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Q98PK9 (TRXB_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thioredoxin reductase

Short name=TRXR
EC=1.8.1.9
Gene names
Name:trxB
Ordered Locus Names:MYPU_7130
OrganismMycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]
Taxonomic identifier272635 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond.

Sequence similarities

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

thioredoxin-disulfide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Thioredoxin reductase
PRO_0000166739

Regions

Nucleotide binding36 – 438FAD By similarity
Nucleotide binding278 – 28710FAD By similarity

Amino acid modifications

Disulfide bond138 ↔ 141Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98PK9 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 04A0F5ED4DA28D97

FASTA30733,456
        10         20         30         40         50         60 
MSQNKIYDVA IIGAGPGALT AAIYTSRGNL DTVFIDNAAP GGKLIYASKI ENWPGDTIVK 

        70         80         90        100        110        120 
GTDLAIRFFE HAQAFGAKYE YGKVVDLINI KDDLKELVLE DGKKIQAKSV IIASGMVSRK 

       130        140        150        160        170        180 
PREILNYDEF ENRGVSYCVI CDGPMYGHNP AIIIGGGNSA VEEGTFLSSI ASKVYVIVRD 

       190        200        210        220        230        240 
SDFIAEKALV NDLKSRKNIE VLFNASVKEL HGKDALEYAI VNHNGKEVKL EVASLFPYIG 

       250        260        270        280        290        300 
FLPSAEYAKN AGVLEPNGFI KTDEFMETKV PGIYAIGDIR IKDIRQILTA TSDGTIAGKI 


LTNRIKK 

« Hide

References

[1]"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis."
Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.
Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UAB CTIP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445565 Genomic DNA. Translation: CAC13886.1.
PIRA99601.
RefSeqNP_326544.1. NC_002771.1.

3D structure databases

ProteinModelPortalQ98PK9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID911034.
GenomeReviewsGene locus MYPU_7130 in contig AL445566_GR.
KEGGmpu:MYPU_7130.
PATRIC20024384. VBIMycPul29704_0728.

Organism-specific databases

GenoListMYPU_7130.
CMRSearch...

Phylogenomic databases

HOGENOMHBG669726.
OMAAIYARRA.
PhylomeDBQ98PK9.

Enzyme and pathway databases

BioCycMPUL272635:MYPU_7130-MONOMER.

Family and domain databases

InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR008255. Pyr_nucl-diS_OxRdtase_2_AS.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
KOK00384.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
PROSITEPS00573. PYRIDINE_REDOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRXB_MYCPU
AccessionPrimary (citable) accession number: Q98PK9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families