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Protein

Homeobox protein Hox-A1a

Gene

hoxa1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi225 – 284HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A1a
Short name:
Hox-A1
Gene namesi
Name:hoxa1a
Synonyms:hoxa1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-000823-5 hoxa1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000331 – 329Homeobox protein Hox-A1aAdd BLAST329

Proteomic databases

PaxDbiQ98SI1

Expressioni

Gene expression databases

BgeeiENSDARG00000104307
ExpressionAtlasiQ98SI1 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000074910

Structurei

3D structure databases

ProteinModelPortaliQ98SI1
SMRiQ98SI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi200 – 205Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiQ98SI1
KOiK09301
OMAiSPQYIHH
OrthoDBiEOG091G0LR2
PhylomeDBiQ98SI1
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q98SI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTFLDFSSI SGGGDGGSGG SCSVRAFHGD HGLSTFQSSC AVRLNSCSGD
60 70 80 90 100
ERFMSNISSQ DVINSQPQQA GSYQSPGTLS ITYSAHPSYG TQSFCTGYNH
110 120 130 140 150
YALNQDVESS VSFPQCGPLV YSGNISSTVV QHRHHRHGYS SGNVHLHGQF
160 170 180 190 200
QYGSATYGNS SDQANLTFVA GCSNPLSPLH VPHHDACCSP LSDGVPTGQT
210 220 230 240 250
FDWMKVKRNP PKTGKAGEYG FGGQPNTVRT NFSTKQLTEL EKEFHFNKYL
260 270 280 290 300
TRARRVEIAA SLQLNETQVK IWFQNRRMKQ KKREKEGLLP KSLSEQKDGL
310 320
EKTEDASEKS PSAPSTPSPS PTVEAYSSN
Length:329
Mass (Da):35,737
Last modified:June 1, 2001 - v1
Checksum:iCBF2C722F50A85D5
GO
Isoform 2 (identifier: Q98SI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: Missing.

Show »
Length:294
Mass (Da):32,178
Checksum:i8A603E507F410727
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 28MSTFL…VRAFH → MEVAGARAQSGRSQ (PubMed:9831563).CuratedAdd BLAST28
Sequence conflicti296Q → E in CAC34566 (PubMed:11493564).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012678158 – 192Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306430 mRNA Translation: CAC34565.1
AJ306431 mRNA Translation: CAC34566.1
AF071243 Genomic DNA Translation: AAD15937.1
AL645756 Genomic DNA Translation: CAD52136.1
AL645756 Genomic DNA Translation: CAD52137.1
CR382300 Genomic DNA Translation: CAK10852.1
DQ060531 mRNA Translation: AAY67909.1
RefSeqiNP_571611.1, NM_131536.2 [Q98SI1-1]
XP_017207752.1, XM_017352263.1 [Q98SI1-2]
UniGeneiDr.83046

Genome annotation databases

EnsembliENSDART00000163546; ENSDARP00000133812; ENSDARG00000104307 [Q98SI1-2]
ENSDART00000167757; ENSDARP00000133272; ENSDARG00000104307 [Q98SI1-1]
GeneIDi58051
KEGGidre:58051

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHXA1A_DANRE
AccessioniPrimary (citable) accession number: Q98SI1
Secondary accession number(s): Q1L968
, Q4PRB2, Q8AWZ1, Q98SI0, Q9YGT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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