Q98MD7 (Q98MD7_RHILO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

mll0621

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800 EMBL BAB48176.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q98MD7 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 80E85E9CA323E039	FASTA	415	45,163
	10 20 30 40 50 60 MRAPLDLAAV EALDAADPLR AMRDRFILPE GVIYLDGNSL GAAAPAVFNE LQKAATQEWA 70 80 90 100 110 120 QDLIRAWNTA SWFDMPVALG DQLGRLIGAV SGQTVVCDTT SINIYKVLHA ALGMRPNRSV 130 140 150 160 170 180 IVAEGDSFPT DLYMAEGVAS TRPGTVLRLE GVDAPTIEEL IDERVAVILV NHVNYKTGQL 190 200 210 220 230 240 RDMAALTCKA HQVGALIVWD LCHTAGALPV ELDAANADFA IGCTYKYLNG GPGAPAFIYA 250 260 270 280 290 300 AKRHHEDVHQ PLSGWWGHAR PFAFEQSYTA GSGIRRFLCG TQPVLSMRAL KGALDIWDDV 310 320 330 340 350 360 DMAAVRKKSI GLTDLFIQLV EARCGAYGLE LEGPRDGNAR GSQVSFLHPH GYQVMRALIE 370 380 390 400 410 RGVIGDFRAP STIRFGFTPL YVGYKDVWQA VEVLEDILRT GAWQEARFAV KTAVT

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB48176.1.
RefSeq	NP_102390.1. NC_002678.2.
3D structure databases
ProteinModelPortal	Q98MD7.
SMR	Q98MD7. Positions 11-403.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1225053.
GenomeReviews	Gene locus mll0621 in contig BA000012_GR.
KEGG	mlo:mll0621.
NMPDR	fig|266835.1.peg.495.
PATRIC	22475156. VBIMesLot2464_0498.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG523016.
OMA	RGSQVSF.
ProtClustDB	CLSK542366.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. Kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q98MD7_RHILO

Accession

Primary (citable) accession number: Q98MD7

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2001
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)