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Protein

NAD kinase

Gene

nadK

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46Proton acceptorUniRule annotation1
Binding sitei146NADUniRule annotation1
Binding sitei154NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 47NADUniRule annotation2
Nucleotide bindingi116 – 117NADUniRule annotation2
Nucleotide bindingi157 – 162NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-173-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:mll0225
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206501 – 257NAD kinaseAdd BLAST257

Interactioni

Protein-protein interaction databases

STRINGi266835.mll0225

Structurei

3D structure databases

ProteinModelPortaliQ98NA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000139847
KOiK00858
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q98NA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAANSIAF VSSDTADAKA ALESLSARYG QCSVAEAVVV VALGGDGFLL
60 70 80 90 100
QTLRDTMGTG KKVYGMNRGT IGFLMNEYRS GGLTERIAAA VAETIRPLEM
110 120 130 140 150
LAVTSEGETV SALAINEVAL WRQSYQTAKI RISVDDQIRL EELSCDGVMI
160 170 180 190 200
ATPAGSTAYN LSAHGPILPL DAPLLALTPV SPFRPRRWRG ALLSNKATVR
210 220 230 240 250
FDILEPEKRP VNAAADHTEV KAVTSVTVRE SPTATATLLF DPNHSWNERI

LAEQFRY
Length:257
Mass (Da):27,670
Last modified:October 25, 2002 - v2
Checksum:i38F69D1E41A30986
GO

Sequence cautioni

The sequence BAB47855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB47855.1 Different initiation.
RefSeqiWP_044547489.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB47855; BAB47855; BAB47855
KEGGimlo:mll0225
PATRICifig|266835.9.peg.174

Similar proteinsi

Entry informationi

Entry nameiNADK_RHILO
AccessioniPrimary (citable) accession number: Q98NA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: May 23, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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