Reviewed, UniProtKB/Swiss-Prot Q98NJ1 (UPPP2_RHILO)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	mlr0116

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000151186
Regions
	Transmembrane	29 – 49	21	Potential
	Transmembrane	77 – 97	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	137 – 157	21	Potential
	Transmembrane	180 – 200	21	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	243 – 263	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q98NJ1-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: E85B086E1FDE6453	FASTA	264	28,109
	10 20 30 40 50 60 MQGITELLPI SSTAHMRIVP ALLGWQDPGS AFSAAMQLAA LAAVISYFWG DVRDLLFGSL 70 80 90 100 110 120 DALTRRDFSD RHFRLASWIV LATIPIVIAG VALSGVLNAC NSPLRSLTVI GWSCIAMAIL 130 140 150 160 170 180 LALAEIFARH KRTIAEASLA DALLVGVAQI GALIPGVSRS GSTLTAALGL GFKRAEAARF 190 200 210 220 230 240 SFLLGLPAIA LAGLKELWEL HKVHLDAHGW SVLATGLVVA SISAFFAIWG LMRVLERFSA 250 260 WPFVIYRGLL GVVLLLGLAM GWLA

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB47770.1.
RefSeq	NP_101984.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1224647.
GenomeReviews	Gene locus mlr0116 in contig BA000012_GR.
KEGG	mlo:mlr0116.
NMPDR	fig|266835.1.peg.89.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q98NJ1.
OMA	FTRYSSS.
Enzyme and pathway databases
BRENDA	3.6.1.27. 3315.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP2_RHILO

Accession

Primary (citable) accession number: Q98NJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)