Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor MafB

Gene

mafb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • lymphangiogenesis Source: ZFIN
  • pronephric glomerulus development Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB
  • rhombomere 5 development Source: ZFIN
  • rhombomere 6 development Source: ZFIN
  • rhombomere boundary formation Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafB
Short name:
Maf-B
Alternative name(s):
Transcription factor Val
Valentino
Gene namesi
Name:mafb
Synonyms:mafba, val
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-980526-515 mafba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003661251 – 356Transcription factor MafBAdd BLAST356

Proteomic databases

PaxDbiQ98UK5
PRIDEiQ98UK5

Expressioni

Developmental stagei

Expressed in cells that spans the width of the neuronal plate in the presumptive hindbrain at the end of gastrulation. Expressed in r5- and r6-derived neuronal crest cells at the 14 somite stage. Expressed in r5 and r6 until the 20 somite stage (19 hours). Expressed in Mauthner cells of the r4, in cells of the blood-forming region at the base of the yolk extension, in Rohon-Beard cells in the trunk and tail, in a bilateral patch of cells ventral to the third somite which corresponds to the position of the primordial germ cells at 20 somite stage (19 hours). Expressed in r6 at 24 hours. Expressed in r4 and r5 at 42 hours.1 Publication

Gene expression databases

BgeeiENSDARG00000017121

Interactioni

Subunit structurei

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018087

Structurei

3D structure databases

ProteinModelPortaliQ98UK5
SMRiQ98UK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini270 – 333bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni270 – 295Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni298 – 319Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 166Gln-richAdd BLAST38
Compositional biasi144 – 231His-richAdd BLAST88

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG410XQUF LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000261683
HOVERGENiHBG000313
InParanoidiQ98UK5
OMAiCNRLQPQ
OrthoDBiEOG091G0H46
PhylomeDBiQ98UK5
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028571 MafB
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF10 PTHR10129:SF10, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q98UK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADLAMGPE LPTSPLALEY VNDFDLMKFE VKKEAMAAHD RANIRQCNRL
60 70 80 90 100
QPQGSVSSTP ISTPCSSVPS SPSFSPTEQK NHLEELYWMP SGAYPQQIDP
110 120 130 140 150
QTLSLTPEDA VEALIGATAH GHPPPPHVQQ QLQAGAFDGY RGAHHHHGHA
160 170 180 190 200
QQQQQQQPQH HHHQHQYGAI PHHPDDLSGH PGAHGHHPHH HHHHHHSQDP
210 220 230 240 250
DSPSPTSPEQ LHHRHHHHHH PHGHPGQQGH HGVGGGLNVE DRFSDDQLVT
260 270 280 290 300
MSVRELNRHL RGFTKDEVIR LKQKRRTLKN RGYAQSCRFK RVQQKHLLEN
310 320 330 340 350
EKTQLINQVE QLKQEINRLA RERDAYKLKC EKLTGANGFR EAGSTSDNPS

SPEFFM
Length:356
Mass (Da):40,233
Last modified:June 1, 2001 - v1
Checksum:iDE4C96B62C058865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006641 mRNA Translation: AAC18821.1
AB006322 mRNA Translation: BAB21102.1
BC117640 mRNA Translation: AAI17641.1
UniGeneiDr.75475

Genome annotation databases

EnsembliENSDART00000002309; ENSDARP00000018087; ENSDARG00000017121

Similar proteinsi

Entry informationi

Entry nameiMAFB_DANRE
AccessioniPrimary (citable) accession number: Q98UK5
Secondary accession number(s): O73679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health