Reviewed, UniProtKB/Swiss-Prot Q98QB7 (ATPA2_MYCPU)

Names and origin

Protein names

Recommended name:
    ATP synthase subunit alpha 2
    EC=3.6.3.14
Alternative name(s):
    F-ATPase subunit alpha 2
    ATP synthase F1 sector subunit alpha 2

Gene names

Name:	atpA2
Ordered Locus Names:	MYPU_4490

Organism

Mycoplasma pulmonis [Complete proteome] [HAMAP]

Taxonomic identifier

2107 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. HAMAP MF_01346
Catalytic activity	ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(1) Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	plasma membrane ATP synthesis coupled proton transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW proton-transporting ATP synthase complex, catalytic core F(1) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: HAMAP proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 513	513	ATP synthase subunit alpha 2 HAMAP MF_01346		PRO_0000144338
Regions
	Nucleotide binding	152 – 159	8	ATP Potential
Sites
	Site	341	1	Required for activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98QB7-1 [UniParc]. Last modified September 26, 2001. Version 1. Checksum: D0E19C8CDEB9A4E9	FASTA	513	58,129
	10 20 30 40 50 60 MDNAKIVIKS IKDYIVEVQG DYDFRLYEVF QLTDDVKGFC LSVDEKRTFL LIDGDTSKIK 70 80 90 100 110 120 VGTEIIPLES RFIAKTYKDY FGKIIDIDGK VLYSESEDQE ISEKAYENEN SAFKVASGIQ 130 140 150 160 170 180 DRVKLNEPLE TGIFSIDILL PIGKGQRQLI LGDSKTGKTS IALSTMINQK ENDIKIIYVS 190 200 210 220 230 240 IGLKSNDLKR IYKTIVEQKI AHKTILMHAS SDNSFQQFLI PYVAMAHAEN IMQSGEDVLI 250 260 270 280 290 300 IFDDLTNHAN VLREIALLTG KPVGKEAFPG DLFYSHSKLL ERAGKFKNGY SITCFPIVRT 310 320 330 340 350 360 INNDMTSLLA SNIASITDGQ IVTNSEIKDQ GILPAIDIGL SVSRTGSSVQ SVSLSKIAIE 370 380 390 400 410 420 ISKIYSKYKQ NEKFSDTNFD LNDSVRDIIK KGKILLKILN QKEFQAYSRS FNLIIAYIVV 430 440 450 460 470 480 WGIFEDEEKI YDKLIYLYFV LRYDYIGKIL VNVVDKKSGV DGMVDEGVLK AEIMRLLAHF 490 500 510 KDIHNIKTKS YNDGKFNLST RVLHKVKDRI WEK

References

[1]

"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL445564 Genomic DNA. Translation: CAC13622.1.
PIR	A99568.
RefSeq	NP_326280.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	911609.
GenomeReviews	Gene locus MYPU_4490 in contig AL445566_GR.
KEGG	mpu:MYPU_4490.
Organism-specific databases
MypuList	MYPU_4490.
CMR	Search...
Phylogenomic databases
HOGENOM	Q98QB7.
OMA	DMAGRII.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_4490-MON.
BRENDA	3.6.3.14. 274806.
Family and domain databases
HAMAP	MF_01346. [Tree]
InterPro	IPR005294. ATPase_F1-cplx_asu. IPR017458. ATPase_F1-cplx_asu_C. IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. [Graphical view]
PANTHER	PTHR15184:SF3. ATPase_F1_a. 1 hit.
Pfam	PF00006. ATP-synt_ab. 1 hit. [Graphical view]
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATPA2_MYCPU

Accession

Primary (citable) accession number: Q98QB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	September 26, 2001
Last modified:	November 3, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)