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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileUniRule annotation
Metal bindingi9 – 91MagnesiumUniRule annotation
Metal bindingi11 – 111MagnesiumUniRule annotation
Metal bindingi171 – 1711MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-420-MONOMER.
UniPathwayiUPA00865; UER00834.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:mlr0528
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Phosphoglycolate phosphatasePRO_0000108037Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr0528.

Structurei

3D structure databases

ProteinModelPortaliQ98ML8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiCTNKLTH.
OrthoDBiPOG091H010N.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98ML8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPIIVFDL DGTLIDTAPD LLDSLNHSLA ASELTAVDEA GFRRFVGHGG
60 70 80 90 100
RVMIERAHAA QQRSLDVAEH DRLLKLFLDH YTDNIPGKSR PYPGVIEAIA
110 120 130 140 150
RFEKAGYLLA ICTNKYEANS LALIEALGLT RHFAAIAGQD TFAFRKPDPR
160 170 180 190 200
HLTETIRLAG GDAHRALMVG DSQTDIDTAK AAGIPVVAVD FGYTDRHVRE
210 220
FEPSAVISHF DALTVELAER LIRAAGH
Length:227
Mass (Da):24,821
Last modified:October 1, 2001 - v1
Checksum:i16E0FD3B8A359C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48095.1.
RefSeqiWP_010909451.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB48095; BAB48095; BAB48095.
GeneIDi1224972.
KEGGimlo:mlr0528.
PATRICi22475004. VBIMesLot2464_0423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48095.1.
RefSeqiWP_010909451.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98ML8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr0528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB48095; BAB48095; BAB48095.
GeneIDi1224972.
KEGGimlo:mlr0528.
PATRICi22475004. VBIMesLot2464_0423.

Phylogenomic databases

eggNOGiENOG4108VXP. Bacteria.
COG0546. LUCA.
HOGENOMiHOG000248344.
KOiK01091.
OMAiCTNKLTH.
OrthoDBiPOG091H010N.

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834.
BioCyciMLOT266835:GJ9L-420-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_00495. GPH_hydrolase_bact. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR006346. PGP_bact.
IPR023198. PGP_dom2.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01449. PGP_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPH_RHILO
AccessioniPrimary (citable) accession number: Q98ML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.