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Q98T91

- C340_ORYLA

UniProt

Q98T91 - C340_ORYLA

Protein

Cytochrome P450 3A40

Gene

cyp3a40

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A40 (EC:1.14.14.1)
    Gene namesi
    Name:cyp3a40
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Cytochrome P450 3A40PRO_0000051812Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8090.ENSORLP00000024339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98T91.
    SMRiQ98T91. Positions 29-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG108567.
    KOiK17860.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98T91-1 [UniParc]FASTAAdd to Basket

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    MGNFLYFSAE TWTLLVAFIT LLLVYAYWPY GTFKRLGIPG PKPVPFFGTM    50
    LAYRKGFFNF DDECRKKYGK TWGIYDGRQP VLCITDPATI KAVLVKECYS 100
    LFTNRRNFRL NGPLYDAVSI AEDDQWKRIR SVLSPSFTSG RLKEMFDIMK 150
    HHSANLIQSM KKKVDKDEPL EMKEYFGPYS MDVVTSTAFS VDIDSLNNPS 200
    DPFVTNIKKM LKFDFLNPLF LAVAFFPFLG PILEKFEFSL FPSSVMDFFF 250
    AALRKIKANH ENNKQKSRID FLQLMIDSQK NNQNGLQDKG LSDHEILSQA 300
    MIFIFAGYET TSSSLTFLAY NLATNPEVMK KLQKEIDATF PNKAPVQYVP 350
    LMEMEYLDCV VNESLRLYPI AARLERVAKA TVEVNGLVIP KDMVVMVPTW 400
    PLHRDPELWP EPEKFKPERF SKENKDTFDP YTYMPFGAGP RNCIGMRFAL 450
    VMMKLAVVEI LQTYDFSVCK ETEVPFEMDV QGFLAPKRPI QLKLTPRSAS 500
    SS 502
    Length:502
    Mass (Da):57,707
    Last modified:June 1, 2001 - v1
    Checksum:i1E9FE38B21CED1D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251272 mRNA. Translation: AAK37960.1.
    RefSeqiNP_001098565.1. NM_001105095.1.
    UniGeneiOla.146.

    Genome annotation databases

    GeneIDi100125817.
    KEGGiola:100125817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251272 mRNA. Translation: AAK37960.1 .
    RefSeqi NP_001098565.1. NM_001105095.1.
    UniGenei Ola.146.

    3D structure databases

    ProteinModelPortali Q98T91.
    SMRi Q98T91. Positions 29-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8090.ENSORLP00000024339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125817.
    KEGGi ola:100125817.

    Organism-specific databases

    CTDi 100125817.

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG108567.
    KOi K17860.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes)."
      Kullman S.W., Hinton D.E.
      Mol. Reprod. Dev. 58:149-158(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiC340_ORYLA
    AccessioniPrimary (citable) accession number: Q98T91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3