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Q98NJ1

- UPPP2_RHILO

UniProt

Q98NJ1 - UPPP2_RHILO

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-89-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Synonyms:bacA2, upk2
    Ordered Locus Names:mlr0116
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Undecaprenyl-diphosphatase 2PRO_0000151186Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mlr0116.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalUniRule annotationAdd
    BLAST
    Transmembranei77 – 9721HelicalUniRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalUniRule annotationAdd
    BLAST
    Transmembranei137 – 15721HelicalUniRule annotationAdd
    BLAST
    Transmembranei180 – 20021HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiSDIMRIA.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q98NJ1-1 [UniParc]FASTAAdd to Basket

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    MQGITELLPI SSTAHMRIVP ALLGWQDPGS AFSAAMQLAA LAAVISYFWG    50
    DVRDLLFGSL DALTRRDFSD RHFRLASWIV LATIPIVIAG VALSGVLNAC 100
    NSPLRSLTVI GWSCIAMAIL LALAEIFARH KRTIAEASLA DALLVGVAQI 150
    GALIPGVSRS GSTLTAALGL GFKRAEAARF SFLLGLPAIA LAGLKELWEL 200
    HKVHLDAHGW SVLATGLVVA SISAFFAIWG LMRVLERFSA WPFVIYRGLL 250
    GVVLLLGLAM GWLA 264
    Length:264
    Mass (Da):28,109
    Last modified:October 1, 2001 - v1
    Checksum:iE85B086E1FDE6453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB47770.1.
    RefSeqiNP_101984.1. NC_002678.2.
    WP_010909140.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB47770; BAB47770; BAB47770.
    GeneIDi1224647.
    KEGGimlo:mlr0116.
    PATRICi22474328. VBIMesLot2464_0091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB47770.1 .
    RefSeqi NP_101984.1. NC_002678.2.
    WP_010909140.1. NC_002678.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mlr0116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB47770 ; BAB47770 ; BAB47770 .
    GeneIDi 1224647.
    KEGGi mlo:mlr0116.
    PATRICi 22474328. VBIMesLot2464_0091.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi SDIMRIA.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci MLOT266835:GJ9L-89-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiUPPP2_RHILO
    AccessioniPrimary (citable) accession number: Q98NJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3