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Protein

Selenoprotein Pb

Gene

sepp1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Might be responsible for some of the extracellular antioxidant defense properties of selenium.By similarity

GO - Molecular functioni

  1. selenium binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein Pb
Short name:
zSelPb
Gene namesi
Name:sepp1b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030311-2. sepp1b.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 265247Selenoprotein PbPRO_0000022301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 26449His-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78314.
HOVERGENiHBG056814.
InParanoidiQ98SV0.
PhylomeDBiQ98SV0.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR007671. Selenoprotein-P_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04592. SelP_N. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98SV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALWPLLLS ALPALLGASS LFVEKESNGS RICKPAPQWE IDGKTPMKEL
60 70 80 90 100
LGNVVVVALL KASUHFCLTQ AARLGDLRDK LANGGLTNIS FMVVNEQDSQ
110 120 130 140 150
SRAMYWELKR RTAQDIPVYQ QSPLQNDVWE ILEGDKDDFL VYDRCGYLTF
160 170 180 190 200
HIVLPFSFLH YPYIEAAIRA TYHKNMCNCS LNANFSISES SDSTKNDPAG
210 220 230 240 250
ENNQRPNSTE PVTAAHHHHH QQHEPHHHHH NPYPNSHKKS GDSDVTGKPK
260
EPPHHSHQEH VHNHR
Length:265
Mass (Da):30,040
Last modified:February 26, 2008 - v3
Checksum:iD858FC5CD7EDEB13
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei64 – 641Selenocysteine1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322072 mRNA. Translation: AAG53689.1.
UniGeneiDr.8516.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322072 mRNA. Translation: AAG53689.1.
UniGeneiDr.8516.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-030311-2. sepp1b.

Phylogenomic databases

eggNOGiNOG78314.
HOVERGENiHBG056814.
InParanoidiQ98SV0.
PhylomeDBiQ98SV0.

Miscellaneous databases

PROiQ98SV0.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR007671. Selenoprotein-P_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04592. SelP_N. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues."
    Kryukov G.V., Gladyshev V.N.
    Genes Cells 5:1049-1060(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSELPB_DANRE
AccessioniPrimary (citable) accession number: Q98SV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: February 26, 2008
Last modified: April 29, 2015
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.