Reviewed, UniProtKB/Swiss-Prot Q98QU3 (ATPA1_MYCPU)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit alpha 1
    EC=3.6.3.14
Alternative name(s):
    F-ATPase subunit alpha 1
    ATP synthase F1 sector subunit alpha 1

Gene names

Name:	atpA1
Ordered Locus Names:	MYPU_2680

Organism

Mycoplasma pulmonis [Complete proteome] [HAMAP]

Taxonomic identifier

2107 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity.
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	ATP synthase subunit alpha 1 HAMAP MF_01346		PRO_0000238297
Regions
	Nucleotide binding	169 – 176	8	ATP By similarity
Sites
	Site	362	1	Required for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98QU3-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: B6AEFF8378D1A13B	FASTA	528	58,229
	10 20 30 40 50 60 MALKNKDISS IIKERIRNYK IEKINDEVGK VISIGDGIAL VSGLKNVKNG ELIIFNESVY 70 80 90 100 110 120 GLTLNLEIDY IGVAILGNDT LLKEGDEAKR TFEVISIKVG PEILGRVINA LGEPIDGKGE 130 140 150 160 170 180 IDSEIHRQIF RVAPGVMARE SVNEALSTGI LAIDSMIPIG KGQRELIIGD RQTGKTAIAI 190 200 210 220 230 240 DAIINQKGKN VKCIYVAIGQ KNSTVAQIVR KLENHGAMEY TSVVSASASE LSPMQYLAPY 250 260 270 280 290 300 TGVTIAEEFM ETGQDVLIVY DDLSKHAVAY RTLSLLLRRP PGREAYPGDV FYLHSQLLER 310 320 330 340 350 360 AAKVNKENGG GSITALPIIE TQQGDISAYI ATNVISITDG QIFTKESLFN SGQRPAIDVG 370 380 390 400 410 420 FSVSRVGSSA QISAMKEVTS SLKLQLAQYN EMLAFSQFGS DLDDSTKAIL ENGSKIYEIL 430 440 450 460 470 480 KQDQYSPIDQ YTQVILFLAI KQNLINPIPL EYISKFKKAI IHKFNKDAKA LNLKTLIRND 490 500 510 520 KKLSTKLRNE ITKIIIEEIK NITKSIANYN PKDHRPIPEE YAKLVESK

References

[1]

"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL445563 Genomic DNA. Translation: CAC13441.1.
PIR	D90545.
RefSeq	NP_326099.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	911478.
GenomeReviews	Gene locus MYPU_2680 in contig AL445566_GR.
KEGG	mpu:MYPU_2680.
Organism-specific databases
MypuList	MYPU_2680.
CMR	Search...
Phylogenomic databases
HOGENOM	Q98QU3.
OMA	RITEETE.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_2680-MON.
BRENDA	3.6.3.14. 274806.
Family and domain databases
HAMAP	MF_01346. [Tree]
InterPro	IPR005294. ATPase_F1-cplx_asu. IPR017458. ATPase_F1-cplx_asu_C. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
PANTHER	PTHR15184:SF3. ATPase_F1_a. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00962. atpA. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA1_MYCPU

Accession

Primary (citable) accession number: Q98QU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)