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Q98T89

- TWSG1_CHICK

UniProt

Q98T89 - TWSG1_CHICK

Protein

Twisted gastrulation protein homolog 1

Gene

TWSG1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development By similarity.By similarity

    GO - Biological processi

    1. BMP signaling pathway Source: Ensembl
    2. camera-type eye development Source: Ensembl
    3. cell differentiation Source: Ensembl
    4. forebrain development Source: Ensembl
    5. hemopoiesis Source: Ensembl
    6. mesoderm formation Source: Ensembl
    7. negative regulation of BMP signaling pathway Source: Ensembl
    8. negative regulation of osteoblast differentiation Source: Ensembl
    9. ossification Source: Ensembl
    10. positive regulation of BMP signaling pathway Source: Ensembl
    11. salivary gland morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Twisted gastrulation protein homolog 1
    Gene namesi
    Name:TWSG1
    Synonyms:TSG
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 224198Twisted gastrulation protein homolog 1PRO_0000278811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ98T89.

    Interactioni

    Subunit structurei

    Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013669.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 7852Cys-richAdd
    BLAST

    Domaini

    The N-terminal domain is sufficient to interact with BMP4.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG70213.
    GeneTreeiENSGT00390000007058.
    HOGENOMiHOG000044674.
    HOVERGENiHBG055753.
    InParanoidiQ98T89.
    OMAiNCTVAFM.
    OrthoDBiEOG7J70GN.
    PhylomeDBiQ98T89.
    TreeFamiTF323922.

    Family and domain databases

    InterProiIPR006761. Tsg.
    [Graphical view]
    PANTHERiPTHR12312. PTHR12312. 1 hit.
    PfamiPF04668. Tsg. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q98T89-1 [UniParc]FASTAAdd to Basket

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    MRSPCAALSA SLLLLLLLLW ARSSVGCNKA LCASDVSKCL IQELCQCRPG    50
    EGNCSCCKEC MLCLGTLWDE CCDCVGMCNP RNYSDTPPTS KSTVEELHEP 100
    IPSLFRALTE GDTQLNWNIV SFPVAEELSH HENLVSFLET VNQPQHQNVS 150
    VPSNNIHAPY SSDKEHMCTV VYFDDCMSIH QCKISCESMG ASKYRWFHNA 200
    CCECIGPECI DYGSKTVKCM NCMF 224
    Length:224
    Mass (Da):24,904
    Last modified:June 1, 2001 - v1
    Checksum:i42AD74E8A2DAC9F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255731 mRNA. Translation: AAK27324.1.
    RefSeqiNP_989529.1. NM_204198.1.
    UniGeneiGga.43831.

    Genome annotation databases

    EnsembliENSGALT00000013684; ENSGALP00000013669; ENSGALG00000008400.
    GeneIDi374024.
    KEGGigga:374024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255731 mRNA. Translation: AAK27324.1 .
    RefSeqi NP_989529.1. NM_204198.1.
    UniGenei Gga.43831.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013669.

    Proteomic databases

    PaxDbi Q98T89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000013684 ; ENSGALP00000013669 ; ENSGALG00000008400 .
    GeneIDi 374024.
    KEGGi gga:374024.

    Organism-specific databases

    CTDi 57045.

    Phylogenomic databases

    eggNOGi NOG70213.
    GeneTreei ENSGT00390000007058.
    HOGENOMi HOG000044674.
    HOVERGENi HBG055753.
    InParanoidi Q98T89.
    OMAi NCTVAFM.
    OrthoDBi EOG7J70GN.
    PhylomeDBi Q98T89.
    TreeFami TF323922.

    Miscellaneous databases

    NextBioi 20813551.
    PROi Q98T89.

    Family and domain databases

    InterProi IPR006761. Tsg.
    [Graphical view ]
    PANTHERi PTHR12312. PTHR12312. 1 hit.
    Pfami PF04668. Tsg. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
      Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
      Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTWSG1_CHICK
    AccessioniPrimary (citable) accession number: Q98T89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3