Q98RF7 (KTHY_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	MYPU_0520

Organism

Mycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]

Taxonomic identifier

272635 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Thymidylate kinase HAMAP MF_00165		PRO_0000155308
Regions
	Nucleotide binding	20 – 27	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q98RF7 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: C9C9B5DFD96F9AC4	FASTA	234	27,382
	10 20 30 40 50 60 MKIENKSDKE EDQMFITFEG IDASGKTSLL AKLKAHVVQK NLQGKCTFTW EPGGRKSPEI 70 80 90 100 110 120 QTIRHLILNK ESNLSPIAEA FLYSSARRIH LDKVILPNLA KNKVVFCDRF VDSSFAYQAF 130 140 150 160 170 180 GRDLGFEKIK LLNELATDKK YPDITFILKI SYEESMERRK ARQEDEDRLE KEENSFYQKV 190 200 210 220 230 IKGYDFLASY PEFQKRIFVI DASKNQEEIF ESVLKILKDH KTFQTHPIYK DFFS

References

[1]

"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445563 Genomic DNA. Translation: CAC13225.1.
PIR	D90518.
RefSeq	NP_325883.1. NC_002771.1.
3D structure databases
ProteinModelPortal	Q98RF7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911421.
GenomeReviews	Gene locus MYPU_0520 in contig AL445566_GR.
KEGG	mpu:MYPU_0520.
PATRIC	20022968. VBIMycPul29704_0051.
Organism-specific databases
GenoList	MYPU_0520.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG626009.
OMA	EAYLFAA.
PhylomeDB	Q98RF7.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_0520-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_MYCPU

Accession

Primary (citable) accession number: Q98RF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program