Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor MafB

Gene

mafb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • lymphangiogenesis Source: ZFIN
  • pronephric glomerulus development Source: ZFIN
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • rhombomere 5 development Source: ZFIN
  • rhombomere 6 development Source: ZFIN
  • rhombomere boundary formation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafB
Short name:
Maf-B
Alternative name(s):
Transcription factor Val
Valentino
Gene namesi
Name:mafb
Synonyms:mafba, val
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-980526-515. mafba.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Transcription factor MafBPRO_0000366125Add
BLAST

Proteomic databases

PaxDbiQ98UK5.

Expressioni

Developmental stagei

Expressed in cells that spans the width of the neuronal plate in the presumptive hindbrain at the end of gastrulation. Expressed in r5- and r6-derived neuronal crest cells at the 14 somite stage. Expressed in r5 and r6 until the 20 somite stage (19 hours). Expressed in Mauthner cells of the r4, in cells of the blood-forming region at the base of the yolk extension, in Rohon-Beard cells in the trunk and tail, in a bilateral patch of cells ventral to the third somite which corresponds to the position of the primordial germ cells at 20 somite stage (19 hours). Expressed in r6 at 24 hours. Expressed in r4 and r5 at 42 hours.1 Publication

Gene expression databases

BgeeiQ98UK5.

Interactioni

Subunit structurei

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018087.

Structurei

3D structure databases

ProteinModelPortaliQ98UK5.
SMRiQ98UK5. Positions 243-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 33364bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni270 – 29526Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni298 – 31922Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 16638Gln-richAdd
BLAST
Compositional biasi144 – 23188His-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG410XQUF. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiQ98UK5.
OMAiHHAEELS.
OrthoDBiEOG7BGHMQ.
PhylomeDBiQ98UK5.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028571. MafB.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF10. PTHR10129:SF10. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98UK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADLAMGPE LPTSPLALEY VNDFDLMKFE VKKEAMAAHD RANIRQCNRL
60 70 80 90 100
QPQGSVSSTP ISTPCSSVPS SPSFSPTEQK NHLEELYWMP SGAYPQQIDP
110 120 130 140 150
QTLSLTPEDA VEALIGATAH GHPPPPHVQQ QLQAGAFDGY RGAHHHHGHA
160 170 180 190 200
QQQQQQQPQH HHHQHQYGAI PHHPDDLSGH PGAHGHHPHH HHHHHHSQDP
210 220 230 240 250
DSPSPTSPEQ LHHRHHHHHH PHGHPGQQGH HGVGGGLNVE DRFSDDQLVT
260 270 280 290 300
MSVRELNRHL RGFTKDEVIR LKQKRRTLKN RGYAQSCRFK RVQQKHLLEN
310 320 330 340 350
EKTQLINQVE QLKQEINRLA RERDAYKLKC EKLTGANGFR EAGSTSDNPS

SPEFFM
Length:356
Mass (Da):40,233
Last modified:June 1, 2001 - v1
Checksum:iDE4C96B62C058865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006641 mRNA. Translation: AAC18821.1.
AB006322 mRNA. Translation: BAB21102.1.
BC117640 mRNA. Translation: AAI17641.1.
UniGeneiDr.75475.

Genome annotation databases

EnsembliENSDART00000002309; ENSDARP00000018087; ENSDARG00000017121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006641 mRNA. Translation: AAC18821.1.
AB006322 mRNA. Translation: BAB21102.1.
BC117640 mRNA. Translation: AAI17641.1.
UniGeneiDr.75475.

3D structure databases

ProteinModelPortaliQ98UK5.
SMRiQ98UK5. Positions 243-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000018087.

Proteomic databases

PaxDbiQ98UK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000002309; ENSDARP00000018087; ENSDARG00000017121.

Organism-specific databases

ZFINiZDB-GENE-980526-515. mafba.

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG410XQUF. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiQ98UK5.
OMAiHHAEELS.
OrthoDBiEOG7BGHMQ.
PhylomeDBiQ98UK5.
TreeFamiTF325689.

Miscellaneous databases

PROiQ98UK5.

Gene expression databases

BgeeiQ98UK5.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028571. MafB.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF10. PTHR10129:SF10. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Equivalence in the genetic control of hindbrain segmentation in fish and mouse."
    Moens C.B., Cordes S.P., Giorgianni M.W., Barsh G.S., Kimmel C.B.
    Development 125:381-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Isolation, characterization, and expression analysis of zebrafish large Mafs."
    Kajihara M., Kawauchi S., Kobayashi M., Ogino H., Takahashi S., Yasuda K.
    J. Biochem. 129:139-146(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "valentino: a zebrafish gene required for normal hindbrain segmentation."
    Moens C.B., Yan Y.-L., Appel B., Force A.G., Kimmel C.B.
    Development 122:3981-3990(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMAFB_DANRE
AccessioniPrimary (citable) accession number: Q98UK5
Secondary accession number(s): O73679
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.