Q98PK9 (TRXB_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	MYPU_7130

Organism

Mycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]

Taxonomic identifier

272635 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Thioredoxin reductase		PRO_0000166739
Regions
	Nucleotide binding	36 – 43	8	FAD By similarity
	Nucleotide binding	278 – 287	10	FAD By similarity
Amino acid modifications
	Disulfide bond	138 ↔ 141		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98PK9 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 04A0F5ED4DA28D97	FASTA	307	33,456
	10 20 30 40 50 60 MSQNKIYDVA IIGAGPGALT AAIYTSRGNL DTVFIDNAAP GGKLIYASKI ENWPGDTIVK 70 80 90 100 110 120 GTDLAIRFFE HAQAFGAKYE YGKVVDLINI KDDLKELVLE DGKKIQAKSV IIASGMVSRK 130 140 150 160 170 180 PREILNYDEF ENRGVSYCVI CDGPMYGHNP AIIIGGGNSA VEEGTFLSSI ASKVYVIVRD 190 200 210 220 230 240 SDFIAEKALV NDLKSRKNIE VLFNASVKEL HGKDALEYAI VNHNGKEVKL EVASLFPYIG 250 260 270 280 290 300 FLPSAEYAKN AGVLEPNGFI KTDEFMETKV PGIYAIGDIR IKDIRQILTA TSDGTIAGKI LTNRIKK

References

[1]	"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445565 Genomic DNA. Translation: CAC13886.1.
PIR	A99601.
RefSeq	NP_326544.1. NC_002771.1.
3D structure databases
ProteinModelPortal	Q98PK9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	911034.
GenomeReviews	Gene locus MYPU_7130 in contig AL445566_GR.
KEGG	mpu:MYPU_7130.
PATRIC	20024384. VBIMycPul29704_0728.
Organism-specific databases
GenoList	MYPU_7130.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	AIYARRA.
PhylomeDB	Q98PK9.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_7130-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_MYCPU

Accession

Primary (citable) accession number: Q98PK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program