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Q98NA6

- NADK_RHILO

UniProt

Q98NA6 - NADK_RHILO

Protein

NAD kinase

Gene

nadK

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptorUniRule annotation
    Binding sitei146 – 1461NADUniRule annotation
    Binding sitei154 – 1541NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 472NADUniRule annotation
    Nucleotide bindingi116 – 1172NADUniRule annotation
    Nucleotide bindingi157 – 1626NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-175-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:mll0225
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257NAD kinasePRO_0000120650Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll0225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98NA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000139847.
    KOiK00858.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98NA6-1 [UniParc]FASTAAdd to Basket

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    MSTAANSIAF VSSDTADAKA ALESLSARYG QCSVAEAVVV VALGGDGFLL    50
    QTLRDTMGTG KKVYGMNRGT IGFLMNEYRS GGLTERIAAA VAETIRPLEM 100
    LAVTSEGETV SALAINEVAL WRQSYQTAKI RISVDDQIRL EELSCDGVMI 150
    ATPAGSTAYN LSAHGPILPL DAPLLALTPV SPFRPRRWRG ALLSNKATVR 200
    FDILEPEKRP VNAAADHTEV KAVTSVTVRE SPTATATLLF DPNHSWNERI 250
    LAEQFRY 257
    Length:257
    Mass (Da):27,670
    Last modified:October 25, 2002 - v2
    Checksum:i38F69D1E41A30986
    GO

    Sequence cautioni

    The sequence BAB47855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB47855.1. Different initiation.
    RefSeqiNP_102069.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB47855; BAB47855; BAB47855.
    GeneIDi1224732.
    KEGGimlo:mll0225.
    PATRICi22474496. VBIMesLot2464_0174.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB47855.1 . Different initiation.
    RefSeqi NP_102069.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98NA6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll0225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB47855 ; BAB47855 ; BAB47855 .
    GeneIDi 1224732.
    KEGGi mlo:mll0225.
    PATRICi 22474496. VBIMesLot2464_0174.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000139847.
    KOi K00858.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci MLOT266835:GJ9L-175-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiNADK_RHILO
    AccessioniPrimary (citable) accession number: Q98NA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3