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Q98RB6

- SYL_MYCPU

UniProt

Q98RB6 - SYL_MYCPU

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Protein
Leucine--tRNA ligase
Gene
leuS, MYPU_0930
Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MYPU_0930
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000528: Chromosome

Organism-specific databases

GenoListiMYPU_0930.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Leucine--tRNA ligaseUniRule annotation
PRO_0000152051Add
BLAST

Proteomic databases

PRIDEiQ98RB6.

Interactioni

Protein-protein interaction databases

STRINGi272635.MYPU_0930.

Structurei

3D structure databases

ProteinModelPortaliQ98RB6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 4912"HIGH" regionUniRule annotation
Add
BLAST
Motifi579 – 5835"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98RB6-1 [UniParc]FASTAAdd to Basket

« Hide

MYNHKEIEKK WQKIWDQSKA FKTGNKSDKK YYVLDMFPYP SGSGLHVGHP    50
EGYTATDIIA RFKRLKGFDV LHPMGWDAFG LPAEQYAIST GNNPNEFTQK 100
NIATFKKQIK SLGLSYDFDK EVNTTDPKFY EQTQWIFKEL YKKGLAVLAD 150
IDVNWCEELG TVLANEEVLI DKDGNKVSER GSFPVVKKKM RQWVLKITNY 200
ADKLLEGLED LDWENSLKLL QKNWIGKSTG TKVKFALELL DESIEVFTTR 250
IETIFGATFL TISPEHPLVE KIVTSENKEK VKDFIKEFEK LDDRQKADKN 300
EKNGIFTGSY AINPFNQKKI PIWIGDFVLL SYGTGAIMSV PAHDKRDYEF 350
ANKYGLEIKQ VIVSKENVEL PYLESGHLIN SSEFNGLSSK EAIEKLNQYV 400
EKNNLGQVET FYKLRDWIFS RQRYWGEPFP VAFDDENNVY LIDGLVELPF 450
MENIKPSKNG QSPLFNNKKW LYFEKDGKKL TRETNTMPQW AGSNWYYLAY 500
ILKNADGSYE KLDSEEAKKR FKKWLPVDLY IGGQEHAVLH LLYSRFWHRF 550
LYDIGVVPTK EPFQKVVNQG MILGTDGQKM SKSRGNIINP SEIVDELGAD 600
TLRVYEMFMG PLTDDKDWQV ESIKGIRKWL ERVYRLFEMF FDGQKTIEKS 650
NEDHLILSQY NKLIKEIENE VELLKFNTAI SKLMVFVNLL YKVEKIPSWE 700
ILKNFALILS LFAPHIAEEL LEKMNQKQVK DQIWPTYDPT YLESNLTKYV 750
IQINGKVRAI VDFELDKTQE EVLAKAMQIE KIKTLLENKN IIKVIFVANK 800
VLNLIVK 807
Length:807
Mass (Da):93,884
Last modified:October 1, 2001 - v1
Checksum:iC888CC0524A9A3A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445563 Genomic DNA. Translation: CAC13266.1.
PIRiE90523.
RefSeqiNP_325924.1. NC_002771.1.
WP_010924897.1. NC_002771.1.

Genome annotation databases

EnsemblBacteriaiCAC13266; CAC13266; CAC13266.
GeneIDi911597.
KEGGimpu:MYPU_0930.
PATRICi20023052. VBIMycPul29704_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445563 Genomic DNA. Translation: CAC13266.1 .
PIRi E90523.
RefSeqi NP_325924.1. NC_002771.1.
WP_010924897.1. NC_002771.1.

3D structure databases

ProteinModelPortali Q98RB6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272635.MYPU_0930.

Proteomic databases

PRIDEi Q98RB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC13266 ; CAC13266 ; CAC13266 .
GeneIDi 911597.
KEGGi mpu:MYPU_0930.
PATRICi 20023052. VBIMycPul29704_0092.

Organism-specific databases

GenoListi MYPU_0930.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAB CTIP.

Entry informationi

Entry nameiSYL_MYCPU
AccessioniPrimary (citable) accession number: Q98RB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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