ID   TWSG1_CHICK             Reviewed;         224 AA.
AC   Q98T89;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=Twisted gastrulation protein homolog 1;
DE   Flags: Precursor;
GN   Name=TWSG1; Synonyms=TSG;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11260715; DOI=10.1038/35068572;
RA   Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y.,
RA   Greenspan D.S.;
RT   "Homologues of Twisted gastrulation are extracellular cofactors in
RT   antagonism of BMP signalling.";
RL   Nature 410:475-478(2001).
RN   [2]
RP   ERRATUM OF PUBMED:11260715.
RA   Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y.,
RA   Greenspan D.S.;
RL   Nature 411:720-720(2001).
CC   -!- FUNCTION: May be involved in dorsoventral axis formation. Seems to
CC       antagonize BMP signaling by forming ternary complexes with CHRD and
CC       BMPs, thereby preventing BMPs from binding to their receptors. In
CC       addition to the anti-BMP function, also has pro-BMP activity, partly
CC       mediated by cleavage and degradation of CHRD, which releases BMPs from
CC       ternary complexes. May be an important modulator of BMP-regulated
CC       cartilage development and chondrocyte differentiation. May play a role
CC       in thymocyte development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHRD and BMP4. This interaction enhances
CC       CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal domain is sufficient to interact with BMP4.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the twisted gastrulation protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF255731; AAK27324.1; -; mRNA.
DR   RefSeq; NP_989529.1; NM_204198.1.
DR   AlphaFoldDB; Q98T89; -.
DR   STRING; 9031.ENSGALP00000065324; -.
DR   GlyCosmos; Q98T89; 3 sites, No reported glycans.
DR   PaxDb; 9031-ENSGALP00000013669; -.
DR   Ensembl; ENSGALT00000130953; ENSGALP00000088366; ENSGALG00000052629.
DR   Ensembl; ENSGALT00015024589; ENSGALP00015014690; ENSGALG00015010042.
DR   GeneID; 374024; -.
DR   KEGG; gga:374024; -.
DR   CTD; 57045; -.
DR   VEuPathDB; HostDB:geneid_374024; -.
DR   eggNOG; ENOG502QRE9; Eukaryota.
DR   HOGENOM; CLU_082511_1_0_1; -.
DR   InParanoid; Q98T89; -.
DR   PhylomeDB; Q98T89; -.
DR   TreeFam; TF323922; -.
DR   PRO; PR:Q98T89; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000052629; Expressed in colon and 14 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030510; P:regulation of BMP signaling pathway; IBA:GO_Central.
DR   InterPro; IPR006761; Tsg.
DR   PANTHER; PTHR12312:SF16; TWISTED GASTRULATION PROTEIN HOMOLOG 1; 1.
DR   PANTHER; PTHR12312; TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED; 1.
DR   Pfam; PF04668; Tsg; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..224
FT                   /note="Twisted gastrulation protein homolog 1"
FT                   /id="PRO_0000278811"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  24904 MW;  42AD74E8A2DAC9F5 CRC64;
     MRSPCAALSA SLLLLLLLLW ARSSVGCNKA LCASDVSKCL IQELCQCRPG EGNCSCCKEC
     MLCLGTLWDE CCDCVGMCNP RNYSDTPPTS KSTVEELHEP IPSLFRALTE GDTQLNWNIV
     SFPVAEELSH HENLVSFLET VNQPQHQNVS VPSNNIHAPY SSDKEHMCTV VYFDDCMSIH
     QCKISCESMG ASKYRWFHNA CCECIGPECI DYGSKTVKCM NCMF
//