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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMPUL272635:G1GT6-146-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:MYPU_1450Imported
OrganismiMycoplasma pulmonis (strain UAB CTIP)Imported
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000528 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272635.MYPU_1450

Structurei

3D structure databases

ProteinModelPortaliQ98R65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q98R65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNRFNKGMI EVITGPMFSG KTEELLRRFR LLNYAKAKTL LIKPAFDTRF
60 70 80 90 100
SKEEIISRAG VKTKTHSVKN TEQIRKILEK EKFDALVIDE IHFFDFDIVY
110 120 130 140 150
LIEELANSGY HIIVSGLDQN FKREPFEVVS YLLSIAEKVT KLQAICVKCQ
160 170 180 190
RAATTTFRKV ESKEIKLLGD VDEYEARCRK CHIQGSKDKN
Length:190
Mass (Da):22,048
Last modified:October 1, 2001 - v1
Checksum:iAD80B99FBFE498B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445563 Genomic DNA Translation: CAC13318.1
PIRiA90530
RefSeqiWP_010924949.1, NC_002771.1

Genome annotation databases

EnsemblBacteriaiCAC13318; CAC13318; CAC13318
KEGGimpu:MYPU_1450

Similar proteinsi

Entry informationi

Entry nameiQ98R65_MYCPU
AccessioniPrimary (citable) accession number: Q98R65
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health