Reviewed, UniProtKB/Swiss-Prot Q98NM8 (PUR71_RHILO)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase 1
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase 1

Gene names

Name:	purC1
Synonyms:	purC
Ordered Locus Names:	mll0069

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Phosphoribosylaminoimidazole-succinocarboxamide synthase 1 HAMAP MF_00137		PRO_0000100859

Sequences

	Sequence		Length	Mass (Da)
	Q98NM8-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 09D03A085FFBB8E9	FASTA	264	29,949
	10 20 30 40 50 60 MKNRRRIYEG KAKILYEGPE PGTLIQFFKD DATAFNKKKH EVVDGKGVLN NRISEHIFNH 70 80 90 100 110 120 LNRMGIPTHF IRRLNMREQL IKEVEIIPLE VVVRNVAAGS LSKRLGIEEG TVLPRSIIEF 130 140 150 160 170 180 YYKADALDDP MVSEEHITAF GWASPQEIDD VMALAIRVND FLSGLFMGVG IQLVDFKIEC 190 200 210 220 230 240 GRLFEGDMMR IVVADEISPD SCRLWDVATQ DKLDKDRFRR DMGGLVEAYQ EVARRLGIMN 250 260 ENEPPRPTGP VLVASTDVVK GKPH

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB47733.1.
RefSeq	NP_101947.1.
3D structure databases
SMR	Q98NM8. Positions 1-237.
ModBase	Search...
Genome annotation databases
GeneID	1224610.
GenomeReviews	Gene locus mll0069 in contig BA000012_GR.
KEGG	mlo:mll0069.
NMPDR	fig|266835.1.peg.52.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG306070.
OMA	TAFNAQK.
Enzyme and pathway databases
BRENDA	6.3.2.6. 3315.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR71_RHILO

Accession

Primary (citable) accession number: Q98NM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	October 1, 2001
Last modified:	February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)