Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q98SH9

- HXC1A_DANRE

UniProt

Q98SH9 - HXC1A_DANRE

Protein

Homeobox protein Hox-C1a

Gene

hoxc1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi215 – 27460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C1a
    Gene namesi
    Name:hoxc1a
    ORF Names:si:dkey-81p22.13
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 23

    Organism-specific databases

    ZFINiZDB-GENE-000822-2. hoxc1a.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Homeobox protein Hox-C1aPRO_0000200162Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization.1 Publication

    Gene expression databases

    BgeeiQ98SH9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98SH9.
    SMRiQ98SH9. Positions 219-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiKOG0489.
    GeneTreeiENSGT00750000117389.
    HOVERGENiHBG094309.
    InParanoidiA2BE59.
    OMAiVIMPESA.
    OrthoDBiEOG7PK91P.
    PhylomeDBiQ98SH9.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98SH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSYHGFRDT TSLFIKGYHA TGVMRLHQDH GSTADFPSRE DVNNEADFLQ    50
    YHFTNLCATA TGACSKPCED PGRANSTRPP FPQNQDFYRP VHPNRPQVPS 100
    FQSCREQGLS RKGFSPSSDT FRTFSSAHCE LGPVNNTQTE VRTYDGPVRH 150
    SAVEDDNTGH GALNTLNETL HSGKTFEWMR VRRNQSRAAK IQLGKCSDRE 200
    LKTNHGRDSD EDTSSGGSRT NFTTKQLTEL EKEFHFNKYL TRARRIEIAN 250
    PLQLSETQVK IWFQNRRMKQ KKMLREGLAQ GLMLISGCDE DSKKSDTCSS 300
    PD 302
    Length:302
    Mass (Da):34,217
    Last modified:June 1, 2001 - v1
    Checksum:i9A7E6B07B9410E55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306432 mRNA. Translation: CAC34567.1.
    BX005254 Genomic DNA. Translation: CAM16413.1.
    DQ060550 mRNA. Translation: AAY67928.1.
    AF071263 Genomic DNA. Translation: AAD15956.1.
    RefSeqiNP_571606.1. NM_131531.1.
    UniGeneiDr.83047.

    Genome annotation databases

    EnsembliENSDART00000103131; ENSDARP00000093905; ENSDARG00000070337.
    GeneIDi58046.
    KEGGidre:58046.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ306432 mRNA. Translation: CAC34567.1 .
    BX005254 Genomic DNA. Translation: CAM16413.1 .
    DQ060550 mRNA. Translation: AAY67928.1 .
    AF071263 Genomic DNA. Translation: AAD15956.1 .
    RefSeqi NP_571606.1. NM_131531.1.
    UniGenei Dr.83047.

    3D structure databases

    ProteinModelPortali Q98SH9.
    SMRi Q98SH9. Positions 219-276.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000103131 ; ENSDARP00000093905 ; ENSDARG00000070337 .
    GeneIDi 58046.
    KEGGi dre:58046.

    Organism-specific databases

    CTDi 58046.
    ZFINi ZDB-GENE-000822-2. hoxc1a.

    Phylogenomic databases

    eggNOGi KOG0489.
    GeneTreei ENSGT00750000117389.
    HOVERGENi HBG094309.
    InParanoidi A2BE59.
    OMAi VIMPESA.
    OrthoDBi EOG7PK91P.
    PhylomeDBi Q98SH9.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 20892310.

    Gene expression databases

    Bgeei Q98SH9.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes."
      McClintock J.M., Carlson R., Mann D.M., Prince V.E.
      Development 128:2471-2484(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
      Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
      Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-197.
      Strain: Tuebingen.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-302.
    5. "Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role."
      Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.
      Dev. Biol. 274:318-333(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHXC1A_DANRE
    AccessioniPrimary (citable) accession number: Q98SH9
    Secondary accession number(s): A2BE59, Q4PR93, Q9YGS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3