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Protein
Submitted name:

Groucho 1

Gene

tle3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-201722. Formation of the beta-catenin:TCF transactivating complex.
R-DRE-3769402. Deactivation of the beta-catenin transactivating complex.
R-DRE-4641265. Repression of WNT target genes.

Names & Taxonomyi

Protein namesi
Submitted name:
Groucho 1Imported
Submitted name:
Groucho-related gene 3 proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:tle3bImported
Synonyms:grg3Imported, gro1Imported, gro3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-990415-85. tle3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini481 – 654174WD_REPEATS_REGIONInterPro annotationAdd
BLAST
Domaini695 – 77177WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili26 – 6035Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.
OMAiHDLDHRE.
OrthoDBiEOG7HQNC3.
TreeFamiTF314167.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98TH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
60 70 80 90 100
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNAILA QIMPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMTELN AIIGVRGLPN LPLTQQQLQA QHLSHAAHGP
160 170 180 190 200
PVQLPPHPSG LQPPGIPPVT GSGSGLLALG ALGSQAHLPV KDEKNHHDLE
210 220 230 240 250
HRERESSTNN SVSPSDSLRA SEKHRGSSEY SLDPKKRRVE EKDNMSRYDS
260 270 280 290 300
DGDKSDDLVV DVSNEDPATP RVSPSHSPPE NGLDKARALK KDAPNSPASV
310 320 330 340 350
ASSGSTPSSK AKDHPHNDKS STPGLKSNTP TPRNDAPTPG TSNTPGLRPH
360 370 380 390 400
PGKPPGMEAL TAPALRTPLS IAPPYGTPFM MGHHPEMNGS LTSPGVYPGL
410 420 430 440 450
HISPQMSAAA AAAYGRTHMP GFDPHPHMRA PVLPASLTSI PGGKPAYSFH
460 470 480 490 500
VSADGQMQPV PFPPDALIGP GIPRHARQIN TLSHGEVVCA VTISNPTRHV
510 520 530 540 550
YTGGKGCVKI WDISQPGSKS PVSQLDCLNR DNYIRSCKLL PDGRTLIVGG
560 570 580 590 600
EASTLTIWDL ASQTPRIKAE LTSSAPACYA LAISPDAKVC FSCCSDGNIA
610 620 630 640 650
VWDLHNQTLV RQFQGHTDGA SCIDISHDGT KLWTGGLDNT VRSWDLREGR
660 670 680 690 700
QLQQHDFTSQ IFSLGYCPTG EWLAVGMESS NVEVLHHTKP DKYQLHLHES
710 720 730 740 750
CVLSLKFAYC GKWFVSTGKD NLLNAWRTPY GASIFQSKES SSVLSCDISA
760 770
DDKYIVTGSG DKKATVYEVI Y
Length:771
Mass (Da):83,789
Last modified:June 1, 2001 - v1
Checksum:i3B9CEB203826E458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954672 Genomic DNA. No translation available.
BC162571 mRNA. Translation: AAI62571.1.
AB040707 mRNA. Translation: BAB40698.1.
RefSeqiNP_571855.1. NM_131780.1.
UniGeneiDr.23459.

Genome annotation databases

EnsembliENSDART00000130553; ENSDARP00000109120; ENSDARG00000069006.
GeneIDi100007463.
KEGGidre:100007463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954672 Genomic DNA. No translation available.
BC162571 mRNA. Translation: AAI62571.1.
AB040707 mRNA. Translation: BAB40698.1.
RefSeqiNP_571855.1. NM_131780.1.
UniGeneiDr.23459.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000130553; ENSDARP00000109120; ENSDARG00000069006.
GeneIDi100007463.
KEGGidre:100007463.

Organism-specific databases

CTDi100007463.
ZFINiZDB-GENE-990415-85. tle3b.

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
GeneTreeiENSGT00550000074465.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.
OMAiHDLDHRE.
OrthoDBiEOG7HQNC3.
TreeFamiTF314167.

Enzyme and pathway databases

ReactomeiR-DRE-201722. Formation of the beta-catenin:TCF transactivating complex.
R-DRE-3769402. Deactivation of the beta-catenin transactivating complex.
R-DRE-4641265. Repression of WNT target genes.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation."
    Kobayashi M., Nishikawa K., Suzuki T., Yamamoto M.
    Dev. Biol. 232:315-326(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ98TH2_DANRE
AccessioniPrimary (citable) accession number: Q98TH2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.