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Q98SN7

- WNT2B_CHICK

UniProt

Q98SN7 - WNT2B_CHICK

Protein

Protein Wnt-2b

Gene

WNT2B

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Signaling molecule which affects the development of discrete regions of tissues. Could participate in the process of blood vessel formation. Is likely to signal over only few cell diameters. May be involved in brain development and in later organogenesis. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo.2 Publications

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB

    GO - Biological processi

    1. camera-type eye photoreceptor cell differentiation Source: AgBase
    2. canonical Wnt signaling pathway Source: AgBase
    3. cell proliferation Source: AgBase
    4. cornea development in camera-type eye Source: BHF-UCL
    5. embryonic camera-type eye formation Source: AgBase
    6. embryonic forelimb morphogenesis Source: AgBase
    7. iris morphogenesis Source: BHF-UCL
    8. lens development in camera-type eye Source: BHF-UCL
    9. morphogenesis of an epithelial sheet Source: AgBase
    10. negative regulation of glial cell differentiation Source: AgBase
    11. negative regulation of neuron differentiation Source: AgBase
    12. neural retina development Source: AgBase
    13. neuron differentiation Source: AgBase
    14. positive regulation of fibroblast growth factor receptor signaling pathway Source: AgBase
    15. regulation of canonical Wnt signaling pathway Source: AgBase
    16. retina layer formation Source: AgBase
    17. Wnt signaling pathway Source: AgBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2b
    Gene namesi
    Name:WNT2B
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 385365Protein Wnt-2bPRO_0000392925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 112By similarity
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 160By similarity
    Disulfide bondi162 ↔ 182By similarity
    Disulfide bondi231 ↔ 245By similarity
    Disulfide bondi233 ↔ 240By similarity
    Lipidationi237 – 2371O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi319 ↔ 334By similarity
    Disulfide bondi349 ↔ 364By similarity
    Disulfide bondi351 ↔ 361By similarity
    Disulfide bondi356 ↔ 357By similarity

    Post-translational modificationi

    Palmitoylation at Ser-237 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ98SN7.
    PRIDEiQ98SN7.

    Expressioni

    Tissue specificityi

    Expressed in the intermediate and the lateral plate mesoderm in the presumptive chick forelimb region. Expressed in the eye, head ectoderm, prospective forelimb mesenchyme, lung bud, pharyngeal arches, the brain and otic vesicle.3 Publications

    Developmental stagei

    At stage 11, expressed in the medial sites of the embryonic right and left coelom, as well as in the medial region of the forming somites. Between stages 14 and 16, expression in the presumptive wing field, with strongest expression at stage 15. At stage 17, a faint expression is detected in the posterior region of the nascent limb bud. Expressed in the ocular surface ectoderm, including the corneal epithelium, starting from the onset of the lens vesicle closing at stage 16.2 Publications

    Interactioni

    Protein-protein interaction databases

    IntActiQ98SN7. 2 interactions.
    STRINGi9031.ENSGALP00000039420.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ9PUI3.
    KOiK00182.
    PhylomeDBiQ98SN7.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q98SN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSPNRLAAS PGIAVAPGRA ECGAFPRTAG AAPRICLPFV LILLALTPRA    50
    DSSWWYIGAL GARVICDNIP GLVNKQRQLC QRYPDIMQSV GEGAKEWIRE 100
    CQYQFRHHRW NCSTLDRDHT VFGRVMLRSS REAAFVYAIS SAGVVYAITR 150
    ACSQGELKAC GCDPLKRGRA KDERGEFDWG GCSDNINYGI RFAKAFVDAK 200
    EKKVKDARAL MNLHNNRCGR MAVKRFLKLE CKCHGVSGSC TLRTCWLAMS 250
    DFRKTGDYLQ KKYNGAIQVI MNQDGTGFTV ANKNFRKPTK TDLVYFENSP 300
    DYCVMDKSAG SLGTAGRVCN KVSRGTDGCE VMCCGRGYDT TRVTRVTKCE 350
    CKFHWCCAVR CKECEDTVDV HTCKAPKRAE WLDQT 385
    Length:385
    Mass (Da):42,953
    Last modified:June 1, 2001 - v1
    Checksum:iFE3204C08A3E6EF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346628 mRNA. Translation: AAK38108.1.
    AF182403 mRNA. Translation: AAD55446.1.
    RefSeqiNP_989667.1. NM_204336.1.
    UniGeneiGga.50310.

    Genome annotation databases

    GeneIDi374243.
    KEGGigga:374243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF346628 mRNA. Translation: AAK38108.1 .
    AF182403 mRNA. Translation: AAD55446.1 .
    RefSeqi NP_989667.1. NM_204336.1.
    UniGenei Gga.50310.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q98SN7. 2 interactions.
    STRINGi 9031.ENSGALP00000039420.

    Proteomic databases

    PaxDbi Q98SN7.
    PRIDEi Q98SN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374243.
    KEGGi gga:374243.

    Organism-specific databases

    CTDi 7482.

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q9PUI3.
    KOi K00182.
    PhylomeDBi Q98SN7.

    Miscellaneous databases

    NextBioi 20813739.
    PROi Q98SN7.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo."
      Kawakami Y., Capdevila J., Buscher D., Itoh T., Esteban C.R., Belmonte J.C.
      Cell 104:891-900(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    2. "Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction."
      Jasoni C., Hendrickson A., Roelink H.
      Dev. Dyn. 215:215-224(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-385, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Head.
    3. "Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
      Fokina V.M., Frolova E.I.
      Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiWNT2B_CHICK
    AccessioniPrimary (citable) accession number: Q98SN7
    Secondary accession number(s): Q9PUI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was initially thought to be WNT13.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3