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Protein

Twisted gastrulation protein homolog 1

Gene

TWSG1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).By similarity

GO - Biological processi

  1. BMP signaling pathway Source: Ensembl
  2. camera-type eye development Source: Ensembl
  3. cell differentiation Source: Ensembl
  4. forebrain development Source: Ensembl
  5. hemopoiesis Source: Ensembl
  6. mesoderm formation Source: Ensembl
  7. negative regulation of BMP signaling pathway Source: Ensembl
  8. negative regulation of osteoblast differentiation Source: Ensembl
  9. ossification Source: Ensembl
  10. positive regulation of BMP signaling pathway Source: Ensembl
  11. salivary gland morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Twisted gastrulation protein homolog 1
Gene namesi
Name:TWSG1
Synonyms:TSG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 224198Twisted gastrulation protein homolog 1PRO_0000278811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ98T89.

Interactioni

Subunit structurei

Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013669.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 7852Cys-richAdd
BLAST

Domaini

The N-terminal domain is sufficient to interact with BMP4.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG70213.
GeneTreeiENSGT00390000007058.
HOGENOMiHOG000044674.
HOVERGENiHBG055753.
InParanoidiQ98T89.
OMAiCCSCVEL.
OrthoDBiEOG7J70GN.
PhylomeDBiQ98T89.
TreeFamiTF323922.

Family and domain databases

InterProiIPR006761. Tsg.
[Graphical view]
PANTHERiPTHR12312. PTHR12312. 1 hit.
PfamiPF04668. Tsg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98T89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPCAALSA SLLLLLLLLW ARSSVGCNKA LCASDVSKCL IQELCQCRPG
60 70 80 90 100
EGNCSCCKEC MLCLGTLWDE CCDCVGMCNP RNYSDTPPTS KSTVEELHEP
110 120 130 140 150
IPSLFRALTE GDTQLNWNIV SFPVAEELSH HENLVSFLET VNQPQHQNVS
160 170 180 190 200
VPSNNIHAPY SSDKEHMCTV VYFDDCMSIH QCKISCESMG ASKYRWFHNA
210 220
CCECIGPECI DYGSKTVKCM NCMF
Length:224
Mass (Da):24,904
Last modified:June 1, 2001 - v1
Checksum:i42AD74E8A2DAC9F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255731 mRNA. Translation: AAK27324.1.
RefSeqiNP_989529.1. NM_204198.1.
UniGeneiGga.43831.

Genome annotation databases

EnsembliENSGALT00000013684; ENSGALP00000013669; ENSGALG00000008400.
GeneIDi374024.
KEGGigga:374024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255731 mRNA. Translation: AAK27324.1.
RefSeqiNP_989529.1. NM_204198.1.
UniGeneiGga.43831.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013669.

Proteomic databases

PaxDbiQ98T89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013684; ENSGALP00000013669; ENSGALG00000008400.
GeneIDi374024.
KEGGigga:374024.

Organism-specific databases

CTDi57045.

Phylogenomic databases

eggNOGiNOG70213.
GeneTreeiENSGT00390000007058.
HOGENOMiHOG000044674.
HOVERGENiHBG055753.
InParanoidiQ98T89.
OMAiCCSCVEL.
OrthoDBiEOG7J70GN.
PhylomeDBiQ98T89.
TreeFamiTF323922.

Miscellaneous databases

NextBioi20813551.
PROiQ98T89.

Family and domain databases

InterProiIPR006761. Tsg.
[Graphical view]
PANTHERiPTHR12312. PTHR12312. 1 hit.
PfamiPF04668. Tsg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
    Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
    Nature 410:475-478(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTWSG1_CHICK
AccessioniPrimary (citable) accession number: Q98T89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.