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Q98NA6

- NADK_RHILO

UniProt

Q98NA6 - NADK_RHILO

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Protein
NAD kinase
Gene
nadK, mll0225
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptor By similarity
Binding sitei146 – 1461NAD By similarity
Binding sitei154 – 1541NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 472NAD By similarity
Nucleotide bindingi116 – 1172NAD By similarity
Nucleotide bindingi157 – 1626NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:mll0225
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257NAD kinaseUniRule annotation
PRO_0000120650Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll0225.

Structurei

3D structure databases

ProteinModelPortaliQ98NA6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98NA6-1 [UniParc]FASTAAdd to Basket

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MSTAANSIAF VSSDTADAKA ALESLSARYG QCSVAEAVVV VALGGDGFLL    50
QTLRDTMGTG KKVYGMNRGT IGFLMNEYRS GGLTERIAAA VAETIRPLEM 100
LAVTSEGETV SALAINEVAL WRQSYQTAKI RISVDDQIRL EELSCDGVMI 150
ATPAGSTAYN LSAHGPILPL DAPLLALTPV SPFRPRRWRG ALLSNKATVR 200
FDILEPEKRP VNAAADHTEV KAVTSVTVRE SPTATATLLF DPNHSWNERI 250
LAEQFRY 257
Length:257
Mass (Da):27,670
Last modified:October 25, 2002 - v2
Checksum:i38F69D1E41A30986
GO

Sequence cautioni

The sequence BAB47855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB47855.1. Different initiation.
RefSeqiNP_102069.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB47855; BAB47855; BAB47855.
GeneIDi1224732.
KEGGimlo:mll0225.
PATRICi22474496. VBIMesLot2464_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB47855.1 . Different initiation.
RefSeqi NP_102069.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q98NA6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266835.mll0225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB47855 ; BAB47855 ; BAB47855 .
GeneIDi 1224732.
KEGGi mlo:mll0225.
PATRICi 22474496. VBIMesLot2464_0174.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci MLOT266835:GJ9L-175-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiNADK_RHILO
AccessioniPrimary (citable) accession number: Q98NA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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