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Q98Q32

- DYR_MYCPU

UniProt

Q98Q32 - DYR_MYCPU

Protein

Dihydrofolate reductase

Gene

folA

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431SubstrateBy similarity
    Binding sitei48 – 481SubstrateBy similarity
    Binding sitei73 – 731SubstrateBy similarity
    Binding sitei134 – 1341SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 232NADPBy similarity
    Nucleotide bindingi30 – 356NADPBy similarity
    Nucleotide bindingi59 – 624NADPBy similarity
    Nucleotide bindingi78 – 814NADPBy similarity
    Nucleotide bindingi115 – 1206NADPBy similarity

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glycine biosynthetic process Source: InterPro
    2. nucleotide biosynthetic process Source: InterPro
    3. one-carbon metabolic process Source: UniProtKB-KW
    4. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00158.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrofolate reductase (EC:1.5.1.3)
    Gene namesi
    Name:folA
    Ordered Locus Names:MYPU_5370
    OrganismiMycoplasma pulmonis (strain UAB CTIP)
    Taxonomic identifieri272635 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000528: Chromosome

    Organism-specific databases

    GenoListiMYPU_5370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Dihydrofolate reductasePRO_0000186397Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272635.MYPU_5370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98Q32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 179163DHFRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dihydrofolate reductase family.Curated
    Contains 1 DHFR (dihydrofolate reductase) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0262.
    HOGENOMiHOG000040233.
    KOiK00287.
    OMAiKNKYPYT.
    OrthoDBiEOG6KT2V2.

    Family and domain databases

    Gene3Di3.40.430.10. 1 hit.
    InterProiIPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view]
    PfamiPF00186. DHFR_1. 1 hit.
    [Graphical view]
    PRINTSiPR00070. DHFR.
    SUPFAMiSSF53597. SSF53597. 1 hit.
    PROSITEiPS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98Q32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMNLIQLLK GKWRFKMIIS IWAMTKEGLI GKDNQMPWHI KEEFQHFRRQ    50
    TLHKTLIMGK NTFFSLPKVF DKRKMYVLSH EKDFKIDHPD VEVIYDYKDL 100
    LKEYANNDKK DIYVAGGLYV YQQLIPLSDI LIVSIVKGSY EGNKYLSVDF 150
    SNFVQYKQPE IYDQFSVYYY KKKDQKNSI 179
    Length:179
    Mass (Da):21,491
    Last modified:August 29, 2001 - v1
    Checksum:i89F35380370C9D06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445565 Genomic DNA. Translation: CAC13710.1.
    PIRiA90579.
    RefSeqiNP_326368.1. NC_002771.1.
    WP_010925338.1. NC_002771.1.

    Genome annotation databases

    EnsemblBacteriaiCAC13710; CAC13710; CAC13710.
    GeneIDi911218.
    KEGGimpu:MYPU_5370.
    PATRICi20024006. VBIMycPul29704_0548.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445565 Genomic DNA. Translation: CAC13710.1 .
    PIRi A90579.
    RefSeqi NP_326368.1. NC_002771.1.
    WP_010925338.1. NC_002771.1.

    3D structure databases

    ProteinModelPortali Q98Q32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272635.MYPU_5370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC13710 ; CAC13710 ; CAC13710 .
    GeneIDi 911218.
    KEGGi mpu:MYPU_5370.
    PATRICi 20024006. VBIMycPul29704_0548.

    Organism-specific databases

    GenoListi MYPU_5370.

    Phylogenomic databases

    eggNOGi COG0262.
    HOGENOMi HOG000040233.
    KOi K00287.
    OMAi KNKYPYT.
    OrthoDBi EOG6KT2V2.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00158 .

    Family and domain databases

    Gene3Di 3.40.430.10. 1 hit.
    InterProi IPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view ]
    Pfami PF00186. DHFR_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00070. DHFR.
    SUPFAMi SSF53597. SSF53597. 1 hit.
    PROSITEi PS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAB CTIP.

    Entry informationi

    Entry nameiDYR_MYCPU
    AccessioniPrimary (citable) accession number: Q98Q32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3