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Q98MD7

- Q98MD7_RHILO

UniProt

Q98MD7 - Q98MD7_RHILO

Protein

Kynureninase

Gene

kynU

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei101 – 1011Pyridoxal phosphateUniRule annotation
    Binding sitei200 – 2001Pyridoxal phosphateUniRule annotation
    Binding sitei203 – 2031Pyridoxal phosphateUniRule annotation
    Binding sitei225 – 2251Pyridoxal phosphateUniRule annotation
    Binding sitei255 – 2551Pyridoxal phosphateUniRule annotation
    Binding sitei281 – 2811Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-502-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:mll0621Imported
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)Imported
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266835.mll0621.

    Structurei

    3D structure databases

    ProteinModelPortaliQ98MD7.
    SMRiQ98MD7. Positions 11-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 1314Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiVWDLAHS.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98MD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAPLDLAAV EALDAADPLR AMRDRFILPE GVIYLDGNSL GAAAPAVFNE    50
    LQKAATQEWA QDLIRAWNTA SWFDMPVALG DQLGRLIGAV SGQTVVCDTT 100
    SINIYKVLHA ALGMRPNRSV IVAEGDSFPT DLYMAEGVAS TRPGTVLRLE 150
    GVDAPTIEEL IDERVAVILV NHVNYKTGQL RDMAALTCKA HQVGALIVWD 200
    LCHTAGALPV ELDAANADFA IGCTYKYLNG GPGAPAFIYA AKRHHEDVHQ 250
    PLSGWWGHAR PFAFEQSYTA GSGIRRFLCG TQPVLSMRAL KGALDIWDDV 300
    DMAAVRKKSI GLTDLFIQLV EARCGAYGLE LEGPRDGNAR GSQVSFLHPH 350
    GYQVMRALIE RGVIGDFRAP STIRFGFTPL YVGYKDVWQA VEVLEDILRT 400
    GAWQEARFAV KTAVT 415
    Length:415
    Mass (Da):45,163
    Last modified:October 1, 2001 - v1
    Checksum:i80E85E9CA323E039
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB48176.1.
    RefSeqiNP_102390.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB48176; BAB48176; BAB48176.
    GeneIDi1225053.
    KEGGimlo:mll0621.
    PATRICi22475156. VBIMesLot2464_0498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB48176.1 .
    RefSeqi NP_102390.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q98MD7.
    SMRi Q98MD7. Positions 11-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll0621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB48176 ; BAB48176 ; BAB48176 .
    GeneIDi 1225053.
    KEGGi mlo:mll0621.
    PATRICi 22475156. VBIMesLot2464_0498.

    Phylogenomic databases

    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi VWDLAHS.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci MLOT266835:GJ9L-502-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099Imported.

    Entry informationi

    Entry nameiQ98MD7_RHILO
    AccessioniPrimary (citable) accession number: Q98MD7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2001
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3