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Q98Q32

- DYR_MYCPU

UniProt

Q98Q32 - DYR_MYCPU

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Protein
Dihydrofolate reductase
Gene
folA, MYPU_5370
Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Substrate By similarity
Binding sitei48 – 481Substrate By similarity
Binding sitei73 – 731Substrate By similarity
Binding sitei134 – 1341Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 232NADP By similarity
Nucleotide bindingi30 – 356NADP By similarity
Nucleotide bindingi59 – 624NADP By similarity
Nucleotide bindingi78 – 814NADP By similarity
Nucleotide bindingi115 – 1206NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. dihydrofolate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycine biosynthetic process Source: InterPro
  2. nucleotide biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: UniProtKB-KW
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductase (EC:1.5.1.3)
Gene namesi
Name:folA
Ordered Locus Names:MYPU_5370
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000528: Chromosome

Organism-specific databases

GenoListiMYPU_5370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Dihydrofolate reductase
PRO_0000186397Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272635.MYPU_5370.

Structurei

3D structure databases

ProteinModelPortaliQ98Q32.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 179163DHFR
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0262.
HOGENOMiHOG000040233.
KOiK00287.
OMAiKNKYPYT.
OrthoDBiEOG6KT2V2.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98Q32-1 [UniParc]FASTAAdd to Basket

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MTMNLIQLLK GKWRFKMIIS IWAMTKEGLI GKDNQMPWHI KEEFQHFRRQ    50
TLHKTLIMGK NTFFSLPKVF DKRKMYVLSH EKDFKIDHPD VEVIYDYKDL 100
LKEYANNDKK DIYVAGGLYV YQQLIPLSDI LIVSIVKGSY EGNKYLSVDF 150
SNFVQYKQPE IYDQFSVYYY KKKDQKNSI 179
Length:179
Mass (Da):21,491
Last modified:August 29, 2001 - v1
Checksum:i89F35380370C9D06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445565 Genomic DNA. Translation: CAC13710.1.
PIRiA90579.
RefSeqiNP_326368.1. NC_002771.1.
WP_010925338.1. NC_002771.1.

Genome annotation databases

EnsemblBacteriaiCAC13710; CAC13710; CAC13710.
GeneIDi911218.
KEGGimpu:MYPU_5370.
PATRICi20024006. VBIMycPul29704_0548.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445565 Genomic DNA. Translation: CAC13710.1 .
PIRi A90579.
RefSeqi NP_326368.1. NC_002771.1.
WP_010925338.1. NC_002771.1.

3D structure databases

ProteinModelPortali Q98Q32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272635.MYPU_5370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC13710 ; CAC13710 ; CAC13710 .
GeneIDi 911218.
KEGGi mpu:MYPU_5370.
PATRICi 20024006. VBIMycPul29704_0548.

Organism-specific databases

GenoListi MYPU_5370.

Phylogenomic databases

eggNOGi COG0262.
HOGENOMi HOG000040233.
KOi K00287.
OMAi KNKYPYT.
OrthoDBi EOG6KT2V2.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00158 .

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view ]
Pfami PF00186. DHFR_1. 1 hit.
[Graphical view ]
PRINTSi PR00070. DHFR.
SUPFAMi SSF53597. SSF53597. 1 hit.
PROSITEi PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UAB CTIP.

Entry informationi

Entry nameiDYR_MYCPU
AccessioniPrimary (citable) accession number: Q98Q32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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