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Q98Q32 (DYR_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase

EC=1.5.1.3
Gene names
Name:folA
Ordered Locus Names:MYPU_5370
OrganismMycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]
Taxonomic identifier272635 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Dihydrofolate reductase
PRO_0000186397

Regions

Domain17 – 179163DHFR
Nucleotide binding22 – 232NADP By similarity
Nucleotide binding30 – 356NADP By similarity
Nucleotide binding59 – 624NADP By similarity
Nucleotide binding78 – 814NADP By similarity
Nucleotide binding115 – 1206NADP By similarity
Region21 – 233Substrate binding By similarity

Sites

Binding site431Substrate By similarity
Binding site481Substrate By similarity
Binding site731Substrate By similarity
Binding site1341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98Q32 [UniParc].

Last modified August 29, 2001. Version 1.
Checksum: 89F35380370C9D06

FASTA17921,491
        10         20         30         40         50         60 
MTMNLIQLLK GKWRFKMIIS IWAMTKEGLI GKDNQMPWHI KEEFQHFRRQ TLHKTLIMGK 

        70         80         90        100        110        120 
NTFFSLPKVF DKRKMYVLSH EKDFKIDHPD VEVIYDYKDL LKEYANNDKK DIYVAGGLYV 

       130        140        150        160        170 
YQQLIPLSDI LIVSIVKGSY EGNKYLSVDF SNFVQYKQPE IYDQFSVYYY KKKDQKNSI 

« Hide

References

[1]"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis."
Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.
Nucleic Acids Res. 29:2145-2153(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UAB CTIP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445565 Genomic DNA. Translation: CAC13710.1.
PIRA90579.
RefSeqNP_326368.1. NC_002771.1.

3D structure databases

ProteinModelPortalQ98Q32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272635.MYPU_5370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC13710; CAC13710; CAC13710.
GeneID911218.
KEGGmpu:MYPU_5370.
PATRIC20024006. VBIMycPul29704_0548.

Organism-specific databases

GenoListMYPU_5370.
CMRSearch...

Phylogenomic databases

eggNOGCOG0262.
HOGENOMHOG000040233.
KOK00287.
OMAKNKYPYT.
OrthoDBEOG6KT2V2.

Enzyme and pathway databases

UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_MYCPU
AccessionPrimary (citable) accession number: Q98Q32
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways