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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateBy similarity1
Binding sitei120NAD or substrateBy similarity1
Binding sitei151SubstrateBy similarity1
Active sitei175Proton acceptorBy similarity1
Binding sitei228SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 38NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.1.27)
Short name:
L-LDH
Gene namesi
Name:ldh
Ordered Locus Names:MYPU_7590
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000528 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683751 – 315L-lactate dehydrogenaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi272635.MYPU_7590.

Structurei

3D structure databases

ProteinModelPortaliQ98PG4.
SMRiQ98PG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00016.
OMAiMDLMQTA.
OrthoDBiPOG091H02EQ.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98PG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVVLIGTG NVGVTVVYTM ITKGIDAEYV LIDINTEFAK GHAMDMSDAI
60 70 80 90 100
ALNSTTGSKI RTGTYADAKG ADLLIVAAGR PQKQGETRLE MIADNSKIMK
110 120 130 140 150
DIALEIKKSG FNGFTIVISN PVDILATVFQ KVTNFPKEKV MSSGTFLDTS
160 170 180 190 200
RFRKFLSEKT GVPTNSVHGF VIGEHGDKSV VVFSRMQIGF SRLDDFLKSK
210 220 230 240 250
ALTEDDLKWI SEKTYKEAYE IINRKRSTYF GIGASVAEMA ESVLYNQRRI
260 270 280 290 300
FPIGIYLDES KPGGGIYISR PAILGENGWE EVKNYDLSPA EQKAFDESAI
310
NLKKHWDDVQ KEISF
Length:315
Mass (Da):34,925
Last modified:October 1, 2001 - v1
Checksum:i1C38941D7312EADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445565 Genomic DNA. Translation: CAC13932.1.
PIRiG90606.
RefSeqiWP_010925559.1. NC_002771.1.

Genome annotation databases

EnsemblBacteriaiCAC13932; CAC13932; CAC13932.
KEGGimpu:MYPU_7590.

Entry informationi

Entry nameiLDH_MYCPU
AccessioniPrimary (citable) accession number: Q98PG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families