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Q98Q23 (RPOB_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene names
Name:rpoB
Ordered Locus Names:MYPU_5460
OrganismMycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]
Taxonomic identifier272635 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length1216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
   Biological processTranscription
   Cellular componentDNA-directed RNA polymerase
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12161216DNA-directed RNA polymerase subunit beta HAMAP MF_01321
PRO_0000047924

Sequences

Sequence LengthMass (Da)Tools
Q98Q23 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: D2FA276E875D4F99

FASTA1,216136,663
        10         20         30         40         50         60 
MPQKINYELK NFGQYTKRRD YSKTRFSLPL TDVLAIQKES FDWFLNKAIE ATLRKYYPIK 

        70         80         90        100        110        120 
SSNNKVEIKY VLGSKRIEKP LVTEQKAVKE AKQKGISYSA RLYVKLQKHI TETGEISFDE 

       130        140        150        160        170        180 
VILCDIPLMT SSGSFIINGF EKVIVSQLIR SPGAYFAQKT RDKQSDDLFN KVEVLPRIGS 

       190        200        210        220        230        240 
WIEIKHKVTS NLDSVKIKID KHKSFLLTTF LSSFGFTEES MYKLFGNSET LKNTLSKDKI 

       250        260        270        280        290        300 
LGKNKDIVEI RKEAQENIFR IVRRGDRITK EASQNLISNL LFNEKRYNLS KTGRYMLNRK 

       310        320        330        340        350        360 
LSLFDRIITT YLAQDIVLKN VDPTMEAKIL YPKGTYITND IAIEIQNAFK EGLIKNIDLK 

       370        380        390        400        410        420 
DYGITSDVYG KLLDTNPKLK NRMNIIGIYI FKSKKAMEKD GEKHFVIGND PTSVENHLLI 

       430        440        450        460        470        480 
SDIVAIINYY FNLNENIGRD DDPDSLINKR IVSVGELLLN QLNIGLLKME KNTREKMSSK 

       490        500        510        520        530        540 
EISRITPKNI TNNKMIQNQI KTFFNSSKLS QFMDQTNPLS EISTKRKITS LGPGGLNRDT 

       550        560        570        580        590        600 
AQFEVRDVHA THYGRICPIE TPEGPNIGLI LNLATYAKVD EYGFLQTPYF KVTNGIVDFS 

       610        620        630        640        650        660 
QPVYLTAHEE INRTFAQSSI SIDENGKITD EQVIVKSNFD YNVVSPKEVD YIDVSSKQMT 

       670        680        690        700        710        720 
SLAASSIPFL ENNDANRALM GSNMQRQAVP LLFAEAPLVA TGIEADIAKF SPNNLKSTVD 

       730        740        750        760        770        780 
GEVVFVDGSQ IKIKDSASEK GSIKTYQLKT FEKTNQGTVI SQSPIVKMGD KVLKGDLISD 

       790        800        810        820        830        840 
SSSFKDGEMA LGKNVLVGFS TWNGYNYEDA IIVSERLVKD DVFTSIHIEE QTIQFRKSKA 

       850        860        870        880        890        900 
GDDKLTADIP NASLKSRRHL DENGIVRIGS EVVTGDILVG RVSPKGDENI SPAEKLLNGI 

       910        920        930        940        950        960 
FNQKISNEKD TSLKVKNGHQ GTVIDVEILS RENGNVLEEE IDMMIKVYVA QKRKIKVGDK 

       970        980        990       1000       1010       1020 
MAGRHGNKGV ISRVLPVEDM PYLEDGTPLD IILNPQGVPS RMNIGQVLEL HLGMAAKKLG 

      1030       1040       1050       1060       1070       1080 
VKFVSPVFDG VKKADIMDAL EEAKLPRTGK MKVFDPTTGE KIDNEISVGV MYMFKLSHMV 

      1090       1100       1110       1120       1130       1140 
DDKMHSRSIG PYSLITQQPL GGKSQNGGQR FGEMETWALE SYGAANILQE ILTYKSDDIQ 

      1150       1160       1170       1180       1190       1200 
GRNNLYSALT SGTKLPKPGV PESFSVLAYE LRGLGIKLQI HEKEEEKQEL PSQEYESLNL 

      1210 
DQELKTASEN VSESEF

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References

[1]"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis."
Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.
Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UAB CTIP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL445565 Genomic DNA. Translation: CAC13719.1.
PIRB90580.
RefSeqNP_326377.1. NC_002771.1.

3D structure databases

ProteinModelPortalQ98Q23.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911205.
GenomeReviewsGene locus MYPU_5460 in contig AL445566_GR.
KEGGmpu:MYPU_5460.
PATRIC20024024. VBIMycPul29704_0557.

Organism-specific databases

GenoListMYPU_5460.
CMRSearch...

Phylogenomic databases

HOGENOMHBG285547.
OMATERRDYS.
PhylomeDBQ98Q23.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycMPUL272635:MYPU_5460-MONOMER.

Family and domain databases

HAMAPMF_01321. RNApol_bact_RpoB.
[Tree]
InterProIPR010243. DNA-dir_RNA_pol_bsu_bac-type.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
Gene3DG3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit.
G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits.
G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KOK03043.
PANTHERPTHR20856:SF3. PTHR20856:SF3. 1 hit.
PTHR20856. RNA_pol_I_sub2. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPOB_MYCPU
AccessionPrimary (citable) accession number: Q98Q23
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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