Q98PG4 (LDH_MYCPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase
Short name=L-LDH
EC=1.1.1.27

Gene names

Name:	ldh
Ordered Locus Names:	MYPU_7590

Organism

Mycoplasma pulmonis (strain UAB CTIP) [Complete proteome] [HAMAP]

Taxonomic identifier

272635 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488
Subunit structure	Homotetramer By similarity. HAMAP MF_00488
Subcellular location	Cytoplasm By similarity HAMAP MF_00488.
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	L-lactate dehydrogenase HAMAP MF_00488		PRO_0000168375
Regions
	Nucleotide binding	10 – 38	29	NAD By similarity
Sites
	Active site	175	1	Proton acceptor By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	120	1	NAD or substrate By similarity
	Binding site	151	1	Substrate By similarity
	Binding site	228	1	Substrate By similarity
Amino acid modifications
	Modified residue	219	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98PG4 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 1C38941D7312EADC	FASTA	315	34,925
	10 20 30 40 50 60 MKKVVLIGTG NVGVTVVYTM ITKGIDAEYV LIDINTEFAK GHAMDMSDAI ALNSTTGSKI 70 80 90 100 110 120 RTGTYADAKG ADLLIVAAGR PQKQGETRLE MIADNSKIMK DIALEIKKSG FNGFTIVISN 130 140 150 160 170 180 PVDILATVFQ KVTNFPKEKV MSSGTFLDTS RFRKFLSEKT GVPTNSVHGF VIGEHGDKSV 190 200 210 220 230 240 VVFSRMQIGF SRLDDFLKSK ALTEDDLKWI SEKTYKEAYE IINRKRSTYF GIGASVAEMA 250 260 270 280 290 300 ESVLYNQRRI FPIGIYLDES KPGGGIYISR PAILGENGWE EVKNYDLSPA EQKAFDESAI 310 NLKKHWDDVQ KEISF

References

[1]	"The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis." Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F., Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A. Nucleic Acids Res. 29:2145-2153(2001) [PubMed: 11353084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UAB CTIP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445565 Genomic DNA. Translation: CAC13932.1.
PIR	G90606.
RefSeq	NP_326590.1. NC_002771.1.
3D structure databases
ProteinModelPortal	Q98PG4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	910987.
GenomeReviews	Gene locus MYPU_7590 in contig AL445566_GR.
KEGG	mpu:MYPU_7590.
PATRIC	20024478. VBIMycPul29704_0775.
Organism-specific databases
GenoList	MYPU_7590.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG566126.
OMA	DINTEFA.
PhylomeDB	Q98PG4.
Enzyme and pathway databases
BioCyc	MPUL272635:MYPU_7590-MONOMER.
Family and domain databases
HAMAP	MF_00488. Lactate_dehydrog. [Tree]
InterPro	IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00016.
PANTHER	PTHR11540:SF3. PTHR11540:SF3. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01771. L-LDH-NAD. 1 hit.
PROSITE	PS00064. L_LDH. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LDH_MYCPU

Accession

Primary (citable) accession number: Q98PG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program