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Protein

Protein Wnt-2b

Gene

WNT2B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Signaling molecule which affects the development of discrete regions of tissues. Could participate in the process of blood vessel formation. Is likely to signal over only few cell diameters. May be involved in brain development and in later organogenesis. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo.2 Publications

GO - Molecular functioni

  • frizzled binding Source: UniProtKB

GO - Biological processi

  • camera-type eye photoreceptor cell differentiation Source: AgBase
  • canonical Wnt signaling pathway Source: AgBase
  • cell proliferation Source: AgBase
  • cornea development in camera-type eye Source: BHF-UCL
  • embryonic camera-type eye formation Source: AgBase
  • embryonic forelimb morphogenesis Source: AgBase
  • iris morphogenesis Source: BHF-UCL
  • lens development in camera-type eye Source: BHF-UCL
  • limb development Source: AgBase
  • morphogenesis of an epithelial sheet Source: AgBase
  • negative regulation of glial cell differentiation Source: AgBase
  • negative regulation of neuron differentiation Source: AgBase
  • neural retina development Source: AgBase
  • neuron differentiation Source: AgBase
  • positive regulation of fibroblast growth factor production Source: AgBase
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: AgBase
  • regulation of canonical Wnt signaling pathway Source: AgBase
  • regulation of fibroblast growth factor production Source: AgBase
  • retina layer formation Source: AgBase
  • Wnt signaling pathway Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2b
Gene namesi
Name:WNT2B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 385365Protein Wnt-2bPRO_0000392925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 112By similarity
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 160By similarity
Disulfide bondi162 ↔ 182By similarity
Disulfide bondi231 ↔ 245By similarity
Disulfide bondi233 ↔ 240By similarity
Lipidationi237 – 2371O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi319 ↔ 334By similarity
Disulfide bondi349 ↔ 364By similarity
Disulfide bondi351 ↔ 361By similarity
Disulfide bondi356 ↔ 357By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ98SN7.
PRIDEiQ98SN7.

Expressioni

Tissue specificityi

Expressed in the intermediate and the lateral plate mesoderm in the presumptive chick forelimb region. Expressed in the eye, head ectoderm, prospective forelimb mesenchyme, lung bud, pharyngeal arches, the brain and otic vesicle.3 Publications

Developmental stagei

At stage 11, expressed in the medial sites of the embryonic right and left coelom, as well as in the medial region of the forming somites. Between stages 14 and 16, expression in the presumptive wing field, with strongest expression at stage 15. At stage 17, a faint expression is detected in the posterior region of the nascent limb bud. Expressed in the ocular surface ectoderm, including the corneal epithelium, starting from the onset of the lens vesicle closing at stage 16.2 Publications

Interactioni

Protein-protein interaction databases

IntActiQ98SN7. 2 interactions.
STRINGi9031.ENSGALP00000039420.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ98SN7.
PhylomeDBiQ98SN7.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98SN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSPNRLAAS PGIAVAPGRA ECGAFPRTAG AAPRICLPFV LILLALTPRA
60 70 80 90 100
DSSWWYIGAL GARVICDNIP GLVNKQRQLC QRYPDIMQSV GEGAKEWIRE
110 120 130 140 150
CQYQFRHHRW NCSTLDRDHT VFGRVMLRSS REAAFVYAIS SAGVVYAITR
160 170 180 190 200
ACSQGELKAC GCDPLKRGRA KDERGEFDWG GCSDNINYGI RFAKAFVDAK
210 220 230 240 250
EKKVKDARAL MNLHNNRCGR MAVKRFLKLE CKCHGVSGSC TLRTCWLAMS
260 270 280 290 300
DFRKTGDYLQ KKYNGAIQVI MNQDGTGFTV ANKNFRKPTK TDLVYFENSP
310 320 330 340 350
DYCVMDKSAG SLGTAGRVCN KVSRGTDGCE VMCCGRGYDT TRVTRVTKCE
360 370 380
CKFHWCCAVR CKECEDTVDV HTCKAPKRAE WLDQT
Length:385
Mass (Da):42,953
Last modified:June 1, 2001 - v1
Checksum:iFE3204C08A3E6EF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346628 mRNA. Translation: AAK38108.1.
AF182403 mRNA. Translation: AAD55446.1.
RefSeqiNP_989667.2. NM_204336.2.
UniGeneiGga.50310.

Genome annotation databases

GeneIDi374243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346628 mRNA. Translation: AAK38108.1.
AF182403 mRNA. Translation: AAD55446.1.
RefSeqiNP_989667.2. NM_204336.2.
UniGeneiGga.50310.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ98SN7. 2 interactions.
STRINGi9031.ENSGALP00000039420.

Proteomic databases

PaxDbiQ98SN7.
PRIDEiQ98SN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374243.

Organism-specific databases

CTDi7482.

Phylogenomic databases

eggNOGiNOG284879.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ98SN7.
PhylomeDBiQ98SN7.

Miscellaneous databases

NextBioi20813739.
PROiQ98SN7.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo."
    Kawakami Y., Capdevila J., Buscher D., Itoh T., Esteban C.R., Belmonte J.C.
    Cell 104:891-900(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  2. "Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction."
    Jasoni C., Hendrickson A., Roelink H.
    Dev. Dyn. 215:215-224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-385, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Head.
  3. "Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
    Fokina V.M., Frolova E.I.
    Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiWNT2B_CHICK
AccessioniPrimary (citable) accession number: Q98SN7
Secondary accession number(s): Q9PUI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was initially thought to be WNT13.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.