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Q98PN3

- DEF_MYCPU

UniProt

Q98PN3 - DEF_MYCPU

Protein

Peptide deformylase

Gene

def

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi123 – 1231IronUniRule annotation
    Metal bindingi170 – 1701IronUniRule annotation
    Active sitei171 – 1711UniRule annotation
    Metal bindingi174 – 1741IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:MYPU_6890
    OrganismiMycoplasma pulmonis (strain UAB CTIP)
    Taxonomic identifieri272635 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000528: Chromosome

    Organism-specific databases

    GenoListiMYPU_6890.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Peptide deformylasePRO_0000082804Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272635.MYPU_6890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98PN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243507.
    KOiK01462.
    OMAiPINDMER.
    OrthoDBiEOG6PZXGQ.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98PN3-1 [UniParc]FASTAAdd to Basket

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    MLTMFKVEIV QLPKKVLRQK SKNVNIPLNK TNIELAEKMI YHIDDSQGPN    50
    TKFRPGVGVA AVQYGILKNV FYVCVPNDSR LTQRDSSQEV KPEDKYLFRD 100
    VIFNPEVIWK SDEMVAISQG EGCLSVDESW PNQEGLVRRH MEIKVKGYSY 150
    FQKKEMIWHV KGYVAIVFQH ELDHLNGMLF IDRIDPKRLW DKSGIKVL 198
    Length:198
    Mass (Da):23,040
    Last modified:October 1, 2001 - v1
    Checksum:i1A36853577F91CEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445565 Genomic DNA. Translation: CAC13862.1.
    PIRiA90598.
    RefSeqiNP_326520.1. NC_002771.1.
    WP_010925490.1. NC_002771.1.

    Genome annotation databases

    EnsemblBacteriaiCAC13862; CAC13862; CAC13862.
    GeneIDi911068.
    KEGGimpu:MYPU_6890.
    PATRICi20024332. VBIMycPul29704_0702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445565 Genomic DNA. Translation: CAC13862.1 .
    PIRi A90598.
    RefSeqi NP_326520.1. NC_002771.1.
    WP_010925490.1. NC_002771.1.

    3D structure databases

    ProteinModelPortali Q98PN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272635.MYPU_6890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC13862 ; CAC13862 ; CAC13862 .
    GeneIDi 911068.
    KEGGi mpu:MYPU_6890.
    PATRICi 20024332. VBIMycPul29704_0702.

    Organism-specific databases

    GenoListi MYPU_6890.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243507.
    KOi K01462.
    OMAi PINDMER.
    OrthoDBi EOG6PZXGQ.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UAB CTIP.

    Entry informationi

    Entry nameiDEF_MYCPU
    AccessioniPrimary (citable) accession number: Q98PN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3