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Q98QW4 (PGK_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MYPU_2460
OrganismMycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]
Taxonomic identifier272635 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

In the N-terminal section; belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 771771Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145972

Regions

Nucleotide binding361 – 3644ATP By similarity
Region1 – 406406Phosphoglycerate kinase HAMAP-Rule MF_00145
Region20 – 223Substrate binding By similarity
Region58 – 614Substrate binding By similarity
Region407 – 771365Unknown HAMAP-Rule MF_00145

Sites

Binding site351Substrate By similarity
Binding site1181Substrate By similarity
Binding site1551Substrate By similarity
Binding site2061ATP By similarity
Binding site2951ATP; via carbonyl oxygen By similarity
Binding site3341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98QW4 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: CFC542BC9071AB98

FASTA77186,689
        10         20         30         40         50         60 
MKKLITDLNL NDKKVLIRLD LNVPLKGKKI TSLKRIEESI PTIKYVQERG GKIILLSHLG 

        70         80         90        100        110        120 
RVKTKEDKEK KSLSIVVEAL ASLLNSPVKF VDQTRGKKLE SAIEKLKPGD VLLIENTRFE 

       130        140        150        160        170        180 
DLNNNAESNN DPELGKYWAS LGDVFINDAF GTAHRAHASN VGIASNIKES ALGILVQKEV 

       190        200        210        220        230        240 
NALWKLMEQQ EKPFVAILGG SKVSDKINVL EKIIDKVDRL IIGGAMAYTF LKAQGIGIGD 

       250        260        270        280        290        300 
SIYEQDKIEF ATEFLKKYNH KIILPIDHAL AKKFKNAKPI FNNENPLEIP QTFIGMDVGP 

       310        320        330        340        350        360 
KTIELIHKYI KGDTKLGISP AKTIFWNGPM GVTEFEEFQS GSLAVVEAIS QLVGAYSVVG 

       370        380        390        400        410        420 
GGDSIAIIEK LNAQMLFSHI STGGGASLEF IESKVLPGID AIQNYEQTYE QYDSQVQSQD 

       430        440        450        460        470        480 
FSQNFDSPLV EETFSQSTSE NFSDFASSTQ EHFATSENQN TLINNYENPG FDSQDMFKTE 

       490        500        510        520        530        540 
EQNDSTSSFL TSTNPFSSEF SNEFKTSDFQ DLKQTQETET QETLIPHTFE YTTDDLRHTL 

       550        560        570        580        590        600 
EQYVRETSFQ TRESTFPTEE ASFETLEETS FQTLEESFPT QSFEQVEQTS EKNMEVSTEN 

       610        620        630        640        650        660 
FENASSQTNS FTVSDIPKTT STFEDLETPE TQNTTLEEVA LETSNFEAQN LETPNLQTSN 

       670        680        690        700        710        720 
FETSNLETSN FETSNFETST FESFNTGNFS TPSSTFEDLD LQSATFQTND ESERSTQENF 

       730        740        750        760        770 
EPTEVIESDL LAMKTTELEQ EITNNTSRDI LSEDEVAAPH KKRFWFFGRK R 

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References

[1]"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis."
Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.
Nucleic Acids Res. 29:2145-2153(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UAB CTIP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445563 Genomic DNA. Translation: CAC13419.1.
PIRF90542.
RefSeqNP_326077.1. NC_002771.1.

3D structure databases

ProteinModelPortalQ98QW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272635.MYPU_2460.

Proteomic databases

PRIDEQ98QW4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC13419; CAC13419; CAC13419.
GeneID911410.
KEGGmpu:MYPU_2460.
PATRIC20023380. VBIMycPul29704_0249.

Organism-specific databases

GenoListMYPU_2460.
CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMALETSNFE.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCPU
AccessionPrimary (citable) accession number: Q98QW4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways