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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei582ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPUL272635:G1GT6-91-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MYPU_0930
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000528 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520511 – 807Leucine--tRNA ligaseAdd BLAST807

Proteomic databases

PRIDEiQ98RB6

Interactioni

Protein-protein interaction databases

STRINGi272635.MYPU_0930

Structurei

3D structure databases

ProteinModelPortaliQ98RB6
SMRiQ98RB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 49"HIGH" regionAdd BLAST12
Motifi579 – 583"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.6202 hits
3.90.740.101 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q98RB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNHKEIEKK WQKIWDQSKA FKTGNKSDKK YYVLDMFPYP SGSGLHVGHP
60 70 80 90 100
EGYTATDIIA RFKRLKGFDV LHPMGWDAFG LPAEQYAIST GNNPNEFTQK
110 120 130 140 150
NIATFKKQIK SLGLSYDFDK EVNTTDPKFY EQTQWIFKEL YKKGLAVLAD
160 170 180 190 200
IDVNWCEELG TVLANEEVLI DKDGNKVSER GSFPVVKKKM RQWVLKITNY
210 220 230 240 250
ADKLLEGLED LDWENSLKLL QKNWIGKSTG TKVKFALELL DESIEVFTTR
260 270 280 290 300
IETIFGATFL TISPEHPLVE KIVTSENKEK VKDFIKEFEK LDDRQKADKN
310 320 330 340 350
EKNGIFTGSY AINPFNQKKI PIWIGDFVLL SYGTGAIMSV PAHDKRDYEF
360 370 380 390 400
ANKYGLEIKQ VIVSKENVEL PYLESGHLIN SSEFNGLSSK EAIEKLNQYV
410 420 430 440 450
EKNNLGQVET FYKLRDWIFS RQRYWGEPFP VAFDDENNVY LIDGLVELPF
460 470 480 490 500
MENIKPSKNG QSPLFNNKKW LYFEKDGKKL TRETNTMPQW AGSNWYYLAY
510 520 530 540 550
ILKNADGSYE KLDSEEAKKR FKKWLPVDLY IGGQEHAVLH LLYSRFWHRF
560 570 580 590 600
LYDIGVVPTK EPFQKVVNQG MILGTDGQKM SKSRGNIINP SEIVDELGAD
610 620 630 640 650
TLRVYEMFMG PLTDDKDWQV ESIKGIRKWL ERVYRLFEMF FDGQKTIEKS
660 670 680 690 700
NEDHLILSQY NKLIKEIENE VELLKFNTAI SKLMVFVNLL YKVEKIPSWE
710 720 730 740 750
ILKNFALILS LFAPHIAEEL LEKMNQKQVK DQIWPTYDPT YLESNLTKYV
760 770 780 790 800
IQINGKVRAI VDFELDKTQE EVLAKAMQIE KIKTLLENKN IIKVIFVANK

VLNLIVK
Length:807
Mass (Da):93,884
Last modified:October 1, 2001 - v1
Checksum:iC888CC0524A9A3A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445563 Genomic DNA Translation: CAC13266.1
PIRiE90523
RefSeqiWP_010924897.1, NC_002771.1

Genome annotation databases

EnsemblBacteriaiCAC13266; CAC13266; CAC13266
KEGGimpu:MYPU_0930

Similar proteinsi

Entry informationi

Entry nameiSYL_MYCPU
AccessioniPrimary (citable) accession number: Q98RB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: February 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome