Reviewed, UniProtKB/Swiss-Prot Q98T91 (C340_ORYLA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 3A40
    EC=1.14.14.1

Gene names

Name:

cyp3a40

Organism

Oryzias latipes (Medaka fish) (Japanese ricefish)

Taxonomic identifier

8090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Cytochrome P450 3A40		PRO_0000051812
Sites
	Metal binding	443	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98T91-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1E9FE38B21CED1D8	FASTA	502	57,707
	10 20 30 40 50 60 MGNFLYFSAE TWTLLVAFIT LLLVYAYWPY GTFKRLGIPG PKPVPFFGTM LAYRKGFFNF 70 80 90 100 110 120 DDECRKKYGK TWGIYDGRQP VLCITDPATI KAVLVKECYS LFTNRRNFRL NGPLYDAVSI 130 140 150 160 170 180 AEDDQWKRIR SVLSPSFTSG RLKEMFDIMK HHSANLIQSM KKKVDKDEPL EMKEYFGPYS 190 200 210 220 230 240 MDVVTSTAFS VDIDSLNNPS DPFVTNIKKM LKFDFLNPLF LAVAFFPFLG PILEKFEFSL 250 260 270 280 290 300 FPSSVMDFFF AALRKIKANH ENNKQKSRID FLQLMIDSQK NNQNGLQDKG LSDHEILSQA 310 320 330 340 350 360 MIFIFAGYET TSSSLTFLAY NLATNPEVMK KLQKEIDATF PNKAPVQYVP LMEMEYLDCV 370 380 390 400 410 420 VNESLRLYPI AARLERVAKA TVEVNGLVIP KDMVVMVPTW PLHRDPELWP EPEKFKPERF 430 440 450 460 470 480 SKENKDTFDP YTYMPFGAGP RNCIGMRFAL VMMKLAVVEI LQTYDFSVCK ETEVPFEMDV 490 500 QGFLAPKRPI QLKLTPRSAS SS

References

[1]	"Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes)." Kullman S.W., Hinton D.E. Mol. Reprod. Dev. 58:149-158(2001) [PubMed: 11139226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF251272 mRNA. Translation: AAK37960.1.
RefSeq	NP_001098565.1.
UniGene	Ola.146
3D structure databases
HSSP	HSSP built from PDB template 1JPZ based on UniProtKB P14779.
ModBase	Search...
Genome annotation databases
GeneID	100125817.
Phylogenomic databases
HOVERGEN	Q98T91.
Enzyme and pathway databases
BRENDA	1.14.14.1. 19130.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C340_ORYLA

Accession

Primary (citable) accession number: Q98T91

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)