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Protein

Pantothenate synthetase

Gene

panC

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton donorUniRule annotation1
Binding sitei64Beta-alanineUniRule annotation1
Binding sitei64PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1
Binding sitei179ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-151-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:mll0196
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001282611 – 283Pantothenate synthetaseAdd BLAST283

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll0196

Structurei

3D structure databases

ProteinModelPortaliQ98ND0
SMRiQ98ND0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03 Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q98ND0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPEVVNSV AALRAQVSDW RRDGLRVAMV PTMGALHEGH LSLIRIAREK
60 70 80 90 100
AERCVVSIFV NPTQFAPSED LDKYPRQLAR DLDLLARVKA DLAFTPTVGA
110 120 130 140 150
MYPAGFATRI SVGGPSAGLE SDFRPTFFEG VATVVAKLFL QATPDCAVFG
160 170 180 190 200
EKDYQQLCVV RQLCRDLDLP VEIIGAPTIR DAHGLAMSSR NAYLDEAELA
210 220 230 240 250
VARRLNVILH KAAAALAAGT HQDDATGEAN RALIAAGFQK IDYVEARESL
260 270 280
TLAPWRRDRA GRVLAAAWLG KTRLIDNVDV PVA
Length:283
Mass (Da):30,756
Last modified:October 1, 2001 - v1
Checksum:i619B61AB91F3EF83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB47831.1
RefSeqiWP_010909201.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB47831; BAB47831; BAB47831
KEGGimlo:mll0196
PATRICifig|266835.9.peg.152

Similar proteinsi

Entry informationi

Entry nameiPANC_RHILO
AccessioniPrimary (citable) accession number: Q98ND0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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