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Q98SH2

- AT2B1_CHICK

UniProt

Q98SH2 - AT2B1_CHICK

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Protein

Plasma membrane calcium-transporting ATPase 1

Gene
ATP2B1, PMCA1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 1 (EC:3.6.3.8)
Short name:
PMCA1
Alternative name(s):
Plasma membrane calcium ATPase isoform 1
Plasma membrane calcium pump isoform 1
Gene namesi
Name:ATP2B1
Synonyms:PMCA1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Topological domaini22 – 3413Extracellular Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 214159Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 214›214Plasma membrane calcium-transporting ATPase 1PRO_0000046213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Phosphothreonine; by PKC By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ98SH2.

Expressioni

Inductioni

By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018350.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 11118Calmodulin-binding subdomain A By similarityBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
HOGENOMiHOG000265623.
PhylomeDBiQ98SH2.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR022141. ATP_Ca_trans_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q98SH2-1 [UniParc]FASTAAdd to Basket

« Hide

AIFCTIVLGT FVVQIIIVQF GGKPFSCSKL LIEQWLWSVF LGMGTLLWGQ    50
LISTIPTSHL KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL 100
WFRGLNRIQT QIRVVNAFRS SLYEGLEKPE TRSSIHNFMT HPEFRIEDSE 150
PHIPLIDDTD AEDDAPTKRN STPPPSPNKN NNAVDSGIHL TTDMNKSATS 200
SSPGSPLHSL ETSL 214
Length:214
Mass (Da):24,001
Last modified:June 1, 2001 - v1
Checksum:i39CB6B7BA4AD2EFE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08769 mRNA. Translation: AAK14839.1.
PIRiA47276.
UniGeneiGga.30308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08769 mRNA. Translation: AAK14839.1 .
PIRi A47276.
UniGenei Gga.30308.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000018350.

Proteomic databases

PaxDbi Q98SH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0474.
HOGENOMi HOG000265623.
PhylomeDBi Q98SH2.

Miscellaneous databases

PROi Q98SH2.

Family and domain databases

Gene3Di 1.20.1110.10. 1 hit.
InterProi IPR022141. ATP_Ca_trans_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view ]
Pfami PF12424. ATP_Ca_trans_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression."
    Cai Q., Chandler J.S., Wasserman R.H., Kumar R., Penniston J.T.
    Proc. Natl. Acad. Sci. U.S.A. 90:1345-1349(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: White leghorn.
    Tissue: Intestine.

Entry informationi

Entry nameiAT2B1_CHICK
AccessioniPrimary (citable) accession number: Q98SH2
Secondary accession number(s): Q9PSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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