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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Synonyms:bacA2, upk2
Ordered Locus Names:mlr0116
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei107 – 127HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei180 – 200HelicalUniRule annotationAdd BLAST21
Transmembranei212 – 232HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511861 – 264Undecaprenyl-diphosphatase 2Add BLAST264

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr0116.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFVCAYLA.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98NJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGITELLPI SSTAHMRIVP ALLGWQDPGS AFSAAMQLAA LAAVISYFWG
60 70 80 90 100
DVRDLLFGSL DALTRRDFSD RHFRLASWIV LATIPIVIAG VALSGVLNAC
110 120 130 140 150
NSPLRSLTVI GWSCIAMAIL LALAEIFARH KRTIAEASLA DALLVGVAQI
160 170 180 190 200
GALIPGVSRS GSTLTAALGL GFKRAEAARF SFLLGLPAIA LAGLKELWEL
210 220 230 240 250
HKVHLDAHGW SVLATGLVVA SISAFFAIWG LMRVLERFSA WPFVIYRGLL
260
GVVLLLGLAM GWLA
Length:264
Mass (Da):28,109
Last modified:October 1, 2001 - v1
Checksum:iE85B086E1FDE6453
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB47770.1.

Genome annotation databases

EnsemblBacteriaiBAB47770; BAB47770; BAB47770.
KEGGimlo:mlr0116.
PATRICi22474328. VBIMesLot2464_0091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB47770.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr0116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB47770; BAB47770; BAB47770.
KEGGimlo:mlr0116.
PATRICi22474328. VBIMesLot2464_0091.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFVCAYLA.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP2_RHILO
AccessioniPrimary (citable) accession number: Q98NJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.