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Q98RB6

- SYL_MYCPU

UniProt

Q98RB6 - SYL_MYCPU

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei582 – 5821ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MYPU_0930
    OrganismiMycoplasma pulmonis (strain UAB CTIP)
    Taxonomic identifieri272635 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000528: Chromosome

    Organism-specific databases

    GenoListiMYPU_0930.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 807807Leucine--tRNA ligasePRO_0000152051Add
    BLAST

    Proteomic databases

    PRIDEiQ98RB6.

    Interactioni

    Protein-protein interaction databases

    STRINGi272635.MYPU_0930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98RB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi38 – 4912"HIGH" regionAdd
    BLAST
    Motifi579 – 5835"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98RB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNHKEIEKK WQKIWDQSKA FKTGNKSDKK YYVLDMFPYP SGSGLHVGHP    50
    EGYTATDIIA RFKRLKGFDV LHPMGWDAFG LPAEQYAIST GNNPNEFTQK 100
    NIATFKKQIK SLGLSYDFDK EVNTTDPKFY EQTQWIFKEL YKKGLAVLAD 150
    IDVNWCEELG TVLANEEVLI DKDGNKVSER GSFPVVKKKM RQWVLKITNY 200
    ADKLLEGLED LDWENSLKLL QKNWIGKSTG TKVKFALELL DESIEVFTTR 250
    IETIFGATFL TISPEHPLVE KIVTSENKEK VKDFIKEFEK LDDRQKADKN 300
    EKNGIFTGSY AINPFNQKKI PIWIGDFVLL SYGTGAIMSV PAHDKRDYEF 350
    ANKYGLEIKQ VIVSKENVEL PYLESGHLIN SSEFNGLSSK EAIEKLNQYV 400
    EKNNLGQVET FYKLRDWIFS RQRYWGEPFP VAFDDENNVY LIDGLVELPF 450
    MENIKPSKNG QSPLFNNKKW LYFEKDGKKL TRETNTMPQW AGSNWYYLAY 500
    ILKNADGSYE KLDSEEAKKR FKKWLPVDLY IGGQEHAVLH LLYSRFWHRF 550
    LYDIGVVPTK EPFQKVVNQG MILGTDGQKM SKSRGNIINP SEIVDELGAD 600
    TLRVYEMFMG PLTDDKDWQV ESIKGIRKWL ERVYRLFEMF FDGQKTIEKS 650
    NEDHLILSQY NKLIKEIENE VELLKFNTAI SKLMVFVNLL YKVEKIPSWE 700
    ILKNFALILS LFAPHIAEEL LEKMNQKQVK DQIWPTYDPT YLESNLTKYV 750
    IQINGKVRAI VDFELDKTQE EVLAKAMQIE KIKTLLENKN IIKVIFVANK 800
    VLNLIVK 807
    Length:807
    Mass (Da):93,884
    Last modified:October 1, 2001 - v1
    Checksum:iC888CC0524A9A3A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445563 Genomic DNA. Translation: CAC13266.1.
    PIRiE90523.
    RefSeqiNP_325924.1. NC_002771.1.
    WP_010924897.1. NC_002771.1.

    Genome annotation databases

    EnsemblBacteriaiCAC13266; CAC13266; CAC13266.
    GeneIDi911597.
    KEGGimpu:MYPU_0930.
    PATRICi20023052. VBIMycPul29704_0092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445563 Genomic DNA. Translation: CAC13266.1 .
    PIRi E90523.
    RefSeqi NP_325924.1. NC_002771.1.
    WP_010924897.1. NC_002771.1.

    3D structure databases

    ProteinModelPortali Q98RB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272635.MYPU_0930.

    Proteomic databases

    PRIDEi Q98RB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC13266 ; CAC13266 ; CAC13266 .
    GeneIDi 911597.
    KEGGi mpu:MYPU_0930.
    PATRICi 20023052. VBIMycPul29704_0092.

    Organism-specific databases

    GenoListi MYPU_0930.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAB CTIP.

    Entry informationi

    Entry nameiSYL_MYCPU
    AccessioniPrimary (citable) accession number: Q98RB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3