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Q98SH2

- AT2B1_CHICK

UniProt

Q98SH2 - AT2B1_CHICK

Protein

Plasma membrane calcium-transporting ATPase 1

Gene

ATP2B1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasma membrane calcium-transporting ATPase 1 (EC:3.6.3.8)
    Short name:
    PMCA1
    Alternative name(s):
    Plasma membrane calcium ATPase isoform 1
    Plasma membrane calcium pump isoform 1
    Gene namesi
    Name:ATP2B1
    Synonyms:PMCA1
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 214›214Plasma membrane calcium-transporting ATPase 1PRO_0000046213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101Phosphothreonine; by PKCBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ98SH2.

    Expressioni

    Inductioni

    By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000018350.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 3413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 214159CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 11118Calmodulin-binding subdomain ABy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265623.
    PhylomeDBiQ98SH2.

    Family and domain databases

    Gene3Di1.20.1110.10. 1 hit.
    InterProiIPR022141. ATP_Ca_trans_C.
    IPR023298. ATPase_P-typ_TM_dom.
    [Graphical view]
    PfamiPF12424. ATP_Ca_trans_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q98SH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    AIFCTIVLGT FVVQIIIVQF GGKPFSCSKL LIEQWLWSVF LGMGTLLWGQ    50
    LISTIPTSHL KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL 100
    WFRGLNRIQT QIRVVNAFRS SLYEGLEKPE TRSSIHNFMT HPEFRIEDSE 150
    PHIPLIDDTD AEDDAPTKRN STPPPSPNKN NNAVDSGIHL TTDMNKSATS 200
    SSPGSPLHSL ETSL 214
    Length:214
    Mass (Da):24,001
    Last modified:June 1, 2001 - v1
    Checksum:i39CB6B7BA4AD2EFE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08769 mRNA. Translation: AAK14839.1.
    PIRiA47276.
    UniGeneiGga.30308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08769 mRNA. Translation: AAK14839.1 .
    PIRi A47276.
    UniGenei Gga.30308.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000018350.

    Proteomic databases

    PaxDbi Q98SH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265623.
    PhylomeDBi Q98SH2.

    Miscellaneous databases

    PROi Q98SH2.

    Family and domain databases

    Gene3Di 1.20.1110.10. 1 hit.
    InterProi IPR022141. ATP_Ca_trans_C.
    IPR023298. ATPase_P-typ_TM_dom.
    [Graphical view ]
    Pfami PF12424. ATP_Ca_trans_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression."
      Cai Q., Chandler J.S., Wasserman R.H., Kumar R., Penniston J.T.
      Proc. Natl. Acad. Sci. U.S.A. 90:1345-1349(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: White leghorn.
      Tissue: Intestine.

    Entry informationi

    Entry nameiAT2B1_CHICK
    AccessioniPrimary (citable) accession number: Q98SH2
    Secondary accession number(s): Q9PSK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3