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Q98T89 (TWSG1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Twisted gastrulation protein homolog 1
Gene names
Name:TWSG1
Synonyms:TSG
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development By similarity.

Subunit structure

Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 By similarity.

Subcellular location

Secreted By similarity.

Domain

The N-terminal domain is sufficient to interact with BMP4 By similarity.

Sequence similarities

Belongs to the twisted gastrulation protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 224198Twisted gastrulation protein homolog 1
PRO_0000278811

Regions

Compositional bias27 – 7852Cys-rich

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q98T89 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 42AD74E8A2DAC9F5

FASTA22424,904
        10         20         30         40         50         60 
MRSPCAALSA SLLLLLLLLW ARSSVGCNKA LCASDVSKCL IQELCQCRPG EGNCSCCKEC 

        70         80         90        100        110        120 
MLCLGTLWDE CCDCVGMCNP RNYSDTPPTS KSTVEELHEP IPSLFRALTE GDTQLNWNIV 

       130        140        150        160        170        180 
SFPVAEELSH HENLVSFLET VNQPQHQNVS VPSNNIHAPY SSDKEHMCTV VYFDDCMSIH 

       190        200        210        220 
QCKISCESMG ASKYRWFHNA CCECIGPECI DYGSKTVKCM NCMF 

« Hide

References

[1]"Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Erratum
Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
Nature 411:720-720(2001)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255731 mRNA. Translation: AAK27324.1.
RefSeqNP_989529.1. NM_204198.1.
UniGeneGga.43831.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000013669.

Proteomic databases

PaxDbQ98T89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000013684; ENSGALP00000013669; ENSGALG00000008400.
GeneID374024.
KEGGgga:374024.

Organism-specific databases

CTD57045.

Phylogenomic databases

eggNOGNOG70213.
GeneTreeENSGT00390000007058.
HOGENOMHOG000044674.
HOVERGENHBG055753.
InParanoidQ98T89.
OMANCTVAFM.
OrthoDBEOG7J70GN.
PhylomeDBQ98T89.
TreeFamTF323922.

Family and domain databases

InterProIPR006761. Tsg.
[Graphical view]
PANTHERPTHR12312. PTHR12312. 1 hit.
PfamPF04668. Tsg. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813551.
PROQ98T89.

Entry information

Entry nameTWSG1_CHICK
AccessionPrimary (citable) accession number: Q98T89
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families