Q98Q24 (RPOC_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta'
Short name=RNAP subunit beta'
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'

Gene names

Name:	rpoC
Ordered Locus Names:	MYPU_5450

Organism

Mycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]

Taxonomic identifier

272635 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	1426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01322
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01322
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta' chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1426	1426	DNA-directed RNA polymerase subunit beta' HAMAP MF_01322		PRO_0000067764

Sequences

	Sequence		Length	Mass (Da)
	Q98Q24 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 656C4B64EAF6BE39	FASTA	1,426	160,697
	10 20 30 40 50 60 MPKTRKYSTV DEEKILKVSL SLATKEDVLE WSHGEVTKPE TINYKSYKPE RHGLFDELIF 70 80 90 100 110 120 GPATDYKCPI CGKKYKKSNE GLTCNNTPQC EIEKPEILPK ISRRSRMGHI ALQTPVVHFW 130 140 150 160 170 180 FFKIDNSIIS KLLVLRVGES NEYVSKNDLE NIIYYKSHIV LDNGGLKSLP KNKIININNA 190 200 210 220 230 240 AQIYKDALIE LRELNLNDAD ALEIIDGTIN HLNDIVGSKV GNDYGVDFYE LNEVIEEYSS 250 260 270 280 290 300 AKIQTGSKAI EFLLENIDLE EEQRKIKSKI KEINNLEKTS SSRKQDLSKL YKRLQVVESF 310 320 330 340 350 360 INSGQKPTSM LIYNLPVIPA ELRPLVQLDG GRHSTSDINE LYRRIIIRNN RLRKWIELNA 370 380 390 400 410 420 PTLITQNELR MIQEAVDALI DNSKKKPKPV TSKDNRNLKS ISDALTGKKG RFRQNLLGKR 430 440 450 460 470 480 VDYSGRSVIV VGPELKMNQV GIPREMAAKL FEPWIIKELI DQEITLSVKS ARKLIDNLNP 490 500 510 520 530 540 IIWPHVAKVI QGRPVLLNRA PTLHRLSIQA FEPVLIRGKA IKLHPLVTTA FNADFDGDQM 550 560 570 580 590 600 AVHVPISDEA VREAKELLFA NRNILGPKDG EPIINPSQDM ILGIYYLTIE IAGAKGEAKV 610 620 630 640 650 660 FQDVNSMLRA YEEGSVSLHA RVAIPFKKLQ KTFNLKGDKG YIFSTVGKFI FNQAFPENFP 670 680 690 700 710 720 FIFDSSVSSI SDAQEYTKKY YIPYGLNIKE TIQNTPINDA LSKKDLSKII RTIFDKYVPV 730 740 750 760 770 780 LTKEDVASVI NDVNHTNYKD TSTKFANLVT TNKTALEYIH AESLSKFTTK HFVDVNKKLS 790 800 810 820 830 840 LKTPGNPNQP IWEVDQYVEL LENVWFDYVN IVASVLDEIK DLGFKFSTKS GTSISIHDIE 850 860 870 880 890 900 VSDNKKERIK EGDDYTSELK SMYREGLLTD DERYSLTINK WSEVKDNIQN DLKKIVKNNP 910 920 930 940 950 960 LNPIFIMMNS GARSNMANYV QLAGIRGLMT NNTKILKSDA ENERVVRSTV EIPVKSSFLD 970 980 990 1000 1010 1020 GLTAYEFYSS THGARKGLTD TALNTAKSGY LTRRLVDVAQ GIVVTEKDCA TQNGFVVKDI 1030 1040 1050 1060 1070 1080 VDNKTKTVIV PIRERIEGRF TIEDVKDKDG NVIVEKDTLI DAKMAEEIVE VHDVKEVNIR 1090 1100 1110 1120 1130 1140 SILGCEAKNG VCQKCFGKDL ATSRIVSIGE AVGITASQSI GEPGTQLTMR TFHSGGVAGV 1150 1160 1170 1180 1190 1200 EDITGGFGRL TELIDAYRSP WGRPAIISKV DGIITEIKTP KDKNTNLVYI TYLDQDDASQ 1210 1220 1230 1240 1250 1260 TEVVSVPKNR TLRVKVGDKI VKGQKIIDGP IILEELLEYG GPRKVQSYLL KEIQKIYRMQ 1270 1280 1290 1300 1310 1320 GIAINDKYIE IIISQMLSKI EISEPGDSDF IIGSLVNNLD FYNTNNELLE KGLEPAKGKV 1330 1340 1350 1360 1370 1380 VIHGAKRIPL LSNSFLAAAS YQESAKILVN SSISSQQDFL VGVKENIILG KKIPAGTNSQ 1390 1400 1410 1420 YESKSKFDIR DPKEYFKDKS PQRHYKIEMD NEVSDMFNEF RISQNK

References

[1]	"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445565 Genomic DNA. Translation: CAC13718.1.
PIR	A99580.
RefSeq	NP_326376.1. NC_002771.1.
3D structure databases
ProteinModelPortal	Q98Q24.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911208.
GenomeReviews	Gene locus MYPU_5450 in contig AL445566_GR.
KEGG	mpu:MYPU_5450.
PATRIC	20024022. VBIMycPul29704_0556.
Organism-specific databases
GenoList	MYPU_5450.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG621785.
OMA	DINDKHI.
PhylomeDB	Q98Q24.
ProtClustDB	PRK00566.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_5450-MONOMER.
Family and domain databases
HAMAP	MF_01322. RNApol_bact_RpoC. [Tree]
InterPro	IPR012754. DNA-dir_RpoC_beta_prime. IPR000722. RNA_pol_asu. IPR006592. RNA_pol_N. IPR007080. RNA_pol_Rpb1_1. IPR007066. RNA_pol_Rpb1_3. IPR007083. RNA_pol_Rpb1_4. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
KO	K03046.
Pfam	PF04997. RNA_pol_Rpb1_1. 1 hit. PF00623. RNA_pol_Rpb1_2. 1 hit. PF04983. RNA_pol_Rpb1_3. 1 hit. PF05000. RNA_pol_Rpb1_4. 1 hit. PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
SMART	SM00663. RPOLA_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOC_MYCPU

Accession

Primary (citable) accession number: Q98Q24

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program