV
3060 3070 3080 3090 3100
GYVLENGTLY FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV
3110 3120 3130 3140 3150
MSSDNVVAFL YAALINGERW FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF
3160 3170 3180 3190 3200
NMLAAKTGYS VEKLLECIVR LNKGFGGRTI LSYGSLCDEF TPTEVIRQMY
3210 3220 3230 3240 3250
GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN PTFVSVVLAI
3260 3270 3280 3290 3300
TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE
3310 3320 3330 3340 3350
NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF
3360 3370 3380 3390 3400
NIVKLLGMIG EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI
3410 3420 3430 3440 3450
VVYVMQPAFV QDFGFVKCVS IIYMACGYLF CCYYGILYWV NRFTCMTCGV
3460 3470 3480 3490 3500
YQFTVSPAEL KYMTANNLSA PKTAYDAMIL SFKLMGIGGG RNIKISTVQS
3510 3520 3530 3540 3550
KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL CDDPDAVLEK
3560 3570 3580 3590 3600
LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA
3610 3620 3630 3640 3650
RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA
3660 3670 3680 3690 3700
SMYKEARAVD RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS
3710 3720 3730 3740 3750
IIPAASATRL IVVTPNLEVL SKVRQENNVH YAGAIWSIVE VKDANGAQVH
3760 3770 3780 3790 3800
LKEVTAANEL NITWPLSITC ERTTKLQNNE ILPGKLKEKA VKASATIDGD
3810 3820 3830 3840 3850
AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI PIELEAPLRF
3860 3870 3880 3890 3900
YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG
3910 3920 3930 3940 3950
LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN
3960 3970 3980 3990 4000
TQQDSYGGAS VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE
4010 4020 4030 4040 4050
NEVCVVCGCW LTNGCMCDRT SIQGTTIDQS YLNECGVLVQ LDLEPCNGTD
4060 4070 4080 4090 4100
PDHVSRAFDI YNKDVACIGK FLKTNCSRFR NLDKHDAYYV VKRCTKSVMD
4110 4120 4130 4140 4150
HEQVCYNDLK DSGVVAEHDF FLYKEGRCEF GNVARKDLTK YTMMDLCYAI
4160 4170 4180 4190 4200
RNFDEKNCEV LKEILVTLGA CNESFFENKD WFDPVENEAI HEVYARLGPI
4210 4220 4230 4240 4250
VANAMLKCVA FCDAIVEKGY IGIITLDNQD LNGNFYDFGD FVKTTPGFGC
4260 4270 4280 4290 4300
ACVTSYYSYM MPLMGMTSCL ESENFVKSDI YGADYKQYDL LAYDFTDHKE
4310 4320 4330 4340 4350
KLFHKYFKHW DRTYHPNCSD CTSDECIIHC ANFNTLFSMT IPSTAFGPLV
4360 4370 4380 4390 4400
RKVHIDGVPV VVTAGYHFKQ LGIVWNLDVK LDTMKLSMTD LLRFVTDPTL
4410 4420 4430 4440 4450
LVASSPALLD QRTVCFSIAA LSTGVTYQTV KPGHFNKDFY DFITERGFFE
4460 4470 4480 4490 4500
EGSELTLKHF FFAQGGEAAM TDFNYYRYNR VTVLDICQAQ FVYKIVGKYF
4510 4520 4530 4540 4550
ECYDGGCINA REVVVTNYDK SAGYPLNKFG KARLYYETLS YEEQDALFAL
4560 4570 4580 4590 4600
TKRNVLPTMT QMNLKYAISG KARARTVGGV SLLSTMTTRQ YHQKHLKSIA
4610 4620 4630 4640 4650
ATRNATVVIG STKFYGGWDN MLKNLMRDVD NGCLMGWDYP KCDRALPNMI
4660 4670 4680 4690 4700
RMASAMILGS KHVGCCTHSD RFYRLSNELA QVLTEVVHCT GGFYFKPGGT
4710 4720 4730 4740 4750
TSGDGTTAYA NSAFNIFQAV SANVNKLLGV DSNACNNVTV KSIQRKIYDN
4760 4770 4780 4790 4800
CYRSSSIDEE FVVEYFSYLR KHFSMMILSD DGVVCYNKDY ADLGYVADIN
4810 4820 4830 4840 4850
AFKATLYYQN NVFMSTSKCW VEPDLSVGPH EFCSQHTLQI VGPDGDYYLP
4860 4870 4880 4890 4900
YPDPSRILSA GVFVDDIVKT DNVIMLERYV SLAIDAYPLT KHPKPAYQKV
4910 4920 4930 4940 4950
FYTLLDWVKH LQKNLNAGVL DSFSVTMLEE GQDKFWSEEF YASLYEKSTV
4960 4970 4980 4990 5000
LQAAGMCVVC GSQTVLRCGD CLRRPLLCTK CAYDHVMGTK HKFIMSITPY
5010 5020 5030 5040 5050
VCSFNGCNVN DVTKLFLGGL SYYCMDHKPQ LSFPLCANGN VFGLYKSSAV
5060 5070 5080 5090 5100
GSEDVEDFNK LAVSDWTNVE DYKLANNVKE SLKIFAAETV KAKEESVKSE
5110 5120 5130 5140 5150
YAYAILKEVI GPKEIVLQWE ASKTKPPLNR NSVFTCFQIS KDTKIQLGEF
5160 5170 5180 5190 5200
VFEQSEYGSD SVYYKSTSTY KLTPGMIFVL TSHNVSPLKA TILVNQEKYN
5210 5220 5230 5240 5250
TISKLYPVFN IAEAYNTLVP YYQMIGKQKF TTIQGPPGSG KSHCVIGLGL
5260 5270 5280 5290 5300
YYPQARIVYT ACSHAAVDAL CEKAAKNFNV DRCSRIIPQR IRVDCYTGFK
5310 5320 5330 5340 5350
PNNTNAQYLF CTVNALPEAS CDIVVVDEVS MCTNYDLSVI NSRLSYKHIV
5360 5370 5380 5390 5400
YVGDPQQLPA PRTLINKGVL QPQDYNVVTQ RVCTLGPDVF LHKCYRCPAE
5410 5420 5430 5440 5450
IVKTVSALVY ENKFVPVNPE SKQCFKMFVK GQVQIESNSS INNKQLEVVK
5460 5470 5480 5490 5500
AFLAHNPKWR KAVFISPYNS QNYVARRLLG LQTQTVDSAQ GSEYDYVIYT
5510 5520 5530 5540 5550
QTSDTQHATN VNRFNVAITR AKVGILCIMC DRTMYENLDF YELKDSKIGL
5560 5570 5580 5590 5600
QAKPETCGLF KDCSKSEQYI PPAYATTYMS LSDNFKTSDG LAVNIGTKDV
5610 5620 5630 5640 5650
KYANVISYMG FRFEANIPGY HTLFCTRDFA MRNVRAWLGF DVEGAHVCGD
5660 5670 5680 5690 5700
NVGTNVPLQL GFSNGVDFVV QTEGCVVTEK GNSIEVVKAR APPGEQFAHL
5710 5720 5730 5740 5750
IPLMRKGQPW HIVRRRIVQM VCDYFDGLSD ILIFVLWAGG LELTTMRYFV
5760 5770 5780 5790 5800
KIGRPQKCEC GKSATCYSSS QCVYACFKHA LGCDYLYNPY CIDIQQWGYT
5810 5820 5830 5840 5850
GSLSMNHHEV CNIHRNEHVA SGDAIMTRCL AIHDCFVKRV DWSIVYPFID
5860 5870 5880 5890 5900
NEEKINKAGR IVQSHVMKAA LKIFNPAAIH DVGNPKGIRC ATTPIPWFCY
5910 5920 5930 5940 5950
DRDPINNNVR CLEYDYMVHG QMNGLMLFWN CNVDMYPEFS IVCRFDTRTR
5960 5970 5980 5990 6000
SKLSLEGCNG GALYVNNHAF HTPAYDRRAF AKLKPMPFFY YDDSNCELVD
6010 6020 6030 6040 6050
GQPNYVPLKS NVCITKCNIG GAVCKKHAAL YRAYVEDYNM FMQAGFTIWC
6060 6070 6080 6090 6100
PQNFDTYMLW HGFVNSKALQ SLENVAFNVV KKGAFTGLKG DLPTAVIADK
6110 6120 6130 6140 6150
IMVRDGPTDK CIFTNKTSLP TNVAFELYAK RKLGLTPPLT ILRNLGVVAT
6160 6170 6180 6190 6200
YKFVLWDYEA ECPFSNFTKQ VCSYTDLDSE VVTCFDNSIA GSFERFTTTK
6210 6220 6230 6240 6250
DAVLISNNAV KGLSAIKLQY GFLNDLPVST VGNKPVTWYI YVRKNGEYVE
6260 6270 6280 6290 6300
QIDSYYTHGR TFETFKPRST MEEDFLSMDT TLFIQKYGLE DYGFEHVVFG
6310 6320 6330 6340 6350
DVSKTTIGGM HLLISQVRLA KMGLFSVQEF MTNSDSTLKS CCITYADDPS
6360 6370 6380 6390 6400
SKNVCTYMDI LLDDFVTIIK SLDLNVVSKV VDVIVDCKAW RWMLWCENSQ
6410 6420 6430 6440 6450
IKTFYPQLQS AEWNPGYSMP TLYKIQRMCL ERCNLYNYGA QVRLPDGITT
6460 6470 6480 6490 6500
NVVKYTQLCQ YLNTTTVCVP HKMRVLHLGA AGASGVAPGS TVLRRWLPDD
6510 6520 6530 6540 6550
AILVDNDLRD YVSDADFSVT GDCTSLYIED KFDLLISDLY DGSTKSIDGE
6560 6570 6580 6590 6600
NTSKDGFFTY INGFIKEKLS LGGSAAIKIT EFSWNKDLYE LIQRFEYWTV
6610 6620 6630 6640 6650
FCTSVNTSSS EGFLIGINYL GPYCDKAIVD GNIMHANYIF WRNSTIMALS
6660 6670 6680 6690 6700
HNSVLDTPKF KCRCNNALIV NLKEKELNEM VVGLLRKGKL LIRNNGKLLN

FGNHLVNVP

Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.

Length:6,709
Mass (Da):751,196
Last modified:April 17, 2007 - v2
Checksum:iF26AC0FFF5FE27F9
GO
Isoform Replicase polyprotein 1a (identifier: Q98VG9-2) [UniParc]FASTAAdd to Basket

Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform differs from the canonical sequence as follows:
     4043-6709: Missing.

Note: Produced by conventional translation.

Show »
Length:4,042
Mass (Da):449,790
Checksum:i34663B2576D09550
GO

Sequence cautioni

The sequence AAY16374.1 differs from that shown. Reason: Frameshift at position 4033. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1016 – 109277Missing in AAY32594. (PubMed:16033972)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621W → C.
Natural varianti177 – 1771D → G.
Natural varianti388 – 3881W → C.
Natural varianti808 – 8081K → T.
Natural varianti1784 – 17841A → V.
Natural varianti2889 – 28891M → K.
Natural varianti3280 – 32801A → V.
Natural varianti3992 – 39921Q → R.
Natural varianti4304 – 43041H → Q.
Natural varianti5846 – 58461Y → H.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4043 – 67092667Missing in isoform Replicase polyprotein 1a. CuratedVSP_032885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010921 Genomic RNA. Translation: AAY32594.1.
DQ010921 Genomic RNA. Translation: AAY32595.1.
AY994055 Genomic RNA. Translation: AAY16374.1. Frameshift.
AF326575 Genomic RNA. Translation: AAK09095.1.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010921 Genomic RNA. Translation: AAY32594.1 .
DQ010921 Genomic RNA. Translation: AAY32595.1 .
AY994055 Genomic RNA. Translation: AAY16374.1 . Frameshift.
AF326575 Genomic RNA. Translation: AAK09095.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ETI X-ray 2.20 A/B/C/D/E/F/G/H 1331-1498 [» ]
3EW5 X-ray 3.10 A/B/C 1331-1498 [» ]
3GZF X-ray 2.76 A/B/C/D/E 2808-2902 [» ]
3JZT X-ray 3.91 A/B/C/D/E/F/G/H 1331-1498 [» ]
3UB0 X-ray 2.60 A/D 3583-3777 [» ]
B/C/E/F 3500-3582 [» ]
ProteinModelPortali Q98VG9.
SMRi Q98VG9. Positions 2904-3204, 3894-4019.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C30.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q98VG9.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR027351. (+)RNA_virus_helicase_core_dom.
IPR009461. Coronavirus_NSP16.
IPR027352. CV_MBD_dom.
IPR002589. Macro_dom.
IPR009466. NSP11.
IPR014828. NSP7.
IPR014829. NSP8.
IPR014822. NSP9.
IPR027417. P-loop_NTPase.
IPR008740. Peptidase_C30.
IPR013016. Peptidase_C30/C16.
IPR009469. RNA_pol_N_coronovir.
IPR018995. RNA_synth_NSP10_coronavirus.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
IPR014827. Viral_protease.
[Graphical view ]
Pfami PF06478. Corona_RPol_N. 1 hit.
PF01661. Macro. 1 hit.
PF09401. NSP10. 2 hits.
PF06471. NSP11. 1 hit.
PF06460. NSP13. 1 hit.
PF08716. nsp7. 1 hit.
PF08717. nsp8. 1 hit.
PF08710. nsp9. 1 hit.
PF05409. Peptidase_C30. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF08715. Viral_protease. 2 hits.
[Graphical view ]
SMARTi SM00506. A1pp. 1 hit.
[Graphical view ]
SUPFAMi SSF101816. SSF101816. 1 hit.
SSF144246. SSF144246. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEi PS51653. CV_MBD. 1 hit.
PS51442. M_PRO. 1 hit.
PS51154. MACRO. 1 hit.
PS51124. PEPTIDASE_C16. 2 hits.
PS51657. PSRV_HELICASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146."
    Dye C., Siddell S.G.
    J. Gen. Virol. 86:2249-2253(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Haijema B.J., de Groot-Mijnes J.D.F., Vennema H., Raamsman M.J., Rottier P.J.M., de Groot R.J.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Mutational analysis of the active centre of coronavirus 3C-like proteases."
    Hegyi A., Friebe A., Gorbalenya A.E., Ziebuhr J.
    J. Gen. Virol. 83:581-593(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 2894-3215, MUTAGENESIS OF HIS-2944; ASN-2967; GLY-2986; SER-3041; CYS-3047; TYR-3063; MET-3064 AND HIS-3065.

Entry informationi

Entry nameiR1AB_FIPV
AccessioniPrimary (citable) accession number: Q98VG9
Secondary accession number(s): Q4U5G1, Q4U5G2, Q52PA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3