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Protein

Claudin

Gene

cldn5

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:cldn5Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 30HelicalUniRule annotationAdd BLAST24
Transmembranei82 – 105HelicalUniRule annotationAdd BLAST24
Transmembranei117 – 144HelicalUniRule annotationAdd BLAST28
Transmembranei164 – 187HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

  • apical part of cell Source: AgBase
  • bicellular tight junction Source: AgBase
  • cytoplasm Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000001621.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039146.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98SR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAAVEILG LGLGILGWVG VILACGLPMW QVSAFIDVNI VVAQTIWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSI LALRPEVQAG RALTVIVALL GLVALMVTVV
110 120 130 140 150
GAQCTNCIRP GKMKSRIVIA GGTIYILCGV LVLVPLCWFA NIVISDFYDP
160 170 180 190 200
SVPPSQKREI GAALYIGWAA TALLLFGGCL ICCCSCLQRD ETSFPVKYSA
210
PRRPTSSGEY DKKNYV
Length:216
Mass (Da):23,181
Last modified:June 1, 2001 - v1
Checksum:i5037A882DFF5433A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334678 mRNA. Translation: AAK20877.1.
RefSeqiNP_989532.1. NM_204201.1.
UniGeneiGga.3111.

Genome annotation databases

GeneIDi374028.
KEGGigga:374028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334678 mRNA. Translation: AAK20877.1.
RefSeqiNP_989532.1. NM_204201.1.
UniGeneiGga.3111.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374028.
KEGGigga:374028.

Organism-specific databases

CTDi7122.

Phylogenomic databases

eggNOGiENOG410IJT1. Eukaryota.
ENOG410Y9S8. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
KOiK06087.
OMAiLVCCGAW.
OrthoDBiEOG091G0MMR.

Gene expression databases

BgeeiENSGALG00000001621.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003551. Claudin5.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01380. CLAUDIN5.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ98SR1_CHICK
AccessioniPrimary (citable) accession number: Q98SR1
Secondary accession number(s): F1NKZ4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.