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Protein

Cytochrome P450 3A40

Gene

cyp3a40

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A40 (EC:1.14.14.1)
Gene namesi
Name:cyp3a40
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Cytochrome P450 3A40PRO_0000051812Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000024339.

Structurei

3D structure databases

ProteinModelPortaliQ98T91.
SMRiQ98T91. Positions 29-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG108567.
InParanoidiQ98T91.
KOiK17860.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98T91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFLYFSAE TWTLLVAFIT LLLVYAYWPY GTFKRLGIPG PKPVPFFGTM
60 70 80 90 100
LAYRKGFFNF DDECRKKYGK TWGIYDGRQP VLCITDPATI KAVLVKECYS
110 120 130 140 150
LFTNRRNFRL NGPLYDAVSI AEDDQWKRIR SVLSPSFTSG RLKEMFDIMK
160 170 180 190 200
HHSANLIQSM KKKVDKDEPL EMKEYFGPYS MDVVTSTAFS VDIDSLNNPS
210 220 230 240 250
DPFVTNIKKM LKFDFLNPLF LAVAFFPFLG PILEKFEFSL FPSSVMDFFF
260 270 280 290 300
AALRKIKANH ENNKQKSRID FLQLMIDSQK NNQNGLQDKG LSDHEILSQA
310 320 330 340 350
MIFIFAGYET TSSSLTFLAY NLATNPEVMK KLQKEIDATF PNKAPVQYVP
360 370 380 390 400
LMEMEYLDCV VNESLRLYPI AARLERVAKA TVEVNGLVIP KDMVVMVPTW
410 420 430 440 450
PLHRDPELWP EPEKFKPERF SKENKDTFDP YTYMPFGAGP RNCIGMRFAL
460 470 480 490 500
VMMKLAVVEI LQTYDFSVCK ETEVPFEMDV QGFLAPKRPI QLKLTPRSAS

SS
Length:502
Mass (Da):57,707
Last modified:June 1, 2001 - v1
Checksum:i1E9FE38B21CED1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251272 mRNA. Translation: AAK37960.1.
RefSeqiNP_001098565.1. NM_001105095.1.
UniGeneiOla.146.

Genome annotation databases

GeneIDi100125817.
KEGGiola:100125817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251272 mRNA. Translation: AAK37960.1.
RefSeqiNP_001098565.1. NM_001105095.1.
UniGeneiOla.146.

3D structure databases

ProteinModelPortaliQ98T91.
SMRiQ98T91. Positions 29-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000024339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125817.
KEGGiola:100125817.

Organism-specific databases

CTDi100125817.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG108567.
InParanoidiQ98T91.
KOiK17860.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes)."
    Kullman S.W., Hinton D.E.
    Mol. Reprod. Dev. 58:149-158(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiC340_ORYLA
AccessioniPrimary (citable) accession number: Q98T91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: April 29, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.