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Q98MN3 (PCS_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylcholine synthase

Short name=PC synthase
Short name=PCS
EC=2.7.8.24
Alternative name(s):
CDP-diglyceride-choline O-phosphatidyltransferase
Gene names
Name:pcs
Ordered Locus Names:mll0506
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP. Ref.2

Catalytic activity

CDP-diacylglycerol + choline = CMP + phosphatidylcholine. Ref.2

Cofactor

Manganese By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Phosphatidylcholine synthase
PRO_0000056811

Regions

Topological domain1 – 2727Cytoplasmic By similarity
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 535Periplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 8814Cytoplasmic Potential
Transmembrane89 – 10921Helical; Name=3; Potential
Topological domain110 – 1123Periplasmic Potential
Transmembrane113 – 13321Helical; Name=4; Potential
Topological domain134 – 14512Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=5; Potential
Topological domain167 – 1682Periplasmic Potential
Transmembrane169 – 18921Helical; Name=6; Potential
Topological domain190 – 20314Cytoplasmic Potential
Transmembrane204 – 22421Helical; Name=7; Potential
Topological domain225 – 24016Periplasmic Potential
Transmembrane241 – 26121Helical; Name=8; Potential
Topological domain262 – 2687Cytoplasmic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98MN3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: E2C115F15F453A20

FASTA26829,526
        10         20         30         40         50         60 
MAARKAAKKL TDRIPRPKKK VTWPQARAFS VHLLTASGSF LAFLSLVAAS EERWTAMFWW 

        70         80         90        100        110        120 
LGLALFVDGI DGPIARKLEV KEILPTWSGE LLDNIIDYVT YVLIPAFALY QRGFMGEGLS 

       130        140        150        160        170        180 
FLSAAIIVVS SAIYYADTGM KTKENFFKGF PVVWNMVVFT LFVIEPGQWV SFAVVVVAGI 

       190        200        210        220        230        240 
LTFVPINFIH PVRVVRLRPF NLTMTLLWCA FGALALAQAA LAAFYDQIGV LGAQVSTFIK 

       250        260 
IGITITGLYL ACIGGIMQFF PNLGAKKA 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.
[2]"Pathways for phosphatidylcholine biosynthesis in bacteria."
Martinez-Morales F., Schobert M., Lopez-Lara I.M., Geiger O.
Microbiology 149:3461-3471(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB48080.1.
RefSeqNP_102294.1. NC_002678.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mll0506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB48080; BAB48080; BAB48080.
GeneID1224957.
KEGGmlo:mll0506.
PATRIC22474972. VBIMesLot2464_0407.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1183.
HOGENOMHOG000066428.
KOK01004.
OMAFLHPFRV.
OrthoDBEOG6P5ZJN.
ProtClustDBCLSK863002.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-405-MONOMER.

Family and domain databases

InterProIPR000462. CDP-OH_P_trans.
IPR026027. PcS.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000851. PcS. 1 hit.
ProtoNetSearch...

Entry information

Entry namePCS_RHILO
AccessionPrimary (citable) accession number: Q98MN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families