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Protein

Kynureninase

Gene

kynU

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei101Pyridoxal phosphateUniRule annotation1
Binding sitei200Pyridoxal phosphateUniRule annotation1
Binding sitei203Pyridoxal phosphateUniRule annotation1
Binding sitei225Pyridoxal phosphateUniRule annotation1
Binding sitei255Pyridoxal phosphateUniRule annotation1
Binding sitei281Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-512-MONOMER
UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:mll0621Imported
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))Imported
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll0621

Structurei

3D structure databases

ProteinModelPortaliQ98MD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 363Aminotran_5InterPro annotationAdd BLAST280

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 131Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKY Bacteria
COG3844 LUCA
HOGENOMiHOG000242437
KOiK01556
OMAiVCSLHAS
OrthoDBiPOG091H0D63

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

Q98MD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPLDLAAV EALDAADPLR AMRDRFILPE GVIYLDGNSL GAAAPAVFNE
60 70 80 90 100
LQKAATQEWA QDLIRAWNTA SWFDMPVALG DQLGRLIGAV SGQTVVCDTT
110 120 130 140 150
SINIYKVLHA ALGMRPNRSV IVAEGDSFPT DLYMAEGVAS TRPGTVLRLE
160 170 180 190 200
GVDAPTIEEL IDERVAVILV NHVNYKTGQL RDMAALTCKA HQVGALIVWD
210 220 230 240 250
LCHTAGALPV ELDAANADFA IGCTYKYLNG GPGAPAFIYA AKRHHEDVHQ
260 270 280 290 300
PLSGWWGHAR PFAFEQSYTA GSGIRRFLCG TQPVLSMRAL KGALDIWDDV
310 320 330 340 350
DMAAVRKKSI GLTDLFIQLV EARCGAYGLE LEGPRDGNAR GSQVSFLHPH
360 370 380 390 400
GYQVMRALIE RGVIGDFRAP STIRFGFTPL YVGYKDVWQA VEVLEDILRT
410
GAWQEARFAV KTAVT
Length:415
Mass (Da):45,163
Last modified:October 1, 2001 - v1
Checksum:i80E85E9CA323E039
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB48176.1
RefSeqiWP_010909531.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB48176; BAB48176; BAB48176
KEGGimlo:mll0621
PATRICifig|266835.9.peg.498

Similar proteinsi

Entry informationi

Entry nameiQ98MD7_RHILO
AccessioniPrimary (citable) accession number: Q98MD7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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