Q98SH9 (HXC1A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C1a

Gene names

Name:	hoxc1a
ORF Names:	si:dkey-81p22.13

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Developmental stage	Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization. Ref.5
Sequence similarities	Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Homeobox protein Hox-C1a		PRO_0000200162
Regions
	DNA binding	215 – 274	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	Q98SH9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9A7E6B07B9410E55	FASTA	302	34,217
	10 20 30 40 50 60 MNSYHGFRDT TSLFIKGYHA TGVMRLHQDH GSTADFPSRE DVNNEADFLQ YHFTNLCATA 70 80 90 100 110 120 TGACSKPCED PGRANSTRPP FPQNQDFYRP VHPNRPQVPS FQSCREQGLS RKGFSPSSDT 130 140 150 160 170 180 FRTFSSAHCE LGPVNNTQTE VRTYDGPVRH SAVEDDNTGH GALNTLNETL HSGKTFEWMR 190 200 210 220 230 240 VRRNQSRAAK IQLGKCSDRE LKTNHGRDSD EDTSSGGSRT NFTTKQLTEL EKEFHFNKYL 250 260 270 280 290 300 TRARRIEIAN PLQLSETQVK IWFQNRRMKQ KKMLREGLAQ GLMLISGCDE DSKKSDTCSS PD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes." McClintock J.M., Carlson R., Mann D.M., Prince V.E. Development 128:2471-2484(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[3]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 97-197. Strain: Tuebingen.
[4]	"Zebrafish hox clusters and vertebrate genome evolution." Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H. Science 282:1711-1714(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-302.
[5]	"Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role." Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R. Dev. Biol. 274:318-333(2004) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ306432 mRNA. Translation: CAC34567.1. BX005254 Genomic DNA. Translation: CAM16413.1. DQ060550 mRNA. Translation: AAY67928.1. AF071263 Genomic DNA. Translation: AAD15956.1.
IPI	IPI00507708.
RefSeq	NP_571606.1. NM_131531.1.
UniGene	Dr.83047.
3D structure databases
ProteinModelPortal	Q98SH9.
SMR	Q98SH9. Positions 219-276.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000103131; ENSDARP00000093905; ENSDARG00000070337.
GeneID	58046.
KEGG	dre:58046.
Organism-specific databases
CTD	58046.
ZFIN	ZDB-GENE-000822-2. hoxc1a.
Phylogenomic databases
eggNOG	KOG0489.
GeneTree	ENSGT00700000104446.
HOVERGEN	HBG094309.
InParanoid	A2BE59.
Gene expression databases
ArrayExpress	Q98SH9.
Bgee	Q98SH9.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20892310.

Entry information

Entry name

HXC1A_DANRE

Accession

Primary (citable) accession number: Q98SH9
Secondary accession number(s): A2BE59, Q4PR93, Q9YGS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program