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Protein

Kynureninase

Gene

kynU

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei101 – 1011Pyridoxal phosphateUniRule annotation
Binding sitei200 – 2001Pyridoxal phosphateUniRule annotation
Binding sitei203 – 2031Pyridoxal phosphateUniRule annotation
Binding sitei225 – 2251Pyridoxal phosphateUniRule annotation
Binding sitei255 – 2551Pyridoxal phosphateUniRule annotation
Binding sitei281 – 2811Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-502-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:mll0621Imported
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)Imported
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll0621.

Structurei

3D structure databases

ProteinModelPortaliQ98MD7.
SMRiQ98MD7. Positions 11-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1314Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98MD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPLDLAAV EALDAADPLR AMRDRFILPE GVIYLDGNSL GAAAPAVFNE
60 70 80 90 100
LQKAATQEWA QDLIRAWNTA SWFDMPVALG DQLGRLIGAV SGQTVVCDTT
110 120 130 140 150
SINIYKVLHA ALGMRPNRSV IVAEGDSFPT DLYMAEGVAS TRPGTVLRLE
160 170 180 190 200
GVDAPTIEEL IDERVAVILV NHVNYKTGQL RDMAALTCKA HQVGALIVWD
210 220 230 240 250
LCHTAGALPV ELDAANADFA IGCTYKYLNG GPGAPAFIYA AKRHHEDVHQ
260 270 280 290 300
PLSGWWGHAR PFAFEQSYTA GSGIRRFLCG TQPVLSMRAL KGALDIWDDV
310 320 330 340 350
DMAAVRKKSI GLTDLFIQLV EARCGAYGLE LEGPRDGNAR GSQVSFLHPH
360 370 380 390 400
GYQVMRALIE RGVIGDFRAP STIRFGFTPL YVGYKDVWQA VEVLEDILRT
410
GAWQEARFAV KTAVT
Length:415
Mass (Da):45,163
Last modified:October 1, 2001 - v1
Checksum:i80E85E9CA323E039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48176.1.
RefSeqiNP_102390.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB48176; BAB48176; BAB48176.
GeneIDi1225053.
KEGGimlo:mll0621.
PATRICi22475156. VBIMesLot2464_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA. Translation: BAB48176.1.
RefSeqiNP_102390.1. NC_002678.2.

3D structure databases

ProteinModelPortaliQ98MD7.
SMRiQ98MD7. Positions 11-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll0621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB48176; BAB48176; BAB48176.
GeneIDi1225053.
KEGGimlo:mll0621.
PATRICi22475156. VBIMesLot2464_0498.

Phylogenomic databases

HOGENOMiHOG000242437.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.
BioCyciMLOT266835:GJ9L-502-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099Imported.

Entry informationi

Entry nameiQ98MD7_RHILO
AccessioniPrimary (citable) accession number: Q98MD7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.