ID   DYR_MYCPU               Reviewed;         179 AA.
AC   Q98Q32;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Dihydrofolate reductase;
DE            EC=1.5.1.3;
GN   Name=folA; OrderedLocusNames=MYPU_5370;
OS   Mycoplasma pulmonis.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=2107;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   MEDLINE=21267165; PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C.,
RA   Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen
RT   Mycoplasma pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- CATALYTIC ACTIVITY: 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-
CC       dihydrofolate + NADPH.
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis;
CC       tetrahydrofolate from dihydrofolate: step 1/1.
CC   -!- MISCELLANEOUS: The reaction catalyzed by this enzyme represents an
CC       essential step for de novo glycine and purine synthesis, DNA
CC       precursor synthesis, and for the conversion of dUMP to dTMP.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC   -!- SIMILARITY: Contains 1 DHFR (dihydrofolate reductase) domain.
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DR   EMBL; AL445565; CAC13710.1; -; Genomic_DNA.
DR   PIR; A90579; A90579.
DR   RefSeq; NP_326368.1; -.
DR   HSSP; P00378; 8DFR.
DR   GeneID; 911218; -.
DR   GenomeReviews; AL445566_GR; MYPU_5370.
DR   KEGG; mpu:MYPU_5370; -.
DR   MypuList; MYPU_5370; -.
DR   HOGENOM; Q98Q32; -.
DR   OMA; Q98Q32; YITHILQ.
DR   BioCyc; MPUL272635:MYPU_5370-MON; -.
DR   BRENDA; 1.5.1.3; 274806.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:EC.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR001796; DHFR_reg.
DR   InterPro; IPR017925; Dihydrofolate_reductase_CS.
DR   PANTHER; PTHR11549:SF1; DHFR; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; One-carbon metabolism; Oxidoreductase.
FT   CHAIN         1    179       Dihydrofolate reductase.
FT                                /FTId=PRO_0000186397.
FT   DOMAIN       17    179       DHFR.
SQ   SEQUENCE   179 AA;  21491 MW;  89F35380370C9D06 CRC64;
     MTMNLIQLLK GKWRFKMIIS IWAMTKEGLI GKDNQMPWHI KEEFQHFRRQ TLHKTLIMGK
     NTFFSLPKVF DKRKMYVLSH EKDFKIDHPD VEVIYDYKDL LKEYANNDKK DIYVAGGLYV
     YQQLIPLSDI LIVSIVKGSY EGNKYLSVDF SNFVQYKQPE IYDQFSVYYY KKKDQKNSI
//