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Q98SH2 (AT2B1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasma membrane calcium-transporting ATPase 1

Short name=PMCA1
EC=3.6.3.8
Alternative name(s):
Plasma membrane calcium ATPase isoform 1
Plasma membrane calcium pump isoform 1
Gene names
Name:ATP2B1
Synonyms:PMCA1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length214 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Induction

By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency. Ref.1

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 214›214Plasma membrane calcium-transporting ATPase 1
PRO_0000046213

Regions

Transmembrane1 – 2121Helical; Potential
Topological domain22 – 3413Extracellular Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 214159Cytoplasmic Potential
Region94 – 11118Calmodulin-binding subdomain A By similarity UniProtKB P20020

Amino acid modifications

Modified residue1101Phosphothreonine; by PKC By similarity UniProtKB P20020

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q98SH2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 39CB6B7BA4AD2EFE

FASTA21424,001
        10         20         30         40         50         60 
AIFCTIVLGT FVVQIIIVQF GGKPFSCSKL LIEQWLWSVF LGMGTLLWGQ LISTIPTSHL 

        70         80         90        100        110        120 
KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL WFRGLNRIQT QIRVVNAFRS 

       130        140        150        160        170        180 
SLYEGLEKPE TRSSIHNFMT HPEFRIEDSE PHIPLIDDTD AEDDAPTKRN STPPPSPNKN 

       190        200        210 
NNAVDSGIHL TTDMNKSATS SSPGSPLHSL ETSL 

« Hide

References

[1]"Vitamin D and adaptation to dietary calcium and phosphate deficiencies increase intestinal plasma membrane calcium pump gene expression."
Cai Q., Chandler J.S., Wasserman R.H., Kumar R., Penniston J.T.
Proc. Natl. Acad. Sci. U.S.A. 90:1345-1349(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: White leghorn.
Tissue: Intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08769 mRNA. Translation: AAK14839.1.
PIRA47276.
UniGeneGga.30308.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000018350.

Proteomic databases

PaxDbQ98SH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0474.
HOGENOMHOG000265623.
PhylomeDBQ98SH2.

Family and domain databases

Gene3D1.20.1110.10. 1 hit.
InterProIPR022141. ATP_Ca_trans_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PfamPF12424. ATP_Ca_trans_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ98SH2.

Entry information

Entry nameAT2B1_CHICK
AccessionPrimary (citable) accession number: Q98SH2
Secondary accession number(s): Q9PSK0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families