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Q98NJ1 (UPPP2_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:mlr0116
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000151186

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane243 – 26321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q98NJ1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: E85B086E1FDE6453

FASTA26428,109
        10         20         30         40         50         60 
MQGITELLPI SSTAHMRIVP ALLGWQDPGS AFSAAMQLAA LAAVISYFWG DVRDLLFGSL 

        70         80         90        100        110        120 
DALTRRDFSD RHFRLASWIV LATIPIVIAG VALSGVLNAC NSPLRSLTVI GWSCIAMAIL 

       130        140        150        160        170        180 
LALAEIFARH KRTIAEASLA DALLVGVAQI GALIPGVSRS GSTLTAALGL GFKRAEAARF 

       190        200        210        220        230        240 
SFLLGLPAIA LAGLKELWEL HKVHLDAHGW SVLATGLVVA SISAFFAIWG LMRVLERFSA 

       250        260 
WPFVIYRGLL GVVLLLGLAM GWLA 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB47770.1.
RefSeqNP_101984.1. NC_002678.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mlr0116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB47770; BAB47770; BAB47770.
GeneID1224647.
KEGGmlo:mlr0116.
PATRIC22474328. VBIMesLot2464_0091.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAWFAAYR.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-89-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP2_RHILO
AccessionPrimary (citable) accession number: Q98NJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families