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Q98SN7 (WNT2B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-2b
Gene names
Name:WNT2B
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Signaling molecule which affects the development of discrete regions of tissues. Could participate in the process of blood vessel formation. Is likely to signal over only few cell diameters. May be involved in brain development and in later organogenesis. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. Ref.1 Ref.2

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Expressed in the intermediate and the lateral plate mesoderm in the presumptive chick forelimb region. Expressed in the eye, head ectoderm, prospective forelimb mesenchyme, lung bud, pharyngeal arches, the brain and otic vesicle. Ref.1 Ref.2 Ref.3

Developmental stage

At stage 11, expressed in the medial sites of the embryonic right and left coelom, as well as in the medial region of the forming somites. Between stages 14 and 16, expression in the presumptive wing field, with strongest expression at stage 15. At stage 17, a faint expression is detected in the posterior region of the nascent limb bud. Expressed in the ocular surface ectoderm, including the corneal epithelium, starting from the onset of the lens vesicle closing at stage 16. Ref.1 Ref.3

Post-translational modification

Palmitoylation at Ser-237 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-101. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Caution

Was initially thought (Ref.2) to be WNT13.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from mutant phenotype PubMed 12921742. Source: AgBase

camera-type eye photoreceptor cell differentiation

Inferred from expression pattern PubMed 16854977. Source: AgBase

canonical Wnt signaling pathway

Inferred from direct assay PubMed 12490564PubMed 16854977. Source: AgBase

cell proliferation

Inferred from direct assay PubMed 12490564. Source: AgBase

cornea development in camera-type eye

Inferred from expression pattern Ref.3. Source: BHF-UCL

embryonic camera-type eye formation

Inferred from expression pattern PubMed 12921742. Source: AgBase

embryonic forelimb morphogenesis

Inferred from mutant phenotype Ref.1. Source: AgBase

iris morphogenesis

Inferred from expression pattern Ref.3. Source: BHF-UCL

lens development in camera-type eye

Inferred from expression pattern Ref.3. Source: BHF-UCL

morphogenesis of an epithelial sheet

Inferred from direct assay PubMed 12921742. Source: AgBase

negative regulation of glial cell differentiation

Inferred from direct assay PubMed 15901663. Source: AgBase

negative regulation of neuron differentiation

Inferred from direct assay PubMed 15901663. Source: AgBase

neural retina development

Traceable author statement PubMed 15901663. Source: AgBase

neuron differentiation

Inferred from expression pattern PubMed 16854977. Source: AgBase

positive regulation of fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype Ref.1. Source: AgBase

regulation of canonical Wnt signaling pathway

Inferred from direct assay Ref.1. Source: AgBase

retina layer formation

Inferred from direct assay PubMed 12921742. Source: AgBase

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from physical interaction PubMed 12490564. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 385365Protein Wnt-2b
PRO_0000392925

Amino acid modifications

Lipidation1011S-palmitoyl cysteine By similarity
Lipidation2371O-palmitoyl serine; by PORCN By similarity
Glycosylation1111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q98SN7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FE3204C08A3E6EF5

FASTA38542,953
        10         20         30         40         50         60 
MLSPNRLAAS PGIAVAPGRA ECGAFPRTAG AAPRICLPFV LILLALTPRA DSSWWYIGAL 

        70         80         90        100        110        120 
GARVICDNIP GLVNKQRQLC QRYPDIMQSV GEGAKEWIRE CQYQFRHHRW NCSTLDRDHT 

       130        140        150        160        170        180 
VFGRVMLRSS REAAFVYAIS SAGVVYAITR ACSQGELKAC GCDPLKRGRA KDERGEFDWG 

       190        200        210        220        230        240 
GCSDNINYGI RFAKAFVDAK EKKVKDARAL MNLHNNRCGR MAVKRFLKLE CKCHGVSGSC 

       250        260        270        280        290        300 
TLRTCWLAMS DFRKTGDYLQ KKYNGAIQVI MNQDGTGFTV ANKNFRKPTK TDLVYFENSP 

       310        320        330        340        350        360 
DYCVMDKSAG SLGTAGRVCN KVSRGTDGCE VMCCGRGYDT TRVTRVTKCE CKFHWCCAVR 

       370        380 
CKECEDTVDV HTCKAPKRAE WLDQT 

« Hide

References

[1]"WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo."
Kawakami Y., Capdevila J., Buscher D., Itoh T., Esteban C.R., Belmonte J.C.
Cell 104:891-900(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[2]"Analysis of chicken Wnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction."
Jasoni C., Hendrickson A., Roelink H.
Dev. Dyn. 215:215-224(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-385, FUNCTION, TISSUE SPECIFICITY.
Tissue: Head.
[3]"Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
Fokina V.M., Frolova E.I.
Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF346628 mRNA. Translation: AAK38108.1.
AF182403 mRNA. Translation: AAD55446.1.
RefSeqNP_989667.1. NM_204336.1.
UniGeneGga.50310.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ98SN7. 2 interactions.
STRING9031.ENSGALP00000039420.

Proteomic databases

PaxDbQ98SN7.
PRIDEQ98SN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374243.
KEGGgga:374243.

Organism-specific databases

CTD7482.

Phylogenomic databases

eggNOGNOG284879.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ9PUI3.
KOK00182.
PhylomeDBQ98SN7.

Family and domain databases

InterProIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813739.
PROQ98SN7.

Entry information

Entry nameWNT2B_CHICK
AccessionPrimary (citable) accession number: Q98SN7
Secondary accession number(s): Q9PUI3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families