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Protein

Plasma membrane calcium-transporting ATPase 1

Gene

ATP2B1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 1 (EC:3.6.3.8)
Short name:
PMCA1
Alternative name(s):
Plasma membrane calcium ATPase isoform 1
Plasma membrane calcium pump isoform 1
Gene namesi
Name:ATP2B1
Synonyms:PMCA1
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 34ExtracellularSequence analysisAdd BLAST13
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 214CytoplasmicSequence analysisAdd BLAST159

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000046213‹1 – 214Plasma membrane calcium-transporting ATPase 1Add BLAST›214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110Phosphothreonine; by PKCBy similarity1

Keywords - PTMi

Phosphoprotein

PTM databases

SwissPalmiQ98SH2.

Expressioni

Inductioni

By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 111Calmodulin-binding subdomain ABy similarityAdd BLAST18

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265623.
InParanoidiQ98SH2.
PhylomeDBiQ98SH2.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR030320. ATP2B1.
IPR022141. ATP_Ca_trans_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PANTHERiPTHR24093:SF245. PTHR24093:SF245. 1 hit.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q98SH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AIFCTIVLGT FVVQIIIVQF GGKPFSCSKL LIEQWLWSVF LGMGTLLWGQ
60 70 80 90 100
LISTIPTSHL KFLKEAGHGT QKEEIPEEEL AEDVEEIDHA ERELRRGQIL
110 120 130 140 150
WFRGLNRIQT QIRVVNAFRS SLYEGLEKPE TRSSIHNFMT HPEFRIEDSE
160 170 180 190 200
PHIPLIDDTD AEDDAPTKRN STPPPSPNKN NNAVDSGIHL TTDMNKSATS
210
SSPGSPLHSL ETSL
Length:214
Mass (Da):24,001
Last modified:June 1, 2001 - v1
Checksum:i39CB6B7BA4AD2EFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08769 mRNA. Translation: AAK14839.1.
PIRiA47276.
UniGeneiGga.30308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08769 mRNA. Translation: AAK14839.1.
PIRiA47276.
UniGeneiGga.30308.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

SwissPalmiQ98SH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000265623.
InParanoidiQ98SH2.
PhylomeDBiQ98SH2.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR030320. ATP2B1.
IPR022141. ATP_Ca_trans_C.
IPR023298. ATPase_P-typ_TM_dom.
[Graphical view]
PANTHERiPTHR24093:SF245. PTHR24093:SF245. 1 hit.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2B1_CHICK
AccessioniPrimary (citable) accession number: Q98SH2
Secondary accession number(s): Q9PSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: February 17, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.