Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylcholine synthase

Gene

pcs

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.1 Publication

Catalytic activityi

CDP-diacylglycerol + choline = CMP + phosphatidylcholine.1 Publication

Cofactori

Mn2+By similarity

GO - Molecular functioni

  1. phosphatidylcholine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-405-MONOMER.
RETL1328306-WGS:GSTH-2087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine synthase (EC:2.7.8.24)
Short name:
PC synthase
Short name:
PCS
Alternative name(s):
CDP-diglyceride-choline O-phosphatidyltransferase
Gene namesi
Name:pcs
Ordered Locus Names:mll0506
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicBy similarityAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 535PeriplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 8814CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini110 – 1123PeriplasmicSequence Analysis
Transmembranei113 – 13321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini134 – 14512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini167 – 1682PeriplasmicSequence Analysis
Transmembranei169 – 18921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini190 – 20314CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini225 – 24016PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini262 – 2687CytoplasmicBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Phosphatidylcholine synthasePRO_0000056811Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll0506.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1183.
HOGENOMiHOG000066428.
KOiK01004.
OMAiFLHPFRV.
OrthoDBiEOG6P5ZJN.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR026027. PcS.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000851. PcS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98MN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARKAAKKL TDRIPRPKKK VTWPQARAFS VHLLTASGSF LAFLSLVAAS
60 70 80 90 100
EERWTAMFWW LGLALFVDGI DGPIARKLEV KEILPTWSGE LLDNIIDYVT
110 120 130 140 150
YVLIPAFALY QRGFMGEGLS FLSAAIIVVS SAIYYADTGM KTKENFFKGF
160 170 180 190 200
PVVWNMVVFT LFVIEPGQWV SFAVVVVAGI LTFVPINFIH PVRVVRLRPF
210 220 230 240 250
NLTMTLLWCA FGALALAQAA LAAFYDQIGV LGAQVSTFIK IGITITGLYL
260
ACIGGIMQFF PNLGAKKA
Length:268
Mass (Da):29,526
Last modified:October 1, 2001 - v1
Checksum:iE2C115F15F453A20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48080.1.
RefSeqiNP_102294.1. NC_002678.2.
WP_010909436.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB48080; BAB48080; BAB48080.
GeneIDi1224957.
KEGGimlo:mll0506.
PATRICi22474972. VBIMesLot2464_0407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48080.1.
RefSeqiNP_102294.1. NC_002678.2.
WP_010909436.1. NC_002678.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll0506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB48080; BAB48080; BAB48080.
GeneIDi1224957.
KEGGimlo:mll0506.
PATRICi22474972. VBIMesLot2464_0407.

Phylogenomic databases

eggNOGiCOG1183.
HOGENOMiHOG000066428.
KOiK01004.
OMAiFLHPFRV.
OrthoDBiEOG6P5ZJN.

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-405-MONOMER.
RETL1328306-WGS:GSTH-2087-MONOMER.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR026027. PcS.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000851. PcS. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.
  2. "Pathways for phosphatidylcholine biosynthesis in bacteria."
    Martinez-Morales F., Schobert M., Lopez-Lara I.M., Geiger O.
    Microbiology 149:3461-3471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
    Strain: MAFF303099.

Entry informationi

Entry nameiPCS_RHILO
AccessioniPrimary (citable) accession number: Q98MN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2001
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.