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Protein

Phosphoglycolate phosphatase

Gene

gph

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.UniRule annotation

Catalytic activityi

2-phosphoglycolate + H2O = glycolate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycolate from 2-phosphoglycolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoglycolate phosphatase (gph)
This subpathway is part of the pathway glycolate biosynthesis, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycolate from 2-phosphoglycolate, the pathway glycolate biosynthesis and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9NucleophileUniRule annotation1
Metal bindingi9MagnesiumUniRule annotation1
Metal bindingi11MagnesiumUniRule annotation1
Metal bindingi171MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00865; UER00834

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycolate phosphataseUniRule annotation (EC:3.1.3.18UniRule annotation)
Short name:
PGPUniRule annotation
Short name:
PGPaseUniRule annotation
Gene namesi
Name:gphUniRule annotation
Ordered Locus Names:mlr0528
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001080371 – 227Phosphoglycolate phosphataseAdd BLAST227

Proteomic databases

PRIDEiQ98ML8

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr0528

Structurei

3D structure databases

ProteinModelPortaliQ98ML8
SMRiQ98ML8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VXP Bacteria
COG0546 LUCA
HOGENOMiHOG000248344
KOiK01091
OMAiYLCGKFG
OrthoDBiPOG091H010N

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
HAMAPiMF_00495 GPH_hydrolase_bact, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
IPR006346 PGPase/MupP
IPR037512 PGPase_prok
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01549 HAD-SF-IA-v1, 1 hit
TIGR01509 HAD-SF-IA-v3, 1 hit
TIGR01449 PGP_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q98ML8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPIIVFDL DGTLIDTAPD LLDSLNHSLA ASELTAVDEA GFRRFVGHGG
60 70 80 90 100
RVMIERAHAA QQRSLDVAEH DRLLKLFLDH YTDNIPGKSR PYPGVIEAIA
110 120 130 140 150
RFEKAGYLLA ICTNKYEANS LALIEALGLT RHFAAIAGQD TFAFRKPDPR
160 170 180 190 200
HLTETIRLAG GDAHRALMVG DSQTDIDTAK AAGIPVVAVD FGYTDRHVRE
210 220
FEPSAVISHF DALTVELAER LIRAAGH
Length:227
Mass (Da):24,821
Last modified:October 1, 2001 - v1
Checksum:i16E0FD3B8A359C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48095.1
RefSeqiWP_010909451.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB48095; BAB48095; BAB48095
KEGGimlo:mlr0528

Similar proteinsi

Entry informationi

Entry nameiGPH_RHILO
AccessioniPrimary (citable) accession number: Q98ML8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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